NRIX filing — read by section

Item 8. Financial Statements and Supplementary Data

Item 8. Financial Statements and Supplementary Data 
 INDEX TO FINANCIAL STATEMENTS 
 Report of Independent Registered Public Accounting Firm (PCAOB ID 238 ) 
 118 
 
 Consolidated Balance Sheets 
 120 
 
 Consolidated Statements of Operations 
 121 
 
 Consolidated Statements of Comprehensive Loss 
 122 
 
 Consolidated Statements of Stockholders’ Equity 
 123 
 
 Consolidated Statements of Cash Flows 
 124 
 
 Notes to Consolidated Financial Statements 
 125 
 

 117 

 
 
 

 REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM 
 To the Board of Directors and Stockholders of Nurix Therapeutics, Inc. 
 Opinion on the Financial Statements 
 We have audited the accompanying consolidated balance sheets of Nurix Therapeutics, Inc. and its subsidiaries (the “Company”) as of November 30, 2023 and 2022, and the related consolidated statements of operations, of comprehensive loss, of stockholders’ equity and of cash flows for the years then ended, including the related notes (collectively referred to as the “consolidated financial statements”). In our opinion, the consolidated financial statements present fairly, in all material respects, the financial position of the Company as of November 30, 2023 and 2022, and the results of its operations and its cash flows for the years then ended in conformity with accounting principles generally accepted in the United States of America. 
 Basis for Opinion 
 These consolidated financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on the Company’s consolidated financial statements based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB. 
 We conducted our audits of these consolidated financial statements in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audits to obtain reasonable assurance about whether the consolidated financial statements are free of material misstatement, whether due to error or fraud. The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Company's internal control over financial reporting. Accordingly, we express no such opinion. 
 Our audits included performing procedures to assess the risks of material misstatement of the consolidated financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the consolidated financial statements. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the consolidated financial statements. We believe that our audits provide a reasonable basis for our opinion. 
 Emphasis of Matter 
 As discussed in Note 1 to the consolidated financial statements, the Company will need substantial additional funding to support its continuing operations and pursue its long-term business plan. Management’s plans in regard to this matter are described in Note 1. 
 Critical Audit Matters 
 The critical audit matter communicated below is a matter arising from the current period audit of the consolidated financial statements that was communicated or required to be communicated to the audit committee and that (i) relates to accounts or disclosures that are material to the consolidated financial statements and (ii) involved our especially challenging, subjective, or complex judgments. The communication of critical audit matters does not alter in any way our opinion on the consolidated financial statements, taken as a whole, and we are not, by communicating the critical audit matter below, providing a separate opinion on the critical audit matter or on the accounts or disclosures to which it relates. 
 Revenue Recognition - Estimated Costs of Internal Full-Time Employees (FTEs) - Sanofi 
 As described in Note 3 to the consolidated financial statements, the Company’s consolidated revenue was $76.9 million for the year ended November 30, 2023 of which there was revenue of $25.4 million generated from the Company’s collaboration agreement with Sanofi. During the contract term, management uses a cost-based input method, which the Company determined most faithfully depicts the transfer of its performance obligation to Sanofi, to recognize revenue based on the actual costs incurred as a percentage of total estimated costs as the Company completes its performance obligation under the contract. Costs consist primarily of internal FTE and third-party contract costs related to the Sanofi agreement. The cumulative effect of revisions to estimated costs to complete the Company’s performance obligation is recorded in the period in which changes are identified and amounts can be reasonably estimated. Total estimated costs are primarily driven by the number of estimated FTEs, which requires significant management judgment. 
 118 

 
 

 The principal considerations for our determination that performing procedures relating to revenue recognition - estimated costs of internal FTEs is a critical audit matter are (i) the high degree of auditor judgment and subjectivity in performing procedures relating to the estimated costs of internal FTEs due to the significant judgment by management when determining the estimate and (ii) the significant audit effort in evaluating the significant assumption related to the number of estimated FTEs. 
 Addressing the matter involved performing procedures and evaluating audit evidence in connection with forming our overall opinion on the consolidated financial statements. These procedures included, among others, evaluating and testing management’s process for determining the estimated costs of internal FTEs, which included evaluating the reasonableness of the significant assumption related to the number of estimated FTEs, by (i) performing a comparison of management’s estimated costs of internal FTEs to the actual internal FTE costs driven by the number of estimated FTEs; (ii) testing the completeness and accuracy of the data used by management in the estimate; (iii) evaluating management’s timely identification of changes in estimated costs of internal FTEs driven by the number of estimated FTEs; and (iv) evaluating whether the estimate and assumption were consistent with evidence obtained in other areas of the audit. 
 /s/ PricewaterhouseCoopers LLP 
 San Jose, California 
 February 15, 2024 
 We have served as the Company’s auditor since 2014. 
 119 

 
 
 

 NURIX THERAPEUTICS, INC. 
 CONSOLIDATED BALANCE SHEETS 
 (in thousands, except share and per share amounts) 
 
 November 30, 
 2023 2022 
 Assets 
 Current assets: 
 Cash and cash equivalents $ 54,627 $ 64,474 
 Marketable securities, current 233,281 244,667 
 Prepaid expenses and other current assets 7,595 9,308 
 Total current assets 295,503 318,449 
 Marketable securities, non-current 7,421 63,879 
 Operating lease right-of-use assets 31,142 12,345 
 Property and equipment, net 16,808 17,163 
 Restricted cash 901 901 
 Other assets 3,823 4,022 
 Total assets $ 355,598 $ 416,759 
 Liabilities and stockholdersʼ equity 
 Current liabilities: 
 Accounts payable $ 6,401 $ 5,064 
 Accrued expenses and other current liabilities 24,970 22,428 
 Operating lease liabilities, current 7,489 5,530 
 Deferred revenue, current 48,098 37,633 
 Total current liabilities 86,958 70,655 
 Operating lease liabilities, net of current portion 23,125 6,434 
 Deferred revenue, net of current portion 45,022 35,974 
 Total liabilities 155,105 113,063 
 Commitments and contingencies (Note 6) 
 Stockholders’ equity: 
 Preferred stock, $ 0.001 par value— 10,000,000 shares authorized as of November 30, 2023 and 2022; no shares issued and outstanding as of November 30, 2023 and 2022 
 — — 
 Common stock, $ 0.001 par value— 500,000,000 shares authorized as of November 30, 2023 and 2022; 48,718,552 and 47,172,299 shares issued and outstanding as of November 30, 2023 and 2022, respectively 
 49 47 
 Additional paid-in capital 746,299 709,220 
 Accumulated other comprehensive loss ( 655 ) ( 4,319 ) 
 Accumulated deficit ( 545,200 ) ( 401,252 ) 
 Total stockholders’ equity 200,493 303,696 
 Total liabilities and stockholders’ equity $ 355,598 $ 416,759 

 The accompanying notes are an integral part of these consolidated financial statements. 
 120 

 
 
 

 NURIX THERAPEUTICS, INC. 
 CONSOLIDATED STATEMENTS OF OPERATIONS 
 (in thousands, except share and per share amounts) 
 
 Year Ended November 30, 
 2023 2022 
 Revenue: 
 Collaboration revenue $ 56,987 $ 38,627 
 License revenue 20,000 — 
 Total revenue 76,987 38,627 
 Operating expenses: 
 Research and development 189,148 184,497 
 General and administrative 42,902 37,997 
 Total operating expenses 232,050 222,494 
 Loss from operations ( 155,063 ) ( 183,867 ) 
 Interest and other income, net 11,115 3,507 
 Net loss $ ( 143,948 ) $ ( 180,360 ) 
 Net loss per share, basic and diluted $ ( 2.65 ) $ ( 3.71 ) 
 Weighted-average number of shares outstanding, basic and diluted 54,337,901 48,607,990 

 The accompanying notes are an integral part of these consolidated financial statements. 
 121 

 
 
 

 NURIX THERAPEUTICS, INC. 
 CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS 
 (in thousands) 
 
 Year Ended November 30, 
 2023 2022 
 Net loss $ ( 143,948 ) $ ( 180,360 ) 
 Other comprehensive loss, net of tax: 
 Unrealized gain (loss) on available-for-sale marketable securities 3,664 ( 3,711 ) 
 Total comprehensive loss $ ( 140,284 ) $ ( 184,071 ) 

 The accompanying notes are an integral part of these consolidated financial statements. 
 122 

 
 
 

 NURIX THERAPEUTICS, INC. 
 CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY 
 (in thousands, except share amounts) 
 
 Common stock Additional
paid-in
capital Accumulated
other
comprehensive
income (loss) Accumulated 
deficit Total
stockholders’
equity 
 Shares Amount 
 Balance as of November 30, 2021 44,664,371 $ 45 $ 563,757 $ ( 608 ) $ ( 220,892 ) $ 342,302 
 Issuance of pre-funded warrants, net of issuance costs of $ 234 
 — — 94,759 — — 94,759 
 Issuance of common stock in "at the market" financing, net of issuance costs of $ 672 
 2,000,000 2 19,326 — — 19,328 
 Exercise of stock options 325,596 — 1,078 — — 1,078 
 Vesting of restricted stock units 46,028 — — — — — 
 Vesting of early exercised stock options — — 145 — — 145 
 Issuance under employee stock purchase plan 136,304 — 1,955 — — 1,955 
 Stock-based compensation — — 28,200 — — 28,200 
 Unrealized loss on available-for-sale marketable securities — — — ( 3,711 ) — ( 3,711 ) 
 Net loss — — — — ( 180,360 ) ( 180,360 ) 
 Balance as of November 30, 2022 47,172,299 47 709,220 ( 4,319 ) ( 401,252 ) 303,696 
 Exercise of pre-funded warrants 717,360 2 — — — 2 
 Exercise of stock options 120,826 — 986 — — 986 
 Vesting of restricted stock units 441,103 — — — — — 
 Vesting of early exercised stock options — — 117 — — 117 
 Issuance under employee stock purchase plan 266,964 — 2,229 — — 2,229 
 Stock-based compensation — — 33,747 — — 33,747 
 Unrealized gain on available-for-sale marketable securities — — — 3,664 — 3,664 
 Net loss — — — — ( 143,948 ) ( 143,948 ) 
 Balance as of November 30, 2023 48,718,552 $ 49 $ 746,299 $ ( 655 ) $ ( 545,200 ) $ 200,493 

 The accompanying notes are an integral part of these consolidated financial statements. 
 123 

 
 
 

 NURIX THERAPEUTICS, INC. 
 CONSOLIDATED STATEMENTS OF CASH FLOWS 
 (in thousands) 
 
