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Item 1. Business

2026-02-24 compared with 2025-02-25 · 154 added, 111 removed, 198 unchanged (57% of the section changed)

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• Augmenting growth in both of our core business segments, Life Sciences and Diagnostics, through strategic acquisitions and licensing;

• Advancing the use of Artificial Intelligence (“AI”) to further strengthen our differentiated offerings and to drive internal operating efficiencies;

• Engraining focused operational excellence to improve organizational efficiency and agility;

• Opportunistically utilizing our share repurchase programs to help drive shareholder value.

• Taking a disciplined approach to capital allocation to support organic investments, pursue mergers and acquisitions and opportunistic share repurchase programs to drive shareholder value.

Business Segments and Products

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Our comprehensive portfolio of technologies helps life sciences researchers better understand diseases and develop treatments.

We provide a broad suite of products, solutions and services that facilitate optimized workflows, increase productivity, and accelerate every stage of the drug discovery and development pipeline.

We provide a broad suite of products, solutions, software and services that facilitate optimized workflows, increase productivity, and accelerate every stage of the drug discovery and development pipeline.

Our offerings span the areas of cell, gene, and protein research, enabling scientists to work smarter, make research breakthroughs, and transform those breakthroughs into real-world outcomes.

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Our principal products and services for Life Sciences applications include the following:

◦ Radiometric detection solutions, including over 750 radiochemicals and instrumentation such as the Tri-Carb ® and Quantulus ® GCT families of liquid scintillation analyzers, Wizard 2TM Gamma counters and MicroBeta 2TM plate based LSA are used for beta, gamma and luminescence counting in microplate and vial formats utilized in research, environmental and drug discovery applications.

◦ Radiometric detection solutions, including over 750 radiochemicals for use with our liquid and plate-based analyzers, and utilized in research, environmental and drug discovery applications.

◦ Reagents and solutions for microscopy and imaging applications.

These include PhenoVue ® cellular imaging reagents and cell painting kits, PhenoPlate (formerly CellCarrier Ultra™) cellular imaging microplates and GrowDex TM hydrogels, fluorophore-conjugated and enzyme-conjugated antibodies, as well as buffers and solutions, such as our Ce3D™ collection of buffers for 3D tissue imaging.

◦ A wide range of homogeneous biochemical and cell-based reagents using HTRF®, LANCE® Ultra™, DELFIA®, AlphaLISA®, AlphaLISA® SureFire® Ultra™, AlphaScreen®, AlphaPlex® and luminescence assay technologies that can be paired with our microplates, which cover a variety of applications.

These include PhenoVue ® cellular imaging reagents and cell painting kits, PhenoPlate™ (formerly CellCarrier Ultra™) cellular imaging microplates and GrowDex™ hydrogels, fluorophore-conjugated and enzyme-conjugated antibodies, as well as buffers and solutions, such as our Ce3D™ collection of buffers for 3D tissue imaging.

◦ A wide range of homogeneous biochemical and cell-based reagents using HTRF ® , LANCE ® Ultra™, DELFIA ® , AlphaLISA ® , AlphaLISA ® SureFire ® Ultra™, AlphaScreen ® , and AlphaPlex ® luminescence assay technologies that can be paired with our microplates, which cover a variety of applications.

◦ New assay kits for Adeno-associated Virus Vectors (AAVs) and gene therapy applications in our range of HTRF ® and AlphaLISA ® reagents, for detecting and quantifying CHO HCP impurities in biotherapeutics development, as well as kits across oncology, neuroscience, and targeted protein degradation applications.

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◦ BioLegend ® ELISA MAX™ Standard Sets, ELISA MAX™ Deluxe Sets, LEGEND MAX™ ELISA Kits, and RAPID MAX™ ELISA Kits as well as complementary solutions and buffers for immunoassays to cover more than 200 targets for human, mouse, and rat samples, many of which are designed to assess the immune environment and its inflammatory state for vaccine, infectious disease and autoimmune disease research.

◦ BioLegend ® LEGENDplex™ bead-based reagents, which, in contrast to single analyte assays such as enzyme-linked immunosorbent assays (“ELISAs”), can quantitate up to 14 targets from one small sample volume and read on common flow cytometers, and include both desktop and cloud-based analysis software.

◦ BioLegend ® best-in-class antibodies, recombinant proteins, and related reagents are used across multiple applications and research areas, including proteogenomics, tissue, cell and protein analysis, cancer research, immunology, cell and gene therapy, stem cell therapy and neuroscience.

◦ Fluorophore-conjugated antibodies are used in flow cytometers to characterize protein expression on the surface and in internal compartments of cells.

◦ BioLegend ® LEGENDplex™ bead-based reagents, which, in contrast to single analyte assays such as enzyme-linked immunosorbent assays (“ELISAs”), can quantitate up to 14 targets from one small sample volume and be read on common flow cytometers, and include both desktop and cloud-based analysis software.

◦ BioLegend ® best-in-class antibodies, recombinant proteins, and related reagents, which are used across multiple applications and research areas, including flow cytometry, microscopy, proteogenomics, tissue, cell and protein analysis, cancer research, immunology, cell and gene therapy, stem cell therapy and neuroscience.

◦ Fluorophore-conjugated antibodies that are used in flow cytometers to characterize protein expression on the surface and in internal compartments of cells.

The large collection of dyes and antibodies allows for an increasing number of conjugate options, facilitating the use of bigger and better flow cytometry panels using conventional and spectral flow cytometers.

Notable products are Brilliant Violet™ and the Spark and Fire TM dye series, among others.

◦ BioLegend ® TotalSeq™ reagents are oligonucleotide-barcoded antibodies that enable protein detection to be combined with traditional RNA or DNA sequencing experiments with high-parameter protein detection.

Notable products are offered under the Brilliant Violet™, StarBright™ UV, and the Spark and Fire™ dye brands, among others.

◦ BioLegend ® TotalSeq™ reagents are oligonucleotide-barcoded antibodies that enable high-parameter protein detection to be combined with traditional RNA or DNA sequencing experiments.

TotalSeq™ reagents offer individual antibodies as well as hashtags for sample pooling and large cocktails for the analysis of hundreds of protein markers.

Data can be analyzed with their complimentary and comprehensive cloud-based Multiomics Analysis Software.

◦ Cell culture and biofunctional assay reagents, including bioactive recombinant proteins, as well as other specialized reagents such as Cell-Vive™ T-NK Xeno-Free Serum Substitute (compliant with Good Manufacturing Practice requirements (“GMP”)), and other GMP-produced recombinant proteins and reagents.

◦ Cell culture and biofunctional assay reagents, including bioactive recombinant proteins, antibodies, as well as other specialized cell culture media such as Cell-Vive™ T-NK Xeno-Free Serum Substitute (compliant with Good Manufacturing Practice requirements (“GMP”)), and other GMP-produced reagents.

These products serve several markets, notably cell and gene therapy applications.

