4 unchanged sentences
Our material risk factors are disclosed in Item 1A of our Annual Report on Form 10-K for the year ended December 31, 2023.
−Removed: Except as set forth below, there have been no other material changes from the risk factors previously disclosed in such filing.
−Removed: We may not successfully execute or achieve the expected benefits of our strategic pipeline prioritization and restructuring plan or other cost-saving measures that we may take in the future, and our efforts may result in further actions or additional asset impairment charges, any of which may have a material adverse effect our business, financial condition and results of operations.
−Removed: In November 2023, we announced a strategic pipeline prioritization and restructuring plan to increase our focus on our large commercial opportunities in retinal and neuromuscular disease from our strong pipeline of AAV therapeutics.
−Removed: We continue to take actions intended to address the short-term health of our business as well as our long-term objectives based on our current estimates, assumptions and forecasts.
−Removed: These measures are subject to known and unknown risks and uncertainties, including whether we have targeted the appropriate areas for our prioritization and cost-saving efforts and at the appropriate scale, and whether, if required in the future, we will be able to appropriately target any additional areas for our cost-saving efforts.
−Removed: As such, the actions we are taking under the pipeline prioritization and restructuring plan and that we may decide to take in the future may not be successful in yielding our intended results and may not appropriately address either or both of the short-term and long-term strategy for our business.
−Removed: Implementation of the strategic pipeline prioritization and restructuring plan and any other cost-saving initiatives may be costly and disruptive to our business, the expected costs and charges may be greater than we have forecasted, and the estimated cost savings may be lower than we have forecasted.
−Removed: Certain aspects of the restructuring plan, such as severance costs in connection with reducing our headcount, could negatively impact our cash flows.
−Removed: In addition, our initiatives could result in personnel attrition beyond our planned reduction in headcount or reduced employee morale, which could in turn adversely impact productivity, including through a loss of continuity, loss of accumulated knowledge or inefficiency during transitional periods, or our ability to attract and retain highly skilled employees.
−Removed: Unfavorable publicity about us or any of our strategic initiatives, including our pipeline prioritization and restructuring plan, could result in reputational harm and could diminish confidence in our products and services.
−Removed: In addition, the pipeline prioritization and restructuring plan has required, and may continue to require, a significant amount of management’s and other employees’
−Removed: time and focus, which may divert attention from effectively operating and growing our business.
+Added: There have been no material changes from the risk factors previously disclosed in such filing.
+Added: Unregistered Sales of Equit y Securities, Use of Proceeds and Issuer Purchases of Equity Securities.
+Added: Defaults Upo n Senior Securities.
+Added: Mine Safe ty Disclosures.
+Added: Not Applicable.
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.