1 unchanged sentence
Insider Trading Arrangements
−Removed: During the three months ended March 31, 2026, none of our directors or executive officers adopted or terminated a “Rule 10b5-1 trading arrangement” or “non-Rule 10b5-1 trading arrangement,” as each term is defined in Item 408(a) of Regulation S-K.
+Added: During the three months ended June 30, 2026, none of our directors or executive officers adopted or terminated a “Rule 10b5-1 trading arrangement” or “non-Rule 10b5-1 trading arrangement,” as each term is defined in Item 408(a) of Regulation S-K.
+Added: *4.1 — Form of Warrant Agreement , dated May 4, 2026, with Hercules Capital, Inc.
+Added: and affiliated parties.
+Added: *†10.1 — Loan and Security Agreement , dated May 4, 2026, with Hercules Capital, Inc.
+Added: and the lender parties thereto.
+Added: 10.2 — 2026 Equity Incentive Plan (filed as Exhibit 10.1 to the Company’s Current Report on Form 8-K dated April 30, 2026 and incorporated by reference herein).
+Added: 10.3 — 2026 Non-Employee Directors’ Equity Incentive Plan (filed as Exhibit 10.2 to the Company’s Current Report on Form 8-K dated April 30, 2026 and incorporated by reference herein).
— Certification of Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
10 unchanged sentences
* Filed herewith.
+Added: † Certain information (indicated by “[**]”) has been excluded from this exhibit because it is both not material and would likely cause competitive harm to the Company if publicly disclosed.
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
Lexicon Pharmaceuticals, Inc.
−Removed: May 7, 2026 By:
+Added: August 6, 2026 By:
/s/ Michael S.
Chief Executive Officer
−Removed: May 7, 2026 By:
+Added: August 6, 2026 By:
Senior Vice President and Chief Financial Officer
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.