◦ BioLegend ® ’s MojoSort™ for cell separation that complements our fluorophore-antibody conjugates, used for FACS (Fluorescence-activated Cell Sorting), thus covering most cell separation and cell sorting technologies and applications.

◦ BioLegend’s catalog of more than 33,000 SKUs, incorporating antibodies and a large collection of antibody conjugates and modifications as well as recombinant proteins, immunoassays, and other supportive reagents and solutions for cell and molecular analysis.

◦ BioLegend ® MojoSort™ magnetic bead-based reagents for cell isolation with handheld magnets, as well as MojoSort on Columns™, which uses multistands, columns, and separators for cell sorting.

Buffers, magnets, and kits are offered for positive and negative selection.

◦ BioLegend ® catalog of more than 35,000 SKUs, incorporating a large collection of antibody conjugates and modifications, as well as recombinant proteins, immunoassays, and other supportive reagents and solutions for cell and molecular analysis.

◦ Flex-T™ reagents that utilize peptide-loaded major histocompatibility molecules assembled into tetramers for the identification of antigen-specific T cells.

Our Flex-T products can be used to screen the efficacy of antigen peptides for vaccine and drug trials, as well as characterize the dominance of cancer-specific self-peptides, and more recently, SARS-CoV-2 peptides for COVID-19 research.

Our Flex-T reagents can be used to screen the efficacy of antigen peptides for vaccine and drug trials, as well as characterize the dominance of cancer-specific self-peptides.

◦ Antibodies and solutions for Western blotting, as well as supporting buffers and substrates, provide a convenient set of tools to characterize protein size and relative expression levels in cell or tissue lysates.

◦ Mimix TM reference standards are cell line-derived to mimic patient samples and suitable for next generation sequencing, droplet-digital and real-time PCR as well as Sanger sequencing.

The platform is agnostic for seamless integration into quality control workflows.

◦ Mimix™ reference standards, which are cell line-derived to mimic patient samples and suitable for next generation sequencing, droplet-digital and real-time PCR as well as Sanger sequencing.

The controls are agnostic for seamless integration into quality control workflows.

◦ IVISbrite ® bioluminescent and IVISense ® fluorescent imaging agents and imaging reagents for use on our in vivo optical imaging platforms for preclinical research applications.

◦ OptiScint™ NPE-free scintillation cocktails and quench standards, providing a more environmentally friendly alternative without compromising performance.

◦ Expansion of our Western blotting reagents with the addition of the Western Lightning™ One range, which has a pre-mixed one component chemiluminescent HRP substrate for more consistent results.

◦ Additional Spark and Fire TM dye-conjugated antibodies, enabling higher-parameter flow cytometry.

◦ Expansion of our Western blotting reagents with the addition of the Western Lightning™ One range reagents, which have a pre-mixed one component chemiluminescent HRP substrate for more consistent results.

◦ Additional Spark and Fire™ dye-conjugated antibodies, enabling higher-parameter flow cytometry.

Notable products are the Spark PLUS UV395™ and Spark PLUS B550™ conjugates.

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New options were created for intracellular target staining and protein-only analysis.

◦ New fluorescent stains, reagents and secondary antibodies in our PhenoVue TM cellular imaging reagents portfolio for the detection and analysis of cellular components.

◦ GoInVivo™ as well as Ultra-LEAF™ and LEAF™ functional antibodies provide an affordable solution for researchers performing in vivo and ex vivo studies.

◦ New fluorescent stains, reagents and secondary antibodies in our PhenoVue ® cellular imaging reagents portfolio for the detection and analysis of cellular components.

◦ GoInVivo™ antibodies, as well as Ultra-LEAF™ and LEAF™ functional antibodies, which provide an affordable solution for researchers performing in vivo and ex vivo studies.

◦ The PG-Seq™ Rapid kit v2 analyzes picogram quantities of DNA from an embryo biopsy for preimplantation genetic research with enhanced whole genome coverage and accuracy.

◦ The DOPlify ® WGA v2 kit performs fast whole genome amplification on single cells or limited template DNA samples, allowing cell chromosome copy number status to be determined.

◦ NEXTFLEX ® library prep kits simplify library prep with optimized protocols and reagents, making the library preparation process more efficient and reliable.

• Instruments

◦ The Tri-Carb ® , Quantulus ® GCT, and plate-based MicroBeta2 ® families of liquid scintillation analyzers (LSAs), and Wizard2 ® Gamma counters, used for beta, gamma and luminescence counting in microplate and vial formats for research, environmental and drug discovery applications.

◦ The Opera Phenix ® Plus high-content screening system for sensitive and high-speed phenotypic drug screening of complex cellular models.

◦ The Operetta ® CLS™ high-content analysis system enables scientists to reveal fine sub-cellular details from everyday assays as well as more complex studies, for example using live cells, 3D and stem cells.

◦ The VICTOR Nivo TM multimode plate reader benchtop system designed for assay development and academic labs, including those using HTRF® and AlphaLISA® assay technologies.

◦ The EnVision TM multimode plate reader designed for high-throughput screening laboratories, including those using HTRF®, AlphaScreen® and AlphaLISA® assay technologies.

◦ The EnVision Nexus TM multimode plate reader, our next generation system for high-throughput screening with advanced detection technologies for Alpha, TRF, and Luminescence.

◦ In vivo optical imaging platforms and reagents for preclinical research, comprised of the IVIS ® Spectrum™ series for 2D and 3D optical imaging and optionally integrated low-dose CT imaging and the IVIS ® Lumina™ series for benchtop 2D imaging, along with IVISbrite ® bioluminescent and IVISense ® fluorescent imaging agents and imaging reagents.

◦ The Quantum TM GX3 system, which enables low-dose in vivo CT imaging of multiple species and areas of anatomical interest across multiple disease areas by way of high-resolution, tomographic imaging.

◦ The Operetta ® CLS™ high-content analysis system, which enables scientists to reveal fine sub-cellular details from everyday assays as well as more complex studies, for example using live cells, 3D and stem cells.

◦ The VICTOR Nivo ® multimode plate reader benchtop system designed for assay development and academic labs, including those using HTRF ® and AlphaLISA ® assay technologies, updated with new software for streamlined data analysis.

◦ The EnVision ® multimode plate reader designed for high-throughput screening laboratories, including those using HTRF ® , AlphaScreen ® and AlphaLISA ® assay technologies.

◦ In vivo optical imaging platforms for preclinical research, comprised of the IVIS ® Spectrum™ system series for 2D and 3D optical imaging and optionally integrated low-dose CT imaging and the IVIS ® Lumina™ system series for benchtop 2D imaging.

◦ The Quantum™ GX3 system, which enables low-dose in vivo CT imaging of multiple species and areas of anatomical interest across multiple disease areas by way of high-resolution, tomographic imaging.

◦ The Vega™ ultrasound system, a hands-free automated ultrasound platform delivers high-resolution 2D and 3D imaging in just a few minutes.

This innovative in vivo ultrasound system removes the challenges associated with conventional hand-held systems through the use of automated transducers located under the imaging stage and is easy to use, requires minimal training and produces more consistent results.

