28 unchanged sentences
Preferred stock, $ 0.001 par value:
−Removed: 10,000,000 shares authorized as of March 31, 2023 and December 31, 2022;
−Removed: no shares were issued and outstanding as of March 31, 2023 and December 31, 2022
+Added: 10,000,000 shares authorized as of June 30, 2023 and December 31, 2022;
+Added: no shares were issued and outstanding as of June 30, 2023 and December 31, 2022
Common stock, $ 0.001 par value:
−Removed: 400,000,000 shares authorized as of March 31, 2023 and December 31, 2022;
−Removed: 145,740,333 and 144,438,304 shares issued and outstanding as of March 31, 2023 and December 31, 2022, respectively
+Added: 400,000,000 shares authorized as of June 30, 2023 and December 31, 2022;
+Added: 167,133,664 and 144,438,304 shares issued and outstanding as of June 30, 2023 and December 31, 2022, respectively
Additional paid-in capital 2,039,263 1,911,632
7 unchanged sentences
(In thousands, except share and per share amounts)
−Removed: Three Months Ended March 31,
+Added: Three Months Ended June 30, Six Months Ended June 30,
+Added: 2023 2022 2023 2022
Collaboration revenue - related party $ 44 $ 86 $ 96 $ 147
6 unchanged sentences
Interest and other income, net 3,778 315 5,837 807
−Removed: Other expenses ( 1,693 ) ( 350 )
+Added: Other (expenses) income ( 1,249 ) 1,492 ( 2,942 ) 1,142
Total other income, net 2,529 1,807 2,895 1,949
18 unchanged sentences
Employee stock purchase plan 359,753 1 1,730 — — 1,731
−Removed: 359,753 1 1,730 — — 1,731
Net loss — — — ( 98,704 ) — ( 98,704 )
2 unchanged sentences
Balance - March 31, 2023 145,740,333 146 1,932,734 ( 1,334,684 ) ( 5,934 ) 592,262
+Added: Issuance of common stock from ATM offering, net of commissions and offering costs of $ 1.6 million
+Added: 20,288,330 20 87,898 — — 87,918
+Added: Issuance of common stock upon exercise of stock options and vesting of RSUs
+Added: 1,105,001 1 1,605 — — 1,606
+Added: Vesting of early exercised common stock
+Added: — — 432 — — 432
+Added: Stock-based compensation — — 16,594 — — 16,594
+Added: Net loss — — — ( 77,989 ) — ( 77,989 )
+Added: Net unrealized gain on available-for-sale investments
+Added: — — — — 2,083 2,083
+Added: Balance - June 30, 2023 167,133,664 $ 167 $ 2,039,263 $ ( 1,412,673 ) $ ( 3,851 ) $ 622,906
+Added: The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.
+Added: ALLOGENE THERAPEUTICS, INC.
+Added: Condensed Consolidated Statements of Stockholders’ Equity
+Added: (In thousands, except share amounts)
Common Stock Additional
1 unchanged sentence
Deficit Accumulated
−Removed: Comprehensive
+Added: Comprehensive Loss Total
Stockholders’
6 unchanged sentences
Stock-based compensation — — 22,315 — — 22,315
−Removed: — — 22,315 — — 22,315
Employee stock purchase plan 230,876 — 1,530 — — 1,530
3 unchanged sentences
Balance - March 31, 2022 143,569,902 143 1,847,534 ( 983,198 ) ( 9,249 ) 855,230
+Added: Issuance of common stock upon exercise of stock options and vesting of RSUs
+Added: 153,269 1 24 — — 25
+Added: Vesting of early exercised common stock
+Added: — — 813 — — 813
+Added: Stock-based compensation
+Added: — — 22,891 — — 22,891
+Added: Net loss — — — ( 74,787 ) — ( 74,787 )
+Added: Net unrealized loss on available-for-sale investments
+Added: — — — — ( 2,223 ) ( 2,223 )
+Added: Balance - June 30, 2022 143,723,171 $ 144 $ 1,871,262 $ ( 1,057,985 ) $ ( 11,472 ) $ 801,949
The accompanying notes are an integral part of these unaudited condensed consolidated financial statements.
