55 unchanged sentences
Description of Trading Arrangement
−Removed: Nello Mainolfi
−Removed: Founder, President, Chief Executive Officer
−Removed: Trading plan intended to satisfy the affirmative defense conditions of Securities Exchange Act Rule 10b5- 1(c)
−Removed: ( December 20, 2023 )
−Removed: Termination of previously adopted trading plan
−Removed: Chief Financial Officer
+Added: Elena Ridloff
Trading plan intended to satisfy the affirmative defense conditions of Securities Exchange Act Rule 10b5- 1 (c)
+Added: ( November 25, 2024 )
December 31, 2025
−Removed: Termination of previously adopted trading plan
+Added: Exercises of vested stock options and sales of shares of our common stock pursuant to the terms of the trading plan
Disclosure Regarding Foreign Jurisdictions that Prevent Inspections.
27 unchanged sentences
Form of Pre-Funded Warrant (Incorporated by reference to Exhibit 4.1 to the Registrant’s Current Report on Form 8-K filed with the Securities and Exchange Commission on January 5, 2024).
+Added: Form of Pre-Funded Warrant (Incorporated by reference to Exhibit 4.1 to the Registrant’s Current Report on Form 8-K filed with the Securities and Exchange Commission on August 20, 2024).
2018 Stock Option and Grant Plan, and form of award agreements thereunder (Incorporated by reference to Exhibit 10.1 to the Registrant’s Registration Statement on Form S-1 (File No.
2 unchanged sentences
333-240264) filed with the Securities and Exchange Commission on August 17, 2020).
−Removed: Amended and Restated Non-Employee Director Compensation Policy dated January 17, 2022.
+Added: Amendment No.1 to the 2020 Stock Option and Incentive Plan (Incorporated by reference to Exhibit 10.1 to the Registrant’s Current Report on Form 8-K (File No.
+Added: 001-39460) filed with the Securities and Exchange Commission on June 20, 2024).
+Added: Amended and Restated Non-Employee Director Compensation Policy dated March 27, 2024 (Incorporated by reference to Exhibit 10.1 to the Registrant’s Quarterly Report on Form 10-Q (File No.
+Added: 001-39460) filed with the Securities and Exchange Commission on May 2, 2024).
Senior Executive Cash Incentive Bonus Plan (Incorporated by reference to Exhibit 10.4 to the Registrant’s Registration Statement on Form S-1/A (File No.
8 unchanged sentences
333-240264) filed with the Securities and Exchange Commission on August 13, 2020).
−Removed: Master Collaboration Agreement between the Registrant and Vertex Pharmaceuticals Incorporated, dated as of May 9, 2019 (Incorporated by reference to Exhibit 10.11 to the Registrant’s Registration Statement on Form S-1 (File No.
−Removed: 333-240264) filed with the Securities and Exchange Commission on July 31, 2020).
Amended and Restated Collaboration and License Agreement between the Registrant and Genzyme Corporation, dated as of November 15, 2022.
−Removed: First Amendment to Master Collaboration Agreement between the Registrant and Vertex Pharmaceuticals Incorporated, dated as of August 27, 2020 (Incorporated by reference to Exhibit 10.3 to the Registrant’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2020).
−Removed: Second Amendment to Master Collaboration Agreement between the Registrant and Vertex Pharmaceuticals Incorporated, dated as of October 21, 2021.
+Added: (Incorporated by reference to Exhibit 10.10 to Registrant’s Annual Report on Form 10-K (File No.
+Added: 001-39460) filed with the Securities and Exchange Commission on February 23, 2023).
Lease between the Registrant and ARE-MA REGION NO.
75, LLC dated as of December 20, 2021.
+Added: (Incorporated by reference to Exhibit 10.13 to Registrant’s Annual Report on Form 10-K (File No.
+Added: 001-39460) filed with the Securities and Exchange Commission on February 22, 2024).
Securities Purchase Agreement, dated August 18, 2022, by and among the Registrant and the persons party thereto (Incorporated by reference to Exhibit 10.1 to the Registrant’s Current Report on form 8-K filed with the Securities and Exchange Commission on August 19, 2022).
2 unchanged sentences
Letter between the Registrant and Genzyme Corporation, dated as of November 14, 2023.
+Added: (Incorporated by reference to Exhibit 10.16 to Registrant’s Annual Report on Form 10-K (File No.
+Added: 001-39460) filed with the Securities and Exchange Commission on February 22, 2024)
+Added: Letter between the Registrant and Genzyme Corporation, dated as of July 31, 2024 (Incorporated by reference to Exhibit 10.1 to the Registrant’s Quarterly Report on Form 10-Q (File No.
+Added: 001-39460) filed with the Securities and Exchange Commission on October 31, 2024).
+Added: Open Market Sale Agreement SM , by and between the Registrant and Jefferies LLC, dated October 31, 2024 (Incorporated by reference to Exhibit 10.2 to the Registrant’s Quarterly Report on Form 10-Q (File No.
+Added: 001-39460) filed with the Securities and Exchange Commission on October 31, 2024).
+Added: Amended and Restated Insider Trading Policy
List of Subsidiaries of Registrant.
7 unchanged sentences
Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
−Removed: Compensation Recovery Policy
+Added: Compensation Recovery Policy (Incorporated by reference to Exhibit 97 to Registrant’s Annual Report on Form 10-K (File No.
+Added: 001-39460) filed with the Securities and Exchange Commission on February 22, 2024).
Inline XBRL Instance Document
Inline XBRL Taxonomy Extension Schema Document
−Removed: Inline XBRL Taxonomy Extension Calculation Linkbase Document
−Removed: Inline XBRL Taxonomy Extension Definition Linkbase Document
−Removed: Inline XBRL Taxonomy Extension Label Linkbase Document
−Removed: Inline XBRL Taxonomy Extension Presentation Linkbase Document
Cover Page Interactive Data File (formatted as Inline XBRL with applicable taxonomy extension information contained in Exhibits 101).
+ This certification will not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liability of that section.
−Removed: Such certification will not be deemed to be incorporated by reference into any filing under the Securities Act of 1933, as amended, except to the extent specifically incorporated by reference into such filing.
+Added: Such certification will not be deemed to be incorporated by reference into
+Added: any filing under the Securities Act of 1933, as amended, except to the extent specifically incorporated by reference into such filing.
# Indicates a management contract or any compensatory plan, contract or arrangement.
27 unchanged sentences
Bruce Booth, DPhil
+Added: /s/ Felix Baker, PhD
+Added: Lead Independent Director
+Added: February 27, 2025
+Added: Felix Baker, PhD
/s/ Jeff Albers, MBA
4 unchanged sentences
Pamela Esposito, PhD
−Removed: /s/ Joanna Horobin, MB, ChB
−Removed: February 22, 2024
−Removed: Joanna Horobin, MB, ChB
/s/ Gorjan Hrustanovic, PhD
13 unchanged sentences
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.