Other Information
−Removed: During the three months ended June 30, 2025, the following adopted a “ Rule 10b5-1 trading arrangement ” (as defined in Item 408(a) of Regulation S-K) that is intended to satisfy the affirmative defense of Rule 10b5-1(c) under the Exchange Act and our policies on insider trading:
+Added: During the three months ended September 30, 2025, the following adopted a “ Rule 10b5-1 trading arrangement ” (as defined in Item 408(a) of Regulation S-K) that is intended to satisfy the affirmative defense of Rule 10b5-1(c) under the Exchange Act and our policies on insider trading:
Date Adopted (1)
1 unchanged sentence
Expiration Date (2)
−Removed: Non-executive
−Removed: June 16, 2025
−Removed: June 16, 2027
+Added: Walid Abi-Saab , Chief Medical Officer
+Added: September 26, 2025
+Added: December 31, 2026
+Added: Robert Gut , Non-executive Director
+Added: December 31, 2027
(1) Date of adoption of this Rule 10b5-1 trading arrangement is in accordance with applicable SEC rules and regulations.
1 unchanged sentence
(2) The Rule 10b5-1 trading arrangement permits transactions through and including the earlier to occur of (a) the completion of all sales or (b) the date listed in the table.
−Removed: The arrangement also provides for automatic expiration in the event of bankruptcy, insolvency, death or mental incapacity of the adopting person.
−Removed: Other than those disclosed above, none of our directors or officers adopted , modified , or terminated a “ Rule 10b5-1 trading arrangement ” or “ non-Rule 10b5-1 trading arrangement ,” in each case as defined in Item 408 of Regulation S-K, during the three months ended June 30, 2025.
+Added: Other than those disclosed above, none of our directors or officers adopted, modified, or terminated a “Rule 10b5-1 trading arrangement” or “non-Rule 10b5-1 trading arrangement,” in each case as defined in Item 408 of Regulation S-K, during the three months ended September 30, 2025.
See the Exhibit Index immediately preceding the signature page to this Quarterly Report on Form 10-Q for a list of exhibits filed or furnished with this report, which Exhibit Index is incorporated herein by reference.
EXHIBIT INDEX
−Removed: Amended and Restated 2014 Share Incentive Plan of uniQure N.V.
+Added: Form of Pre-Funded Warrant (incorporated by reference to Exhibit 4.1 of the Company’s Current Report on Form 8-K (File No.
+Added: 001-36294) filed with the SEC on September 29, 2025).
+Added: Amendment No.
+Added: 3 to Third Amended and Restated Loan and Security Agreement, dated of September 22, 2025, by and among uniQure biopharma, B.V., uniQure, Inc., uniQure IP B.V., the Company and Hercules Capital, Inc.
(incorporated by reference to Exhibit 10.1 of the Company’s Current Report on Form 8-K (File No.
−Removed: 001-36294) filed with the SEC on June 13, 2025).
+Added: 001-36294) filed with the SEC on September 24, 2025).
Certification of Chief Executive Officer pursuant to Rule 13a-14(a) or 15d-14(a) of the Securities and Exchange Act of 1934, as amended, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
2 unchanged sentences
Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 .
−Removed: The following financial information from our Quarterly Report on Form 10-Q for the period ended June 30, 2025, filed with the Securities and Exchange Commission on July 29, 2025, is formatted in Inline Extensible Business Reporting Language (“iXBRL”):
+Added: The following financial information from our Quarterly Report on Form 10-Q for the period ended September 30, 2025, filed with the Securities and Exchange Commission on November 10, 2025, is formatted in Inline Extensible Business Reporting Language (“iXBRL”):
(i) Consolidated Balance Sheets;
3 unchanged sentences
and (v) Notes to Consolidated Financial Statements (tagged as blocks of text).
−Removed: The cover page from our Quarterly Report on Form 10-Q for the period ended June 30, 2025, filed with the Securities and Exchange Commission on July 29, 2025, is formatted in Inline Extensible Business Reporting Language (“iXBRL”).
+Added: The cover page from our Quarterly Report on Form 10-Q for the period ended September 30, 2025, filed with the Securities and Exchange Commission on November 10, 2025, is formatted in Inline Extensible Business Reporting Language (“iXBRL”).
* Filed herewith.
± Furnished herewith.
−Removed: t Indicates a management contract or compensatory plan or arrangement.
+Added: ‡ Portions of this exhibit have been omitted pursuant to Item 601(b)(10)(iv) of Regulation S-K.
Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
7 unchanged sentences
(Principal Financial and Accounting Officer)
−Removed: July 29, 2025
+Added: November 10, 2025
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.