2 unchanged sentences
(In thousands)
−Removed: Three Months Ended March 31,
+Added: Six Months Ended June 30,
Cash flows from operating activities:
19 unchanged sentences
Purchase of investments ( 170,514 ) ( 150,864 )
−Removed: Net cash provided by (used in) investing activities 112,935 ( 22,377 )
+Added: Net cash provided by investing activities 130,095 31,657
Cash flows from financing activities:
+Added: Proceeds from issuance of common stock from ATM offering, net of commissions and issuance costs 87,918 —
Proceeds from issuance of common stock upon exercise of stock options 1,606 308
4 unchanged sentences
Cash and cash equivalents and restricted cash — end of period $ 165,050 $ 106,333
+Added: Non-cash investing activities:
+Added: Right-of-use asset obtained in exchange for lease liability $ — $ 31,361
Supplemental disclosure:
9 unchanged sentences
The Company is developing a pipeline of off-the-shelf T cell product candidates that are designed to target and kill cancer cells.
+Added: Public Offerings
+Added: In November 2019, the Company entered into a sales agreement with Cowen and Company, LLC (Cowen), as amended on November 2, 2022, under which the Company may from time-to-time issue and sell shares of its common stock through Cowen in at-the-market (ATM) offerings for an aggregate offering price of up to $ 250.0 million.
+Added: The aggregate compensation payable to Cowen as the Company's sales agent equals up to 3.0 % of the gross sales price of the shares sold through Cowen pursuant to the sales agreement.
+Added: During the three months ended June 2023, the Company sold an aggregate of 20,288,330 shares of common stock in ATM offerings resulting in net proceeds of $ 87.9 million.
+Added: As of June 30, 2023, $ 77.9 million remains available for sale under the sales agreement with Cowen.
Need for Additional Capital
1 unchanged sentence
The Company’s ultimate success depends on the outcome of its research and development activities as well as the ability to commercialize the Company's product candidates.
−Removed: The Company had cash and cash equivalents and investments of $ 514.0 million as of March 31, 2023.
−Removed: Since inception through March 31, 2023, the Company has incurred cumulative net losses of $ 1,334.7 million.
+Added: The Company had cash and cash equivalents and investments of $ 544.5 million as of June 30, 2023.
+Added: Since inception through June 30, 2023, the Company has incurred cumulative net losses of $ 1.4 billion.
Management expects to incur additional losses in the future to fund its operations and conduct product research and development and recognizes the need to raise additional capital to fully implement its business plan.
9 unchanged sentences
All material intercompany balances and transactions have been eliminated during consolidation.
−Removed: The condensed consolidated balance sheet as of March 31, 2023, the condensed consolidated statements of operations and comprehensive loss for the three months ended March 31, 2023 and 2022, the condensed consolidated statements of stockholders’ equity as of March 31, 2023 and 2022, the condensed consolidated statements of cash flows for the three months ended March 31, 2023 and 2022, and the financial data and other financial information disclosed in the notes to the condensed consolidated financial statements are unaudited.
−Removed: The results of operations for the three months ended March 31, 2023 are not necessarily indicative of the results to be expected for the year ending December 31, 2023, or for any other future annual or interim period.
−Removed: These condensed consolidated financial statements should be read in conjunction with the Company’s audited financial statements and related notes for the year ended December 31, 2022, included in the Company’s Annual Report on Form 10-K filed with the SEC on February 28, 2023.
+Added: The condensed consolidated balance sheet as of June 30, 2023, the condensed consolidated statements of operations and comprehensive loss for the three and six months ended June 30, 2023 and 2022, the condensed consolidated statements of stockholders’ equity as of June 30, 2023 and 2022, the condensed consolidated statements of cash flows for the six months ended June 30, 2023 and 2022, and the financial data and other financial information disclosed in the notes to the condensed consolidated financial statements are unaudited.
