20 unchanged sentences
(the Company) maintained, in all material respects, effective internal control over financial reporting as of December 31, 2025, based on the COSO criteria.
−Removed: We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States) (PCAOB), the consolidated balance sheets of the Company as of December 31, 2024 and 2023, the related consolidated statements of operations, comprehensive income (loss), stockholders’ equity and cash flows for each of the three years in the period ended December 31, 2024, and the related notes and our report dated February 21, 2025 expressed an unqualified opinion thereon.
+Added: We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States) (PCAOB), the consolidated balance sheets of the Company as of December 31, 2025 and 2024, the related consolidated statements of operations, comprehensive (loss) income, stockholders’ equity and cash flows for each of the three years in the period ended December 31, 2025, and the related notes and our report dated February 25, 2026 expressed an unqualified opinion thereon.
Basis for Opinion
19 unchanged sentences
b) Trading Plans
−Removed: On December 15, 2024 , William D.
−Removed: Waddill , a member of our Board , adopted a trading plan intended to satisfy Rule 10b5-1(c) to sell up to 24,000 shares of the Company’s common stock through December 31, 2025 , or such earlier date when all transactions under the trading plan are completed, subject to certain conditions.
−Removed: During the quarter ended December 31, 2024, none of our other Section 16 officers or directors adopted or terminated a Rule 10b5-1 trading arrangement or a non-Rule 10b5-1 trading arrangement, as such terms are defined under Item 408(a) of Regulation S-K.
+Added: During the fiscal quarter ended December 31, 2025, no director or Section 16 officer adopted or terminated any Rule 10b5-1 trading arrangement or a non-Rule 10b5-1 trading arrangement (in each case as defined in Item 408(a) of Regulation S-K).
Disclosure Regarding Foreign Jurisdictions that Prevent Inspections
32 unchanged sentences
2007 Stock Option and Incentive Plan, as amended and restated, and form of option agreement, exercise notice, joinder, and adoption agreement thereunder.
+Added: Incorporation By Reference
+Added: Filed or Furnished
+Added: Exhibit Description
Protagonist Therapeutics, Inc.
9 unchanged sentences
and Zealand Pharma A/S.
−Removed: Incorporation By Reference
−Removed: Filed or Furnished
−Removed: Exhibit Description
Contract Extension Letter of Agreement, dated June 1, 2013, by and among the Registrant, Protagonist Pty.
7 unchanged sentences
and Zealand Pharma A/S.
+Added: Incorporation By Reference
+Added: Filed or Furnished
+Added: Exhibit Description
Registration Rights Agreement, dated August 8, 2018, by and between the Registrant and certain parties identified on the signature pages thereto .
3 unchanged sentences
First Amendment, dated January 31, 2019, to Lease, dated March 6, 2017, by and between Protagonist Therapeutics, Inc., as Tenant, and BMR-Pacific Research Center LP, as Landlord .
−Removed: Severance Agreement, dated March 14, 2019, by and among Protagonist Therapeutics, Inc.
−Removed: and Suneel Gupta, Ph.D.
−Removed: Incorporation By Reference
−Removed: Filed or Furnished
−Removed: Exhibit Description
Open Market Sale Agreement SM , dated August 5, 2022, by and between Protagonist Therapeutics, Inc.
11 unchanged sentences
and Arturo Molina, M.D., Ph.D., dated November 7, 2022.
+Added: Incorporation By Reference
+Added: Filed or Furnished
+Added: Exhibit Description
License and Collaboration Agreement by and between Protagonist Therapeutics, Inc.
6 unchanged sentences
List of Subsidiaries .
−Removed: Incorporation By Reference
−Removed: Filed or Furnished
−Removed: Exhibit Description
Consent of Independent Registered Public Accounting Firm .
7 unchanged sentences
Inline XBRL Instance Document – the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL Document.
+Added: Incorporation By Reference
+Added: Filed or Furnished
+Added: Exhibit Description
Inline XBRL Taxonomy Extension Schema Document.
38 unchanged sentences
February 25, 2026
−Removed: Williams, M.D., Ph.D.
+Added: /s/ Lewis T Williams, M.D., Ph.D.
February 25, 2026
1 unchanged sentence
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.