It is complemented by GoInVivo™ as well as Ultra-LEAF™ and LEAF™ functional antibodies providing an affordable solution for researchers performing in vivo and ex vivo studies.

◦ The high-throughput, microwell Celigo ® image cytometry system, the Cellaca ® MX high-throughput cell counter, the Cellaca ® PLX image cytometry system, and the Cellometer ® automated cell counters, complemented by consumables and reagents, including reagents and kits for cell counting assays and cell viability, microplates, slides, and counting beads.

◦ Cellaca ® PLX™ image cytometry system combines best-in-class image cytometer hardware, software, validated consumables and optimized reagent kits with validated antibodies from our BioLegend business, and trackable data reporting to enable the simultaneous detection of multiple markers and to streamline cell and gene therapy workflows.

◦ The Signals Image Artist™ next-generation image analysis and management platform for drug discovery research, to help scientists process and analyze high-content screening (HCS) and cellular imaging data in a matter of hours versus days or weeks, so they can make more informed decisions faster.

◦ Signals Research platform equips pharmaceutical scientists with the essential tools to gather, search, mine, analyze and visualize critical data, yielding actionable insights in an automated, predictive, and scalable manner.

◦ The high-throughput, microwell Celigo ® image cytometry system, the Cellaca ® MX high-throughput cell counter, and the Cellometer ® automated cell counters, complemented by consumables and reagents, including reagents and kits for cell counting assays and cell viability, microplates, slides, and counting beads.

◦ The Cellaca ® PLX™ image cytometry system combines best-in-class image cytometer hardware, software, validated consumables and optimized reagent kits with validated antibodies from our BioLegend business, and trackable data reporting to enable the simultaneous detection of multiple markers and to streamline cell and gene therapy workflows.

◦ The Cellometer ® Ascend™ automated cell counter accelerates lab workflow by reducing human error, all while providing a consistent, standardized cell count.

Incorporated with its user-friendly Matrix™ software, this product performs an automated and sophisticated image analysis workflow that delivers reliable results in seconds.

◦ The BioLegend ® Mini ELISA Plate Reader™ streamlines ELISA workflows by providing a fast, compact instrument designed to take up minimal space in a lab.

A single USB cord enables plug-and-play functionality, and 96 detection units scan all 96 wells simultaneously.

Intuitive operation makes it easy to rapidly read a plate and obtain data.

◦ The Omni Bead Ruptor ® Elite Bead Mill homogenizer enables grinding, lysing, and homogenization of biological samples prior to molecular analyte extraction, delivering repeatable sample disassociation.

◦ Automated liquid handling platforms (Fontus ® , JANUS ® , Sciclone ® , Zephyr ® and FlexDrop™) offering a choice of robotic solutions in genomics, biotherapeutics, high throughput screening and high content analysis to assist life science research from bench to clinic.

◦ The JANUS ® BioTx™ and PreNAT II™ workstations for automated small-scale purification, offering column, tip and plate-based chromatography on a single platform.

◦ The LabChip ® GXII Touch™ protein characterization system provides a means of characterizing multiple protein product attributes for research labs through QC.

◦ The LabChip ® Plasmid DNA assay, which enables purity and sizing analysis of the three primary isoforms of pDNA during the manufacturing of proteins, viral vectors, and messenger RNA.

◦ The explorer™ automated workstation allows integration of multiple laboratory instrumentation using a centralized robotic interface, allowing high throughput and turnkey-application focused solutions.

◦ The plate::handler™ FLEX automated plate loading solution for our high-content imagers, cell counters and image cytometers.

◦ The Fontus ® liquid handler is available in multiple versions to automate both NGS and life science workflows.

◦ The Zephyr ® G3 SPE workstation is a liquid handler that automates the critical steps required in high-throughput Solid Phase Extraction (SPE).

◦ Harmony 5.3™ high-content imaging and analysis software supports end-to-end workflows from acquisition through quantitative analysis and results interpretation.

It improves image data handling and search functionality while enabling 2D and 3D cellular phenotyping, live-cell analysis, and standardized assays on our Opera Phenix™ Plus and Operetta CLS™ systems.

◦ The Signals Image Artist™ next-generation image analysis and management platform for drug discovery research helps scientists process and analyze high-content screening (HCS) and cellular imaging data in a matter of hours rather than days or weeks, enabling faster and more informed decisions.

The latest version provides improved 3D cell segmentation and analysis, an AWS S3 cloud deployment option and enhanced cloud security, and compatibility with a broader range of systems, including our Celigo ® image cytometer.

◦ The Signals Research™ platform equips pharmaceutical scientists with the essential tools to gather, search, mine, analyze and visualize critical data, yielding actionable insights in an automated, predictive, and scalable manner.

Within life science research and development and clinical research applications, our software accelerates innovation, development, collaboration and research, ultimately leading to accelerated life-enhancing medical breakthroughs, promoting our vision of a healthier humankind.

In addition, it also

empowers scientists and formulators in specialty chemical and food sciences to analyze food, and additives, and create high-performing materials that align with sustainability initiatives, promoting energy efficiency, lower toxicity and a circular economy.

◦ The Signals Notebook TM secure cloud-native electronic lab notebook (ELN) for chemistry, biology, research, and formulations.

It also empowers scientists and formulators in specialty chemical and food sciences to analyze food, and additives, and create high-performing materials that align with sustainability initiatives, promoting energy efficiency, lower toxicity and a circular economy.

◦ The Signals Notebook TM software is a secure cloud-native electronic lab notebook (ELN) for chemistry, biology, research, and formulations.

From increased collaboration to securely accessible data, the Signals Notebook TM offering accelerates research and development workflows, increases collaboration, integrates with Microsoft Office and more.

◦ Signals ChemDraw ® software providing solutions with powerful capabilities and integrations to help quickly turn ideas and drawings into publications since 1985.

◦ Since 1985, Signals ChemDraw ® software provides solutions with powerful capabilities to help quickly turn ideas and drawings into publications.

Signals ChemDraw ® software automates chemical drawings and transforms them into chemical knowledge by facilitating the management, reporting and presenting of chemistry research.

◦ Signals Clinical offering provides a single unified platform to support data access, preparation and analytics, from source to visualization to action.

With unrivaled workflow flexibility to support dynamic collaboration, Signals Clinical’s SaaS solution helps accelerate the delivery of urgently needed therapeutics to patients.

◦ Signals DLX™ powered by Scitara ® establishes seamless, bidirectional connectivity across instruments, LIMS, ELNs and other critical lab systems that previously existed in isolation.

◦ The latest version of the Signals Image Artist™ next-generation image analysis and management platform provides improved 3D cell segmentation and analysis, an AWS S3 cloud deployment option and enhanced cloud security, and compatibility with a broader range of systems, including the Nexcelom from Revvity Celigo ®TM image cytometer.

◦ An updated VICTOR Nivo™ multimode plate reader with a new software version for streamlined data analysis.

◦ Software solutions for BioLegend ® LEGENDplex ™ assays and multiomics analysis with TotalSeq™ reagents, that are now part of BioLegend’s data integration offerings.