+Added: The results of operations for the three and six months ended June 30, 2023 are not necessarily indicative of the results to be expected for the year ending December 31, 2023, or for any other future annual or interim period.
+Added: These condensed consolidated financial statements should be read in conjunction with the Company’s audited
+Added: financial statements and related notes for the year ended December 31, 2022, included in the Company’s Annual Report on Form 10-K filed with the SEC on February 28, 2023.
Use of Estimates
1 unchanged sentence
Significant estimates and assumptions made in the accompanying condensed consolidated financial statements include but are not limited to the fair value of common stock, the fair value of stock options, the fair value of investments, income tax uncertainties, and certain accruals.
−Removed: The Company evaluates its estimates and assumptions on an ongoing basis using historical
−Removed: experience and other factors and adjusts those estimates and assumptions when facts and circumstances change.
+Added: The Company evaluates its estimates and assumptions on an ongoing basis using historical experience and other factors and adjusts those estimates and assumptions when facts and circumstances change.
Actual results could differ from those estimates.
Significant Accounting Policies
−Removed: There have been no significant changes to the accounting policies during the three months ended March 31, 2023, as compared to the significant accounting policies described in Note 1 of the “Notes to Financial Statements” in the Company’s audited financial statements included in its Annual Report.
+Added: There have been no significant changes to the accounting policies during the three and six months ended June 30, 2023, as compared to the significant accounting policies described in Note 1 of the “Notes to Financial Statements” in the Company’s audited financial statements included in its Annual Report.
Recently Adopted Accounting Pronouncements
7 unchanged sentences
treasury securities which are classified as Level 1.
−Removed: There were no Level 3 assets or liabilities as of March 31, 2023 and as of December 31, 2022.
−Removed: Financial assets subject to fair value measurements on a recurring basis and the level of inputs used in such measurements by major security type as of March 31, 2023 and as of December 31, 2022 are presented in the following tables:
−Removed: March 31, 2023
+Added: There were no Level 3 assets or liabilities as of June 30, 2023 and as of December 31, 2022.
+Added: Financial assets subject to fair value measurements on a recurring basis and the level of inputs used in such measurements by major security type as of June 30, 2023 and as of December 31, 2022 are presented in the following tables:
+Added: June 30, 2023
Level 1 Level 2 Level 3 Fair Value
19 unchanged sentences
Financial Instruments
−Removed: The fair value and amortized cost of cash equivalents and available-for-sale securities by major security type as of March 31, 2023 and as of December 31, 2022 are presented in the following tables:
−Removed: March 31, 2023
+Added: The fair value and amortized cost of cash equivalents and available-for-sale securities by major security type as of June 30, 2023 and as of December 31, 2022 are presented in the following tables:
+Added: June 30, 2023
Amortized Cost Unrealized Gains Unrealized Losses Fair Value
25 unchanged sentences
Total cash equivalents and investments $ 526,327
−Removed: As of March 31, 2023, the remaining contractual maturities of available-for-sale securities were less than 2 years.
−Removed: Realized losses on available-for-sale securities for the three months ended March 31, 2023 and 2022 were $ 1.0 million and zero , respectively.
−Removed: As of March 31, 2023, unrealized losses on available-for-sale securities are not attributed to credit risk.
+Added: As of June 30, 2023, the remaining contractual maturities of available-for-sale securities were less than 2 years.
+Added: Realized losses on available-for-sale securities for the three and six months ended June 30, 2023 were zero and $ 1.0 million, respectively.
+Added: There were no significant realized losses on available-for-sale securities for the three and six months ended June 30, 2022.
+Added: As of June 30, 2023, unrealized losses on available-for-sale securities are not attributed to credit risk.
The Company believes that it is more likely than not that investments in an unrealized loss position will be held until maturity and all interest and principal will be received.
The Company believes that an allowance for credit losses is unnecessary because the unrealized losses on certain of the Company’s available-for-sale securities are due to market factors.
−Removed: As of March 31, 2023 and December 31, 2022, securities with a fair value of $ 279.6 million and $ 329.4 million, respectively, were in a continuous net unrealized loss position for more than 12 months.
