21 unchanged sentences
(b) Director and Section 16 Officer Rule 10b5-1 Trading Arrangements
−Removed: On November 12, 2024 , Hans van Houte , Chief Financial Officer of the Company, entered into a prearranged trading plan intended to satisfy the affirmative defense of Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended (van Houte Plan), providing for the potential sale of up to 162,877 shares of the Company’s common stock, including shares of common stock previously issued to Mr.
−Removed: van Houte pursuant to the exercise of option awards, shares of common stock issuable upon the exercise of option awards, and shares of common stock to be acquired upon the vesting and settlement of restricted stock units (RSUs) granted, each so long as the market price of the Company’s common stock is higher than certain minimum threshold prices specified in the van Houte Plan.
−Removed: A portion of the shares underlying the options are expected to be sold in the market to cover the exercise price and taxes associated with the exercise of the options.
−Removed: The remaining shares underlying the options will be sold in the open market at the times and prices specified in the van Houte Plan.
−Removed: The actual number of shares sold in connection with the vesting and settlement of RSUs will be net of shares mandatorily sold in the open market to cover tax withholding obligations.
−Removed: The first potential sale date under the van Houte Plan is March 3, 2025.
−Removed: The van Houte Plan expires on December 31, 2025, or upon the earlier completion of all authorized transactions thereunder.
+Added: On November 10, 2025 , Christine Ring , Chief Legal Officer of the Company, entered into a prearranged trading plan intended to satisfy the affirmative defense of Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended (Ring Plan), providing for the potential sale of up to 208,840 shares of the Company’s common stock, including shares issuable upon the exercise of option awards previously granted to Dr.
+Added: Ring and shares to be acquired upon the vesting and settlement of restricted stock units previously granted to Dr.
+Added: The shares will be sold at the times and prices specified in the Ring Plan.
+Added: The Ring Plan expires on January 29, 2027 , or upon the earlier completion of all authorized transactions thereunder .
No other director or Section 16 officer of the Company adopted or terminated a “Rule 10b5-1 trading arrangement” or “non-Rule 10b5-1 trading arrangement,” as each term is defined in Item 408(a) of Regulation S-K, during the quarter ended November 30, 2025.
30 unchanged sentences
3.1 Restated Certificate of Incorporation
−Removed: 10-Q 001-39398 3.1 October 14, 2020
+Added: 001-39398 3.1 October 14, 2020
3.2 Amended and Restated Bylaws
30 unchanged sentences
10-K 001-39398 10.11 January 28, 2022
−Removed: 10.12 Lease Agreement, dated as of March 24, 2014, between ARE-San Francisco No.
−Removed: 26, LLC and the Registrant
−Removed: S-1 333-239651 10.8 July 2, 2020
−Removed: 10.13 First Amendment to Lease Agreement, dated as of October 3, 2014, by and between ARE-San Francisco No.
−Removed: 26, LLC and the Registrant
−Removed: S-1 333-239651 10.8 July 2, 2020
−Removed: 10.14 Second Amendment to Lease Agreement, dated as of November 8, 2017, by and between ARE-San Francisco No.
−Removed: 26, LLC and the Registrant
−Removed: S-1 333-239651 10.8 July 2, 2020
−Removed: 10.15 Third Amendment to Lease Agreement, dated March 2, 2021, by and between ARE-San Francisco No.
−Removed: 26 Owner, LLC and the Registrant
−Removed: 10-Q 001-39398 10.1 October 11, 2024
−Removed: 10.16 Fourth Amendment to Lease Agreement, dated April 30 , 202 1 , by and between ARE-San Francisco No.
−Removed: 26 Owner, LLC and the Registrant
−Removed: 10-Q 001-39398 10.2 October 11, 2024
−Removed: 10.17 Fifth Amendment to Lease Agreement, dated September 13, 2024, by and between ARE-San Francisco No.
−Removed: 26 Owner, LLC and the Registrant
−Removed: 10-Q 001-39398 10.3 October 11, 2024
−Removed: 10.18 Lease Agreement, dated as of June 21, 2021, between ARE-San Francisco No.
−Removed: 19 LLC and the Registrant
−Removed: 10-Q 001-39398 10.2 October 14, 2021
−Removed: 10.19 First Amendment to Lease Agreement, dated June 28, 2023, by and between ARE-San Francisco No.
−Removed: 19 Owner, LLC and the Registrant
−Removed: 10-Q 001-39398 10.1 October 12, 2023
−Removed: 10.20 Second Amendment to Lease Agreement, dated March 25, 2024, by and between ARE-San Francisco No.
−Removed: 19 Owner, LLC and the Registrant
−Removed: 10-Q 001-39398 10.2 April 10, 2024
−Removed: 10.21 Third Amendment to Lease Agreement, dated September 13, 2024, by and between ARE-San Francisco No.
−Removed: 19 Owner, LLC and the Registrant
−Removed: 10-Q 001-39398 10.4 October 11, 2024
10.12 Lease Agreement, dated as of March 1, 2022, between 8800 Technology Forest Pl, LLC and the Registrant
2 unchanged sentences
10-Q 001-39398 10.2 October 12, 2023
+Added: 10.14†‡ Sublease Agreement, dated as of February 21 , 2025, between Janssen Research & Development, LLC and the Registrant
+Added: 10-Q 001-39398 10.1 April 8, 2025
+Added: 10.15†‡ A mendment No.
+Added: 1 to Sublease Agreement, dated as of May 31, 2025, between Janssen Research & Development, LLC and the Registrant
+Added: 10-Q 001-39398 10.1 July 9, 2025
10.16†‡ Collaboration, Option and License Agreement, dated June 10, 2019, by and between the Registrant and Gilead Sciences, Inc., as amended
29 unchanged sentences
19.1 Insider Trading Policy
+Added: 10-K 001-39398 19.1 January 28, 2025
21.1 Subsidiaries of the Registrant
43 unchanged sentences
Chairman and Director January 28, 2026
−Removed: /s/ Anil Kapur Director January 28, 2025
Director January 28, 2026
+Added: Baynes, M.D., Ph.D.
+Added: /s/ R OGER D ANSEY
+Added: Director January 28, 2026
+Added: Roger Dansey, M.D.
+Added: /s/ A NIL K APUR
+Added: Director January 28, 2026
Lacey Director January 28, 2026
6 unchanged sentences
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.