HYPERION DEFI, INC. 10-Q

Item 5. Other Information. Securities Trading Plans of Directors and Executive Officers During the three months ended March 31, 2025, none of our directors or officers, or the Company, adopted or terminated any contract , instruction or written plan for the purchase or sale of our securities that was intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) promulgated under the Exchange Act or any “non-Rule 10b5-1 trading arrangement.” ​ 23 Table of Contents Item 6. Exhibits. ​ Exhibit Incorporated by Reference from Filings as Noted Below (Unless Otherwise Indicated) Number Exhibit Description Form File No. Exhibit Filing Date 3.1 Third Amended and Restated Certificate of Incorporation 8-K 001-38365 3.1 January 29, 2018 3.1.1 Certificate of Amendment to the Third Amended and Restated Certificate of Incorporation 8-K 001-38365 3.1.1 June 14, 2018 3.1.2 Certificate of Amendment to the Third Amended and Restated Certificate of Incorporation 8-K 001-38365 3.1 June 14, 2024 3.1.3 ​ Certificate of Amendment to the Third Amended and Restated Certificate of Incorporation ​ 8-K ​ 001-38365 ​ 3.1 ​ January 31, 2025 3.2 ​ Second Amended and Restated Bylaws ​ 8-K ​ 001-38365 ​ 3.1 ​ February 7, 2022 4.8 ​ Form of Series A Warrant Issued on January 17, 2025 ​ 8-K ​ 001-38365 ​ 4.1 ​ January 16, 2025 4.9 ​ Form of Series B Warrant Issued on January 17, 2025 ​ 8-K ​ 001-38365 ​ 4.2 ​ January 16, 2025 10.1 Inducement Letter, dated January 16, 2025 10-K 001-38365 10.26 April 15, 2025 10.2 Second Amendment to Supplement to Loan and Security Agreement, dated as of February 21, 2025, by and among the Company, Avenue Capital Management II, L.P., Avenue Venture Opportunities Fund, L.P. and Avenue Venture Opportunities Fund II, L.P. 8-K 001-38365 10.1 February 24, 2025 31.1 Certification of the Principal Executive Officer and Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 — — — Filed herewith 32.1* Certification of the Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 — — — Filed herewith 32.2* Certification of the Principal Financial Officer pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 — — — Filed herewith 101.INS ​ Inline XBRL Instance Document ​ — ​ — ​ — ​ Filed herewith 101.SCH ​ Inline XBRL Taxonomy Extension Schema Document ​ — ​ — ​ — ​ Filed herewith 101.CAL ​ Inline XBRL Taxonomy Extension Calculation Linkbase Document ​ — ​ — ​ — ​ Filed herewith 101.DEF ​ nline XBRL Taxonomy Extension Definition Linkbase Document ​ — ​ — ​ — ​ Filed herewith 101.LAB Inline XBRL Taxonomy Extension Label Linkbase Document — — — Filed herewith 101.PRE Inline XBRL Taxonomy Extension Presentation Linkbase Document — — — Filed herewith 104 Cover Page Interactive Data File - the cover page XBRL tags are embedded within the Inline XBRL document contained in Exhibit 101 — — — Filed herewith * This certification is deemed not filed for purpose of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liability of that section, nor shall it be deemed incorporated by reference into any filing under the Securities Act of 1933. ​ 24 Table of Contents SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized. ​ EYENOVIA, INC. Date: May 19, 2025 By: /s/ Michael Rowe Michael Rowe Chief Executive Officer (Principal Executive Officer) ​ ​ 25