1 unchanged sentence
Insider Trading Arrangements
−Removed: During the three months ended June 30, 2025, none of our directors or executive officers adopted or terminated a “Rule 10b5-1 trading arrangement” or “non-Rule 10b5-1 trading arrangement,” as each term is defined in Item 408(a) of Regulation S-K.
−Removed: 10.1 — 2017 Equity Incentive Plan , as amended (filed as Exhibit 10.1 to the Company’s Current Report on Form 8-K dated June 2, 2025 and incorporated by reference herein).
−Removed: 10.2 — 2017 Non-Employee Directors’ Equity Incentive Plan , as amended (filed as Exhibit 10.2 to the Company’s Current Report on Form 8-K dated June 2, 2025 and incorporated by reference herein).
+Added: During the three months ended September 30, 2025, none of our directors or executive officers adopted or terminated a “Rule 10b5-1 trading arrangement” or “non-Rule 10b5-1 trading arrangement,” as each term is defined in Item 408(a) of Regulation S-K.
— Certification of Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
12 unchanged sentences
Lexicon Pharmaceuticals, Inc.
−Removed: August 6, 2025 By:
+Added: November 6, 2025 By:
/s/ Michael S.
Chief Executive Officer
−Removed: August 6, 2025 By:
+Added: November 6, 2025 By:
Senior Vice President and Chief Financial Officer
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.