HYPERION DEFI, INC. 10-Q

Item 1. Financial Statements. EYENOVIA, INC. Condensed Balance Sheets ​ ​ ​ ​ ​ ​ ​ ​ ​ March 31, December 31, ​ 2022 2021 ​ (unaudited) ​ ​ ​ Assets ​ ​ ​ ​ ​ Current Assets: ​ ​ Cash and cash equivalents ​ $ 26,716,269 ​ $ 19,461,850 License fee and expense reimbursements receivable ​ ​ 1,364,309 ​ ​ 1,805,065 Prepaid expenses and other current assets ​ 2,318,047 ​ 734,942 Total Current Assets ​ 30,398,625 ​ 22,001,857 ​ ​ ​ ​ ​ ​ ​ Restricted cash ​ 7,875,000 ​ 7,875,000 Property and equipment, net ​ 1,370,359 ​ 1,271,225 Security deposits ​ 119,035 ​ 119,035 Equipment deposits ​ 425,036 ​ 391,941 ​ ​ ​ ​ ​ ​ ​ Total Assets ​ $ 40,188,055 ​ $ 31,659,058 ​ ​ ​ Liabilities and Stockholders’ Equity ​ ​ ​ ​ ​ Current Liabilities: ​ ​ Accounts payable ​ $ 1,534,764 ​ $ 1,614,104 Accrued compensation ​ 675,394 ​ 1,543,618 Accrued expenses and other current liabilities ​ 404,707 ​ 845,719 Deferred rent - current portion ​ ​ 23,780 ​ ​ 18,685 Notes payable - current portion, net ​ ​ 7,740,120 ​ ​ 7,150,368 ​ ​ ​ ​ ​ Total Current Liabilities ​ 10,378,765 ​ 11,172,494 ​ ​ ​ ​ ​ Deferred rent - non-current portion ​ 15,080 ​ 19,949 ​ ​ ​ ​ ​ Total Liabilities ​ 10,393,845 ​ 11,192,443 ​ ​ ​ Commitments and contingencies (Note 7) ​ ​ ​ ​ ​ Stockholders’ Equity: ​ ​ Preferred stock, $ 0.0001 par value, 6,000,000 shares authorized; 0 shares issued and outstanding as of March 31, 2022 and December 31, 2021 ​ — ​ — Common stock, $ 0.0001 par value, 90,000,000 shares authorized; 31,698,424 and 28,426,616 shares issued and outstanding as of March 31, 2022 and December 31, 2021, respectively ​ 3,171 ​ 2,844 Additional paid-in capital ​ 127,350,010 ​ 110,683,077 Accumulated deficit ​ ( 97,558,971 ) ​ ( 90,219,306 ) Total Stockholders’ Equity ​ ​ 29,794,210 ​ ​ 20,466,615 Total Liabilities and Stockholders’ Equity ​ $ 40,188,055 ​ $ 31,659,058 ​ The accompanying notes are an integral part of these condensed financial statements. ​ 2 Table of Contents EYENOVIA, INC. Condensed Statements of Operations (unaudited) ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ For the Three Months Ended ​ ​ March 31, ​ 2022 2021 Operating Income ​ ​ ​ ​ ​ ​ Revenue ​ $ — ​ $ 2,000,000 Cost of revenue ​ ​ — ​ ​ ( 800,000 ) Gross Profit ​ ​ — ​ ​ 1,200,000 ​ ​ ​ ​ ​ ​ ​ Operating Expenses: ​ ​ ​ ​ Research and development ​ ​ 3,712,584 ​ ​ 4,322,648 General and administrative ​ 3,474,965 ​ 2,243,990 Total Operating Expenses ​ 7,187,549 ​ 6,566,638 ​ ​ ​ ​ ​ Loss From Operations ​ ( 7,187,549 ) ​ ( 5,366,638 ) ​ ​ ​ Other Income (Expense): ​ ​ ​ ​ ​ Other (expense) income,net ​ ​ ( 7,073 ) ​ ​ 18,585 Interest expense ​ ​ ( 145,237 ) ​ ( 5,148 ) Interest income ​ 194 ​ 1,534 ​ ​ ​ ​ ​ Net Loss ​ $ ( 7,339,665 ) ​ $ ( 5,351,667 ) ​ ​ ​ Net Loss Per Share - Basic and Diluted ​ $ ( 0.24 ) ​ $ ( 0.21 ) ​ ​ ​ Weighted Average Number of Common Shares Outstanding - Basic and Diluted ​ 30,008,194 ​ 25,330,563 ​ The accompanying notes are an integral part of these condensed financial statements. ​ 3 Table of Contents EYENOVIA, INC. Condensed Statements of Changes in Stockholders’ Equity (unaudited) ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ For the Three Months Ended March 31, 2022 ​ ​ ​ ​ ​ ​ ​ Additional ​ ​ ​ ​ Total ​ ​ Common Stock ​ Paid-In ​ Accumulated ​ Stockholders’ ​ Shares Amount Capital Deficit Equity Balance - January 1, 2022 28,426,616 ​ $ 2,844 ​ $ 110,683,077 ​ $ ( 90,219,306 ) ​ $ 20,466,615 ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Issuance of common stock and warrants in registered direct offering [1] 3,000,000 ​ 300 ​ 14,897,608 ​ — ​ 14,897,908 ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Issuance of common stock in At the Market offering [2] 252,449 ​ 25 ​ 860,340 ​ — ​ 860,365 ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Stock-based compensation — ​ — ​ 908,987 ​ — ​ 908,987 ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Issuance of common stock related to vested restricted stock units 19,359 ​ 2 ​ ( 2 ) ​ — ​ — ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Net loss ​ — ​ ​ — ​ ​ — ​ ​ ( 7,339,665 ) ​ ​ ( 7,339,665 ) ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Balance - March 31, 2022 ​ 31,698,424 ​ $ 3,171 ​ $ 127,350,010 ​ $ ( 97,558,971 ) ​ $ 29,794,210 [1] Includes gross proceeds of $ 14,981,299 less total issuance costs of $ 83,391 . [2] Includes gross proceeds of $ 886,974 , less total issuance costs of $ 26,609 . ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ For the Three Months Ended March 31, 2021 ​ ​ ​ ​ ​ ​ ​ Additional ​ ​ ​ ​ Total ​ ​ Common Stock ​ Paid-In ​ Accumulated ​ Stockholders’ ​ Shares Amount Capital Deficit Equity Balance - January 1, 2021 ​ 24,978,585 ​ $ 2,498 ​ $ 92,742,306 ​ $ ( 77,440,919 ) ​ $ 15,303,885 ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Exercise of stock warrants ​ 644,992 ​ ​ 65 ​ ​ 1,530,925 ​ ​ — ​ ​ 1,530,990 ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Stock-based compensation ​ — ​ ​ — ​ ​ 656,913 ​ ​ — ​ ​ 656,913 ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Net loss ​ — ​ ​ — ​ ​ — ​ ​ ( 5,351,667 ) ​ ​ ( 5,351,667 ) ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Balance - March 31, 2021 ​ 25,623,577 ​ $ 2,563 ​ $ 94,930,144 ​ $ ( 82,792,586 ) ​ $ 12,140,121 ​ The accompanying notes are an integral part of these condensed financial statements. ​ 4 Table of Contents EYENOVIA, INC. Condensed Statements of Cash Flows (unaudited) ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ For the Three Months Ended ​ ​ March 31, ​ 2022 2021 Cash Flows From Operating Activities ​ ​ Net loss ​ $ ( 7,339,665 ) ​ $ ( 5,351,667 ) Adjustments to reconcile net loss to net cash used in operating activities: ​ ​ ​ ​ Stock-based compensation ​ ​ 908,987 ​ ​ 656,913 Depreciation of property and equipment ​ 75,432 ​ 33,281 Amortization of debt discount ​ ​ 26,215 ​ ​ — Changes in operating assets and liabilities: ​ ​ ​ ​ Prepaid expenses and other current assets ​ ( 907,774 ) ​ ( 251,091 ) License fee and expense reimbursements receivables ​ ​ 440,756 ​ ​ 2,057,808 Deferred license costs ​ ​ — ​ ​ 800,000 Accounts payable ​ ( 79,340 ) ​ 353,452 Accrued compensation ​ ( 868,224 ) ​ ( 579,940 ) Accrued expenses and other current liabilities ​ ( 441,012 ) ​ ( 291,600 ) Deferred license fee ​ ​ — ​ ​ ( 2,000,000 ) Deferred rent ​ 226 ​ ( 1,002 ) Net Cash Used In Operating Activities ​ ( 8,184,399 ) ​ ( 4,573,846 ) ​ ​ ​ ​ ​ Cash Flows From Investing Activities ​ ​ ​ ​ ​ ​ Purchases of property and equipment ​ ​ ( 174,567 ) ​ ​ ( 344,320 ) Vendor deposits for property and equipment ​ ​ ( 33,095 ) ​ ​ — Net Cash Used In Investing Activities ​ ​ ( 207,662 ) ​ ​ ( 344,320 ) ​ ​ ​ ​ ​ ​ ​ Cash Flows From Financing Activities ​ ​ ​ ​ Proceeds from sale of common stock and warrants in registered direct offering [1] ​ 14,981,299 ​ — Issuance of common stock in At the Market Offering [2] ​ ​ 860,365 ​ ​ — Proceeds from exercise of stock warrants ​ ​ — ​ ​ 1,530,990 Repayments of notes payable ​ ​ ( 111,793 ) ​ ​ ( 77,604 ) Payment of offering issuance costs ​ ​ ( 83,391 ) ​ ​ — Net Cash Provided By Financing Activities ​ 15,646,480 ​ 1,453,386 Net Increase (Decrease) in Cash and Cash Equivalents ​ 7,254,419 ​ ( 3,464,780 ) Cash and cash equivalents - Beginning of Period ​ 27,336,850 ​ 28,371,828 Cash and cash equivalents - End of Period ​ $ 34,591,269 ​ $ 24,907,048 [1] Includes gross proceeds of $ 14,981,299 , of which $ 5,741,299 is pre-funded warrants. [2] Includes gross proceeds of $ 886,974 , less total issuance costs of $ 26,609 . ​ ​ ​ ​ ​ ​ ​ ​ Cash,cash equivalents and restricted cash consisted of the following: ​ ​ ​ ​ Cash and cash equivalents ​ $ 26,716,269 ​ $ 24,907,048 Restricted cash ​ ​ 7,875,000 ​ ​ — ​ ​ $ 34,591,269 ​ $ 24,907,048 Supplemental Disclosure of Cash Flow Information: ​ ​ Cash paid during the periods for: ​ ​ ​ ​ ​ ​ Interest ​ $ 95,585 ​ $ 3,997 ​ ​ ​ ​ ​ ​ ​ Supplemental Disclosure of Non-Cash Investing and Financing Activities ​ ​ ​ ​ ​ ​ Purchase of insurance premium financed by note payable ​ $ 675,331 ​ $ 705,360 Issuance of common stock related to vested restricted stock units ​ $ 2 ​ $ — ​ The accompanying notes are an integral part of these condensed financial statements. ​ ​ 5 Table of Contents EYENOVIA, INC. NOTES TO CONDENSED FINANCIAL STATEMENTS (UNAUDITED) Note 1 – Business Organization, Nature of Operations and Basis of Presentation Eyenovia, Inc. (“Eyenovia” or the “Company”) is a clinical stage ophthalmic company developing a pipeline of advanced therapeutics based on the Company’s proprietary microdose array print (MAP TM ) platform technology. The Company aims to achieve clinical microdosing of next-generation formulations of novel and existing ophthalmic pharmaceutical agents using its high-precision targeted ocular delivery system, branded the Optejet®. Optejet µ-therapeutics have the potential to replace conventional eye dropper delivery and improve safety, tolerability, patient compliance and topical delivery success for ophthalmic eye treatments. In the clinic, the Optejet has demonstrated that its targeted horizontal microdose delivery can achieve a significantly higher rate of successful ocular topical delivery compared to the established rate reported with traditional eye drops (~ 90 % vs. ~ 50 %). The Company’s technology is designed to achieve single-digit µl-volume physiologic drug delivery with up to a 75% reduction in ocular drug and preservative topical dosing and has demonstrated significant improvement in the therapeutic index in drugs used for presbyopia, mydriasis and intraocular pressure (“IOP”) lowering through six Phase II and Phase III trials. Conventional eye formulations lack high-precision micro-volume delivery and expose the ocular surface to approximately 300% more medication and preservatives than are physiologically indicated leading to clinically