13 unchanged sentences
Based on our evaluation under that framework, our management concluded that our internal control over financial reporting was effective as of December 31, 2025 .
−Removed: As a “smaller reporting company”, we are not required to provide an attestation report of our registered public accounting firm on the effectiveness of our internal control over financial reporting.
+Added: As a “smaller reporting company,” as defined by Rule 12b-2 under the Exchange Act, we are not required to provide an attestation report of our registered public accounting firm on the effectiveness of our internal control over financial reporting.
Changes in Internal Control over Financial Reporting
No change in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act) occurred during our fiscal quarter ended December 31, 2025 that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.
+Added: Table of Co ntents
Other Information.
5 unchanged sentences
None of our directors or officers adopted or terminated a Rule 10b5-1 trading arrangement or a non-Rule 10b5-1 trading arrangement (as defined in Item 408(c) of Regulation S-K) during the fourth quarter of 2025.
−Removed: Common Stock Sales Agreement Amendment
−Removed: On March 5, 2025, we entered in a second amendment to the Common Stock Sales Agreement with TD Cowen, pursuant to which we may offer and sell from time to time shares of our common stock through or to TD Cowen as our sales agent or principal, in order to reduce the aggregate offering amount of shares that may be sold thereunder from $300.0 million to $150.0 million.
−Removed: The foregoing description of the amendment is qualified in its entirety by reference to the full text of the amendment, a copy of which is included as Exhibit 10.38 to this Annual Report on Form 10-K.
Disclosure Regarding Foreign Jurisdictions that Prevent Inspections.
Not applicable.
+Added: Table of Co ntents
Directors, Executive Officers and Corporate Governance.
−Removed: Except to the extent provided below, the information required by this Item 10 will be included in the section captioned “Corporate Governance” and the subsections thereof, “Nominees for Election as Class III Directors,” “Directors Continuing in Office,” “Executive Officers Who Are Not Directors,” “Delinquent Section 16(a) Reports,” if applicable, and “Insider Trading Policy,” in our definitive proxy statement to be filed with the Securities and Exchange Commission (“SEC”) with respect to our 2025 Annual Meeting of Stockholders, which information is incorporated herein by reference.
+Added: Except to the extent provided below, the information required by this Item 10 will be included in the section captioned “Corporate Governance” and the subsections thereof, “Nominees for Election as Class I Directors,” “Directors Continuing in Office,” “Executive Officers Who Are Not Directors,” “Delinquent Section 16(a) Reports,” if applicable, and “Insider Trading Policy,” in our definitive proxy statement to be filed with the Securities and Exchange Commission (“SEC”) with respect to our 2026 Annual Meeting of Stockholders, which information is incorporated herein by reference.
We have adopted a written code of business conduct and ethics that applies to our directors, officers, and employees, including our principal executive officer, principal financial officer, principal accounting officer or controller, or persons performing similar functions.
12 unchanged sentences
The information required by this Item 13 will be included in the sections captioned “Transactions with Related Persons” and “Director Independence” in our definitive proxy statement to be filed with the SEC with respect to our 2026 Annual Meeting of Stockholders, which information is incorporated herein by reference .
−Removed: Principal Accounting Fees and Services.
+Added: Principal Accountant Fees and Services.
The information required by this Item 14 will be included in the sections captioned “Audit Fees” and “Audit Committee Pre-Approval Policy and Procedures” in our definitive proxy statement to be filed with the SEC with respect to our 2026 Annual Meeting of Stockholders, which information is incorporated herein by reference .
+Added: Table of Co ntents
Exhibits and Financial Statement Schedules.