◦ The Signals Clinical offering provides a single unified platform to support data access, preparation and analytics, from source to visualization to action.

With unrivaled workflow flexibility to support dynamic collaboration, the Signals Clinical’s SaaS solution helps accelerate the delivery of urgently needed therapeutics to patients.

◦ Signals DLX™ software powered by Scitara ® , which establishes seamless, bidirectional connectivity across instruments, LIMS, ELNs and other critical lab systems that previously existed in isolation.

◦ Software solutions for BioLegend ® LEGENDplex ™ assays, multiomics analysis with TotalSeq™ reagents, and CytoScribe ™ software for flow cytometry data analysis that are now part of BioLegend ® data integration offerings.

• Technology and Licensing

◦ The Pin-point™ base editing platform is a CRISPR-Cas9-based technology that allows researchers to make precision base changes in genomic DNA.

◦ The Pin-point ® base editing platform, a CRISPR-Cas9-based technology that allows researchers to make precision base changes in genomic DNA.

Editing with such precision can be used to silence disease-causing genes, correct disease-associated mutations, and optimize cell therapies.

◦ CHOSOURCE™ platform was expanded to include a CHO-K1 ADCC+ expression cell line for development of therapeutic antibodies in oncology, infectious disease and autoimmune conditions.

◦ The CHOSOURCE ® expression platform, a robust CHO expression system for the development and manufacturing of biotherapeutics with a track record of over 100 regulatory filings in multiple countries.

◦ Gene Delivery services and technologies to design and manufacture viral vectors for cell and gene therapy research and preclinical development.

This includes LentiBOOST ® transduction enhancer technology for improved lentiviral transduction efficiency, helping to reduce the cost of goods for cell therapies.

This includes the LentiBOOST ® transduction enhancer technology for improved lentiviral transduction efficiency, helping to reduce the cost of goods for cell therapies.

◦ Preclinical services for oncology, leveraging capabilities such as cell panel screening, cell line engineering, functional genomic screening, and immune cell screening, for a range of applications to help accelerate the drug development process.

New Products:

New products introduced or acquired for Life Sciences applications in fiscal year 2024 include the following:

◦ Biolegend launched new dyes to expand flow cytometry panel building options, including PE/Fire™ 744, Spark PLUS UV395™, Spark PLUS™ B550 antibody conjugates and Zombie UV387™ for dead cell analysis.

In addition, the Flexi-Fluor™ portfolio of reagents was created as a made-to-order, rapid alternative to traditional custom products.

◦ Oligo-conjugated antibodies for intracellular detection of proteins and cytokines introduced in BioLegend's TotalSeq TM portfolio.

BioLegend also introduced a solution for high-throughput, high-parameter single-cell protein analysis - TotalSeq™ PhenoCyte TM .

PhenoCyte TM provides a streamlined, instrument-free workflow for scalable single-cell immunoprofiling.

New products introduced or acquired for Life Sciences applications in fiscal year 2025, including from our recent acquisition, include the following:

◦ pHSense™ reagents, a powerful technology designed to advance internalization studies in drug discovery.

pHSense reagents are designed for high-throughput, plate-based workflows and intended for researchers studying G protein-coupled receptors (GPCRs) or antibody-drug conjugates (ADCs).

They offer a scalable, accurate, and easy-to-implement solution for monitoring antibody, ADC, or receptor internalization.

◦ BioLegend ® StarBright™ UltraViolet 575, 740, and 795 dyes to expand flow cytometry panel building options for the ultraviolet laser.

New Spark PLUS dyes were released that offer improved brightness and performance, including Spark PLUS V475, B488, and B574.

The Human General Phenotyping (26c) Optimized Panel was also released, providing researchers with pre-selected and optimized choices for antibody/fluorophore combinations.

◦ BioLegend ® TotalSeq™ cocktails improve ease of use, including Essential Cocktails which examine 100 of the most commonly cited proteins in phenotyping immune cells and Universal V2.0 cocktails, which offer 50 plus new antibody targets over the V1.0 format.

◦ The BioLegend ® MojoSort™ on Columns™ cell separation system utilizes columns, multistands, and separators, in conjunction with MojoSort magnetic bead-based kits, for positive and negative selection of immune cells from mixed samples or populations.

◦ BioLegend ® LEGENDplex™ panels for cytokine detection, including Human Inflammation Panel 3, Mouse CD8/NK Panel, Mouse Immune Checkpoint Panel 1, and Mouse Inflammation Panel 2.

◦ BioLegend ® chemical probes designed for use in flow cytometry and/or microscopy assays, including ATP Red for cell health and metabolism studies;

Swift-Click™ Green EdU kits for cell cycle analysis;

and LysoFix-GBA™ (Lysosomal GCase) probes for monitoring of GBA1 activity.

◦ The BioLegend ® Human GPI-APD cocktail for WBC with Control Cells uniquely combines a ready-to-use cocktail to identify rare glycosylphosphatidylinositol (GPI)-deficient cell populations with a patented positive control, offering an important tool for paroxysmal nocturnal hemoglobinuria research.

◦ BioLegend ® FluoroSpot MAX™ kits combine the principles of ELISpot with fluorescence-based multiplexing, enabling simultaneous detection of two key cytokines at the single-cell level.

Researchers can quantify polyfunctional immune responses with clarity, making it suitable for studies in infectious disease, vaccine development, and autoimmunity.

◦ BioLegend ® Cell-Vive™ GMP CD3/CD28 Human T Cell Activation Beads and Cell-Vive™ GMP NKp46/CD2 NK Cell activation beads, designed to activate T cells and Natural Killer cells respectively without the need for antigen presenting cells.

◦ Mimix™ Geni™ reference standards are highly characterized somatic cancer controls developed in collaboration with the Medical Device Innovation Consortium (MDIC) and the National Institute of Standards and Technology (NIST) as part of the Somatic Reference Samples (SRS) Initiative to help clinical diagnostic labs improve the accuracy of cancer diagnostic assays and medical device manufacturers verify their tests and platforms.

• Instruments

◦ The Cellometer ™ Ascend™ automated cell counter accelerates lab workflow by mitigating human error, all while providing a consistent, standardized cell count.

Incorporated with its user-friendly Matrix software, this product performs an automated and sophisticated image analysis workflow that delivers reliable results in seconds.

◦ The AssayMate™ workstation, a benchtop-sized, automated liquid handler designed to optimize a wide range of laboratory applications, integrating technologies such as collision detection, error handling, and real-time run visualization.

◦ The VivoJect™ image-guided injection system, designed to work with the Vega™ automated preclinical ultrasound system, and is an innovative, compact injection system that enables researchers to rapidly administer targeted delivery of cells and drug therapies into mice.

◦ The EnVision Nexus ® multimode plate reader for high-throughput screening with advanced detection technologies for Alpha™, TRF, and Luminescence assays.

◦ The VICTOR Kira™ multimode plate reader with advanced monochromator technology for absorbance, fluorescence, and luminescence measurements across multiple wavelengths.

