36 unchanged sentences
/s/ Ernst & Young LLP
−Removed: Redwood City, California
+Added: San Mateo, California
February 27, 2023
31 unchanged sentences
S-1/A 333-221522 4.2 11/27/2017
+Added: 4.3 Form of Indenture.
+Added: S-3ASR 333-263107 4.3 2/28/2022
4.4 Description of the Registrant’s Common Stock.
14 unchanged sentences
S-1 333-221522 10.6 11/13/2017
−Removed: 10.7+ Offer Letter between the Registrant and Steve E.
−Removed: Krognes, dated November 10, 2017.
−Removed: S-1 333-221522 10.7 11/13/2017
10.8+ Offer Letter between the Registrant and Carole Ho, M.D., dated November 10, 2017.
7 unchanged sentences
S-1 333-221522 10.11 11/13/2017
−Removed: 10.12Ü Development and Manufacturing Services Agreement between the Registrant and Lonza Sales AG, dated September 6, 2017, as amended by Amendment No.
−Removed: 1 on October 18, 2017.
+Added: 10.12Ü Development and Manufacturing Services Agreement between the Registrant and Lonza Sales AG, dated September 6, 2017.
S-1 333-221522 10.12 11/13/2017
10.12.1# Amendment No.
−Removed: 2 to Development and Manufacturing Services Agreement between the Registrant and Lonza Sales AG, dated September 6, 2017, as amended by Amendment No.
−Removed: 1 on October 18, 2017, dated January 18, 2018.
+Added: 2 to Development and Manufacturing Services Agreement between the Registrant and Lonza Sales AG, dated January 18, 2018.
10-K 001-38311 10.12.1 3/19/2018
10.12.2# Amendment No.
−Removed: 3 to Development and Manufacturing Services Agreement between the Registrant and Lonza Sales AG, dated September 6, 2017, as amended by Amendment No.
−Removed: 1 on October 18, 2017 and Amendment No.
−Removed: 2 dated January 18, 2018, dated July 2, 2018 .
+Added: 3 to Development and Manufacturing Services Agreement between the Registrant and Lonza Sales AG, dated July 2, 2018.
10-Q 001-38311 10.1 11/8/2018
10.12.3# Amendment No.
−Removed: 4 to Development and Manufacturing Services Agreement between the Registrant and Lonza Sales AG, dated September 6, 2017, as amended by Amendment No.
−Removed: 1 on October 18, 2017 and Amendment No.
−Removed: 2 dated January 18, 2018, and Amendment No.
−Removed: 3 dated July 2, 2018, dated August 30, 2018 .
+Added: 4 to Development and Manufacturing Services Agreement between the Registrant and Lonza Sales AG, dated August 30, 2018.
10-Q 001-38311 10.2 11/8/2018
10.12.4# Amendment No.
−Removed: 5 to Development and Manufacturing Services Agreement between the Registrant and Lonza Sales AG, dated September 6, 2017, as amended by Amendment No.
−Removed: 1 on October 18, 2017, Amendment No.
−Removed: 2 dated January 18, 2018, Amendment No.
−Removed: 3 dated July 2, 2018 and Amendment No.
−Removed: 4 dated August 30, 2018, dated August 6, 2019 .
+Added: 5 to Development and Manufacturing Services Agreement between the Registrant and Lonza Sales AG, dated August 6, 2019.
10-K 001-38311 10.12.4 2/26/2021
10.12.5# Amendment No.
−Removed: 3 to Development and Manufacturing Services Agreement between the Registrant and Lonza Sales AG, dated September 6, 2017, as amended by Amendment No.
−Removed: 1 on October 18, 2017, Amendment No.
−Removed: 2 dated January 18, 2018, Amendment No.
−Removed: 3 dated July 2, 2018, Amendment No.
−Removed: 4 dated August 30, 2018 and Amendment No.
−Removed: 5 dated August 6, 2019, dated September 11, 2020 .
+Added: 3 to Development and Manufacturing Services Agreement between the Registrant and Lonza Sales AG, dated September 11, 2020.
