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under the Securities Act or the Exchange Act.
−Removed: On September 21, 2020, pursuant to a statutory scheme of arrangement under U.K.
−Removed: law, all of Summit Therapeutics plc’s outstanding ordinary shares were exchanged on a five-for-one basis for newly issued shares of Summit Therapeutics Inc.’s common stock.
−Removed: Summit Therapeutics plc’s American Depositary Shares (“ADSs”) had traded on the Nasdaq Global Market under the symbol “SMMT” since March 2015 and its ordinary shares previously traded on AIM, a sub-market of the London Stock Exchange plc, under the symbol “SUMM”.
−Removed: Each ADS represented five ordinary shares of Summit Therapeutics plc.
−Removed: We canceled the admission of the ordinary shares to trading on AIM on February 24, 2020.
−Removed: The following graph illustrates a comparison for the five years ended December 31, 2024 of the cumulative total return for our common stock (prior to September 21, 2020, Summit Therapeutics plc’s ADSs), the Nasdaq Biotechnology Index and the Nasdaq Composite Index each of which assumes an initial investment of $100.
+Added: The following graph illustrates a comparison for the five years ended December 31, 2025 of the cumulative total return for our common stock, the Nasdaq Biotechnology Index and the Nasdaq Composite Index each of which assumes an initial investment of $100.
Such returns are based on historical results and are not intended to suggest future performance.
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We currently intend to retain all available funds and any future earnings to fund the development and expansion of our business and we do not anticipate paying any cash dividends in the foreseeable future.
−Removed: Any future determination to declare and pay dividends will be made at the discretion of our Board of Directors and will depend on then-existing conditions, including our results of operations, financial condition, contractual restrictions, capital requirements, business prospects, and other factors our Board of Directors may deem relevant.
+Added: Any future determination to declare and pay dividends will be made at the discretion of our Board of Directors and will depend on then-existing conditions, including our results of operations, financial
+Added: condition, contractual restrictions, capital requirements, business prospects, and other factors our Board of Directors may deem relevant.
Recent Sales of Unregistered Securities
3 unchanged sentences
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.