◦ The LH 96 automated homogenizer workstation combines intuitive software with on-deck weighing, sample dilution, homogenization, and reformatting.

◦ Phenologic.AI™ software, a module in our Harmony™ high-content imaging and analysis software and in our Signals Image Artist™ image analysis and data management platform, uses a pre-trained deep-learning image-analysis model to enable analysis of brightfield images and provides an additional channel for multiplexing and easier analysis of live cell assays.

Its Nuclei AI building block enables reliable nucleus detection without staining, eliminating manual tuning and accelerating image analysis with greater precision.

◦ The Living Image™ Synergy AI in vivo imaging software platform enables acquisition, visualization, and quantitative analysis across optical, microCT, ultrasound, and multimodal workflows.

It supports longitudinal studies and standardized reporting to evaluate disease progression and therapeutic response.

◦ BioLegend ® CytoScribe™ cloud-based software allows researchers to access and analyze data with advanced tools for data visualization, centralized data storage, and seamless collaboration with colleagues.

◦ Katalyst D2D ® software provides integrated experiment design, planning, execution, and analysis capabilities supporting high-throughput synthesis, process optimization, and preformulation studies.

The platform enables scientists to manage data across the complete design-make-test-analyze cycle and leverage structured data to support AI-driven decision-making.

◦ Luminata ® enterprise decision-support software that consolidates analytical and chemical data for pharmaceutical and chemical product development.

The software constructs process maps for visualization of impurities at each route stage, stores experimental context and expert interpretations, and enables rapid assessment of impurity control effectiveness.

◦ Spectrus ® software delivers vendor neutral comprehensive processing, analysis, and management of analytical data across multiple techniques including nuclear magnetic resonance, mass spectrometry, chromatography, and optical spectroscopy.

The platform provides spectral prediction, no code-automation, and unified data management capabilities that support efficient analytical workflows.

◦ AutoChrom ® software enables chromatographic separation development using quality by design principles through a workflow-based structure that streamlines project management from initiation through completion.

The platform automatically designs screening and optimization experiments, models separations, and maintains a project database to enable organizational learning and method reuse.

◦ The Percepta ® platform provides prediction and management capabilities for physicochemical, absorption-distribution-metabolism-excretion-toxicity, and other molecular property data.

The platform enables users to predict molecular properties from chemical structure, train predictive models, and integrate custom in-house models for consistent enterprise-wide predictions.

• Technology and Licensing

◦ The Pin-point ® base editing platform was expanded to include AI-enhanced adenine deaminase editors in collaboration with Profluent, providing a toolkit for therapeutic applications where control, safety, and reproducibility are paramount.

◦ The HostDetect™ PCR DNA quant kits detect host cell contamination throughout bioprocessing workflows.

Our Life Sciences segment offers additional products under various brand names:

Accell™, AdenoBOOST™, AlphaLISA ® , AlphaPlex ™ , AlphaScreen ® , Alpha™ SureFire ® , BioLegend ® , Brilliant Violet™, Ce3D™, CellCarrier ® , Cellaca™, Celigo™, Cellometer™, cell::explorer ™ , Cell-Vive™, Chalice™, Chem3D ® , ChemDraw ® , ChemOffice ® , CHOSOURCE™, DELFIA ® , Dharmacon™, DharmaFECT™, Edit-R™, ELISA MAX™, EnVision TM , EnVision Nexus TM , Flex-T™, FMT ® , FolateRSense ™ , GoInVivo™, HTRF ® , ImmuSignature ™ , IVIS ® , IVISbrite ® , IVISense ® , LANCE ® , LANCE ® Ultra ™, LEAF™, LEGEND MAX™, LEGENDplex™, LentiBOOST ® , Lincode™, Living Image ® , Lumina™, MicroBeta TM , Mimix TM , Mini ELISA Plate Reader™, miRIDIAN™, MojoSort™, MuviCyte™, NEN ® , OncoSignature™, OncoSpan TM , ON-TARGET™, ON-TARGETplus™, Opera Phenix TM Plus, Operetta-CLS™, OptiScint™, PhenoPlate™, PhenoVue™, Pin-point™, Quantulus ™ GCT, Quantum™, RAPID MAX™, RediJect™, RNAiONE™, Signals™, Signals Image Artist™, SMARTpools ™ , SMARTvector ™ , Spark PLUS™, Spectrum™, TotalSeq™, Tri-Carb TM , Ultra-LEAF™, Vega TM , VesselVue ® , ViaStain™, VICTOR Nivo ™ , Western Lightning ™ , and Wizard2 TM .

Accell™, AlphaLISA ® , AlphaPlex ™ , AlphaScreen ® , Alpha™ SureFire ® , AssayMate™, BIOCHIPs™, BioLegend ® , Bioo Scientific ® , BioQule™, Brilliant Violet™, Ce3D™, CellCarrier ® , Cellaca™, Celigo™, Cellometer™, cell::explorer™, Cell-Vive™, Chalice™, ChemDraw ® , CHOSOURCE ® , DELFIA ® , Dharmacon™, DharmaFECT ® , DOPlify ® , Edit-R™, ELISA MAX™, EnVision ® , EnVision Nexus ® , explorer™, Flex-T™, FolateRSense ™ , Fontus ® , GoInVivo™, HostDetect ® , HTRF ® , ImmuSignature ™ , IVIS ® , IVISbrite ® , IVISense ® , JANUS ® , LabChip ® , LANCE ® , LANCE ® Ultra ™, LEAF™, LEGEND MAX™, LEGENDplex™, LentiBOOST ® , Lincode™, Living Image ® , Lumina™, MicroBeta2 ® , Mimix™, Mini ELISA Plate Reader™, miRIDIAN™, MojoSort™, NEXTFLEX ® , NextPrep™, Omni Bead Ruptor ® , Omni Bead Ruptor ® Elite™, Omni Tip™, OncoSpan™, ON-TARGETplus ® , Opera Phenix ® Plus, Operetta_CLS™, OptiScint™, PhenoPlate™, PG-Seq™, PG-Find™, PhenoVue ® , Pin-point ® , Protein Clear™, ProteinEXact™, QuantiVac™, Quantulus ® GCT, Quantum™, RAPID MAX™, RediJect™, RNAiONE™, Sciclone ® , Signals™, Signals Image Artist™, SMARTpool ® , SMARTvector ™ , Spark PLUS™, Spectrum™, TotalSeq™, Tri-Carb ® , Ultra-LEAF™, VariSpec™, Vega ® , VesselVue ® , ViaStain™, VICTOR Nivo ® , Western Lightning ™ , Wizard2 ® , and Zephyr ® .

Diagnostics Segment

We offer instruments, reagents, assay platforms and software to hospitals, medical labs, clinicians and medical research professionals to help improve the health of families.

Our Diagnostics segment is especially focused on reproductive health, immunodiagnostics, emerging market diagnostics and applied genomics.

We provide early detection for genetic disorders from pregnancy to early childhood, and infectious disease testing for the diagnostics market.

