ALNYLAM PHARMACEUTICALS, INC. 10-K

ITEM 5. MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES Market Information Our common stock trades on The Nasdaq Global Select Market under the symbol “ALNY.” Holders of Record At January 31, 2022, there were 24 holders of record of our common stock. Because many of our shares are held by brokers and other institutions on behalf of stockholders, we are unable to estimate the total number of beneficial holders represented by these record holders. 80 Table of Contents Stock Performance Graph The following performance graph and related information shall not be deemed “soliciting material” or to be “filed” with the SEC, nor shall such information be incorporated by reference into any future filing under the Securities Act of 1933 or Securities Exchange Act of 1934, each as amended, except to the extent that we specifically incorporate it by reference into such filing. The comparative stock performance graph below compares the five-year cumulative total stockholder return (assuming reinvestment of dividends, if any) from investing $100 on the last trading day of 2016, to the close of the last trading day of 2021, in each of our common stock and the selected indices. The stock price performance reflected in the graph below is not necessarily indicative of future price performance. Comparison of Five-Year Cumulative Total Return Among Alnylam Pharmaceuticals, Inc., Nasdaq Composite Total Return and Nasdaq Biotechnology Total Return 12/30/2016 12/29/2017 12/31/2018 12/31/2019 12/31/2020 12/31/2021 Alnylam Pharmaceuticals, Inc. $ 100.00 $ 339.34 $ 194.74 $ 307.61 $ 347.14 $ 452.94 Nasdaq Composite Total Return $ 100.00 $ 129.64 $ 125.96 $ 172.17 $ 249.51 $ 304.85 Nasdaq Biotechnology Total Return $ 100.00 $ 121.63 $ 110.85 $ 138.69 $ 175.33 $ 175.37 ITEM 6. RESERVED Not applicable. 81 Table of Contents