Other Information.
−Removed: On May 8, 2025 , Derek Maetzold , our Chief Executive Officer , adopted a Rule 10b5-1 trading arrangement providing for the sale from time to time of an aggregate of up to 48,204 shares of our common stock and up to 100% of the shares of our common stock issued upon the settlement of 48,919 outstanding RSUs, less the number of shares withheld to cover tax withholding obligations in connection with the vesting and settlement of such RSUs.
+Added: Insider Trading Arrangements
+Added: On August 12, 2025 , Frank Stokes , our Chief Financial Officer , adopted a Rule 10b5-1 trading arrangement providing for the sale from time to time of an aggregate of up to 5,388 shares of our common stock.
The trading arrangement is intended to satisfy the affirmative defense in Rule 10b5-1(c).
−Removed: The duration of the trading arrangement is estimated to be from August 14, 2025 until the earlier of all transaction under the trading arrangement being completed or February 13, 2026 .
−Removed: No other officers or directors, as defined in Rule 16a-1(f), adopted and/or terminated a Rule 10b5-1 trading arrangement or a non-Rule 10b5-1 trading arrangement, as defined in Regulation S-K Item 408, for the three months ended June 30, 2025.
−Removed: Exhibit Number Description of document
+Added: The duration of the trading arrangement is estimated to be from November 11, 2025 until the earlier of all transaction under the trading arrangement being completed or November 30, 2025 .
+Added: No other officers or directors, as defined in Rule 16a-1(f), adopted and/or terminated a Rule 10b5-1 trading arrangement or a non-Rule 10b5-1 trading arrangement, as defined in Regulation S-K Item 408, for the three months ended September 30, 2025.
+Added: Exhibit Number Description
3.1 Amended and Restated Certificate of Incorporation of the Registrant, incorporated by reference to Exhibit 3.1 of the Registrant’s Current Report on Form 8-K filed with the SEC on May 23 , 2025.
−Removed: 3.2 Amended and Restated Bylaws of the Registrant, incorporated by reference to Exhibit 3.2 of the Registrant’s Current Report on Form 8-K filed with the SEC on July 29, 2019.
+Added: 3.2 Amended and Restated Bylaws of the Registrant, incorporated by reference to Exhibit 3.
+Added: 1 of the Registrant’s Current Report on Form 8-K filed with the SEC on August 8, 2025.
4.1 Form of Common Stock Certificate of the Registrant, incorporated by reference to Exhibit 4.1 of the Registrant’s Registration Statement on Form S-1 (File No.
2 unchanged sentences
333-232369), as amended, originally filed with the SEC on June 26, 2019.
−Removed: 10.1#+ Consent and First Amendment to the Loan and Security Agreement, dated April 4, 2025, by and among the Registrant, Castle Narnia Way Real Estate Holding 1, LLC a nd Silicon Valley Bank incorporated by reference to Exhibit 10.1 of the Registrant ’ s Quarterly Report on Form 10-Q filed with the SEC on May 5, 2025
−Removed: 10.2 Third Amendment to Commercial Lease, executed April 14, 2025, by and between the Registrant and Tannos Land Holdings III, LLC i ncorporated by reference to Exhibit 10.
−Removed: 2 of the Registrant’s Quarterly Report on Form 10-Q filed with the SEC on May 5, 2025
−Removed: 10.3* Office L ease A greement dated M a y 1 4 , 2025, by and between the Registrant and Perimeter Gateway Portfolio LLC.
−Removed: Non-Employee Director Compensation Policy, as amended effective May 22, 2025.
−Removed: Amended P articipation A greement, dated June 20, 2025 by and between the Registrant and Frank Stokes.
−Removed: Amended P articipation A greement, dated June 20, 2025 by and between the Registrant and Toby Juvenal.
−Removed: Amended P articipation A greement, dated June 20, 2025 by and between the Registrant and Kristen Oelschlager.
+Added: Non-Employee Director Compensation Policy, as amended effective August 5, 2025.
+Added: Castle Biosciences, Inc.
+Added: 2022 Inducement Plan, as amended and restated.
31.1* Certification of Principal Executive Officer pursuant to Rules 13a-14(a) and 15d-14(a) of the Exchange Act.
9 unchanged sentences
104* Cover Page Interactive Data File (embedded within the Inline XBRL and contained in Exhibit 101).
−Removed: _____________________________________
* Filed herewith
1 unchanged sentence
Indicates management contract or compensatory plan.
−Removed: # Certain schedules or exhibits have been omitted pursuant to Item 601(a)(5) of Regulation S-K.
−Removed: A copy of any omitted schedule or exhibit will be furnished to the SEC upon request;
−Removed: provided, however, that we may request confidential treatment pursuant to Rule 24b-2 of the Exchange Act for any schedule or exhibit so furnished.
−Removed: + Pursuant to Item 601(b)(10) of Regulation S-K, certain portions of this exhibit have been omitted (indicated by “[***]”) because the Company has determined that the information is not material and is the type that the Company treats as private or confidential.
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
CASTLE BIOSCIENCES, INC.
−Removed: August 4, 2025 By:
+Added: November 3, 2025 By:
President and Chief Executive Officer
(Principal Executive Officer)
−Removed: August 4, 2025 By:
+Added: November 3, 2025 By:
/s/ Frank Stokes
2 unchanged sentences
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.