15 unchanged sentences
4.2 Description of Registrant’s Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934
−Removed: 10-K 001-37687 2/28/2024 4.2
10.1+ 2013 Stock Incentive Plan, as amended
8 unchanged sentences
S-1 333-208856 1/4/2016 10.9
−Removed: 10.6+ 2015 Stock Incentive Plan
−Removed: S-1 333-208856 1/4/2016 10.10
+Added: 10.6+ Amended and Re stated 2015 Stock Incentive Plan
+Added: 8-K 333-208856 6/2/2025 10.1
10.7+ Form of Incentive Stock Option Agreement under 2015 Stock Incentive Plan
6 unchanged sentences
10-K 001-37687 2/28/2024 10.10
−Removed: 10.11+ Employment Offer Letter, dated April 13, 2022, between the Registrant and Gilmore O’Neill
−Removed: 10-Q 001-37687 8/3/2022 10.1
+Added: Table of Co ntents
Incorporated by Reference
1 unchanged sentence
Filing Exhibit
−Removed: 10.12+ Employment Offer Letter, dated May 12, 2023, between the Registrant and Erick Lucera
+Added: 10.11+ Employment Offer Letter, dated April 13, 2022, between the Registrant and Gilmore O’Neill
10-Q 001-37687 8/3/2022 10.1
+Added: 10.12+ Employment Offer Letter, dated July 7, 2022, between the Registrant and Amy Parison
+Added: 10.13+ Promotion Letter, dated March 19, 2025, between the Registrant and Amy Parison
10.14+ Employment Offer Letter, dated July 3, 2023, between the Registrant and Linda C.
10-Q 001-37687 8/2/2023 10.3
−Removed: 10.14+ Employment Offer Letter, dated June 14, 2022, between the Registrant and Baisong Mei
−Removed: 10-K 001-37687 8/3/2022 10.3
−Removed: 10.15+ Separation Agreement, dated December 16, 2024 between the Registrant and Baisong Mei
10.15+ Form of Inducement Stock Option Agreement for the Registrant’s executive officers
18 unchanged sentences
10.24* Purchase and Sale Agreement, dated October 3, 2024, between the Registrant and DRI Healthcare Acquisitions LP
−Removed: 10.26+ Summary of Director Compensation Program
10.K 001-37687 3/5/2025 10.25
+Added: 10.25+ Summary of Director Compensation Program
10.26+ 2015 Employee Stock Purchase Plan
7 unchanged sentences
8-K 001-37687 2/19/2016 99.1
+Added: Table of Co ntents
Incorporated by Reference
18 unchanged sentences
19.1 Insider Trading Policy
+Added: 10-K 001-37687 3/5/2025 19.1
21.1 Subsidiaries of the Registrant
7 unchanged sentences
101 The following financial statements from the Company’s Annual Report on Form 10-K for the year ended December 31, 2025, formatted in Inline XBRL (eXtensible Business Reporting Language):
−Removed: (i) Consolidated Balance Sheets, (ii) Consolidated Statements of Operations, (iii) Consolidated Statements of Comprehensive Loss, (iv) Consolidated Statement of Stockholders’ Equity, (v) Consolidated Statements of Cash Flows and (vi) Notes to Condensed Consolidated Financial Statements, tagged as blocks of text and including detailed tags.
+Added: (i) Consolidated Balance Sheets, (ii) Consolidated Statements of Operations, (iii) Consolidated Statements of Comprehensive Loss, (iv) Consolidated Statement of Stockholders’ Equity, (v) Consolidated Statements of Cash Flows and (vi) Notes to Consolidated Financial Statements, tagged as blocks of text and including detailed tags.
104 The cover page from the Company’s Annual Report on Form 10-K for the year ended December 31, 2025, formatted in Inline XBRL.
4 unchanged sentences
+ Management contract or compensatory plan or arrangement.
+Added: Table of Co ntents
Form 10-K Summary.
+Added: Table of Co ntents
Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
8 unchanged sentences
Gilmore O’Neill, M.B., M.M.Sc.
−Removed: /s/ Erick Lucera Chief Financial Officer (principal financial and accounting officer) March 5, 2025
+Added: /s/ Amy Parison Chief Financial Officer (principal financial and accounting officer) March 9, 2026
/s/ Jessica Hopfield Chair of the Board March 9, 2026
9 unchanged sentences
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.