 Year Ended November 30, 
 2023 2022 
 Cash flows from operating activities 
 Net loss $ ( 143,948 ) $ ( 180,360 ) 
 Adjustments to reconcile net loss to net cash used in operating activities: 
 Depreciation and amortization 7,533 5,349 
 Stock-based compensation 33,673 28,131 
 Net amortization (accretion) of premium (discount) on marketable securities ( 5,421 ) 426 
 Loss on disposal of property and equipment 556 9 
 Amortization of operating lease right-of-use assets 6,121 5,459 
 Other — 201 
 Changes in operating assets and liabilities: 
 Accounts receivable — 6,000 
 Prepaid expenses and other assets 2,139 ( 1,094 ) 
 Accounts payable 1,614 85 
 Deferred revenue 19,513 ( 26,627 ) 
 Operating lease liabilities ( 6,268 ) ( 4,871 ) 
 Accrued expenses and other liabilities 3,123 7,485 
 Net cash used in operating activities ( 81,365 ) ( 159,807 ) 
 Cash flows from investing activities 
 Purchases of marketable securities ( 246,334 ) ( 239,366 ) 
 Maturities of marketable securities 323,036 278,808 
 Purchases of property and equipment ( 8,401 ) ( 12,244 ) 
 Net cash provided by investing activities 68,301 27,198 
 Cash flows from financing activities 
 Proceeds from issuances of pre-funded warrants, net of issuance costs — 94,759 
 Proceeds from issuances of common stock in equity financing, net of issuance costs — 19,400 
 Proceeds from exercise of stock options and pre-funded warrants 988 1,078 
 Proceeds from issuance under employee stock purchase plan 2,229 1,955 
 Net cash provided by financing activities 3,217 117,192 
 Net decrease in cash, cash equivalents and restricted cash ( 9,847 ) ( 15,417 ) 
 Cash, cash equivalents and restricted cash at beginning of period 65,375 80,792 
 Cash, cash equivalents and restricted cash at end of period $ 55,528 $ 65,375 
 Supplemental disclosures of non-cash investing and financing activities: 
 Additions to property and equipment included in accounts payable and accrued expenses and other liabilities $ 632 $ 1,373 
 Capitalized stock-based compensation related to internal-use software development 
 $ 74 $ 69 
 Right-of-use assets recognized in exchange for lease obligations $ 23,995 $ 5,068 
 Vesting of early exercised stock options $ 117 $ 145 
 Deferred issuance costs recognized related to equity financing $ — $ 72 

 
 As of November 30, 
 2023 2022 
 Reconciliation of cash, cash equivalents and restricted cash: 
 Cash and cash equivalents $ 54,627 $ 64,474 
 Restricted cash 901 901 
 Cash, cash equivalents and restricted cash $ 55,528 $ 65,375 

 The accompanying notes are an integral part of these consolidated financial statements. 
 124 

 
 
 

 NURIX THERAPEUTICS, INC. 
 NOTES TO CONSOLIDATED FINANCIAL STATEMENTS 
 
 1. Organization 
 Description of Business 
 Nurix Therapeutics, Inc. (the Company) was incorporated in the state of Delaware on August 27, 2009, and is headquartered in San Francisco, California. The Company is a clinical stage biopharmaceutical company focused on the discovery, development and commercialization of innovative small molecules and antibody therapies based on the modulation of cellular protein levels as a novel treatment approach for cancer, inflammatory conditions and other challenging diseases. Leveraging the Company’s expertise in E3 ligases together with its proprietary DNA-encoded libraries, the Company has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. The Company’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin-proteasome system to selectively decrease or increase cellular protein levels. The Company’s wholly owned, clinical stage pipeline includes targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene B, an E3 ligase that regulates activation of multiple immune cell types including T cells and NK cells. The Company’s partnered drug discovery pipeline consists of multiple programs under collaboration agreements with Gilead Sciences, Inc. (Gilead), Sanofi S.A. (Sanofi) and Seagen Inc. (now a part of Pfizer Inc. (Pfizer)), within which the Company retains certain options for co-development, co-commercialization and profit sharing in the United States for multiple drug candidates. 
 Equity Distribution Agreement 
 In August 2021, the Company filed a shelf registration statement on Form S-3 with the Securities and Exchange Commission, which was amended in February 2023. This shelf registration statement, which includes a base prospectus, allows the Company at any time to offer and sell up to $ 450.0 million of the Company’s registered common stock, preferred stock, debt securities, warrants, subscriptions rights and or units or any combination of securities described in the prospectus in one or more offerings. In addition, in August 2021, the Company entered into an Equity Distribution Agreement with Piper Sandler & Co. (Piper Sandler) pursuant to which, from time to time, the Company may offer and sell through Piper Sandler up to $ 150.0 million of the common stock registered under the shelf registration statement pursuant to one or more “at the market” offerings. 
 The Company is not required to sell any shares at any time during the term of the Equity Distribution Agreement. The Company agreed to pay Piper Sandler a commission of 3 % of the gross sales price of any shares sold pursuant to the Equity Distribution Agreement. In June 2022, the Company issued and sold 2,000,000 shares of common stock under the Equity Distribution Agreement at a price of $ 10.0001 per share of common stock for net proceeds of $ 19.3 million, after deducting offering commissions and expenses paid by the Company. As of November 30, 2023, the Company had $ 130.0 million of common stock remaining available for sale under the Equity Distribution Agreement. 
 Registered Direct Offerings 
 In July 2022, the Company entered into separate securities purchase agreements with certain purchasers to issue and sell pre‑funded warrants to purchase an aggregate of 6,814,920 shares of the Company’s common stock in registered direct offerings (RDOs) at a price of $ 13.939 per pre-funded warrant. Net proceeds from the RDOs were $ 94.8 million, after deducting offering expenses of $ 0.2 million. Refer to Note 7 for more information regarding the pre-funded warrants issued in the RDOs. 
 Liquidity and Management Plans 
 As of November 30, 2023, the Company had cash, cash equivalents and short-term marketable securities of $ 287.9 million, working capital of $ 208.5 million and an accumulated deficit of $ 545.2 million. The Company’s operations have historically been financed through the issuance of common stock, redeemable convertible preferred stock and pre-funded warrants and proceeds received under the Company’s collaboration and license agreements. Since inception, the Company has generally incurred significant losses and negative net cash flows from operations. The Company does not expect its existing cash, cash equivalents and marketable securities to be sufficient to fund the completion of its clinical trials through commercialization and will need substantial additional funding to support its continuing operations and pursue its long-term business plan. The Company anticipates incurring additional losses until such time, if ever, that it can generate significant sales of its drug candidates currently in development. 
 125 

 
 

 The accompanying consolidated financial statements have been prepared assuming that the Company will continue as a going concern. Management believes that its cash, cash equivalents and short-term marketable securities are sufficient to continue operating activities for at least 12 months following the issuance date of these consolidated financial statements. Future capital requirements will depend on many factors, including the timing and extent of spending on research and development and payments the Company may receive under its collaboration agreements with Sanofi, Gilead and Pfizer or future collaboration agreements, if any. There can be no assurance that, in the event the Company requires additional financing, such financing will be available at terms acceptable to the Company if at all. If additional capital is not available, failure to generate sufficient cash flows from operations, raise additional capital and reduce discretionary spending could have a material adverse effect on the Company’s ability to achieve its intended business objectives. Management considered whether there are conditions or events that raise substantial doubt about the Company’s ability to continue as a going concern and evaluated the funds necessary to maintain operations. If the Company is unable to obtain additional funding, management will be required to implement plans that are within the Company’s control, which may include the delay or scaling back of certain research and development programs, to maintain liquidity and operations. Based on the Company’s current forecast of future operating results and management’s plans to improve liquidity, the Company has concluded that its cash, cash equivalents and short-term marketable securities are sufficient to continue operating activities for at least 12 months following the issuance date of these consolidated financial statements. 
 
 2. Summary of Significant Accounting Policies 
 Basis of Presentation and Principles of Consolidation 
 The Company’s consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (U.S. GAAP) and include the accounts of the Company and its wholly owned subsidiaries, including DeCART Therapeutics Inc., which was legally dissolved in July 2022. All intercompany balances and transactions have been eliminated in consolidation. 
 Use of Estimates 
 The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosures of contingent assets and liabilities at the date of the financial statements and reported amounts of revenues and expenses during the reporting period. On an ongoing basis, management evaluates its estimates, including those related to the useful lives of long-lived assets, the measurement of stock-based compensation, accruals for research and development activities, income taxes and revenue recognition. The Company also makes certain commencement date estimates for its leases, including the incremental borrowing rate, the expected lease term and the fair value of the leased asset. The Company bases its estimates on historical experience and on other relevant assumptions that are reasonable under the circumstances. Actual results could materially differ from those estimates. Refer to Note 3 for more information regarding the estimates related to revenue recognition. 
 Concentration of Credit Risk 
 Financial instruments that potentially subject the Company to concentration of credit risk consist of cash, cash equivalents and marketable securities. The Company’s marketable securities consist of debt securities issued by highly rated corporate entities, the U.S. federal government or state and local governments. The Company’s exposure to any individual corporate entity is limited by policy. Deposits may, at times, exceed federally insured limits. The Company invests its cash equivalents in highly rated money market funds. During the periods presented, the Company has not experienced any losses on its deposits of cash, cash equivalents or marketable securities. 
 Other Risks and Uncertainties 
 The Company is subject to a number of risks similar to other clinical stage biopharmaceutical companies, including, but not limited to, changes in any of the following areas that the Company believes could have a material adverse effect on its future financial position or results of operations: risks related to the successful discovery and development of its drug candidates, ability to raise additional capital, development of new technological innovations by its competitors and delay or inability to obtain drug substance and finished drug product from the Company’s third-party contract manufacturers necessary for the Company’s drug candidates, protection of intellectual property rights, litigation or claims against the Company based on intellectual property rights and regulatory clearance and market acceptance for any of the Company’s products candidates for which the Company receives marketing approval. 
 126 

 
 

 Moreover, the Company is subject to risks and uncertainties as a result of global business, political and macroeconomic events and conditions, including increasing financial market volatility and uncertainty, inflation, increasing interest rates, uncertainty with respect to the federal budget and debt ceiling and potential government shutdowns related thereto, potential instability in the global banking system, cybersecurity events, the impact of war or military conflict, including regional conflicts around the world, and public health pandemics. The extent to which business, political and macroeconomic factors, including increasing financial market volatility and uncertainty, will impact the Company’s business will depend on future developments that are highly uncertain and cannot be predicted at this time. 
 The preparation of financial statements in conformity with generally accepted accounting principles requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. The extent to which the increasing financial market volatility and uncertainty may directly or indirectly impact the Company’s financial statements is highly uncertain and subject to change. 
 The Company relies on single source manufacturers and suppliers for the supply of its drug candidates. Disruption from these manufacturers or suppliers would have a negative impact on the Company’s business, financial position and results of operations. 
 Segments 
 The Company operates and manages its business as one reportable and operating segment. Operating segments are defined as components of an enterprise where separate financial information is evaluated regularly by the chief operating decision maker (CODM) in deciding how to allocate resources and assess performance. The Company’s CODM is the Chief Executive Officer, who reviews consolidated financial information on a company-wide basis for purposes of allocating resources and assessing financial performance. 
 Cash and Cash Equivalents 
 The Company considers all highly liquid marketable securities with a maturity of three months or less when purchased to be cash equivalents. Cash equivalents, which consist of money market funds, are stated at fair value. 
 Restricted Cash 
 The Company had $ 0.9 million of restricted cash recorded as a non-current asset as of each of November 30, 2023 and 2022. Restricted cash as of each of November 30, 2023 and 2022 consisted of $ 0.1 million that serves as collateral for a business credit card account and $ 0.8 million for letters of credit required under operating leases. These balances are included within the cash, cash equivalents and restricted cash balance in the accompanying consolidated statements of cash flows. 
 Fair Value of Financial Instruments 
 The carrying amounts of the Company’s financial instruments, including cash equivalents, accounts payable and accrued liabilities included in the Company’s consolidated financial statements approximate their fair value due to the nature of the financial instruments. Refer to Note 5 for more information regarding the fair value of the Company’s marketable securities. 
 Marketable Securities 
 Marketable securities consist of money market funds, U.S. Treasuries, corporate debt securities, U.S. government agency securities, corporate commercial paper and foreign government securities. The Company’s marketable securities are classified as available-for-sale and carried at estimated fair values and reported in cash equivalents, short-term marketable securities or long-term marketable securities. Management determines the appropriate classification of the marketable securities at the time they are acquired and evaluates the appropriateness of such classifications at each consolidated balance sheet date. Marketable securities with contractual maturities greater than 12 months are considered long-term marketable securities. 
 127 

