What changed in this filing

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Item 1A. Risk Factors

2021-08-09 compared with 2021-05-10 · 11 added, 58 removed, 0 unchanged (100% of the section changed)

Except as set forth below, there were no material changes from the risk factors set forth under Part I, Item 1A., “Risk Factors”

in our Annual Report on Form 10-K for the fiscal year ended December 31, 2020.

You should carefully consider the risk factors set forth

in our Annual Report on Form 10-K for the fiscal year ended December 31, 2020, as well as other reports and statements that we file and

have filed with the SEC, in addition to the other information set forth in this report which could materially affect our business, financial

condition or future results.

The risks and uncertainties described in this report and in our Annual Report on Form 10-K for the year ended

December 31, 2020, as well as other reports and statements that we file with the SEC, are not the only risks and uncertainties facing

Additional risks and uncertainties not currently known to us or that we currently deem to be immaterial may also have a material adverse

effect on our financial position, results of operations or cash flows.

market price of our common stock has been extremely volatile and may continue to be volatile due to numerous circumstances beyond

market price of our common stock has fluctuated, and may continue to fluctuate, widely, due to many factors, some of which may

be beyond our control.

These factors include, without limitation:

“short squeezes”;

comments by securities analysts or other third parties, including blogs, articles, message boards and social and other media;

large stockholders exiting their position in our common stock or an increase or decrease in the short interest in our common stock;

actual or anticipated fluctuations in our financial and operating results;

risks and uncertainties associated with the ongoing COVID-19 pandemic;

the timing and allocations of new product candidates;

public perception of our product candidates and competitive products;

overall general market fluctuations.

Stock markets in general and our stock price in particular have experienced extreme price and volume fluctuations that have often been

unrelated or disproportionate to the operating performance of those companies and our company.

For example, on February 1, 2021 and February

11, 2021, the closing price of our common stock on The NASDAQ Global Market was $0.97 and $2.00, respectively, and daily trading volume

on these days was approximately 20.2 million and 128.0 million shares, respectively.

During this time, we made announcements regarding

the addition of product candidates to our pipeline, and completed a $70.0 million public offering of our common stock at $1.20 per share.

These broad market fluctuations may adversely affect the trading price of our common stock.

In particular, a proportion of our common

stock has been and may continue to be traded by short sellers which may put pressure on the supply and demand for our common stock, further

influencing volatility in its market price.

Additionally, these and other external factors have caused and may continue to cause the market

price and demand for our common stock to fluctuate, which may limit or prevent investors from readily selling their shares of common stock

and may otherwise negatively affect the liquidity of our common stock.

A “short squeeze”

due to a sudden increase in demand for shares of our common stock that largely could lead to extreme price

volatility in shares of our common stock.

Investors may purchase shares of our common stock to hedge existing exposure or to speculate on the price of our common stock.

on the price of our common stock may involve long and short exposures.

To the extent aggregate short exposure exceeds the number of shares

of our common stock available for purchase on the open market, investors with short exposure may have to pay a premium to repurchase shares

of our common stock for delivery to lenders of our common stock.

Those repurchases may in turn, dramatically increase the price of our

common stock until additional shares of our common stock are available for trading or borrowing.

This is often referred to as a “short

squeeze.”

A proportion of our common stock has been and may continue to be traded by short sellers which may increase the likelihood

that our common stock will be the target of a short squeeze.

A short squeeze could lead to volatile price movements in shares of our common

stock that are unrelated or disproportionate to our operating performance or prospectus and, once investors purchase the shares of our

common stock necessary to cover their short positions, the price of our common stock may rapidly decline.

Investors that purchase shares

of our common stock during a short squeeze may lose a significant portion of their investment.

Unregistered Sales of Equity Securities and Use of Proceeds

Defaults Upon Senior Securities

Mine Safety Disclosures

There were no material

changes from the risk factors set forth under Part I, Item 1A., “Risk Factors” in our Annual Report on Form 10-K for the

fiscal year ended December 31, 2020, and under Part II, Item 1A., “Risk Factors” in our Quarterly Report on Form 10-Q

for the quarter ended March 31, 2021.

You should carefully consider the risk factors set forth in our Annual Report on Form 10-K for

the fiscal year ended December 31, 2020, as well as other reports and statements that we file and have filed with the SEC, in

addition to the other information set forth in this report which could materially affect our business, financial condition or future

The risks and uncertainties described in this report and in our Annual Report on Form 10-K for the year ended December 31,

2020 and our Quarterly Report on Form 10-Q for the quarter ended March 31, 2021, as well as other reports and statements that we file with the SEC, are not the only risks and uncertainties facing us.

Additional risks and uncertainties not currently known to us or that we currently deem to be immaterial may also have a material

adverse effect on our financial position, results of operations or cash flows.

Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.

What changed 10-Q

Item 1A. Risk Factors