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Director and Executive Officer Trading Arrangements
−Removed: During the three months ended September 30, 2025, none of our directors or officers adopted or terminated any contract, instruction or written plan for the purchase or sale of our securities intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act or any “non-Rule 10b5-1 trading arrangement” (as defined in Item 408(c) of Regulation S-K).
−Removed: On May 6, 2025, Kanya Rajangam, our President and Chief Medical Officer, adopted a Rule 10b5-1 trading plan for the sale of our common stock that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act (the “Rajangam Trading Plan”).
−Removed: The Rajangam Trading Plan provides for potential sales beginning on August 5, 2025 of up to an aggregate of 12,628 shares to be sold pursuant to limit orders.
−Removed: The Rajangam Trading Plan will expire upon the date all sales contemplated by the Rajangam Trading Plan have been executed.
+Added: During three months ended March 31, 2026, none of our directors or officers adopted or terminated any contract, instruction or written plan for the purchase or sale of our securities intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act or any “non-Rule 10b5-1 trading arrangement” (as defined in Item 408(c) of Regulation S-K).
The following exhibits are filed as part of, or incorporated by reference into, this Quarterly Report on Form 10-Q.
−Removed: Exhibit Number Description
+Added: Exhibit Number
+Added: Amendment No.1 to the Research and Development and Laboratory Lease Agreement, by and between 1430 Harbor Bay Pkwy LLC and Senti Biosciences, Inc .
+Added: Amendment No.
+Added: 1 to the Sublease Agreement by and between Senti Biosciences, Inc.
+Added: and GeneFab, LLC .
+Added: Amendment No.1 to the Lan dlord ’ s Consent to Subleasse, by and between 1430 Harbor Bay Pkwy LLC , Senti Biosciences, Inc.
+Added: and GeneFab LLC.
+Added: L etter Agreement by and be tween Senti Biosciences, Inc.
+Added: and GeneFab LLC.
Certification of Principal Executive Officer Pursuant to Securities Exchange Act Rules 13a-14(a) and 15(d)-14(a), as adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
4 unchanged sentences
Section 1350, as adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
−Removed: 101.INS* Inline XBRL Instance Document – the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document.
−Removed: 101.SCH* Inline XBRL Taxonomy Extension Schema Document.
−Removed: 101.CAL* Inline XBRL Taxonomy Extension Calculation Linkbase Document.
−Removed: 101.DEF* Inline XBRL Taxonomy Extension Definition Linkbase Document.
−Removed: 101.LAB* Inline XBRL Taxonomy Extension Label Linkbase Document.
−Removed: 101.PRE* Inline XBRL Taxonomy Extension Presentation Linkbase Document.
+Added: Inline XBRL Instance Document – the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document.
+Added: Inline XBRL Taxonomy Extension Schema Document
+Added: Inline XBRL Taxonomy Extension Calculation Linkbase Document
+Added: Inline XBRL Taxonomy Extension Definition Linkbase Document
+Added: Inline XBRL Taxonomy Extension Label Linkbase Document
+Added: Inline XBRL Taxonomy Extension Presentation Linkbase Document
The cover page for the Company’s Quarterly Report on Form 10-Q has been formatted in Inline XBRL and contained in Exhibit 101.
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Such certification will not be deemed to be incorporated by reference into any filing under the Securities Act of 1933, as amended, or the Exchange Act, except to the extent specifically incorporated by reference into such filing.
−Removed: Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized on this 13 th day of November, 2025.
−Removed: November 13, 2025
−Removed: SENTI BIOSCIENCES, INC.
+Added: Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized on this 14 th day of May, 2026.
+Added: SENTI BIOSCIENCES HOLDINGS, INC.
/s/ Timothy Lu, M.D., Ph.D.
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Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.