 
 

 The Company regularly reviews its marketable securities for declines in estimated fair value below amortized cost. The factors considered in determining whether a credit loss exists include the creditworthiness of the security issuers, the number of marketable securities in an unrealized loss position, the severity and duration of the unrealized losses, and whether it is more likely than not that the Company will be required to sell the marketable securities before the recovery of their amortized cost basis. The cost of marketable securities sold is based on the specific identification method. In circumstances when an unrealized loss is determined to be credit-related, or when the Company intends to sell or is more likely than not required to sell a security before it recovers its amortized cost basis, the difference between the fair value and the amortized cost of the security is recognized as interest and other income, net in the consolidated statements of operations, and an allowance for credit loss is recorded on the consolidated balance sheet. In circumstances when the decline in fair value is non-credit related, the difference is reported in accumulated other comprehensive income (loss), net of tax as a separate component of stockholders’ equity. 
 The Company excludes accrued interest from both the fair value and the amortized cost basis of marketable securities for the purposes of identifying and measuring an impairment. The Company writes off accrued interest receivables that have become more than 90 days delinquent by reversing interest income. To date, the Company has not written off any accrued interest receivables associated with its marketable securities. 
 Property and Equipment 
 Property and equipment are stated at cost, net of accumulated depreciation and amortization. Major improvements are capitalized, while maintenance and repairs are expensed when incurred. Depreciation is computed using the straight-line method over the estimated useful lives of the assets. The useful life of laboratory equipment, computer equipment, furniture and fixtures and software is generally three years . Tenant improvements are depreciated over the shorter of the lease term or the estimated useful life of the improvements. When assets are retired or disposed of, the cost together with related accumulated depreciation is removed from the Company’s accounts and the resulting gain or loss is reflected in the Company’s consolidated statements of operations. 
 Leases 
 The Company determines if an arrangement contains a lease and the classification of the lease at inception. An arrangement contains a lease if there is an identified asset and if the Company controls the use of the identified asset throughout the period of use.The evaluation of whether the lease is an operating or a finance lease requires judgments in determining the fair value of the leased asset. Lease right-of-use (ROU) assets and lease liabilities are recognized at the lease commencement date based on the present value of the future minimum lease payments over the lease term at the commencement date. ROU assets also include any initial direct costs incurred and any lease payments made on or before the lease commencement date, less any lease incentives received. The Company uses its incremental borrowing rate, if an implicit rate is not readily available, and the information available at the date of lease commencement in determining its lease liabilities. The Company’s incremental borrowing rate is based on the rate of interest that the Company would have to pay to borrow on a collateralized basis over a similar term, an amount equal to the lease payments in a similar economic environment, and the determination of the rate requires the Company to make certain assumptions and judgements, including on its synthetic credit rating. Leases may include options to extend or early terminate the lease term. If the Company, using judgement, is reasonably certain that an option will be exercised, then the option will be included in the calculation of the lease term. The Company elected to combine lease and non-lease components for all underlying assets groups, and not recognize ROU assets or lease liabilities for short-term leases. A short-term lease is a lease that, at the commencement date, has a lease term of 12 months or less and does not include an option to purchase the underlying asset that the lessee is reasonably certain to exercise. Lease expense for operating leases is recognized on a straight-line basis over the lease term. The Company does not have any finance leases. 
 Internal-Use Software Development Costs 
 The Company capitalizes qualifying costs incurred during the application development stage related to software developed for internal-use and amortizes them over the estimated useful life of three years . Amortization of such costs begins when the project is substantially complete and ready for its intended use. Capitalized software development costs are classified as property and equipment, net on the consolidated balance sheet. The Company expenses costs incurred related to the planning and post-implementation phases of development as incurred. 
 128 

 
 

 Long-Lived Assets 
 Long-lived assets, such as property and equipment are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be fully recoverable. If circumstances require a long-lived asset or asset group to be tested for possible impairment, the Company first compares undiscounted cash flows expected to be generated by that asset or asset group to its carrying value. If the carrying value of the long-lived asset or asset group is not recoverable on an undiscounted cash flow basis, an impairment is recognized to the extent that the carrying value exceeds its fair value. Fair value is determined through various valuation techniques including discounted cash flow models, quoted market values and third-party independent appraisals, as considered necessary. There were no such impairment losses during the years ended November 30, 2023 and 2022. 
 Deferred Offering Costs 
 The Company capitalizes within other assets certain legal, accounting and other third-party fees that are directly related to the Company’s in-process equity financings until such financings are consummated. After consummation of an equity financing, these costs are recorded in stockholder’s equity as a reduction of additional paid-in capital generated as a result of the offering. Should a planned equity financing be abandoned, terminated or significantly delayed, the deferred offering costs are immediately written off to operating expenses. As of both November 30, 2023 and 2022, there was $ 0.5 million of deferred offering costs included in other assets on the consolidated balance sheet. 
 Revenue Recognition 
 The Company recognizes revenue when its customer obtains control of promised goods or services, in an amount that reflects the consideration which the Company expects to receive in exchange for those goods or services. To recognize revenue from a contract with a customer, the Company performs the following five steps: 
 (i) identify the contract(s) with a customer; 
 (ii) identify the performance obligations in the contract; 
 (iii) determine the transaction price; 
 (iv) allocate the transaction price to the performance obligations in the contract; and 
 (v) recognize revenue when (or as) the Company satisfies a performance obligation. 
 At contract inception, the Company assesses the goods or services promised within each contract, whether each promised good or service is distinct, and determines those that are performance obligations. The Company then recognizes as revenue the amount of the transaction price that is allocated to the respective performance obligation when or as the performance obligation is satisfied. 
 The Company enters into collaboration agreements under which it may obtain upfront payments, milestone payments, royalty payments and other fees. Promises under these arrangements may include research licenses, research services, including selection campaign research services for certain replacement targets, the obligation to share information during the research and the participation of alliance managers and in joint research committees, joint patent committees and joint steering committees. The Company assesses these promises within the context of the agreements to determine the performance obligations. 
 Exclusive license rights : If a license to the Company’s intellectual property is determined to be distinct from the other promises identified in the arrangement, the Company recognizes revenue from nonrefundable, upfront payments allocated to the license when the license is transferred to the customer and the customer is able to use and benefit from the license and the underlying intellectual property. If the license is the predominant promise, and it is determined that the license represents functional intellectual property, revenue is recognized at the point in time when control of the license is transferred. If it is determined that the license does not represent functional intellectual property, revenue is recognized over time using an appropriate method of measuring progress. 
 Research and collaboration licenses : Collaboration agreements may include research licenses and research and development services to be performed by the Company. For research licenses that are bundled with other promises, the Company utilizes judgment to assess the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring proportional performance for purposes of recognizing revenue from non-refundable, upfront payments. The Company evaluates the measure of proportional performance each reporting period and, if necessary, adjusts the measure of performance and related revenue recognition. 
 129 

 
 

 Milestone payments : At the inception of each arrangement that includes research, development or regulatory milestone payments, the Company evaluates whether the milestones are considered probable of being reached and estimates the amount to be included in the transaction price. The Company uses the most likely amount method for research, development and regulatory milestone payments. Under the most likely amount method, an entity considers the single most likely amount in a range of possible consideration amounts. If it is probable that a significant revenue reversal would not occur, the associated milestone amount is included in the transaction price. 
 Sales-based milestones and royalties : For arrangements that include sales-based milestone or royalty payments based on the level of sales, and in which the license is deemed to be the predominant item to which the sales-based milestone or royalties relate to, the Company recognizes revenue in the period in which the sales-based milestone is achieved and in the period in which the sales associated with the royalty occur. To date, the Company has not recognized any sales-based milestone or royalty revenue resulting from its collaboration arrangements. 
 Customer options : Customer options, such as options granted to allow a licensee to extend a license or research term, to select additional research targets or to choose to research, develop and commercialize licensed compounds are evaluated at contract inception to determine whether those options provide a material right (i.e., an optional good or service offered for free or at a discount) to the customer. If the customer options represent a material right, the material right is treated as a separate performance obligation at the outset of the arrangement. The Company allocates the transaction price to material rights based on the standalone selling price. As a practical alternative to estimating the standalone selling price of a material right when the underlying goods or services are both (i) similar to the original goods or services in the contract and (ii) provided in accordance with the terms of the original contract, the Company allocates the total amount of consideration expected to be received from the customer to the total goods or services expected to be provided to the customer. Amounts allocated to any material right are recognized as revenue when or as the related future goods or services are transferred or when the option expires. 
 Deferred revenue, which is a contract liability, represents net amounts received by the Company for which the related revenues have not been recognized because one or more of the revenue recognition criteria have not been met. The current portion of deferred revenue represents the amount to be recognized within one year from the consolidated balance sheet date based on the estimated performance period of the underlying performance obligation. The non-current portion of deferred revenue represents amounts to be recognized after one year through the end of the performance period of the performance obligation. 
 All revenue was derived from customers located in the United States during the years ended November 30, 2023 and 2022. 
 Research and Development Expenses 
 The Company expenses all research and development costs as incurred. Research and development costs include, but are not limited to, payroll and personnel expenses, laboratory supplies, preclinical study costs, clinical trial costs, compound manufacturing costs, consulting costs and allocated overhead, including rent, equipment, depreciation and utilities. 
 The Company records accrued expenses for estimated costs of research and development activities conducted by third-party service providers, which include preclinical studies and clinical trials and contract manufacturing activities. The Company records the estimated costs of research and development activities based upon the estimated amount of services provided but not yet invoiced and includes these costs in accrued expenses and other current liabilities on the consolidated balance sheet. 
 The Company estimates the amount of work completed through discussions with internal personnel and external service providers as to the progress or stage of completion of the services and the agreed-upon fee to be paid for such services. The Company makes significant judgments and estimates in determining the accrued balance in each reporting period. As actual costs become known, the Company adjusts its accrued estimates. The Company’s accrued expenses are dependent, in part, upon the receipt of timely and accurate reporting from clinical research organizations and other third-party service providers. The Company records advance payments to service providers as prepaid assets, which are expensed as the contracted services are performed. 
 130 