recognized ocular and non-ocular side effects. Using the Optejet, the Company is developing the next generation of smart ophthalmic therapeutics which target new indications or new combinations where there are currently no or few drug therapies approved by the U.S. Food and Drug Administration (“FDA”). The Company’s microdose therapeutics follow the FDA-designated combination product registration and regulatory process. The Company’s products are classified by the FDA as drug-device combination products with drug primary mode of action, meaning that the Center for Drug Evaluation and Research (“CDER”) is designated as the lead center with primary jurisdictional oversight. Accordingly, the product candidates are submitted to the FDA CDER for premarket review and approval under new drug applications, or NDAs. The accompanying unaudited condensed financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“U.S. GAAP”) for interim financial information and with the instructions to Form 10-Q and Article 8 of Regulation S-X. Accordingly, they do not include all of the information and disclosures required by U.S. GAAP for complete financial statements. In the opinion of management, such statements include all adjustments (consisting only of normal recurring items) which are considered necessary for a fair presentation of the condensed financial statements of the Company as of March 31, 2022 and for the three months ended March 31, 2022 and 2021. The results of operations for the three months ended March 31, 2022 are not necessarily indicative of the operating results for the full year ending December 31, 2022 or any other period. These unaudited condensed financial statements should be read in conjunction with the audited financial statements and related disclosures of the Company as of December 31, 2021 and for the year then ended, which were included in the Company’s Annual Report on Form 10-K filed with the Securities and Exchange Commission (“SEC”) on March 30, 2022. ​ Note 2 – Summary of Significant Accounting Policies Since the date of the Company’s Annual Report on Form 10-K for the year ended December 31, 2021, there have been no material changes to the Company’s significant accounting policies, except as disclosed below. Liquidity and Going Concern As of March 31, 2022, the Company had unrestricted cash of approximately $ 26.7 million and an accumulated deficit of approximately $ 97.6 million. For the three months ended March 31, 2022 and 2021, the Company incurred net losses of approximately $ 7.3 million and $ 5.4 million, respectively, and used cash in operations of approximately $ 8.2 million and $ 4.6 million, respectively. The Company does not have recurring revenue and has not yet achieved profitability. The Company expects to continue to incur cash outflows from operations. The Company expects that its research and development and general and administrative expenses will continue to increase and, as a result, it will eventually need to generate significant product revenues to achieve profitability. These circumstances raise substantial doubt about the Company’s ability to continue as a going concern for at least one year from the date that these financial statements are issued. Implementation of the Company’s plans and its ability to continue as a going concern will depend upon the Company’s ability to raise further capital, through the sale of additional equity or debt securities or otherwise, to support its future operations. The Company’s operating needs include the planned costs to operate its business, including amounts required to fund working capital and capital expenditures. The Company’s future capital requirements and the adequacy of its available funds will depend on many factors, including the Company’s ability to successfully commercialize its products and services, competing technological and market developments, and the need to enter into collaborations with other companies or acquire other companies or technologies to enhance or 6 Table of Contents EYENOVIA, INC. NOTES TO CONDENSED FINANCIAL STATEMENTS (UNAUDITED) complement its product and service offerings. If the Company is unable to secure additional capital, it may be required to curtail its research and development initiatives and take additional measures to reduce costs in order to conserve its cash. Cash, Cash Equivalents and Restricted Cash The Company considers all highly liquid investments with an original maturity of three months or less to be cash equivalents in the financial statements. Cash and cash equivalents that are restricted as to withdrawal or use under the terms of certain executed agreements are recorded as Restricted Cash on the balance sheets, such as the collateralized money market account pursuant to the Loan and Security Agreement, dated May 7, 2021 with Silicon Valley Bank (“SVB”), as amended on September 29, 2021 by the First Amendment to the Loan and Security Agreement (the “First Amendment”). See Note 6 - Notes Payable - Silicon Valley Bank Loan. In connection with the First Amendment, the Company pledged to establish and maintain a collateralized money market account in the amount of $ 7,875,000 . The Company has cash deposits in a financial institution which, at times, may be in excess of Federal Deposit Insurance Corporation (“FDIC”) insurance limits. The Company has not experienced losses in such accounts and periodically evaluates the creditworthiness of its financial institutions. As of March 31, 2022 and December 31, 2021, the Company had cash balances in excess of FDIC insurance limits of $ 26,466,269 and $ 19,211,850 , respectively. Net Loss Per Common Share Basic net loss per common share is computed by dividing net loss by the weighted average number of common shares outstanding during the period plus fully vested shares that are subject to issuance for little or no monetary consideration. Diluted earnings per share reflects the potential dilution that could occur if securities or other instruments to issue common stock were exercised or converted into common stock. The following securities are excluded from the calculation of weighted average diluted common shares because their inclusion would have been anti-dilutive: ​ ​ ​ ​ ​ ​ ​ ​ March 31, ​ 2022 2021 Options 4,774,473 3,429,342 Warrants 7,957,975 1,366,321 Restricted stock units 115,329 105,306 Total potentially dilutive shares 12,847,777 4,900,969 ​ Revenue Recognition The Company’s revenues are generated primarily through research, development and commercialization agreements. The terms of such agreements may contain multiple promised goods and services, which may include (i) licenses to its intellectual property, and (ii) in certain cases, payment in connection with the manufacturing and delivery of clinical supply materials. Payments to us under these arrangements typically include one or more of the following: non-refundable, upfront license fees; milestone payments; payments for clinical product supply, and royalties on future product sales. The Company analyzes its arrangements to assess whether such arrangements involve joint operating activities. For collaboration arrangements that are deemed to be within the scope of Accounting Standards Codification (“ASC”) Topic 808, “Collaborative Arrangements” (“ASC 808”), the Company allocates the contract consideration between such joint operating activities and elements that are reflective of a vendor-customer relationship and, therefore, within the scope of ASC Topic 606, “Revenue from Contracts with Customers” (“ASC 606”). The Company’s policy is to recognize amounts allocated to joint operating activities as a reduction in research and development expense. 7 Table of Contents EYENOVIA, INC. NOTES TO CONDENSED FINANCIAL STATEMENTS (UNAUDITED) Under ASC 606, the Company recognizes revenue when its customers obtain control of promised goods or services, in an amount that reflects the consideration the Company expects to receive in exchange for those goods or services. To determine revenue recognition for arrangements that the Company determines are within the scope of ASC 606, the Company performs the following five steps: ● Step 1: Identify the contract with the customer; ● Step 2: Identify the performance obligations in the contract; ● Step 3: Determine the transaction price; ● Step 4: Allocate the transaction price to the performance obligations in the contract; and ● Step 5: Recognize revenue when the company satisfies a performance obligation. The Company must make significant judgments in its revenue recognition process, including identifying performance obligations in the contract, estimating the amount of variable consideration to include in the transaction price and allocating the transaction price to each performance obligation. In addition, arrangements that include rights to additional goods or services that are exercisable at a customer’s discretion are generally considered discretionary purchase options. The Company assesses whether these options provide a material right to the customer and if so, they are considered performance obligations. For upfront license fees, the Company must consider how many performance obligations are in the contract and, if more than one, how to allocate the fee to those performance obligations upon satisfaction of the performance obligation(s). Milestone payments represent variable consideration that will be recognized when the performance obligation is achieved. Sales-based royalty payments derived from usage of intellectual property are recognized when those sales occur. During 2020, the Company entered into a license agreement (the “Arctic Vision License Agreement”) with Arctic Vision (Hong Kong) Limited (“Arctic Vision”) and a license agreement (the “Bausch License Agreement”) with Bausch Health Companies, Inc. (“Bausch Health”). Each license has three revenue components: 