26 unchanged sentences
Changes in Internal Control Over Financial Reporting
−Removed: During the year ended December 31, 2024, there have been no changes in our internal control over financial reporting, as such term is defined in Rules 13a-15(f) and 15d-15(f) promulgated under the Exchange Act, that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.
+Added: During the quarter ended December 31, 2025, there have been no changes in our internal control over financial reporting, as such term is defined in Rules 13a-15(f) and 15d-15(f) promulgated under the Exchange Act, that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.
OTHER INFORMATION.
7 unchanged sentences
Election of Directors,” “Proposal No.
−Removed: Election of Directors─Information Regarding the Board and Corporate Governance,” “Executive Officers,” and “Delinquent Section 16(a) Reports,” if applicable, in our 2025 Proxy Statement.
+Added: Election of Directors─Information Regarding the Board of Directors and Corporate Governance,” “Executive Officers,” and “Delinquent Section 16(a) Reports,” if applicable, in our 2026 Proxy Statement.
Such information to be included in our 2026 Proxy Statement is incorporated herein by reference.
39 unchanged sentences
001-38899), filed with the SEC on March 27, 2023).
+Added: Form of Pre-Funded Warrant (incorporated herein by reference to Exhibit 4.1 to the Registrant’s Current Report on Form 8-K (File No.
+Added: 001-38899), filed with the SEC on July, 14, 2025).
+Added: Form of Series A Common Warrant (incorporated herein by reference to Exhibit 4.2 to the Registrant’s Current Report on Form 8-K (File No.
+Added: 001-38899), filed with the SEC on July, 14, 2025).
+Added: Form of Series B Common Warrant (incorporated herein by reference to Exhibit 4.3 to the Registrant’s Current Report on Form 8-K (File No.
+Added: 001-38899), filed with the SEC on July, 14, 2025).
Third Amended and Restated Stock Option Plan (incorporated herein by reference to Exhibit 10.1 to the Registrant’s Registration Statement on Form S-1 (File No.
2 unchanged sentences
333-230846), filed with the SEC on April 12, 2019).
−Removed: Amended 2019 Equity Incentive Plan (incorporated herein by reference to Exhibit 10.1 to the Registrant’s Quarterly Report on Form 10-Q (File No.
−Removed: 001-38899), filed with the SEC on November 10, 2022).
+Added: Amended 2019 Equity Incentive Plan (incorporated herein by reference to Exhibit 10.1 to the Registrant’s Current Report on Form 8-K (File No.
+Added: 001-38899), filed with the SEC on June 12, 2025).
Stock Option Grant Notice and Stock Option Agreement under the 2019 Equity Incentive Plan (incorporated herein by reference to Exhibit 10.4 to Amendment No.
35 unchanged sentences
001-38899), filed with the SEC on July 23, 2020).
−Removed: Open Market Sale Agreement SM , dated July 29, 2020, by and between Milestone Pharmaceuticals Inc.
+Added: Amended and Restated Open Market Sale Agreement SM , dated March 18, 2025, by and between Milestone Pharmaceuticals Inc.
and Jefferies LLC (incorporated herein by reference to Exhibit 1.1 to the Registrant’s Current Report on Form 8-K (File No.
−Removed: 001-38899), filed with the SEC on July 29, 2020).
+Added: 001-38899), filed with the SEC on March 18, 2025).
Form of Indemnity Agreement (incorporated herein by reference to Exhibit 10.14 to the Registrant’s Registration Statement on Form S-1 (File No.
14 unchanged sentences
001-38899), filed with the SEC on March 31, 2023).
+Added: Amendment No.
+Added: 1 to the Purchase and Sale Agreement, dated August 12, 2024, by and between the Company and RTW Royalty I DAC.
+Added: Amendment No.
+Added: 2 to the Purchase and Sale Agreement, dated July 10, 2025, by and between the Company and RTW Royalty I DAC.
+Added: Amendment No.
+Added: 3 to and Assignment of the Purchase and Sale Agreement, dated December 12, 2025, by and among the Company, Milestone Pharmaceuticals USA, Inc.
+Added: and RTW Royalty I DAC.
Note Purchase Agreement, dated as of March 27, 2023, by and among the Company and RTW (incorporated herein by reference to Exhibit 10.2 to the Registrant’s Current Report on Form 8-K (File No.
5 unchanged sentences
001-38899), filed with the SEC on July 15, 2024).
−Removed: Insider Trading Policy.
+Added: Insider Trading Policy (incorporated herein by reference to Exhibit 19.1 to the Registrant’s Annual Report on Form 10-K (File No.
+Added: 001-38899), filed with the SEC on March 13, 2025).
Consent of PricewaterhouseCoopers LLP, Independent Registered Public Accounting Firm.
47 unchanged sentences
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.