Our Diagnostics segment is especially focused on reproductive health, immunodiagnostics and emerging market diagnostics.

We provide early detection for common and rare conditions from pregnancy to early childhood, and infectious disease testing for the diagnostics market.

Our screening products are designed to provide early and accurate insights into the health of expectant mothers during pregnancy and into the health of their babies.

Diagnostic labs use our instruments, reagents and software for testing and screening genetic abnormalities and certain disorders and diseases, including Down syndrome, hypothyroidism, muscular dystrophy, infertility and various metabolic conditions.

We also develop technologies that enable and support genomic workflows using PCR and next-generation DNA sequencing for applications in oncology, immunodiagnostics and drug discovery.

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• Reproductive Health

◦ The DELFIA ® Xpress screening platform, a complete solution for prenatal and maternal health screening including a fast continuous loading system.

◦ The DELFIA ® Xpress screening platform is a complete solution for prenatal and maternal health screening including a fast continuous loading system.

It is supported by kits for first, second and third trimester analyses for prenatal screening and clinically validated LifeCycle™ software.

◦ The DELFIA ® Xpress sFlt-1 kit enables short term prediction of pre-eclampsia and aids in diagnosis in the second and third trimesters of pregnancy together with the previously launched DELFIA™ Xpress PlGF 1-2-3™ assay.

◦ The NeoBase™ non-derivatized MS/MS AAAC kits is used to support detection of metabolic disorders in newborns through tandem mass spectrometry.

◦ The NeoBase™ non-derivatized MS/MS AAAC kits are used to support detection of metabolic disorders in newborns through tandem mass spectrometry.

The kits analyze newborn dry blood spot samples for measurement of amino acids and other metabolic analytes for specific diseases.

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◦ The NeoLSD™ MS/MS kit, the first commercial IVD kit for screening of Pompe, MPS-I, Fabry, Gaucher, Niemann-Pick A/B and Krabbe disorders from a single dried blood spot sample.

◦ QSight ® 210MD and 225MD UHPLC MS/MS instruments used for newborn screening.

◦ Vanadis® NIPT, a non-PCR non-sequencing fully automated cfDNA technology for use in any laboratory for screening common trisomies in the pregnant population.

◦ The QSight ® 210MD and 225MD UHPLC MS/MS instruments used for newborn screening.

◦ The Vanadis ® NIPT offering, a non-PCR non-sequencing fully automated cfDNA technology for use in any laboratory for screening common trisomies in the pregnant population.

◦ The EONIS ® assay, a CE marked and United States Food and Drug Administration (“FDA”) authorized system utilizing real-time PCR technology, which allows for simultaneous screening of SMA, SCID and XLA in newborns from a single DBS punch.

◦ EONIS™ Q novel “dry-chemistry” qPCR newborn screening workflow for SCID, SMA, and XALD screening.

◦ DELFIA™ Trio automated plate dispenser, washer and disk remover for the manual newborn screening and prenatal workflows.

◦ EVOYA ® cloud-based, newborn screening, informatics and data management software.

◦ The EONIS ® Q novel “dry-chemistry” qPCR newborn screening workflow for SCID, SMA, and XALD screening.

◦ The DELFIA™ Trio automated plate dispenser, washer and disk remover for the manual newborn screening and prenatal workflows.

◦ The EVOYA ® cloud-based, newborn screening, informatics and data management software.

◦ The NEXTFLEX ® Neo NGS RUO Panel 1 kit, which is part of a new end-to-end workflow solution for newborn sequencing research.

◦ The Revvity Genomics LIMS cloud-based, genomic platform solution is primed for secure data management and LIS integration.

◦ The Revvity Genomics Analyze™ genomics primary and secondary analysis software for variant calling.

◦ The Revvity Genomics Interpret™ tertiary and reporting software for genomic testing.

◦ The Revvity Transcribe AI™ innovative OCR service designed to convert handwritten text on test request forms into a digitized format.

◦ ViaCord ® umbilical cord blood banking services for the banking of stem cells harvested from umbilical cord blood and cord tissue, for potential therapeutic application in transplant and regenerative medicine.

◦ Revvity Omics global laboratory network offering multi-OMIC clinical grade services for testing over an individual’s lifetime (prenatal to adults) in cytogenetics, biochemical genetics, molecular genetics and immunodiagnostics.

The laboratory network includes testing laboratories in the United States, Sweden, India, China and the United Kingdom.

◦ Utilizing next-generation sequencing, Revvity Omics labs provide testing solutions including but not limited to whole genome sequencing, whole exome sequencing, curated and customized gene panels.

◦ CD34+ hematopoietic stem cells from human umbilical cord blood (for research use only and not for use in diagnostic procedures).

◦ Revvity Omics global laboratory network offers multi-OMIC clinical grade services for testing over an individual’s lifetime (prenatal to adults) in cytogenetics, biochemical genetics, molecular genetics and immunodiagnostics.

The laboratory network includes testing laboratories in the United States, India, China and the United Kingdom.

◦ Revvity Omics ® labs utilize next-generation sequencing to provide testing solutions including but not limited to whole genome sequencing, whole exome sequencing, curated and customized gene panels.

◦ Revvity Omics ® whole genome sequencing test provides dual genome analysis (nuclear and mitochondrial) detecting single nucleotide variants, chromosomal and intragenic copy number events, short tandem repeats analysis for >30genes and SMN1 copy number characterization.

This test also provides additional findings like pharmacogenomic analysis and carrier status among others.

◦ Ultrarapid Whole Genome Sequencing test, a variant of the whole genome sequencing (WGS) analysis, bundles the StepOne biochemical profile, cCMV analysis and metagenomic analysis with the standard WGS analysis to help babies in the NICU with a result as fast as five days.

◦ Ultrarapid™ whole genome sequencing test, a variant of the whole genome sequencing (WGS) analysis, which bundles the StepOne™ biochemical profile, cCMV analysis and metagenomic analysis with the standard WGS analysis to help babies in the NICU with a result as fast as five days.

◦ Using WGS as a backbone, Revvity Omics provides two unique products, the CNGnome ® NGS array and WholePanel™ test.

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The WholePanel™ test provides enhanced coverage including the intronic regions for the expertly curated WholeCancer™, WholeAtaxia™, WholeCardiology™ and WholeMuscularDystrophy™ gene panels.

• Applied Genomics

◦ The Omni Bead Ruptor ® Elite Bead Mill Homogenizer enables grinding, lysing, and homogenization of biological samples prior to molecular analyte extraction, delivering repeatable sample disassociation.

◦ The Omni Prep 96 Automated Homogenizer Workstation, a fully automated homogenizer enabling true walk-away processing for high-throughput labs.

◦ Automated liquid handling platforms (Fontus™, JANUS®, Sciclone®, Zephyr® and FlexDrop™) offering a choice of robotic solutions in genomics, biotherapeutics, high throughput screening and high content analysis to assist life science research from bench to clinic.