 
 

 Stock-Based Compensation 
 The Company accounts for stock-based compensation using a fair value-based method, which requires the recognition of compensation expense for costs related to all stock-based payments including stock options, restricted stock units (RSUs) and purchase rights under the Company’s 2020 Employee Stock Purchase Plan (ESPP). The Company estimates the fair value of stock options and purchase rights granted under the ESPP on the date of grant using the Black-Scholes option pricing model, which is impacted by the fair value of the Company’s common stock, as well as changes in assumptions regarding a number of highly complex and subjective variables. The model requires management to make a number of assumptions including expected volatility, expected term, risk-free interest rate and expected dividend yield. The Company determines the fair value of stock options, RSUs and purchase rights under the ESPP using the market closing price of the Company’s common stock on the date of grant. 
 For stock-based payments with service conditions only, the Company uses the straight-line method to allocate compensation cost to reporting periods over the requisite service period, which is generally the vesting period. Stock-based compensation expense for non-employee stock-based awards is also measured based on the grant date fair value with the estimated fair value expensed over the period for which the non-employee is required to provide service in exchange for the award. For stock-based payments with performance conditions, the Company evaluates the probability of achieving performance conditions at each reporting date. The Company begins to recognize compensation cost using an accelerated attribution method when it is deemed probable that the performance condition will be met. The Company accounts for forfeitures as they occur. 
 Income taxes 
 The Company accounts for income taxes under the asset and liability method. Under this method, deferred tax assets and liabilities are determined based on the difference between the financial statement and tax bases of assets and liabilities using enacted tax rates in effect for the year in which the differences are expected to affect taxable income. Valuation allowances are established when in management’s estimate, it is more likely than not, that the deferred tax assets will not be recovered. 
 Financial statement effects of uncertain tax positions are recognized when it is more likely than not, based on the technical merits of the position, that it will be sustained upon examination. It is the Company’s policy to include penalties and interest expense related to income taxes as a component of the provision for income taxes. Non-income-based taxes are expensed as incurred within operating expenses on the Company’s consolidated statements of operations. 
 Comprehensive loss 
 Comprehensive loss represents the net loss for the period and other comprehensive income (loss). Other comprehensive income (loss) reflects certain gains and losses that are recorded as a component of stockholders’ equity (deficit) and are not reflected in the consolidated statements of operations. The Company’s other comprehensive income (loss) consists of changes in unrealized gains and losses on available-for-sale marketable securities. 
 Net loss per share 
 Basic net loss per share is calculated by dividing the net loss by the weighted-average number of shares of common stock (including non-voting common stock and pre-funded warrants) outstanding during the period, without consideration for all other common stock equivalents. Shares of common stock into which the pre-funded warrants may be exercised are considered outstanding for the purposes of computing net loss per share because the shares may be issued for little or no consideration, are fully vested and are exercisable after the original issuance date. Diluted net loss is calculated by dividing the net loss by the weighted-average number of common stock and potentially dilutive securities outstanding for the period. For purposes of the diluted net loss per share calculation, options to purchase common stock, options early exercised subject to vesting, RSUs and shares expected to be purchased under the ESPP are considered to be potentially dilutive securities. Diluted net loss per share is the same as basic net loss per share, since the effects of potentially dilutive securities are antidilutive given the net loss for each period presented. 
 Recent Accounting Pronouncements Not Yet Adopted 
 In November 2023, the Financial Accounting Standards Board (FASB) issued Accounting Standard Update (ASU) No. 2023‑07, Segment Reporting (Topic 280)—Improvements to Reportable Segment Disclosures (ASU 2023-07), which is intended to improve reportable segment disclosure requirements, primarily through enhanced disclosures about significant segment expenses. ASU 2023-07 should be applied on a retrospective basis. ASU 2023-07 is effective for annual periods beginning after December 15, 2023, and interim periods within fiscal years beginning after December 15, 2024. Early adoption is permitted. The Company is in the process of evaluating the impact of this new guidance on its disclosures. 
 131 

 
 

 In December 2023, the FASB issued ASU 2023-09—Income Taxes (Topic 740): Improvements to Income Tax Disclosures (ASU 2023-09), which is intended to enhance the transparency and decision usefulness of income tax disclosures, primarily by amending disclosure requirements for the effective tax rate reconciliation and income taxes paid. ASU 2023-09 should be applied on a prospective basis, and retrospective application is permitted. ASU 2023-09 is effective for annual periods beginning after December 15, 2024. Early adoption is permitted. The Company is in the process of evaluating the impact of this new guidance on its disclosures. 
 
 3. Collaboration Agreements 
 Gilead 
 In June 2019, the Company entered into a global strategic collaboration agreement with Gilead (as subsequently amended, the Gilead Agreement) to discover, develop and commercialize a pipeline of targeted protein degradation drugs for patients with cancer and other challenging diseases using the Company’s DELigase platform to identify novel agents that utilize E3 ligases to induce degradation of five specified drug targets. In August 2019 and September 2022, the Company entered into the First Amendment and the Second Amendment, respectively, to the Gilead Agreement to clarify certain language of the Gilead Agreement. These amendments had no impact on revenue recognition. 
 Under the Gilead Agreement, Gilead has the option to license drug candidates directed to up to five targets resulting from the collaboration and is responsible for the clinical development and commercialization of drug candidates resulting from the collaboration. The Company retains the option to co-develop and co-promote, under a profit share structure, up to two drug candidates in the United States, provided that the Company may only exercise such option once per licensed product and Gilead retains the right to veto the Company’s option selection for any one drug candidate of its choice. The collaboration excludes the Company’s current internal protein degradation programs for which the Company retains all rights, and also excludes the Company’s future internal programs, provided that the Company has distinguished future programs as excluded from the scope of the collaboration. In March 2023, Gilead exercised the option, which did not represent a material right at contract inception, since it was not offered for free or at a discount, to exclusively license one target (Gilead License Option Exercise), the first development candidate resulting from the Gilead Agreement. Pursuant to the Gilead Agreement, the Company received a license option exercise payment of $ 20.0 million in April 2023 for the Gilead License Option Exercise. The license to the functional intellectual property and all goods and services related to the Gilead License Option Exercise were transferred during the second quarter of fiscal year 2023. 
 Over time, Gilead may elect to replace the initial drug targets with other drug targets. For drug targets that are subject to the collaboration, the Company is obligated to use commercially reasonable efforts to undertake a research program in accordance with a research plan agreed to by the parties and established on a target-by-target basis. The Company has primary responsibility under the Gilead Agreement for performing preclinical research activities (including target validation, drug discovery, identification or synthesis) pursuant to a research plan. Each party will bear its own costs in the conduct of research activities. Gilead will be responsible for any development, commercialization and manufacturing activities, unless the Company exercises its co-development and co-promotion option. For those programs that the Company exercises its option to co-develop and co-promote, the Company and Gilead will split U.S. development costs as well as U.S. profits and losses evenly, and the Company will be eligible to receive royalties on net ex-U.S. sales and reduced milestone payments. 
 Upon signing the Gilead Agreement, Gilead paid the Company an upfront payment of $ 45.0 million plus $ 3.0 million in additional fees. In addition, from the signing of the Gilead Agreement to November 30, 2023, the Company has received payments of $ 47.0 million for research milestones and additional payments and $ 20.0 million for a license option exercise payment. As of November 30, 2023, the Company is eligible to receive up to approximately $ 2.3 billion in total additional payments based on certain additional fees, payments and the successful completion of certain preclinical, clinical, development and sales milestones. The Company also is eligible to receive mid-single digit to low tens percentage tiered royalties on annual net sales from any commercial products directed to the optioned collaboration targets, subject to certain reductions and excluding sales in the United States of any products for which the Company exercises its option to co-develop and co-promote, for which the parties share profits and losses evenly. 
 Subject to earlier expiration in certain circumstances, the Gilead Agreement expires on a licensed product-by-licensed product and country-by-country basis upon the later of (1) the expiration of the last to expire patent with a valid claim covering the applicable licensed product in the applicable country, (2) the expiration of any regulatory exclusivity for the applicable licensed product in the applicable country or (3) ten years after the first commercial sale of the applicable licensed product in the applicable country covered by the Gilead Agreement, provided that the term for any profit-shared licensed product in the United States will expire upon the expiration or termination of the applicable profit-share term as set forth in an applicable profit-share agreement to be negotiated upon the Company’s exercise of its option to co-develop and co-promote such licensed product. If Gilead does not exercise an option to license a drug candidate, then the Gilead Agreement will terminate at the end of the last to expire option period. 
 132 

 
 

 The Company identified the following promises in the Gilead Agreement: (1) the research licenses, (2) the research services, including selection campaign research services for certain replacement targets, (3) the obligation to share information during the research term and (4) the participation in the joint research committee and joint steering committee. The Company determined that the research licenses, the obligation to share information and the participation in joint committees are not capable of being distinct from the research services due to the specialized nature of the research services to be provided by the Company, and, accordingly, the promises identified were combined as one single performance obligation. The Company also concluded that, at the inception of the Gilead Agreement, Gilead’s options to obtain an exclusive development, manufacturing and commercialization license for each collaboration target, to extend the five-year research term and to perform selection campaign research services for certain replacement targets do not represent material rights and are not considered performance obligations because they do not contain a significant and incremental discount. The Company concluded that Gilead’s target reservation right is not a performance obligation as it does not require any specific action from the Company and it is rather an exclusivity right and an attribute of other performance obligations in the Gilead Agreement, such as the research licenses. 
 In order to determine the transaction price, the Company evaluated all the payments to be received during the duration of the contract. Certain milestone payments and additional fees were considered variable consideration, which were not included in the transaction price based on the most likely amount method as of November 30, 2023. The Company re-evaluates the transaction price in each reporting period and as uncertain events are resolved or other changes in circumstances occur. The Company determined that the transaction price at the inception of the Gilead Agreement consisted of the upfront payment of $ 45.0 million and $ 3.0 million in additional fees. Upon the achievement of research milestones and additional fees related to target reservations, $ 47.0 million in variable consideration was added to the transaction price, and a cumulative effect was recorded as revenue in the period the transaction price increased. The transaction price is recognized as collaboration revenue using the cost-based input method over the estimated research term of five years . The contract term was determined to be the five-year initial research term which represents the estimated timing of completion of the identified deliverables. Additionally, the Company considered the impact of Gilead terminating the Gilead Agreement prior to the completion of the research services during the initial five-year research term and determined that there were significant economic costs to Gilead for doing so, and as such, did not adjust the contract term. 
 Using the cost-based input method, which the Company determined most faithfully depicts the transfer of its performance obligation to Gilead, the Company recognizes revenue based on actual costs incurred as a percentage of total estimated costs as the Company completes its performance obligation under the contract. Costs consist primarily of internal full-time employee (FTE) and third-party contract costs related to the Gilead Agreement. The cumulative effect of revisions to estimated costs to complete the Company’s performance obligation is recorded in the period in which changes are identified and amounts can be reasonably estimated. Total estimated costs are primarily driven by the number of estimated FTEs, which requires significant management judgment. 
 For the year ended November 30, 2023, the Company recognized collaboration revenue related to the Gilead Agreement of $ 29.9 million, of which $ 20.3 million was included in deferred revenue as of November 30, 2022, and $ 7.9 million was related to performance obligations satisfied in previous periods. For the year ended November 30, 2022, the Company recognized collaboration revenue related to the Gilead Agreement of $ 23.7 million, of which $ 18.4 million was included in deferred revenue as of November 30, 2021, and $ 4.0 million was related to performance obligations satisfied in previous periods. As of November 30, 2023, deferred revenue related to the Gilead Agreement was $ 10.0 million, all of which was current. As of November 30, 2022, deferred revenue related to the Gilead Agreement was $ 27.4 million, of which $ 18.2 million was current. 
 Sanofi 
 In December 2019, the Company entered into a strategic collaboration with Genzyme Corporation, a subsidiary of Sanofi, which became effective in January 2020 (as subsequently expanded and amended, the Sanofi Agreement), to discover, develop and commercialize a pipeline of targeted protein degradation drugs for patients with challenging diseases in multiple therapeutic areas using the Company’s DELigase platform to identify small molecules designed to induce degradation of three specified initial drug targets. In January 2021, as part of the existing Sanofi Agreement, Sanofi paid the Company $ 22.0 million to exercise its option to expand the number of targets in the Sanofi Agreement from three to a total of five targets. 
 133 

