1 unchanged sentence
Insider Trading Arrangements
−Removed: During the three months ended June 30, 2025, none of our directors or officers (as that term is defined by the SEC in Rule 16a-1(f) under the Exchange Act) adopted or terminated a Rule 10b5-1 trading arrangement or a non-Rule 10b5-1 trading arrangement.
+Added: On September 4, 2025 , Krish Krishnan , our Chief Executive Officer and Chairman of our Board of Directors , adopted a Rule 10b5-1 trading arrangement (the “Trading Plan”) that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act for the sale of up to 100,000 shares of our Common Stock, subject to certain conditions.
+Added: The end date of the Trading Plan is December 4, 2026 , subject to early termination in accordance with the terms of the Trading Plan, including upon completion of the sale of all of the shares of our Common Stock subject to the Trading Plan.
+Added: On September 4, 2025 , Suma Krishnan , our President and a member of our Board of Directors , adopted a Rule 10b5-1 trading arrangement (the “Trading Arrangement”) that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act for the sale of up to 100,000 shares of our Common Stock, subject to certain conditions.
+Added: The end date of the Trading Arrangement is December 4, 2026 , subject to early termination in accordance with the terms of the Trading Arrangement, including upon completion of the sale of all of the shares of our Common Stock subject to the Trading Arrangement.
+Added: During the three months ended September 30, 2025, no other director or officer (as that term is defined by the SEC in Rule 16a-1(f) under the Exchange Act) adopted or terminated a “Rule 10b5-1 trading arrangement” or a “non-Rule 10b5-1 trading arrangement,” as each term is defined in Item 408(a) of Regulation S-K.
31.1 Certification of Periodic Report by Chief Executive Officer under Section 302 of the Sarbanes-Oxley Act of 2002.
3 unchanged sentences
101 Inline XBRL (Extensible Business Reporting Language).
−Removed: The following materials from this Quarterly Report on Form 10-Q for the period ended June 30, 2025, are formatted in Inline XBRL:
+Added: The following materials from this Quarterly Report on Form 10-Q for the period ended September 30, 2025, are formatted in Inline XBRL:
(i) consolidated balance sheets of Krystal Biotech, Inc., (ii) consolidated statements of operations of Krystal Biotech, Inc., (iii) consolidated statements of operations and comprehensive income of Krystal Biotech, Inc., (iv) consolidated statements of changes in equity of Krystal Biotech, Inc., (v) consolidated statements of cash flows of Krystal Biotech, Inc.
4 unchanged sentences
KRYSTAL BIOTECH, INC.
−Removed: August 4, 2025
+Added: November 3, 2025
President and Chief Executive Officer
(Principal executive officer)
−Removed: August 4, 2025
+Added: November 3, 2025
/s/ Kathryn A.
2 unchanged sentences
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.