+Added: As of June 30, 2023 and December 31, 2022, securities with a fair value of $ 191.8 million and $ 329.4 million, respectively, were in a continuous net unrealized loss position for more than 12 months.
To date, the Company has not recorded any impairment charges on available-for-sale securities.
−Removed: As of March 31, 2023 and December 31, 2022, the Company recognized $ 1.0 million and $ 1.8 million, respectively, of accrued interest receivable from available-for-sale securities within prepaid expenses and other current assets on the consolidated balance sheets.
+Added: As of June 30, 2023 and December 31, 2022, the Company recognized $ 1.1 million and $ 1.8 million, respectively, of accrued interest receivable from available-for-sale securities within prepaid expenses and other current assets on the consolidated balance sheets.
Balance Sheet Components
19 unchanged sentences
In October 2019, the Territory was expanded to all countries in the world.
−Removed: No milestone or royalty payments were made in the three months ended March 31, 2023 or 2022.
+Added: No milestone or royalty payments were made in the three and six months ended June 30, 2023 or 2022.
Pfizer is also eligible to receive, on a product-by-product and country-by-country basis, royalties in single-digit percentages on annual net sales for products covered by the Pfizer Agreement.
6 unchanged sentences
Pursuant to the Cellectis Agreement, Cellectis granted to the Company an exclusive, worldwide, royalty-bearing license, on a target-by-target basis, with sublicensing rights under certain conditions, under certain of Cellectis’s intellectual property, including its TALEN and electroporation technology, to make, use, sell, import, and otherwise exploit and commercialize CAR T products directed at certain targets, including BCMA, CD70, Claudin 18.2, DLL3 and FLT3 (the Allogene Targets), for human oncologic therapeutic, diagnostic, prophylactic and prognostic purposes.
−Removed: In addition, certain Cellectis intellectual property rights granted by Cellectis to the Company and to Servier pursuant to the Exclusive License and Collaboration Agreement by and between Servier and Pfizer, dated October 30, 2016, which Pfizer assigned to the Company in April 2018, will survive the termination of the Original Cellectis Agreement.
+Added: In addition, certain Cellectis intellectual property rights granted by Cellectis to the Company and to Servier pursuant to the Exclusive License and Collaboration
+Added: Agreement by and between Servier and Pfizer, dated October 30, 2016, which Pfizer assigned to the Company in April 2018, will survive the termination of the Original Cellectis Agreement.
Pursuant to the Cellectis Agreement, the Company granted Cellectis a non-exclusive, worldwide, royalty-free, perpetual and irrevocable license, with sublicensing rights under certain conditions, under certain of the Company's intellectual property, to make, use, sell, import and otherwise commercialize CAR T products directed at certain targets (the Cellectis Targets).
14 unchanged sentences
All costs the Company incurred in connection with this agreement were recognized as research and development expenses in the condensed consolidated statements of operations.
−Removed: For the three months ended March 31, 2023 and 2022, zero clinical development milestones were achieved.
+Added: For the three and six months ended June 30, 2023 and 2022, zero costs were incurred related to the achievement of a clinical development milestone under this agreement.
License and Collaboration Agreement with Servier
1 unchanged sentence
In October 2019, the Company agreed to waive its rights to the one additional target.
−Removed: Under the Servier Agreement, the Company has an exclusive license to develop, manufacture and commercialize UCART19, ALLO-501 and ALLO-501A in the field of anti-tumor adoptive immunotherapy in the United States, with an exclusive option to obtain the same rights for additional product candidates in the United States and, if Servier does not elect to pursue development or commercialization of those product candidates in certain markets outside of the United States pursuant to its
−Removed: license, outside of the United States as well.
+Added: Under the Servier Agreement, the Company has an exclusive license to develop, manufacture and commercialize UCART19, ALLO-501 and ALLO-501A in the field of anti-tumor adoptive immunotherapy in the United States, with an exclusive option to obtain the same rights for additional product candidates in the United States and, if Servier does not elect to pursue development or commercialization of those product candidates in certain markets outside of the United States pursuant to its license, outside of the United States as well.
