ALNYLAM PHARMACEUTICALS, INC. 10-K

ITEM 5. MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES Market Information Our common stock trades on The Nasdaq Global Select Market under the symbol “ALNY.” Holders of Record At January 31, 2023, there were 24 holders of record of our common stock. Because many of our shares are held by brokers and other institutions on behalf of stockholders, we are unable to estimate the total number of beneficial holders represented by these record holders. Issuer Purchases of Equity Securities The following table provides information about our purchases of shares of Alnylam common stock during the three-month period ended December 31, 2022: Period Total Number of Shares Purchased (1) Average Price per Share Total Number of Shares Purchased as Part of Publicly Announced Plans or Programs Maximum Number (or Approximated Dollar Value) of Shares that May Yet Be Purchased Under the Plans or Programs October 1, 2022 - October 31, 2022 — $ — — — November 1, 2022 - November 30, 2022 — — — — December 1, 2022 - December 31, 2022 3,182 231.84 — — Total 3,182 $ 231.84 — — (1) Share repurchases reported in this column consist of shares of Alnylam's common stock tendered by employees in December 2022 to cover the exercise price of certain stock options exercised by those employees. 83 Table of Contents Stock Performance Graph The following performance graph and related information shall not be deemed “soliciting material” or to be “filed” with the SEC, nor shall such information be incorporated by reference into any future filing under the Securities Act of 1933 or Securities Exchange Act of 1934, each as amended, except to the extent that we specifically incorporate it by reference into such filing. The comparative stock performance graph below compares the five-year cumulative total stockholder return (assuming reinvestment of dividends, if any) from investing $100 on the last trading day of 2017, to the close of the last trading day of 2022, in each of our common stock and the selected indices. The stock price performance reflected in the graph below is not necessarily indicative of future price performance. Comparison of Five-Year Cumulative Total Return Among Alnylam Pharmaceuticals, Inc., Nasdaq Composite Total Return and Nasdaq Biotechnology Total Return 12/29/2017 12/31/2018 12/31/2019 12/31/2020 12/31/2021 12/30/2022 Alnylam Pharmaceuticals, Inc. $ 100.00 $ 57.39 $ 90.65 $ 102.30 $ 133.48 $ 187.05 Nasdaq Composite Total Return $ 100.00 $ 97.16 $ 132.81 $ 192.47 $ 235.15 $ 158.65 Nasdaq Biotechnology Total Return $ 100.00 $ 91.14 $ 114.02 $ 144.15 $ 144.18 $ 129.59 ITEM 6. RESERVED Not applicable.