What changed in this filing

We lease all of our facilities, other than the following facilities that we own:

our offices and laboratories in Changping, Beijing, our manufacturing facility in Guangzhou, China, and the site for our planned manufacturing facility and clinical R&D center at the Princeton Innovation Park in Hopewell, New Jersey.

We lease an aggregate of approximately 91,000 square meters of office space at approximately 42 other locations across the United States, China, and Europe, in cities such as Cambridge, Massachusetts;

our offices and laboratories in Changping, Beijing, our manufacturing facility in Guangzhou, China, and our manufacturing facility and clinical R&D center currently under construction at the Princeton Innovation Park in Hopewell, New Jersey.

We lease an aggregate of approximately 107,000 square meters of office space at approximately 45 other locations across the U.S., China, and Europe, in cities such as Cambridge, Massachusetts;

Ridgefield Park, New Jersey;

and Emeryville and San Mateo, California in the United States;

and Emeryville and San Mateo, California in the U.S.;

Beijing, Shanghai, Suzhou, and Guangzhou in China;

What changed 10-K

Item 2. Properties