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Cambridge, Massachusetts 729,000 Corporate headquarters and laboratory Leased - Expires 2028
−Removed: Weston, Massachusetts 357,000 Office Leased - Expires 2025
RTP, North Carolina 1,237,000 Office, laboratory, manufacturing, warehouse Owned
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Baar, Switzerland 81,800 International headquarters Leased - Expires 2028
+Added: Athlone, Ireland 47,500 Fill finish manufacturing facility Leased - Expires 2047
(1) We also lease office space in other international regions including:
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Our international lease agreements expire at various dates through the year 2047.
−Removed: In the fourth quarter of 2021 we began construction of a new gene therapy, clinical packaging and other manufacturing facility in RTP, North Carolina to support our gene therapy pipeline across multiple therapeutic areas.
−Removed: The new manufacturing facility will be approximately 197,000 square feet.
−Removed: We estimate the construction of this manufacturing facility will be completed during 2025.
−Removed: We believe that our our existing properties, including both owned and leased sites, are adequate and suitable for the conduct of our business.
+Added: In the fourth quarter of 2021 we began construction of a new clinical packaging and other manufacturing facility in RTP, North Carolina to support our R&D pipeline across multiple therapeutic areas.
+Added: The new manufacturing facility is approximately 197,000 square feet.
+Added: The construction of this manufacturing facility was completed during 2025 and the majority of the facility was placed in service during the fourth quarter of 2025.
+Added: NEW CORPORATE HEADQUARTERS LEASE
+Added: In March 2025 we entered into a lease agreement with MIT Investment Management Company and BioMed Realty for the lease of approximately 580,000 square feet of office and research and development space located at 75 Broadway, Cambridge, Massachusetts, which will be used as our new global corporate headquarters, as well as integrating our research and development and technical operations teams alongside our North American commercial organization.
+Added: As part of a multi-year real estate consolidation plan that is expected to result in a reduction of approximately 40% of our real estate footprint in Massachusetts, this new lease is intended to replace two existing leases, both in Cambridge, Massachusetts, including our current corporate headquarters.
+Added: We expect the initial lease term of approximately 15.5 years to commence on May 31, 2028.
+Added: We believe that our existing properties, including both owned and leased sites, are adequate and suitable for the conduct of our business.
We believe our capital resources are sufficient to purchase, lease or construct any additional facilities required to meet our expected long-term growth needs.
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Not applicable.
−Removed: Table o f Contents
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.