◦ JANUS ® BioTx™ and PreNAT II™ workstations for automated small-scale purification, offering column, tip and plate-based chromatography on a single platform.

◦ The LabChip® GXII Touch™ protein characterization system provides a means of characterizing multiple protein product attributes for research labs through QC.

◦ The PG-Seq™ Rapid kit v2 analyzes picogram quantities of DNA from an embryo biopsy for preimplantation genetic research with enhanced whole genome coverage and accuracy.

◦ DOPlify ® WGA V2 kit performs fast whole genome amplification on single cells or limited template DNA samples, allowing cell chromosome copy number status to be determined.

◦ NEXTFLEX ® library prep kits simplify library prep with optimized protocols and reagents, making the library preparation process more efficient and reliable.

◦ Automation protocols and kits launched for the BioQule™ NGS System, making it an open system that combines automation, reagents, consumables and scripts, enabling walkaway automation to simplify low throughput nucleic acid isolation, NGS library preparation and quantitation.

◦ The Fontus™ liquid handler is available in multiple versions to automate both NGS and life science workflows.

• Immunodiagnostics

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◦ The chemagic ® 360 instrument is a flexible solution for automated nucleic acid isolation from 0.5-18 ml sample volumes of diverse sample materials.

The chemagic™ 360-D instrument (IVDR) and chemagic™

Prime™ Junior-D instrument (IVDR), together with the chemagic™ IVD Kits, are the optimal choice for automated IVDR compliant nucleic acid isolation for clinical diagnostics.

The chemagic 360-D instrument (IVDR) and chemagic Prime™ Jr-D instrument (IVDR), together with the chemagic ® IVD kits, are the optimal choice for automated IVDR compliant nucleic acid isolation for clinical diagnostics.

◦ The Oxford Immunotec T-SPOT ® Technology platform, a modified ELISPOT used to detect a T cell immune response to infection.

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It is intended for use as an aid in the diagnosis of tuberculosis infection.

◦ Auto-Pure™ 2400 automated liquid handling platform designed to provide efficient workflows in the lab for T-SPOT.TB testing.

◦ An expanded portfolio of molecular-based infectious disease screening technologies for blood bank and clinical laboratory settings in China.

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◦ TRF-based Anti HBs/HCV/TP kits for infectious disease testing.

◦ Chitas ® instrument and HBV/HCV/HIV 3-in-1 PCR reagents for blood screening, and Hi Sensitivity HBV DNA and HCV RNA assays for clinical infectious disease testing.

◦ The Chitas™ instrument and HBV/HCV/HIV 3-in-1 PCR reagents for blood screening, and Hi Sensitivity HBV DNA and HCV RNA assays for clinical infectious disease testing.

◦ Chemiluminescence immunoassays and ELISA for therapeutic drug monitoring.

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◦ A complete portfolio of chemiluminescence immunoassays (“ChLIA”) for precise Alzheimer’s disease diagnostics providing reliable analysis of the established CSF biomarkers beta-amyloid (1-40), beta-amyloid (1-42), total tau and pTau (181) and a high degree of standardization due to fully automated processing.

◦ EUROLabPolaris platform provides the secure transfer of indirect immunofluorescence data to several locations enabling central evaluation within the software.

◦ EUROLabOffice TM 4.0 laboratory management system provides a central interface between devices to simplify and speed up the diagnostic routine and increases security through organization of all lab procedures and traceable documentation of all data and processes.

◦ EUROPattern Classifier TM 2.4 AI-enhanced software module of EUROLabOffice TM 4.0 offers automated result proposals from images captured with the all-in-one IFA instrument UNIQO 160 as well as from the automated microscopes EUROPattern and EUROPattern Microscope Live.

◦ EUROLabWorkstation TM IFA and EUROLabWorkstation ELISA provide fully automated processing of IIFT and ELISA, respectively, for laboratories with high sample throughput.

◦ EUROPattern TM microscope provides fully automated immunofluorescence microscopy including IIFT pattern recognition and titer determination.

◦ EUROPattern TM microscope live provides fully automated and fast image recording and modern on-screen reporting, also including IIFT pattern recognition and titer determination.

◦ EUROBlotOne TM compact tabletop device for complete processing of immunoblots.

◦ UNIQO160 TM device for fully automated processing of IIFT from primary sample to final microscopy result for up to 160 samples and 18 slides.

◦ IDS-i10 TM compact random-access solution for the processing of ChLIA in the field of autoimmune and infection diagnostics as well as antigen detection, providing sample throughput of up to 170 tests per hour.

◦ The EUROLabPolaris TM platform, which provides the secure transfer of indirect immunofluorescence data to several locations enabling central evaluation within the software.

◦ The EUROLabOffice™ 4.0 laboratory management system, which provides a central interface between devices to simplify and speed up the diagnostic routine and increases security through organization of all lab procedures and traceable documentation of all data and processes.

◦ The EUROPattern™ Classifier 2.4 AI-enhanced software compatible to EUROLabOffice™4.0 laboratory management software, which offers automatically generated result proposals from images captured with the all-in-one IFA instrument UNIQO 160 as well as from the EUROPattern and EUROPattern Microscope Live automated microscopes.

◦ The EUROLabWorkstation™ IFA and EUROLabWorkstation TM ELISA platforms provide fully automated processing of IIFT and ELISA, respectively, for laboratories with high sample throughput.

◦ The EUROPattern™ microscope provides fully automated immunofluorescence microscopy including IIFT pattern recognition and titer determination.

◦ The EUROPattern™ Microscope Live provides fully automated and fast image recording and modern on-screen reporting, also including IIFT pattern recognition and titer determination.

◦ The EUROBlotOne™ compact tabletop device for complete processing of immunoblots.

◦ The UNIQO160 TM device for fully automated processing of IIFT from primary sample to final microscopy result for up to 160 samples and 18 slides.

◦ The EUROStar™ IV Plus microscope, a model of Euroimmun's successful LED microscope series for convenient manual fluorescence microscopy with attractive new features for easy and ergonomic manual microscopy.

◦ The IDS-i10™ compact random-access solution for the processing of ChLIA in the field of autoimmune and infection diagnostics as well as antigen detection, providing sample throughput of up to 170 tests per hour.

◦ IDS-iSYS™ multi-discipline automated system is a compact automation solution for the processing of ChLIA in the field of autoimmune, infection and allergy diagnostics as well as antigen detection, providing sample throughput of up to 120 samples per hour.

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• Reproductive Health

◦ CD34+ hematopoietic stem cells from human umbilical cord blood (for research use only and not for use in diagnostic procedures).

◦ The NEXTFLEX ® Neo NGS RUO Panel 1 kit, which is part of a new end-to-end workflow solution for newborn sequencing research.

◦ Revvity Genomics LIMS cloud-based, genomic platform solution is primed for secure data management and LIS integration.

◦ Revvity Genomics Analyze TM genomics primary and secondary analysis software for variant calling.

◦ Revvity Genomics Interpret TM tertiary and reporting software for genomic testing.

◦ Revvity Transcribe AI TM innovative OCR service designed to convert handwritten text on test request forms into a digitized format.