10-K 001-38311 10.12.5 2/26/2021
10.12.6# Amendment No.
−Removed: 6 to Development and Manufacturing Services Agreement between the Registrant and Lonza Sales AG, dated September 6, 2017, as amended by Amendment No.
−Removed: 1 on October 18, 2017, Amendment No.
−Removed: 2 dated January 18, 2018, Amendment No.
−Removed: 3 dated July 2, 2018, Amendment No.
−Removed: 4 dated August 30, 2018, Amendment No.
−Removed: 5 dated August 6, 2019 and Amendment No.
−Removed: 3 dated September 11, 2020, dated December 8, 2020.
+Added: 6 to Development and Manufacturing Services Agreement between the Registrant and Lonza Sales AG, dated December 8, 2020.
10-K 001-38311 10.12.6 2/26/2021
+Added: 10.12.7 Amendment No.
+Added: 7 to Development and Manufacturing Services Agreement between the Registrant and Lonza Sales AG, dated March 29, 2021.
+Added: — — — Filed herewith
+Added: 10.12.8# Amendment No.
+Added: 8 to Development and Manufacturing Services Agreement between the Registrant and Lonza Sales AG, dated September 8, 2022.
+Added: — — — Filed herewith
+Added: 10.12.9 Amendment No.
+Added: 9 to Development and Manufacturing Services Agreement between the Registrant and Lonza Sales AG, dated December 7, 2022.
+Added: — — — Filed herewith
10.13+ Amended and Restated Key Executive Change in Control and Severance Plan.
3 unchanged sentences
10.15+ Amended and Restated Outside Director Compensation Policy.
−Removed: — — — Filed herewith
+Added: 10-K 001-38311 10.15 2/28/2022
10.16# Option and Collaboration Agreement between the Registrant and Takeda Pharmaceutical Company Limited, dated January 3, 2018.
24 unchanged sentences
10-Q 001-38311 10.5 11/5/2020
−Removed: 10.29# Sid e Letter between the Registrant and F-star Gamma Limited, dated June 30, 2021
+Added: 10.29# Side Letter between the Registrant and F-star Gamma Limited, dated June 30, 2021.
10-Q 001-38311 10.1 8/4/2021
+Added: 10.30 Equity Distribution Agreement, dated February 28, 2022 between the Registrant and Goldman Sachs & Co.
+Added: LLC, SVB Securities LLC and Cantor Fitzgerald & Co.
+Added: S-3ASR 333-263107 1.2 2/28/2022
21.1 Subsidiaries of the Registrant.
26 unchanged sentences
Each person whose signature appears below constitutes and appoints Ryan J.
−Removed: Krognes, and each of them acting individually, as his or her true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments to this Annual Report on Form 10-K, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their or his substitutes, may lawfully do or cause to be done by virtue thereof.
−Removed: Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated:
+Added: and Alexander O.
+Added: Schuth, M.D., and each of them acting individually, as his or her true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments to this Annual Report on Form 10-K, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their or his substitutes, may lawfully do or cause to be done by virtue thereof.
+Added: Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed by the following persons on behalf of the registrant and in the capacities and on the dates indicated:
Signature Title Date
2 unchanged sentences
February 27, 2023
−Removed: Chief Financial Officer and Treasurer
+Added: /s/ Alexander O.
+Added: Chief Operating and Financial Officer
(Principal Financial and Accounting Officer)
3 unchanged sentences
Vicki Sato, Ph.D.
−Removed: /s/ Marc Tessier-Lavigne
−Removed: Director February 28, 2022
−Removed: Marc Tessier-Lavigne, Ph.D.
/s/ Douglas Cole
8 unchanged sentences
/s/ Peter Klein Director February 27, 2023
−Removed: /s/ Robert Nelsen
Director February 27, 2023
−Removed: Robert Nelsen
/s/ David Schenkein
1 unchanged sentence
David Schenkein, M.D.
+Added: /s/ Marc Tessier-Lavigne
Director February 27, 2023
+Added: Marc Tessier-Lavigne, Ph.D.
+Added: Director February 27, 2023
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.