Legal Proceedings
−Removed: We are not currently a party to any material legal or arbitration proceedings.
−Removed: No governmental proceedings are pending or, to our knowledge, contemplated against us.
−Removed: We are not currently a party to any material proceedings in which any director, member of senior management or affiliate of ours is either a party adverse to us or our subsidiaries or has a material interest adverse to us or our subsidiaries.
−Removed: In the ordinary course of business, we are from time to time involved in lawsuits, claims, investigations, proceedings, and threats of litigation related to intellectual property, commercial arrangements, and other matters.
−Removed: The outcome of any such legal proceedings, regardless of the merits, is inherently uncertain.
−Removed: In addition, litigation and related matters are costly and may divert the attention of our management and other resources that would otherwise be engaged in other activities.
−Removed: If we were unable to prevail in any such legal proceedings, our business, results of operations, liquidity, and financial condition could be adversely affected.
+Added: We are currently engaged in arbitration proceedings with Beam regarding the Beam Collaboration Agreement.
+Added: A dispute arose between the parties following our March 18, 2025 announcement that we are developing a Prime Editing-based treatment for AATD.
+Added: Refer to Note 9, License and Collaboration Agreements, to our consolidated financial statements appearing elsewhere within this Annual Report on Form 10-K for information of our ongoing arbitration proceedings with Beam.
Mine Safety Disclosures
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Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.