 
 

 In January 2021, the Company entered into the First Amendment to the Sanofi Agreement to modify the research term on all targets (the First Sanofi Amendment). In December 2021, the Company entered into the Second Amendment to the Sanofi Agreement to extend the substitution deadline on certain targets. In July 2022, the Company entered into the Third Amendment to the Sanofi Agreement to further extend the substitution deadline on certain targets. The extensions of the substitution deadline had no impact on revenue recognition. Also in July 2022, Sanofi elected to replace certain drug targets, and the substitution extended the research term of those targets by one year to 5.25 years and increased overall forecasted costs, which had an immaterial impact on revenue recognition. In August 2022 and November 2023, the Company entered into the Fourth Amendment and Fifth Amendment, respectively, to the Sanofi Agreement to modify the research plan for certain targets, which had no impact on revenue recognition. 
 Under the Sanofi Agreement, Sanofi has exclusive rights and is responsible for the clinical development, commercialization and manufacture of drug candidates resulting from the collaboration while the Company retains the option to co-develop, co-promote and co-commercialize all drug candidates in the United States directed to up to two targets, one of which must be selected from a list of targets designated at the execution of the Sanofi Agreement or any replacement of such targets, and one of which must be selected from targets identified by Sanofi as part of their January 2021 expansion. The Company’s right to exercise its option to co-develop, co-promote and co-commercialize a given target is dependent on its ability to demonstrate, within a given timeframe, that it has sufficient cash resources and personnel to commercialize the product. The collaboration excludes the Company’s current internal protein degradation programs for which it retains all rights, and also excludes future internal programs, provided that the Company distinguished future programs as excluded from the scope of the collaboration. 
 For drug targets that are subject to the collaboration, the Company has primary responsibility for conducting preclinical research activities (including target validation, drug discovery, identification or synthesis) in accordance with the applicable research plan agreed to by the parties and established on a target-by-target basis. The Company is obligated to use commercially reasonable efforts to identify relevant target binders and targeted protein degraders in order to identify development candidates. Subject to certain exceptions, each party will bear its own costs in the conduct of such research. Sanofi will be responsible for any development and commercialization activities unless the Company exercises its co-development and co-promotion option. For those programs that the Company exercises its option to co-develop, co-promote and co-commercialize, the Company will be responsible for a portion of the U.S. development costs, and the parties will split U.S. profits and losses evenly and the Company will be eligible to receive royalties on ex-U.S. net sales and reduced milestone payments on such optioned products. 
 Upon signing the Sanofi Agreement, Sanofi paid the Company an upfront payment of $ 55.0 million. Subsequently, in January 2021, Sanofi paid the Company an additional $ 22.0 million to exercise its option to expand the number of targets beyond the initial targets included in the collaboration. In addition, from the signing of the Sanofi Agreement to November 30, 2023, the Company has received payments of $ 7.0 million for research milestones. Additionally, the Company achieved two research milestones in November 2023 and received payments totaling $ 4.0 million in January 2024 as a result. As of November 30, 2023, the Company is eligible to receive up to approximately $ 2.5 billion in total additional payments based on certain additional fees, payments and the successful completion of certain research development, regulatory and sales milestones, as well as mid-single digit to low teen percentage tiered royalties on annual net sales of any commercial products that may result from the collaboration, subject to certain reductions and excluding sales in the United States of any products for which the Company exercises its option to co-develop and co-promote, for which the parties share profits and losses evenly. 
 Subject to earlier expiration in certain circumstances, the Sanofi Agreement expires on a licensed product-by-licensed product or profit-shared licensed product-by-profit-shared licensed product basis and country-by-country basis upon on the later of (1) the expiration of the last-to-expire patent with a valid claim covering the applicable licensed product in the applicable country, (2) the expiration of any regulatory exclusivity for the applicable licensed product in the applicable country or (3) ten years after the first commercial sale of the applicable licensed product in the applicable country covered by the Sanofi Agreement. 
 The Company identified the following promises in the Sanofi Agreement: (1) the research licenses, (2) the research services, (3) the obligation to share information during the research term and (4) the participation of alliance managers in the joint research committee and joint patent committee. The Company determined that the research licenses, the obligation to share information and the participation in the joint committees are not capable of being distinct from the research services due to the specialized nature of the research services to be provided by the Company, and, accordingly, the promises identified were combined as one single performance obligation. The Company also determined that Sanofi’s exclusive right to add up to two additional targets constitutes a material right as it represents a significant and incremental discount that Sanofi would not have received without entering into the Sanofi Agreement. The option to extend the license term does not represent a material right because it does not contain a significant and incremental discount. 
 134 

 
 

 In order to determine the transaction price, the Company evaluated all the payments to be received during the duration of the contract. Certain milestone payments and additional fees were considered variable consideration, which were not included in the transaction price based on the most likely amount method as of November 30, 2023. The Company re-evaluates the transaction price in each reporting period and as uncertain events are resolved or other changes in circumstances occur. At the inception of the Sanofi Agreement, the Company determined that the transaction price consisted of the upfront payment of $ 55.0 million for three initial drug targets and $ 22.0 million for two additional targets. Subsequently, upon the achievement of research milestones, $ 11.0 million in variable consideration was added to the transaction price, which includes $ 4.0 million added during the three months ended November 30, 2023, and a cumulative effect was recorded as revenue in the period the transaction price increased. Revenue is recognized using the cost-based input method over the research term of 4.25 years, the revised research period that was agreed to in January 2021 in the First Sanofi Amendment, for certain targets, and 5.25 years, the revised research period due to the target substitutions in July 2022, for certain other targets. 
 Using the cost-based input method, which the Company determined most faithfully depicts the transfer of its performance obligation to Sanofi, the Company recognizes revenue based on actual costs incurred as a percentage of total estimated costs as the Company completes its performance obligation under the contract. Costs consist primarily of internal FTE and third-party contract costs related to the Sanofi Agreement. The cumulative effect of revisions to estimated costs to complete the Company’s performance obligation is recorded in the period in which changes are identified and amounts can be reasonably estimated. Total estimated costs are primarily driven by the number of estimated FTEs, which requires significant management judgment. 
 For the year ended November 30, 2023, the Company recognized collaboration revenue related to the Sanofi Agreement of $ 25.4 million, of which $ 21.0 million was included in deferred revenue as of November 30, 2022, and $ 2.6 million was related to performance obligations satisfied in previous periods. For the year ended November 30, 2022, the Company recognized collaboration revenue related to the Sanofi Agreement of $ 15.0 million, of which $ 14.0 million was included in deferred revenue as of November 30, 2021, and $ 0.6 million was related to performance obligations satisfied in previous periods. As of November 30, 2023, deferred revenue related to the Sanofi Agreement was $ 24.9 million, of which $ 20.3 million was current and includes $ 4.0 million in contract assets representing the unbilled amount related to the research milestones recognized in November 2023. As of November 30, 2022, deferred revenue related to the Sanofi Agreement was $ 46.2 million, of which $ 19.4 million was current and includes $ 1.0 million in contract assets representing the unbilled amount related to the research milestone recognized in November 2022. 
 Pfizer 
 In September 2023, the Company entered into a strategic collaboration with Seagen Inc. (now a part of Pfizer Inc.) (the Pfizer Agreement) to develop a suite of targeted protein degraders against multiple targets nominated by Pfizer that are suitable for antibody conjugation. Pfizer will be responsible for conjugating these degraders to antibodies to make Degrader-Antibody Conjugates (DACs), a new class of medicines for use in cancer treatment, and advancing these DAC drug candidates through preclinical and clinical development and commercialization. 
 Under the Pfizer Agreement, Pfizer has the option to obtain exclusive licenses to develop and commercialize certain degraders, while the Company retains an option for U.S. profit sharing and co-promotion on two products arising from the collaboration. The collaboration excludes the Company’s current internal protein degradation programs for which the Company retains all rights, and also excludes the Company’s future internal programs, provided that the Company has distinguished future programs as excluded from the scope of the collaboration. 
 For the targets nominated by Pfizer under the collaboration, the Company shall use commercially reasonable efforts to identify, synthesize, characterize and deliver targeted protein degraders that selectively bind to and degrade such targets. Development of licensed degraders, with the exception of licensed products for which the Company exercises its profit-share options, will be at Pfizer’s sole cost and expense. For the profit-share products, the parties will share net profits and net losses and global development costs, and the Company will be eligible to receive royalty and milestone payments on such optioned products. 
 Under the terms of the Pfizer Agreement, the Company received an upfront payment of $ 60.0 million. The Company is eligible to receive up to approximately $ 3.4 billion in contingent payments based on specified research, development, regulatory and commercial milestones across multiple programs, and is eligible for mid-single to low double digit percentage tiered royalties on future sales. 
 Subject to the exceptions described in the Pfizer Agreement, the Pfizer Agreement expires upon the first to occur of (1) the expiration of the last-to-expire option exercise period under the Pfizer Agreement if no such option has been exercised prior to such expiration and (2) the expiration of the last-to-expire royalty term under the Pfizer Agreement. 
 135 

 
 

