Innoviva, Inc. 10-Q

Item 1 A. Risk Factors Our business is subject to a number of risks, including those identified in Item 1A of Part I of our 2024 Form 10-K. There have been no material changes to the risk factors described in our 2024 Form 10-K. 45 Item 2. Un registered Sales of Equity Securities and Use of Proceeds a) Sales of Unregistered Securities None. (b) Use of Proceeds from Public Offering of Common Stock None. (c) Purchases of Equity Securities by the Issuer None. Item 3: D efaults Upon Senior Securities None. Item 4: Mine Safety Disclosures None. Item 5: Oth er Information Trading Arrangements None of the Company’s directors or officers adopted , modified , or terminated a Rule 10b5-1 trading arrangement or a non-Rule 10b5-1 trading arrangement during the quarter ended September 30, 2025, as such terms are defined in Item 408(a) of Regulation S-K. 46 Item 6. Exhibit s (a) Index to Exhibits Incorporated by Reference Exhibit Number Description Form Exhibit Filing Date/Period End Date 3.1 Amended and Restated Certificate of Incorporation 8-K 99.2 4/28/2016 3.2 Amended and Restated Bylaws, amended and restated as of January 1, 2023 8-K 3.1 1/4/2023 4.1 Specimen certificate representing the common stock of the registrant 10-K 4.1 12/31/2006 4.2 Form of 2.125% Convertible Subordinated Note Due 2023 (included in Exhibit 4.2) 8-K 4.2 1/25/2013 4.3 Indenture (including form of Note) with respect to Innoviva’s 2.5% Convertible Senior Notes due 2025, dated as of August 7, 2017, between Innoviva and The Bank of New York Mellon Trust Company, N.A., as trustee 8-K 4.1 8/7/2017 4.4 Description of Registrant’s Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934 10-K 4.9 2/19/2020 4.5 Indenture (including form of Note) with respect to Innoviva’s 2.125% Convertible Senior Notes due 2028, dated as of March 7, 2022, between Innoviva and The Bank of New York Mellon Trust Company, N.A., as trustee 8-K 4.1 3/8/2022 31.1* Certification of Principal Executive Officer pursuant to Rules 13a‑14 pursuant to the Securities Exchange Act of 1934 31.2* Certification of Chief Financial Officer pursuant to Rules 13a‑14 pursuant to the Securities Exchange Act of 1934 32* Certifications Pursuant to 18 U.S.C. Section 1350 101.INS Inline XBRL Instance Document – the instance document does not appear in the Interactive Data File because XBRL tags are embedded within the Inline XBRL document. 101.SCH Inline XBRL Taxonomy Extension Schema Document 101.CAL Inline XBRL Taxonomy Extension Calculation Linkbase Document 101.DEF Inline XBRL Taxonomy Extension Definition Linkbase Document 101.LAB Inline XBRL Taxonomy Extension Label Linkbase Document 101.PRE Inline XBRL Taxonomy Extension Presentation Linkbase Document 104 Cover Page Interactive Data File (embedded within the Inline XBRL document) + Management contract or compensatory plan or arrangement. * Furnished herewith. 47 SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized. Innoviva, Inc. Date: November 5, 2025 /s/ Pavel Raifeld Pavel Raifeld Chief Executive Officer (Principal Executive Officer) Date: November 5, 2025 /s/ Stephen Basso Stephen Basso Chief Financial Officer (Principal Financial Officer) 48