• Applied Genomics

◦ LabChip ® Plasmid DNA assay enables purity and sizing analysis of the three primary isoforms of pDNA during the manufacturing of proteins, viral vectors, and messenger RNA.

◦ The NeoLSD™ 7 Plex MS/MS kit, the first commercial IVD kit for screening of MLD plus 6 lysosomal storage disorders from a single dried blood spot sample.

◦ The Bile Acid B MSMS RUO test reagents measure bile acid B from DBS samples using LC-MS/MS, supported by the Bile Acid B internal standard.

◦ The Vanadis Core ® Reagent Cartridge II qualitative assay for screening the risk of trisomy 21, 18, 13 and sex chromosome aneuploidies in fetal cell-free DNA from pregnant women.

• Immunodiagnostics

◦ Auto-Pure TM 2400 automated liquid handling platform designed to provide efficient workflows in the lab for T-SPOT.TB ® testing.

◦ EUROStar IV Plus, a new model of EUROIMMUN's successful LED microscope series for convenient manual fluorescence microscopy with attractive new features for easy and ergonomic manual microscopy.

◦ The optimised (IVDR-compliant) “RVTY” "CSF ELISA 2.0" series for facilitated handling and resource savings.

◦ The GeneProof-ALPCO TM portfolio for molecular diagnostics.

◦ EURORealTime APOE for APOE genotyping to assess a patient’s risk for side effects prior to the start of an anti-amyloid (beta) therapy in Alzheimer’s disease.

◦ The T-SPOT.Flex™ interferon-gamma (IFN-γ) ELISPOT kit enables researchers to design their own customized assays with their preferred antigens.

◦ The ELISA 2.0 series for infection diagnostics, IVDR-compliant follow-up products are also validated for dried blood spots as sample material besides serum/plasma.

◦ The IDS i20 TM random access solution for processing of ChLIA from six diagnostic specialties (endocrinology, allergy, autoimmune and infectious diseases, Alzheimer’s disease and therapeutic drug

monitoring) with an increased capacity of processing 20 analytes in parallel and a throughput of about 140 tests per hour (assay dependent).

Our Diagnostics segment offers additional products under various brand names, including:

AutoDELFIA ® , BACS-on-Beads ® , BIOCHIPs, Bioo Scientific ® , BioQule™, BoBs ® , chemagic™, Chitas ® , DELFIA ® , DELFIA ® Xpress, DOPlify ® , EONIS™, EUROArray™ , EUROIMMUN ® , EUROLabWorkstation™, EUROLINE™, EUROPattern TM , Evolution™ Evoya ® , explorer™, Fontus™, GSP ® , Haoyuan™, IDS ® Immunodiagnosticsystems, IDS-i10 ® , IDS-i10T ® , IDS-iSYS ® , iLab™, iQ™, JANUS ® , LabChip ® , LifeCycle™, LimsLink™, Migele ® , MultiPROBE ® , NEXTFLEX ® , NextPrep™, Omni Bead Ruptor ® , Omni Bead Ruptor Elite™, Omni Tip™, Pannoramic™, Panthera Puncher™, PG-Seq™, PG-Find™, PreNAT II™, Prime™, Protein Clear™, ProteinEXact™, QuantiVac™, RONIA ® , Sciclone ® , SimplicityChrom™, Specimen Gate ® , Superflex™, Symbio™, T-SPOT ® , Touch™, Twister®, Vanadis®, VariSpec™, ViaCord ® , VICTOR2™D, and Zephyr ® .

AutoDELFIA™, chemagic ® , Chitas™, CNGnome ® , DELFIA™, DELFIA™ Xpress, EONIS ® , EUROArray™ , EUROIMMUN ® , EUROLabWorkstation™, EUROLINE™, EUROPattern TM , Evolution™ Evoya ® , GSP ® , Haoyuan™, IDS ® Immunodiagnosticsystems™, IDS-i10 ™ , IDS-i10T ™ , IDS-i20 ™ , IDS-iSYS ™ , iLab™, iQ™, LifeCycle™, LimsLink™, Migele ™ , NeoBase™, NeoLSD™, NEXTFLEX ® , Panthera Puncher™, PreNAT II™, Prime™, RONIA ® , SimplicityChrom™, Specimen Gate ® , Superflex™, Symbio™, T-SPOT ® , Vanadis ® , ViaCord ® , VICTOR2 ® and WholePanel™.

All of our businesses market their products and services primarily through their own specialized sales forces.

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We own numerous United States and foreign patents and have patent applications pending in the United States and abroad.

We also license intellectual property rights to and from third parties, some of which bear royalties and are terminable in

specified circumstances.

We also license intellectual property rights to and from third parties, some of which bear royalties and are terminable in specified circumstances.

In addition to our patent portfolio, we possess a wide array of unpatented proprietary technology and know-how.

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Our operations are subject to various foreign, federal, state and local environmental and safety laws and regulations.

These requirements include the handling, transportation, manufacture and disposal of toxic or hazardous substances, the

remediation of contaminated soil and groundwater, the regulation of radioactive materials, and the health and safety of our employees.

These requirements include the handling, transportation, manufacture and disposal of toxic or hazardous substances, the remediation of contaminated soil and groundwater, the regulation of radioactive materials, and the health and safety of our employees.

We may have liability under the Comprehensive Environmental Response Compensation and Liability Act and comparable state statutes that impose liability for investigation and remediation of contamination without regard to fault, in connection with materials that we or our former businesses sent to various third-party sites.

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There have been no environmental problems to date that have had, or are expected to have, a material adverse effect on our consolidated financial statements.

While it is possible that a loss exceeding the amounts recorded in the consolidated financial statements may be incurred, the potential exposure is not expected to be materially different from those amounts recorded.

While it is possible that a loss exceeding

the amounts recorded in the consolidated financial statements may be incurred, the potential exposure is not expected to be materially different from those amounts recorded.

We may become subject to new or unforeseen environmental costs or liabilities.

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Several of our subsidiaries outside the United States have employment contracts with our employees where the terms and conditions are influenced by labor unions and workers’ councils’ agreements that involve approximately 4,000 of our employees.

During fiscal year 2024, our voluntary turnover rate was approximately 9%.

We believe that management of our human capital resources is vital to the continued growth and success of our company, and we endeavor to create an environment that encourages productivity, rewards performance and values employees.

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We strive to create a workplace where everyone feels valued and respected, believing that this fosters innovation and enables all employees to contribute fully to our shared goals.

In 2025, this commitment was reflected in our Great Place to Work certifications across India, China, Poland, and the United States with Euroimmun also certified in Brazil.

Our overall scores in the U.S.

improved from the prior year, reflecting continued cultural momentum.

The people experience survey provides additional validation as a substantial majority of our employees report pride in working for Revvity and feel encouraged to innovate and share new ideas, a powerful indicator of shared purpose across our global workforce.

We make employment decisions based on legitimate business needs and in compliance with all applicable laws.

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Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.

What changed 10-K

Item 1. Business