 The Company identified the following promises in the Pfizer Agreement: (1) the research licenses, (2) the research services, (3) the participation of a gatekeeper and an alliance managers and the participation in various joint committees, and (4) the obligation to share information during the research term. The Company determined that the research licenses, the participation in the joint committees and the obligation to share information are not capable of being distinct from the research services, and, accordingly, the identified promises were combined as one single performance obligation. The Company also determined that, at the inception of the Pfizer Agreement, Pfizer’s options to obtain an exclusive development, manufacturing and commercialization license for each collaboration target and to extend the four-year research term do not represent material rights and are not considered performance obligations because they do not contain a significant and incremental discount. Additionally, Pfizer’s target reservation right is not a performance obligation as it is an exclusivity right and an attribute of other performance obligations in the Pfizer Agreement, such as the research licenses, and does not require any specific actions from the Company. 
 In order to determine the transaction price, the Company evaluated all the payments to be received during the duration of the contract. Milestone payments and additional fees were considered variable consideration, which were not included in the transaction price based on the most likely amount method as of November 30, 2023. The Company re-evaluates the transaction price in each reporting period and as uncertain events are resolved or other changes in circumstances occur. The Company determined that the transaction price at the inception of the Pfizer Agreement consisted of the upfront payment of $ 60.0 million. The Company has not yet achieved any research milestones and no variable consideration has been added to the transaction price. The transaction price is recognized as collaboration revenue using the cost-based input method over the estimated research term of four years , which represents the estimated period to complete the identified deliverables. Additionally, the Company considered the impact of Pfizer terminating the Pfizer Agreement prior to the completion of the research services during the initial four-year research term and determined that there were significant economic costs to Pfizer for doing so, and as such, did not adjust the contract term. 
 Using the cost-based input method, which the Company determined most faithfully depicts the transfer of its performance obligation to Pfizer, the Company recognizes revenue based on actual costs incurred as a percentage of total estimated costs as the Company completes its performance obligation under the contract. Costs consist primarily of internal FTE and third-party contract costs related to the Pfizer Agreement. The cumulative effect of revisions to estimated costs to complete the Company’s performance obligation is recorded in the period in which changes are identified and amounts can be reasonably estimated. Total estimated costs are primarily driven by the number of estimated FTEs, which requires significant management judgment. 
 For the year ended November 30, 2023, the Company recognized collaboration revenue related to the Pfizer Agreement of $ 1.7 million. As of November 30, 2023, deferred revenue related to the Pfizer Agreement was $ 58.3 million, of which $ 17.9 million was current. 
 
 4. Consolidated Balance Sheet Components 
 Property and Equipment, Net 
 Property and equipment, net, consisted of the following (in thousands): 
 
 November 30, 
 2023 2022 
 Laboratory equipment $ 32,239 $ 26,385 
 Leasehold improvements 3,238 3,825 
 Computer equipment 938 786 
 Furniture and fixtures 652 452 
 Software 5,403 4,688 
 Software in progress 587 697 
 Total property and equipment, gross 43,057 36,833 
 Less: Accumulated depreciation and amortization ( 26,249 ) ( 19,670 ) 
 Total property and equipment, net $ 16,808 $ 17,163 

 For the years ended November 30, 2023 and 2022, depreciation and amortization expense was $ 7.5 million and $ 5.3 million, respectively, which includes amortization expense related to capitalized software of $ 1.4 million and $ 1.2 million, respectively. All long-lived assets are maintained in the United States. 
 136 

 
 

 Accrued Expenses and Other Current Liabilities 
 Accrued expenses and other current liabilities consisted of the following (in thousands): 
 
 November 30, 
 2023 2022 
 Accrued compensation $ 15,303 $ 13,164 
 Accrued contract research and lab supplies 7,131 6,426 
 Accrued professional services 1,755 1,250 
 Accrued taxes 30 85 
 Other 751 1,503 
 Total accrued expenses and other current liabilities $ 24,970 $ 22,428 

 
 5. Fair Value Measurements 
 In accordance with the authoritative guidance on fair value measurements and disclosures under U.S. GAAP, the Company discloses and recognizes the fair value of its assets and liabilities using a hierarchy that prioritizes the inputs to valuation techniques used to measure fair value. The hierarchy gives the highest priority to valuations based upon unadjusted quoted prices in active markets for identical assets or liabilities (Level 1 measurements) and the lowest priority to valuations based upon unobservable inputs that are significant to the valuation (Level 3 measurements). The guidance establishes three levels of the fair value hierarchy as follows: 
 Level 1—Inputs that reflect unadjusted quoted prices in active markets for identical assets or liabilities that the Company has the ability to access at the measurement date; 
 Level 2—Inputs other than quoted prices included within Level 1 that are observable for the asset or liability either directly or indirectly, including inputs in markets that are not considered to be active; and 
 Level 3—Inputs that are unobservable. 
 Assets and liabilities measured at fair value are classified in their entirety based on the lowest level of input that is significant to the fair value measurement. The Company’s assessment of the significance of a particular input to the fair value measurement in its entirety requires management to make judgments and considers factors specific to the asset or liability. 
 The following tables present the Company’s investments, which consist of cash equivalents and available-for-sale marketable securities, that are measured at fair value on a recurring basis as of November 30, 2023 and 2022 (in thousands): 
 
 November 30, 2023 Level Amortized
cost Unrealized
gain Unrealized
loss Estimated
fair value 
 Money market funds Level 1 $ 44,187 $ — $ — $ 44,187 
 U.S. treasury securities Level 1 160,991 61 ( 29 ) 161,023 
 Corporate debt securities Level 2 3,487 — ( 56 ) 3,431 
 U.S. government agency securities Level 2 69,389 5 ( 567 ) 68,827 
 Long-term marketable securities: 
 U.S. government agency securities Level 2 7,490 — ( 69 ) 7,421 
 Total $ 285,544 $ 66 $ ( 721 ) $ 284,889 
 Included in cash and cash equivalents $ 44,187 $ — $ — $ 44,187 
 Included in marketable securities, current $ 233,867 $ 66 $ ( 652 ) $ 233,281 
 Included in marketable securities, non-current $ 7,490 $ — $ ( 69 ) $ 7,421 

 
 
 137 

 
 

 
 November 30, 2022 Level Amortized
cost Unrealized
gain Unrealized
loss Estimated
fair value 
 Money market funds Level 1 $ 59,452 $ — $ — $ 59,452 
 U.S. treasury securities Level 1 75,322 — ( 1,120 ) 74,202 
 Corporate debt securities Level 2 81,026 — ( 1,279 ) 79,747 
 U.S. government agency securities Level 2 8,998 — ( 135 ) 8,863 
 Corporate commercial paper Level 2 74,896 — — 74,896 
 Foreign government securities Level 2 7,051 — ( 92 ) 6,959 
 Long-term marketable securities: 
 U.S. treasury securities Level 1 5,779 — ( 98 ) 5,681 
 Corporate debt securities Level 2 3,492 — ( 217 ) 3,275 
 U.S. government agency securities Level 2 56,301 1 ( 1,379 ) 54,923 
 Total $ 372,317 $ 1 $ ( 4,320 ) $ 367,998 
 Included in cash and cash equivalents $ 59,452 $ — $ — $ 59,452 
 Included in marketable securities, current $ 247,293 $ — $ ( 2,626 ) $ 244,667 
 Included in marketable securities, non-current $ 65,572 $ 1 $ ( 1,694 ) $ 63,879 

 The following table summarizes the available-for-sale marketable securities in an unrealized loss position for which an allowance for credit losses has not been recorded as of November 30, 2023 and 2022, aggregated by investment category and length of time in a continuous unrealized loss position (in thousands): 
 
 Less than 12 months Greater than 12 months Total 
 November 30, 2023 Fair Value Gross Unrealized Loss Fair Value Gross Unrealized Loss Fair Value Gross Unrealized Loss 
 U.S. treasury securities $ 46,694 $ ( 4 ) $ 5,936 $ ( 25 ) $ 52,630 $ ( 29 ) 
 Corporate debt securities — — 3,431 ( 56 ) 3,431 ( 56 ) 
 U.S. government agency securities 23,599 ( 108 ) 48,805 ( 528 ) 72,404 ( 636 ) 
 Total $ 70,293 $ ( 112 ) $ 58,172 $ ( 609 ) $ 128,465 $ ( 721 ) 

 
 
 
 Less than 12 months Greater than 12 months Total 
 November 30, 2022 Fair Value Gross Unrealized Loss Fair Value Gross Unrealized Loss Fair Value Gross Unrealized Loss 
 U.S. treasury securities $ 40,747 $ ( 377 ) $ 39,136 $ ( 841 ) $ 79,883 $ ( 1,218 ) 
 Corporate debt securities 14,257 ( 152 ) 68,765 ( 1,344 ) 83,022 ( 1,496 ) 
 U.S. government agency securities 45,395 ( 663 ) 15,391 ( 851 ) 60,786 ( 1,514 ) 
 Foreign government securities — — 6,959 ( 92 ) 6,959 ( 92 ) 
 Total $ 100,399 $ ( 1,192 ) $ 130,251 $ ( 3,128 ) $ 230,650 $ ( 4,320 ) 

 The accrued interest receivable related to the Company’s marketable securities was $ 0.8 million and $ 1.1 million as of November 30, 2023 and 2022, respectively, and was included in prepaid expenses and other current assets on the consolidated balance sheet. Long-term marketable securities held by the Company generally mature within two years from the balance sheet date. 
 The Company classifies its money market funds and U.S. treasury securities, which are valued based on quoted market prices in active markets with no valuation adjustment, as Level 1 assets within the fair value hierarchy. 
 138 

 
 

 The Company classifies its marketable securities in corporate debt securities, U.S. government agency securities, corporate commercial paper and foreign government securities as Level 2 assets within the fair value hierarchy. The fair values of these marketable securities are estimated by taking into consideration valuations obtained from third-party pricing services. The pricing services utilize industry standard valuation models, including both income- and market-based approaches, for which all significant inputs are observable, either directly or indirectly, to estimate fair value. These inputs include reported trades of and broker/dealer quotes on the same or similar securities, issuer credit spreads, benchmark securities, prepayment/default projections based on historical data and other observable inputs. There were no transfers of financial instruments between valuation levels during the years ended November 30, 2023 and 2022. 
 As of November 30, 2023 and 2022, the unrealized losses for available-for-sale marketable securities were non-credit related, and the Company does not intend to sell the securities that were in an unrealized loss position, nor will it be required to sell those securities before recovery of their amortized cost basis, which may be maturity. As of November 30, 2023 and 2022, no allowance for credit losses for the Company’s marketable securities was recorded. During the years ended November 30, 2023 and 2022, the Company did not recognize any impairment losses related to marketable securities. 
 