1) an upfront license fee; 2) milestone payments and 3) royalty payments. Clinical Supply Arrangements Bausch Health and Arctic Vision have contracted with the Company to manufacture and supply them with the appropriate drug-device combination products to conduct their clinical trials on a cost plus 10 % mark-up basis. Our licensing agreements with Bausch Health and Arctic Vision represent collaborative arrangements and they are not a customer with respect to the clinical supply arrangements. The Company’s policy is to (a) defer the materials and manufacturing costs in order to properly match them up against the income from the clinical supply arrangements; and (b) to report the net income from the clinical supply arrangements as other income. Reclassifications Certain prior period balances have been reclassified in order to conform to current period presentation. These reclassifications have no effect on previously reported results of operations or loss per share. Recently Adopted Accounting Standards On May 3, 2021, the Financial Accounting Standards Board (the “FASB”) issued Accounting Standards Update (“ASU”) No. 2021-04, “Earnings Per Share (Topic 260), Debt—Modifications and Extinguishments (Subtopic 470-50), Compensation—Stock Compensation (Topic 718), and Derivatives and Hedging—Contracts in Entity’s Own Equity (Subtopic 815-40): Issuer’s Accounting for Certain Modifications or Exchanges of Freestanding Equity-Classified Written Call Options.” This new standard provides clarification and reduces diversity in an issuer’s accounting for modifications or exchanges of freestanding equity-classified written call options (such as warrants) that remain equity classified after modification or exchange. This standard is effective for fiscal years beginning after December 15, 2021, including interim periods within those fiscal years. Issuers should apply the new standard prospectively to modifications or exchanges occurring after the effective date of the new standard. The Company adopted ASU 2021-04 effective January 1, 2022. This standard did not have a material impact on its financial position, results of operations or cash flow. ​ 8 Table of Contents EYENOVIA, INC. NOTES TO CONDENSED FINANCIAL STATEMENTS (UNAUDITED) Note 3 – Prepaid Expenses and Other Current Assets As of March 31, 2022 and December 31, 2021, prepaid expenses and other current assets consisted of the following: ​ ​ ​ ​ ​ ​ ​ ​ ​ March 31, December 31, ​ 2022 2021 Prepaid insurance expenses ​ $ 965,631 ​ $ 171,370 Payroll tax receivable ​ ​ 487,910 ​ ​ 343,785 Clinical supply deferred costs ​ ​ 336,438 ​ ​ — Prepaid professional fees ​ 120,000 ​ — Prepaid general and admin expenses ​ ​ 99,874 ​ ​ 71,375 Prepaid board of directors fees ​ ​ 95,000 ​ ​ 66,250 Prepaid conference expenses ​ ​ 89,627 ​ ​ 12,586 Prepaid patent expenses ​ ​ 53,266 ​ ​ 32,797 Prepaid rent and security deposit ​ 36,722 ​ 32,254 Other ​ 33,579 ​ 4,525 Total prepaid expenses and other current assets ​ $ 2,318,047 ​ $ 734,942 ​ ​ Note 4 – Accrued Compensation As of March 31, 2022 and December 31, 2021, accrued compensation consisted of the following: ​ ​ ​ ​ ​ ​ ​ ​ ​ March 31, December 31, ​ 2022 2021 Accrued bonus expenses ​ $ 332,563 ​ $ 1,245,795 Accrued payroll expenses ​ 342,831 ​ 297,823 Total accrued compensation ​ $ 675,394 ​ $ 1,543,618 ​ ​ Note 5 – Accrued Expenses and Other Current Liabilities As of March 31, 2022 and December 31, 2021, accrued expenses and other current liabilities consisted of the following: ​ ​ ​ ​ ​ ​ ​ ​ ​ March 31, December 31, ​ 2022 2021 Accrued consulting and professional services ​ $ 208,325 ​ $ 250,000 Accrued interest ​ ​ 118,230 ​ ​ 94,792 Accrued research and development expenses ​ ​ 36,667 ​ ​ 436,840 Credit card payable ​ 19,558 ​ 20,000 Accrued franchise tax ​ ​ 13,100 ​ ​ 1,680 Accrued travel and entertainment expenses ​ ​ 5,548 ​ ​ — Other ​ 3,279 ​ 42,407 Total accrued expenses and other current liabilities ​ $ 404,707 ​ $ 845,719 ​ ​ Note 6 – Notes Payable As of March 31, 2022 and December 31, 2021, notes payable consisted of the following: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ March 31, 2022 December 31, 2021 ​ ​ Notes ​ Debt ​ ​ ​ Notes ​ Debt ​ ​ ​ Payable Discount Net Payable Discount Net D&O insurance policy loan ​ $ 563,538 ​ $ — ​ $ 563,538 ​ $ — ​ $ — ​ $ — Silicon Valley Bank loan ​ ​ 7,500,000 ​ ​ ( 323,418 ) ​ ​ 7,176,582 ​ ​ 7,500,000 ​ ​ ( 349,632 ) ​ ​ 7,150,368 Notes payable, current ​ $ 8,063,538 ​ $ ( 323,418 ) ​ $ 7,740,120 ​ $ 7,500,000 ​ $ ( 349,632 ) ​ $ 7,150,368 ​ 9 Table of Contents EYENOVIA, INC. NOTES TO CONDENSED FINANCIAL STATEMENTS (UNAUDITED) On February 24, 2022, the Company issued a note payable for the purchase of a directors and officers’ liability insurance policy (the “D&O Loan”). The D&O Loan is payable in six monthly payments consisting of principal and interest amounting to $ 113,628 for an aggregate principal amount of $ 675,331 . The note accrues interest at a rate of 3.26 % per year and matures on August 24, 2022 . During the three months ended March 31, 2022, the Company repaid $ 111,793 of principal balance on the D&O Loan. During the three months ended March 31, 2022, the Company recorded interest expense of $ 145,237 , of which $ 143,403 is related to the SVB loan (including amortization of debt discount of $ 26,214 ) and $ 1,834 is related to the D&O Loan. ​ ​ Note 7 – Commitments and Contingencies Employment Agreements On February 14, 2022, the Compensation Committee of the Board approved amendments to the Employment Agreements with its executive officers (the “Employment Agreement Addendums”). Each of the Employment Agreement Addendums provides that if the executive’s employment is terminated by the Company without “Cause” or the executive suffers an “Involuntary Termination” (each as defined in the employment agreements), provided that the executive has signed a full release of all claims, the executive will be entitled to receive: (i) severance pay equal to twelve months of his or her then-current base salary (currently estimated at approximately $ 1,331,000 in the aggregate), and (ii) a reimbursement for health insurance benefits under COBRA for the executive and his or her spouse and dependents for a period of twelve months or until the executive becomes eligible for comparable insurance benefits from another employer, whichever is earlier. Operating Leases The Company leases 953 square feet of office space in Reno, Nevada for research and development activities from a company owned by the Company’s former Vice President of Research and Development. The lease, as amended, expires on September 14, 2022 and provides for lease payments of $ 5,404 per month and a security deposit in the amount of $ 5,404 . Since the inception of the lease, the Company has made $ 112,600 of leasehold improvements related to this lease which are included in property and equipment, net on the accompanying balance sheets. The Company’s rent expense amounted to $ 17,095 and $ 17,020 for the three months ended March 31, 2022 and 2021, respectively. Litigations, Claims and Assessments The Company may be involved in legal proceedings, claims and assessments arising in the ordinary course of business. The Company records legal costs associated with loss contingencies as incurred and accrues for all probable and estimable settlements. ​ Note 8 – Stockholders’ Equity At-The-Market Offerings December 2021 Sales Agreement On December 14, 2021, the Company entered into a Sales Agreement (the “December 2021 Sales Agreement”) with SVB Leerink under which the Company may offer and sell, from time to time at its sole discretion, shares of common stock for gross proceeds of up to $ 50.0 million through SVB Leerink as its sales agent (the “At-the-Market Offering”). The Company’s prior sales agreement, with SVB Leerink, entered into in May 2021, was terminated upon the effectiveness of the December 2021 Sales Agreement. The issuance and sale of shares, if any, of common stock by the Company under the December 2021 Sales Agreement will be pursuant to the Company’s Registration Statement on Form S-3 (File No. 333-261638) filed with the SEC on December 14, 2021 (the “Registration Statement”), and the prospectus relating to the At-the-Market Offering filed therewith that forms a part of the Registration Statement. Subject to the terms and conditions of the December 2021 Sales Agreement, SVB Leerink may sell the common stock by any method permitted by law deemed to be an “at –the- market offering” as defined in Rule 415(a)(4) of the Securities Act of 1933, as amended. SVB Leerink will use commercially reasonable efforts to sell the common stock from time to time, based upon instructions from the Company (including any price, time or size limits or other customary parameters or conditions the Company may impose). The Company will pay SVB Leerink a commission equal to three percent ( 3.0 )% of the gross sales proceeds of any common stock sold through SVB Leerink under the December 2021 Sales Agreement, and also has provided SVB Leerink with certain indemnification rights. Through 10 Table of Contents EYENOVIA, INC. NOTES TO CONDENSED FINANCIAL STATEMENTS (UNAUDITED) March 31, 2022, the Company received approximately $ 0.9 million in net proceeds from the sale of 252,449 shares of its common stock pursuant to the December 2021 Sales Agreement. Securities Purchase Agreement On March 3, 2022, the Company entered into a securities purchase agreement (the “Purchase Agreement”) with a certain institutional and accredited investor (the “Purchaser”), relating to the issuance and sale of 3,000,000 shares (the “Shares”) of common stock, pre-funded warrants (the “Pre-Funded Warrants”) to purchase an aggregate of 1,870,130 shares of common stock and warrants to purchase an aggregate of 4,870,130 shares of common stock (the “Investor Warrants”) in a