1 unchanged sentence
Director and Officer Trading Arrangements
−Removed: During the last fiscal quarter, the following directors and “officers,” as defined in Rule 16a-1(f) of the Exchange Act, terminated a “Rule 10b5-1 trading arrangement” or a “non-Rule 10b5-1 trading arrangement,” each as defined in item 408 of Regulation S-K:
−Removed: On April 3, 2025 , Marc Semigran , our former Chief Development Officer , terminated a Rule 10b5-1 trading arrangement providing for the sale from time to time of up to 75,000 shares of our common stock.
−Removed: The trading arrangement was intended to satisfy the affirmative defense in Rule 10b5-1(c).
−Removed: The duration of the trading arrangement was until December 31, 2025 , or earlier if all transactions under the trading arrangement were completed.
−Removed: On June 11, 2025 , Alan Russell , our Chief Scientific Officer and Director , terminated a Rule 10b5-1 trading arrangement providing for the sale from time to time of up to 300,000 shares of our common stock.
−Removed: The trading arrangement was intended to satisfy the affirmative defense in Rule 10b5-1(c).
−Removed: The duration of the trading arrangement was until September 30, 2025 , or earlier if all transactions under the trading arrangement were completed.
+Added: During the last fiscal quarter, the following directors and “officers,” as defined in Rule 16a-1(f) of the Exchange Act, adopted a “Rule 10b5-1 trading arrangement” or a “non-Rule 10b5-1 trading arrangement,” each as defined in item 408 of Regulation S-K:
+Added: On September 24, 2025 , Badreddin Edris , Director , adopted a Rule 10b5-1 trading arrangement providing for the sale from time to time of up to 115,471 shares of our common stock.
+Added: The trading arrangement is intended to satisfy the affirmative defense in Rule 10b5-1(c).
+Added: The duration of the trading arrangement is until December 31, 2026 , or earlier if all transactions under the trading arrangement are completed.
No other directors or “officers,” as defined in Rule 16a-1(f) of the Exchange Act, adopted or terminated a “Rule 10b5-1 trading arrangement” or a “non-Rule 10b5-1 trading arrangement,” each as defined in item 408 of Regulation S-K, during the last fiscal quarter.
30 unchanged sentences
Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, duly authorized.
−Removed: August 7, 2025
+Added: November 6, 2025
EDGEWISE THERAPEUTICS, INC.
7 unchanged sentences
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.