 6. Commitments and Contingencies 
 Legal Proceedings 
 From time to time, the Company may be involved in legal proceedings in the ordinary course of business. The Company accrues a liability for such matters when it is probable that future expenditures will be made and that such expenditures can be reasonably estimated. Significant judgment is required to determine both probability and the estimated amount. Legal fees and other costs associated with such actions are expensed as incurred. As of November 30, 2023, the Company was not a party to any material legal proceedings. 
 Indemnifications 
 In the ordinary course of business, the Company often includes standard indemnification provisions in its arrangements with its partners, suppliers and vendors, among others. Pursuant to these provisions, the Company may be obligated to indemnify such parties for losses or claims suffered or incurred in connection with its service, breach of representations or covenants, intellectual property infringement or other claims made against such parties. These provisions may limit the time within which an indemnification claim can be made. It is not possible to determine the maximum potential amount under these indemnification obligations due to the limited history of prior indemnification claims and the unique facts and circumstances involved in each particular agreement. The Company has not incurred any material costs as a result of such indemnifications and has not accrued any liabilities related to such obligations in these consolidated financial statements as management believes such liability is immaterial. 
 In addition, the Company has entered into indemnification agreements with directors and certain officers and employees that will require the Company, among other things, to indemnify them against certain liabilities that may arise by reason of their status or service as directors, officers or employees. No demands have been made upon the Company to provide indemnification under such agreements, and thus, there are no claims that the Company is aware of that could have a material effect on the Company’s consolidated financial statements. The maximum potential amount of future payments the Company could be required to make under these indemnification agreements is not specified in the agreements. However, the Company currently has directors’ and officers’ insurance that reduces its exposure and may enable the Company to recover a portion of any future amounts paid. 
 Operating Leases 
 The Company leases office and laboratory facilities totaling approximately 57,902 square feet within the same building in San Francisco, California under several lease agreements. The terms of these lease agreements expire in April 2025. The Company has an option to renew these leases for an additional two years , and the renewal term has not been included in the lease term used to calculate the right-of-use asset and lease liability as it is not reasonably certain that the Company will exercise the option. 
 In July 2021, the Company entered into a lease agreement for the lease of approximately 19,320 square feet of office space in a different building in San Francisco, California. The lease commenced in December 2021 and will expire in June 2024, unless terminated earlier. 
 139 

 
 

 In March 2022, the Company entered into a lease agreement for the lease of approximately 46,434 square feet of office space in The Woodlands, Texas. In August 2023, the lease agreement was amended to increase the square footage of the leased premise to 50,094 square feet. The amendment had no impact on the accounting for the lease. The Company has an option to renew for two additional terms of five years each, and the renewal terms have not been included in the lease term used to calculate the right-of-use asset and lease liability as it is not reasonably certain that the Company will exercise the option. The lease commenced in September 2023 when the underlying assets became available for use and will expire in March 2035. 
 The Company is required to pay base rent plus its proportionate share of operating expenses, as defined in the applicable lease agreement on all of its leases. Variable lease payments related to operating expenses including utilities, maintenance costs and real estate taxes were $ 6.2 million and $ 4.4 million for the years ended November 30, 2023 and 2022, respectively. Additionally, for the year ended November 30, 2022, certain leased premises were subject to additional variable lease payments related to landlord-owned improvements which were not estimable at lease inception. The right-of-use asset recognized in exchange for lease obligations for these additional variable lease payments was $ 1.2 million for the year ended November 30, 2022. 
 Operating lease expenses, excluding variable lease payments, were $ 6.8 million and $ 5.9 million for the years ended November 30, 2023 and 2022, respectively. Short-term lease expense was not material for the periods presented. As of November 30, 2023, the weighted average remaining lease term was 9.1 years and the weighted average discount rate was 6.45 %. 
 Other information related to leases were as follows (in thousands): 
 
 Year Ended November 30, 
 2023 2022 
 Cash paid for amounts included in the measurement of lease liabilities: 
 Cash flows from operating leases $ 6,973 $ 6,578 

 The undiscounted future non-cancellable lease payments under the Company’s lease agreements as of November 30, 2023 were as follows (in thousands): 
 
 Year ending November 30, Operating
Leases 
 2024 $ 7,646 
 2025 4,574 
 2026 2,913 
 2027 2,993 
 2028 3,076 
 2029 to 2035 21,244 
 Total undiscounted lease payments 42,446 
 Less: imputed interest ( 11,832 ) 
 Total operating lease liabilities $ 30,614 
 Operating lease liabilities, current $ 7,489 
 Operating lease liabilities, net of current portion 23,125 
 Total operating lease liabilities $ 30,614 

 
 7. Common Stock 
 The Company’s Restated Certificate of Incorporation authorizes the Company to issue up to 500,000,000 shares of common stock, $ 0.001 par value per share, as of November 30, 2023 and 2022. Holders of common stock are entitled to dividends when and if declared by the Company’s board of directors, subject to the prior rights of the holders of shares of preferred stock. The holder of each share of common stock is entitled to one vote. As of November 30, 2023, no dividends have been declared. 
 140 

 
 

 In July 2022, the Company issued pre-funded warrants to purchase an aggregate of 6,814,920 shares of the Company’s common stock in RDOs at a price of $ 13.939 per pre-funded warrant. The pre-funded warrants were immediately exercisable, have an exercise price of $ 0.001 and may be exercised at any time after the date of issuance. A holder of pre-funded warrants may not exercise the warrant if the holder, together with its affiliates, would beneficially own more than 9.99 % of the number of shares of the Company’s common stock outstanding immediately after giving effect to such exercise. A holder of the pre-funded warrants may increase or decrease this percentage not in excess of 19.99 % by providing at least 61 days’ prior notice to the Company. As of November 30, 2023, there were pre-funded warrants to purchase an aggregate of 6,097,560 shares of the Company’s common stock that remained available for exercise. 
 The pre-funded warrants were classified as a component of permanent equity in the Company's consolidated balance sheet as they are freestanding financial instruments that are immediately exercisable, do not embody an obligation for the Company to repurchase its own shares and permit the holders to receive a fixed number of shares of common stock upon exercise. All of the shares underlying the pre-funded warrants have been included in the weighted-average number of shares of common stock used to calculate net loss per share attributable to common stockholders because the shares may be issued for little or no consideration, are fully vested and are exercisable after the original issuance date of the pre-funded warrants. 
 Common stock reserved for future issuance, on an as-if converted basis, as of November 30, 2023 and 2022, consists of the following: 
 
 November 30, 
 2023 2022 
 Options to purchase common stock issued and outstanding 8,340,968 8,256,957 
 Shares available for future equity grants 1,614,035 834,291 
 Shares available for issuance under employee stock purchase plan 1,530,281 1,325,523 
 Restricted stock units issued and outstanding 1,246,031 784,824 
 Pre-funded warrants issued and outstanding 6,097,560 6,814,920 
 Total common stock reserved for future issuance 18,828,875 18,016,515 

 
 8. Stock-Based Compensation 
 Equity Incentive Plans 
 The Company’s 2020 Equity Incentive Plan (the 2020 Plan) serves as the successor to the Company’s 2012 Equity Incentive Plan (together with the 2020 Plan, the Stock Plans) and provides for the granting of stock options, stock appreciation rights, restricted stock awards, RSUs, performance awards and stock bonus awards to employees, directors, consultants, independent contractors and advisors of the Company. 
 Under the Stock Plans, the Company generally grants stock-based awards with service-based vesting conditions only. Options granted typically vest under various different vesting terms over a four-year period and expire ten years from the date of grant. In the case of an incentive stock option granted to an employee who at the time of grant owns stock representing more than 10 % of the total combined voting power of all classes of stock, the exercise price shall be no less than 110 % of the fair value per share on the date of grant, and the award shall expire five years from the date of grant. In the case of all other stock options, the per share exercise price shall be no less than 100 % of the fair value per share on the date of grant. RSUs issued typically vest under various different vesting terms over a two - to four-year period. 
 Following the effectiveness of the 2020 Plan on July 22, 2020, the Company ceased making grants under the 2012 Plan. However, the 2012 Plan continues to govern the terms and conditions of the outstanding awards granted under it. Shares of common stock subject to awards granted under the 2012 Plan that cease to be subject to such awards by forfeiture or otherwise will be available for issuance under the 2020 Plan. 
 As of November 30, 2023, there were 1,614,035 shares of common stock reserved for future issuance pursuant to the 2020 Plan. 
 141 

 
 

 Stock options 
 Option activity under the Stock Plans is set forth below: 
 Number of
options
outstanding Weighted-
average
exercise
price Weighted-
average
contractual
life
(in years) Aggregate 
 intrinsic 
 value (1) 
 (in thousands) 
 
 Balances as of November 30, 2022 8,256,957 $ 19.47 8.44 $ 13,210 
 Options granted 1,991,212 10.29 
 Options exercised ( 120,826 ) 8.16 
 Options forfeited ( 1,786,375 ) 20.74 
 Balances as of November 30, 2023 8,340,968 $ 17.17 7.77 $ 3,295 
 Options vested and expected to vest as of November 30, 2023 (2) 
 8,345,877 $ 17.16 7.77 $ 3,295 
 Options exercisable as of November 30, 2023 4,750,849 $ 17.25 7.12 $ 3,295 

 ____________________________ 
 (1) 
 The aggregate intrinsic values were calculated as the pre-tax difference between the exercise price of stock options and the quoted market price of the Company’s common stock on November 30, 2023 for all in‑the‑money stock options. The total intrinsic value of stock options exercised during the years ended November 30, 2023 and 2022 was $ 0.2 million and $ 4.5 million, respectively. 
 

 
 (2) 
 As of November 30, 2023, a total of 4,909 shares of common stock were early exercised and subject to repurchase by the Company at the lower of (i) the fair value of such shares on the date of repurchase, or (ii) the original exercise price of such shares. The corresponding exercise value was immaterial and recorded as a stock-based compensation liability. 
 

 The fair value of options granted during the years ended November 30, 2023 and 2022 was estimated using the Black-Scholes option pricing model on the grant date using the following assumptions: 
 
 November 30, 
 2023 2022 
 Expected term (years) 5.50 - 6.06 
 5.50 - 6.07 
 
 Expected volatility 74 % - 92 % 
 70 % - 74 % 
 
 Risk-free interest rate 3.27 % - 4.59 % 
 1.31 % - 4.22 % 
 
 Dividend yield 0 % 0 % 

 The expected term represents the weighted-average period the stock-based payments are expected to remain outstanding. The expected term assumption for stock options was determined using the simplified method for “plain-vanilla” options. The expected stock price volatility assumption was determined by examining the historical volatilities for industry peers, as the Company does not have sufficient trading history for its common stock. The risk-free rate assumption is based on the U.S. Treasury instruments. The expected dividend assumption is based on the Company’s history and expectation of dividend payouts. The expected dividend yield is 0 % as the Company has not paid and does not anticipate paying dividends on its common stock. 
 During the years ended November 30, 2023 and 2022, the weighted-average grant date fair value of options granted was $ 7.22 and $ 11.80 per share, respectively. 
 142 

 
 

 Restricted stock units 
 RSU activity under the Stock Plans is set forth below: 
 
 Number of RSUs Weighted-average grant date fair value 
 Balances as of November 30, 2022 784,824 $ 18.97 
 RSUs granted 1,109,427 10.53 
 RSUs vested ( 441,103 ) 17.99 
 RSUs forfeited ( 207,117 ) 14.30 
 Balances as of November 30, 2023 1,246,031 $ 12.58 