registered direct offering (the “March 2022 Offering”). The Company determined that the warrants qualified for equity classification. The offering price for the Shares was $ 3.08 per Share and the offering price for the Pre-Funded Warrants was $ 3.07 per Pre-Funded Warrant, which represents the per Share public offering price less $ 0.01 per share exercise price for each Pre-Funded Warrant. The Investor Warrants have an exercise price of $ 3.54 per share and each Investor Warrant is exercisable for one share of common stock. The Investor Warrants will be exercisable beginning six months from the date of issuance and the Pre-Funded Warrants are exercisable immediately upon issuance. The Pre-Funded Warrants shall terminate when fully exercised and the Investor Warrants will terminate five years from the initial exercisability date. The aggregate gross proceeds to the Company from the March 2022 Offering were approximately $ 15 million, excluding the proceeds, if any, from the exercise of the Pre-Funded Warrants and the Investor Warrants. No underwriter or placement agent participated in the March 2022 Offering. See Note 10 – Subsequent Events for additional information. The March 2022 Offering was made pursuant to an effective registration statement on Form S-3 (Registration Statement No. 333-261638), as previously filed with and declared effective by the Securities and Exchange Commission and a related prospectus. ​ Stock-Based Compensation Expense ​ The Company records stock-based compensation expense related to stock options and restricted stock units (“RSUs”). For the three months ended March 31, 2022 and 2021, the Company recorded expense of $ 908,987 ($ 501,181 of which was included within research and development expenses and $ 407,806 was included within general and administrative expenses on the statements of operations) and $ 656,913 ($ 329,713 of which was included within research and development expenses and $ 327,200 was included within general and administrative expenses on the statements of operations), respectively. ​ Restricted Stock Units ​ A summary of the restricted stock units activity during the three months ended March 31, 2022 is presented below: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Weighted ​ ​ ​ ​ Average ​ ​ Number of ​ Exercise ​ RSUs Price RSUs non-vested January 1, 2022 41,778 ​ $ 3.59 Granted 13,926 ​ 3.10 Vested — ​ — Forfeited ( 6,963 ) ​ 3.59 RSUs non-vested March 31, 2022 48,741 ​ $ 3.45 ​ ​ ​ ​ ​ ​ Vested RSUs undelivered March 31, 2022 66,588 ​ $ 3.85 ​ To date, the RSUs have only been granted to directors in accordance with the Company’s Amended and Restated 2018 Omnibus Stock Incentive Plan. The Company’s policy is not to deliver shares underlying the RSUs until the termination of service. ​ As of March 31, 2022, there was $ 54,688 of unrecognized stock-based compensation expense related to RSUs which will be recognized over a weighted average period of 0.6 years. 11 Table of Contents EYENOVIA, INC. NOTES TO CONDENSED FINANCIAL STATEMENTS (UNAUDITED) Stock Options In applying the Black-Scholes option pricing model to stock options granted, the Company used the following approximate assumptions: ​ ​ ​ ​ ​ ​ ​ ​ For the Three Months Ended ​ ​ ​ March 31, ​ ​ 2022 2021 Expected term (years) ​ 0.58 - 10.00 5.85 Risk free interest rate ​ 0.76 % - 1.98 % ​ 0.92 % ​ Expected volatility ​ 82 % - 90 % ​ 94 % ​ Expected dividends ​ 0.00 % ​ 0.00 % ​ ​ The Company has computed the fair value of stock options granted using the Black-Scholes option pricing model. Option forfeitures are accounted for at the time of occurrence. The expected term is the estimated period of time that options granted are expected to be outstanding. The Company utilizes the “simplified” method to develop an estimate of the expected term of “plain vanilla” employee option grants. The Company uses a blended volatility calculation, the components of which are the Company’s historical volatility for the period from its initial public offering through the valuation date and the average peer-group data of six comparable entities to supplement the Company’s own historical data for the preceding years in computing the expected volatility. Accordingly, the Company is utilizing an expected volatility figure based on a review of the historical volatility of comparable entities over a period of time equivalent to the expected life of the instrument being valued. The risk-free interest rate was determined from the implied yields from U.S. Treasury zero-coupon bonds with a remaining term consistent with the expected term of the instrument being valued. The weighted average estimated grant date fair value of the stock options granted for the three months ended March 31, 2022 and 2021 were approximately $ 2.28 and $ 3.82 per share, respectively. A summary of the option activity during the three months ended March 31, 2022 is presented below: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Weighted ​ ​ ​ ​ Weighted Average ​ ​ ​ ​ ​ ​ Average Remaining Aggregate ​ Number of Exercise Life Intrinsic ​ Options Price In Years Value Outstanding, January 1, 2022 4,377,398 ​ $ 3.89 ​ Granted 408,728 ​ 3.19 ​ Forfeited ( 11,653 ) ​ 4.47 ​ Outstanding March 31, 2022 4,774,473 ​ $ 3.82 7.5 ​ $ 1,387,425 ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Exercisable March 31, 2022 2,962,028 ​ $ 3.67 6.7 ​ $ 1,266,390 ​ 12 Table of Contents EYENOVIA, INC. NOTES TO CONDENSED FINANCIAL STATEMENTS (UNAUDITED) The following table presents information related to stock options as of March 31, 2022: ​ ​ ​ ​ ​ ​ ​ ​ ​ Options Outstanding Options Exercisable ​ ​ ​ ​ Weighted ​ ​ ​ ​ Outstanding Average Exercisable Exercise Number of Remaining Life Number of Price Options In Years Options $ 1.24 260,000 ​ 3.0 260,000 $ 1.95 567,636 ​ 5.3 567,636 $ 2.72 764,419 ​ 8.2 445,912 $ 2.74 667 ​ 6.8 667 $ 2.89 249,751 ​ 8.2 150,202 $ 3.10 336,922 ​ — — $ 3.11 656,078 ​ 7.4 570,728 $ 3.43 ​ 58,920 ​ 8.5 ​ 58,920 $ 3.48 35,000 ​ 8.4 17,500 $ 3.59 67,571 ​ — — $ 3.60 52,500 ​ — — $ 3.71 ​ 43,000 ​ 8.3 ​ 23,889 $ 4.00 ​ 2,000 ​ 6.6 ​ 2,000 $ 4.06 ​ 35,000 ​ — ​ — $ 4.53 ​ 127,000 ​ — ​ — $ 4.68 ​ 20,000 ​ 7.8 ​ 13,890 $ 4.81 ​ 219,000 ​ — ​ — $ 5.10 ​ 6,000 ​ 6.4 ​ 5,833 $ 5.11 ​ 1,637 ​ 9.0 ​ 1,637 $ 5.19 ​ 16,500 ​ 6.4 ​ 16,500 $ 5.25 26,668 ​ 4.5 26,668 $ 5.77 ​ 50,000 ​ 8.7 ​ 20,834 $ 6.01 ​ 652,899 ​ 8.8 ​ 253,907 $ 6.20 ​ 300,387 ​ 6.3 ​ 300,387 $ 6.30 ​ 60,000 ​ 6.3 ​ 60,000 $ 8.72 ​ 164,918 ​ 6.0 ​ 164,918 ​ ​ ​ 4,774,473 ​ 6.7 ​ 2,962,028 ​ As of March 31, 2022, there was $ 5,295,408 of unrecognized stock-based compensation expense related to stock options which will be recognized over a weighted average period of 1.9 years. Warrants A summary of the warrant activity for the three months ended March 31, 2022 is presented below: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Weighted ​ ​ ​ ​ ​ ​ ​ Weighted ​ Average ​ ​ ​ ​ ​ ​ ​ Average ​ Remaining ​ Aggregate ​ ​ Number of ​ Exercise ​ Life ​ Intrinsic ​ Warrants Price In Years Value Outstanding January 1, 2022 1,217,715 ​ $ 2.69 ​ Granted 6,740,260 ​ 2.56 ​ Outstanding March 31, 2022 7,957,975 ​ $ 2.58 3.8 ​ $ 6,283,580 ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Exercisable March 31, 2022 3,087,845 ​ $ 1.07 3.5 ​ $ 6,283,580 ​ 13 Table of Contents EYENOVIA, INC. NOTES TO CONDENSED FINANCIAL STATEMENTS (UNAUDITED) The following table presents information related to warrants as of March 31, 2022: ​ ​ ​ ​ ​ ​ ​ Warrants Outstanding ​ Warants Exercisable ​ ​ ​ ​ Weighted ​ ​ ​ ​ Outstanding ​ Average ​ Exercisable Exercise ​ Number of ​ Remaining Life ​ Number of Price Warrants In Years Warrants $ 0.0100 1,870,130 N/A 1,870,130 $ 2.4696 909,451 3.0 909,451 $ 2.7240 216,380 3.0 216,380 $ 3.5400 ​ 4,870,130 ​ — ​ — $ 4.7600 91,884 9.1 91,884 ​ 7,957,975 3.5 3,087,845 ​ ​ Note 9 – Employee Benefit Plans 401(k) Plan In April 2019, the Company adopted the Eyenovia 401(k) Plan (the “Plan”), which went into effect in May 2019. All Company employees are able to participate in the Plan, subject to eligibility requirements as outlined in the Plan documents. Under the terms of the Plan, eligible employees are able to defer a percentage of their pay every pay period up to annual limitations set by Congress and the Internal Revenue Service under Section 401(k) of the Internal Revenue Code. For 2022 and 2021, the Company’s Board of Directors has approved a matching contribution equal to 100 % of elective deferrals up to 4 % of eligible earnings with the matching contribution subject to certain vesting requirements as outlined in the Plan documents. During the three months ended March 31, 2022 and 2021, the Company recorded expense of $ 86,099 and $ 64,178 associated with its matching contributions, respectively. ​ Note 10 – Subsequent Events The Company has evaluated events that have occurred after the balance sheet date and through the date the financial statements were issued. Based upon the evaluation, the Company did not identify any recognized or non-recognized subsequent events that would have required adjustment or disclosure in the financial statements, except as disclosed below. SVB Loan Amendment On May 6, 2022, the Company and SVB agreed to amend the terms of the SVB Loan dated May 7, 2021. Pursuant to the amendment, the repayment term of the SVB Loan is reduced to 24 consecutive calendar months and the date that the first payment is due by the Company is extended to June 1, 2023. Warrant Exercises Subsequent to March 31, 2022, the Company issued an aggregate of 1,870,130 shares of the Company’s common stock pursuant to the exercise of the Pre-Funded Warrants at an exercise price of $ 0.01 per share for aggregate gross proceeds of $ 18,701 . See Note 8 – Stockholders’ Equity – Securities Purchase Agreement and Note 8 – Stockholders’ Equity - Warrants for additional information. ​ ​ ​ 14 Table of Contents