 During the years ended November 30, 2023 and 2022, the weighted-average grant date fair value of RSUs granted was $ 10.53 and $ 19.11 per share, respectively, and the total fair value of RSUs vested was $ 7.9 million and $ 0.9 million, respectively. 
 Employee Stock Purchase Plan 
 Under the Company’s ESPP, eligible employees are entitled to purchase shares of common stock at a discount with accumulated payroll deductions. The purchase price for shares of common stock purchased under the ESPP will be 85 % of the lesser of the fair market value of the Company’s common stock on (i) the first trading day of the applicable offering period or (ii) the last trading day of each purchase period in the applicable offering period. 
 During the year ended November 30, 2023, the Company issued 266,964 shares pursuant to the ESPP at a weighted-average price of $ 8.35 per share. As of November 30, 2023, there were 1,530,281 shares of common stock reserved for issuance pursuant to the ESPP. 
 The fair value of ESPP granted during the years ended November 30, 2023 and 2022 was estimated using the Black-Scholes option pricing model on the grant date using the following assumptions: 
 
 November 30, 
 2023 2022 
 Expected term (years) 0.5 
 0.5 
 
 Expected volatility 67 % 
 70 % - 101 % 
 
 Risk-free interest rate 4.98 % - 5.54 % 
 0.67 % - 3.12 % 
 
 Dividend yield 0 % 0 % 

 Stock-Based Compensation 
 Stock-based compensation expense related to the Stock Plans and the ESPP that is included in the Company’s consolidated statements of operations is as follows (in thousands): 
 
 Year Ended November 30, 
 2023 2022 
 Research and development $ 18,707 $ 16,808 
 General and administrative 14,966 11,323 
 Total stock-based compensation $ 33,673 $ 28,131 

 During the years ended November 30, 2023 and 2022, capitalized stock-based compensation related to internal-use software development was $ 74,000 and $ 69,000 , respectively. As of November 30, 2023, the total compensation cost related to stock-based awards not yet recognized was $ 53.1 million, which is expected to be amortized on a straight-line basis over the weighted-average remaining vesting period of approximately 2.09 years. 
 
 9. Defined Contribution Plan 
 The Company sponsors a defined-contribution savings plan under Section 401(k) of the Internal Revenue Code of 1986, as amended (the 401(k) Plan), which provides for the Company to make discretionary matching or discretionary annual contributions to the 401(k) Plan, for its employees. Substantially all of the Company’s employees are eligible to participate in the 401(k) Plan. Employees may contribute a percentage of their annual compensation to the plan, subject to statutory limitations. The Company has made contributions to the 401(k) Plan and recorded contribution expense of $ 1.0 million and $ 0.9 million during the years ended November 30, 2023 and 2022, respectively. 
 143 

 
 
 

 10. Income Taxes 
 For the years ended November 30, 2023 and 2022, the Company did not record any current income tax benefit or provision. The Company has generated net operating losses (NOLs) since inception and has established a valuation allowance against its deferred tax assets due to the uncertainty surrounding the realization of such assets. 
 Loss before provision for income taxes includes the following component (in thousands): 
 
 November 30, 
 2023 2022 
 Domestic $ ( 143,948 ) $ ( 180,360 ) 
 $ ( 143,948 ) $ ( 180,360 ) 

 The effective tax rate differs from the federal statutory rate as follows: 
 
 November 30, 
 2023 2022 
 Federal statutory income tax rate 21.0 % 21.0 % 
 State income tax rate 14.1 5.9 
 Research and development tax credits 4.8 3.5 
 
 
 Stock-based compensation ( 4.2 ) ( 2.0 ) 
 Change in valuation allowance ( 35.6 ) ( 28.4 ) 
 Other ( 0.1 ) — 
 Total — % — % 

 Deferred Tax Assets and Liabilities 
 Deferred income taxes reflect the net tax effects of loss and credit carryforwards and temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes. Significant components of the deferred tax assets for federal and state income taxes are as follows (in thousands): 
 
 Year ended November 30, 
 2023 2022 
 Deferred tax assets: 
 Net operating loss carryforwards $ 92,131 $ 83,775 
 Research and development tax credits 37,052 27,096 
 Deferred revenue 11,143 19,950 
 Stock-based compensation 5,472 3,846 
 Accrued expenses and other liabilities 3,723 3,797 
 Operating lease liabilities 8,789 3,199 
 Capitalized research and experimental expenses 44,348 — 
 Gross deferred tax assets 202,658 141,663 
 Valuation allowance ( 193,717 ) ( 138,362 ) 
 Total deferred tax assets 8,941 3,301 
 Deferred tax liabilities: 
 Operating lease right-of-use assets ( 8,941 ) ( 3,301 ) 
 Total deferred tax liabilities ( 8,941 ) ( 3,301 ) 
 Net deferred tax assets $ — $ — 

 Realization of the deferred tax assets is dependent upon future taxable income, the amount, if any, and timing of which are uncertain. The Company has established a valuation allowance to offset deferred tax assets as of November 30, 2023 and 2022 due to the uncertainty of realizing future tax benefits from its NOL carryforwards and other deferred tax assets. The valuation allowance increased by $ 55.4 million to $ 193.7 million during the year ended November 30, 2023, primarily related to an increase on the deferred tax asset for research and development (R&D) credits, NOL carryforwards and Section 174 research and development capitalization. The valuation allowance increased by $ 54.8 million to $ 138.4 million during the year ended November 30, 2022, primarily related to an increase on the deferred tax asset for R&D credits and NOL carryforwards. 
 144 

 
 

 As of November 30, 2023, the Company had NOL carryforwards available to reduce future taxable income, if any, for federal and state income tax purposes of $ 269.3 million and $ 410.9 million, respectively. All outstanding federal NOL carryforwards were generated for tax years beginning after December 31, 2017, and carry forward indefinitely. State NOL carryforwards begin expiring in 2029 . As of November 30, 2023, the Company had federal and state research credit carryforwards of $ 32.3 million and $ 20.2 million, respectively. If not utilized, the federal credit carryforwards will begin expiring in 2032 and the state credits carry forward indefinitely . 
 Section 382 of the Internal Revenue Code of 1986, as amended (IRC) places a limitation on the utilization of NOL and tax credit carryforwards in the event of certain cumulative changes in the ownership interest of significant stockholders over a three-year period in excess of 50 percentage points. The Company has identified two ownership changes that have triggered a limitation on pre-change NOLs under Section 382. A majority of the Company’s pre-change NOLs remain available within the carryforward period provided by the IRC, subject to availability of taxable income. As a result of the ownership changes, the Company has determined that approximately $ 0.4 million of NOLs will expire unutilized, and as such, these NOLs are not reflected in the Company’s deferred tax asset balance. 
 Unrecognized Tax Benefits 
 The Company has recorded a liability related to uncertain tax positions in the financial statements. The Company has unrecognized tax benefits of $ 15.5 million as of November 30, 2023, all of which are offset by a full valuation allowance. There are no tax benefits included in the balance of unrecognized tax benefits that, if recognized, would affect the effective tax rate. There are no interest and penalties accrued as of November 30, 2023. 
 A reconciliation of the beginning and ending amounts of unrecognized income tax benefits during the years ended November 30, 2023 and 2022 is as follows (in thousands): 
 
 Years ended November 30, 
 2023 2022 
 Balance at beginning of period $ 10,261 $ 6,331 
 Additions based on tax positions related to current period 5,247 3,930 
 Balance at end of period $ 15,508 $ 10,261 

 The Company files income tax returns in the United States and in various states. In January 2019, the California Franchise Tax Board (FTB) initiated an examination of the Company’s California tax return for tax years ending in 2015, 2016, 2017 and 2018. During the year ended November 30, 2021, the FTB issued proposed audit assessments related to revenue sourcing and R&D credits. The Company did not agree with the FTB’s assessments and challenged the assessments. Pursuant to a measurement analysis, the Company has not recorded an unrecognized tax benefit related to the FTB’s sourcing position. The Company maintains an unrecognized tax benefit related to its California R&D credits for all years. All of the Company’s tax years will remain open for examination by the federal and state authorities for three and four years , respectively, from the date of the utilization of any NOLs. 
 In August 2022, the U.S. Inflation Reduction Act (the Act) was enacted into law. The Act includes various tax provisions, including an excise tax on stock repurchases, expanded tax credits for clean energy incentives and a corporate alternative minimum tax that generally applies to U.S. corporations with adjusted financial statement income in excess of $1.0 billion. The Company does not expect the Act to have a material impact on its financial statements. 
 In December 2017, the Tax Cuts and Jobs Act (TCJA) was signed into law, significantly reforming the IRC. The TCJA contains a provision impacting Section 174 of the IRC whereby for tax years beginning on or after January 1, 2022, taxpayers are required to capitalize and amortize, rather than deduct, research and experimental (R&E) expenses. The R&E expenses under Section 174 must be amortized over five years for research performed in the United States and 15 years for research performed outside the United States. This rule became effective for the Company during the year ended November 30, 2023. For the year ended November 30, 2023, the Company recorded a deferred tax asset of $ 44.3 million pursuant to the provisions of Section 174 of the IRC. 
 145 

 
 
 

 11. Net Loss Per Share 
 The following table sets forth the computation of the Company’s basic and diluted net loss per share attributable to common stockholders, which excludes shares which are legally outstanding but subject to repurchase by the Company (in thousands, except share and per share data): 
 Year Ended November 30, 
 2023 2022 
 Numerator: 
 Net loss $ ( 143,948 ) $ ( 180,360 ) 
 Denominator: 
 Weighted-average number of shares outstanding, basic and diluted (1) 
 54,337,901 48,607,990 
 Net loss per share, basic and diluted $ ( 2.65 ) $ ( 3.71 ) 

 
 (1) 
 The shares underlying the pre-funded warrants to purchase shares of the Company’s common stock have been included in the calculation of the weighted-average number of shares outstanding, basic and diluted, for the years ended November 30, 2023 and 2022. 
 

 The following potentially dilutive securities were excluded from the computation of the diluted net loss per share of common stock for the periods presented because their effect would have been anti-dilutive: 
 
 Years ended November 30, 
 2023 2022 
 Options to purchase common stock issued and outstanding 8,340,968 8,256,957 
 Options early exercised subject to vesting 4,909 22,246 
 Restricted stock units issued and outstanding 1,246,031 784,824 
 Shares expected to be purchased under employee stock purchase plan 203,314 123,194 
 Total 9,795,222 9,187,221 

 
 12. Related Party Transactions 
 The Company’s Chief Financial Officer is a trustee for the multiple employer welfare association that facilitates the acquisition and administration of the Company’s healthcare plans. Expenses related to the healthcare plan premiums were $ 4.4 million and $ 4.0 million for the years ended November 30, 2023 and 2022, respectively. As of November 30, 2023 and 2022, the amount recorded in accounts payable and accrued expenses and other current liabilities in connection with this healthcare plan provider was not material. 
 146 

 
 
 

 Item 9. Changes in and Disagreements with Accountants on Accounting and Financial Disclosure 
 None.
Nurix Therapeutics, Inc. 10-K

Item 8. Financial Statements and Supplementary Data