The Company is not required to make any additional payments to Servier to exercise an option.
14 unchanged sentences
Unless earlier terminated in accordance with the Servier Agreement, the Servier Agreement will continue, on a licensed product-by-licensed product and country-by-country basis, until the Servier Royalty Term with respect to the sale of such licensed product in such country expires.
−Removed: For the three months ended March 31, 2023 and 2022, the Company recorded $ 0.2 million and $ 5.1 million, respectively, of net cost recoveries under the cost-sharing terms of the Servier Agreement as a reduction to research and development expenses.
−Removed: As of March 31, 2023 and December 31, 2022, amounts due from Servier of $ 1.2 million and $ 1.5 million, respectively, were recorded in other current assets in the accompanying condensed consolidated balance sheets.
+Added: For the three and six months ended June 30, 2023, the Company recorded $ 0.5 million and $ 0.4 million, respectively, of net cost recoveries under the cost-sharing terms of the Servier Agreement as a reduction to research and development expenses.
+Added: For the three and six months ended June 30, 2022, the Company recorded $ 11.6 million and $ 16.7 million, respectively, of net cost recoveries.
+Added: As of June 30, 2023 and December 31, 2022, amounts due from Servier of zero and $ 1.5 million, respectively, were recorded in other current assets in the accompanying condensed consolidated balance sheets.
On September 15, 2022, Servier sent a notice of discontinuation (Discontinuation) of its involvement in the development of all licensed products directed against CD19, including UCART19, ALLO-501 and ALLO-501A (collectively, CD19 Products), pursuant to the Servier Agreement.
2 unchanged sentences
In December 2022, Servier sent the Company a notice for material breach due to the Company's purported refusal to allow an audit of certain manufacturing costs under the cost share arrangement.
−Removed: While the Company does not believe Servier has such an audit right, the Company is currently progressing such audit with Servier to recover outstanding manufacturing costs owed by Servier to the Company.
+Added: While the Company does not believe Servier has such an audit right, the Company submitted to a review of the Company's manufacturing costs of CD19 Products to recover outstanding manufacturing costs owed by Servier to the Company.
+Added: In July 2023, Servier sent the Company a second notice for material breach alleging that the Company overcharged Servier based on Servier and its accounting firm’s review of costs eligible for cost-sharing under the Servier Agreement.
+Added: The Company disagrees with the material breach allegations and the Company is disputing such allegations.
+Added: Absent a resolution between the parties, disputed matters may be resolved in arbitration as specified in the Servier Agreement.
Research Collaboration and License Agreement with Notch Therapeutics
11 unchanged sentences
Immediately following this transaction, the Company's share in Notch was 23.0 % on a voting interest basis.
−Removed: The Company did not have a controlling interest in Notch as of March 31, 2023, and continued to account for its investment in Notch as an equity method investment.
+Added: The Company did not have a controlling interest in Notch as of June 30, 2023, and continued to account for its investment in Notch as an equity method investment.
Under the Notch Agreement, Notch will be eligible to receive up to $ 7.25 million upon achieving certain agreed research milestones, up to $ 4.0 million per exclusive target upon achieving certain pre-clinical development milestones, and up to $ 283.0 million per exclusive target and cell type (i.e., T cell or NK cell) upon achieving certain clinical, regulatory and commercial milestones.
4 unchanged sentences
Either party may also terminate the Collaboration Agreement with written notice upon material breach by the other party, if such breach has not been cured within a defined period of receiving such notice, or in the event of the other party’s insolvency.
−Removed: For the three months ended March 31, 2023 and 2022, the Company recorded $ 1.0 million and $ 0.8 million, respectively, in collaboration costs as research and development expenses.
+Added: For the three and six months ended June 30, 2023, the Company recorded $ 0.8 million and $ 1.8 million, respectively, in collaboration costs as research and development expenses.
+Added: For the three and six months ended June 30, 2022, the Company recorded $ 0.9 million and $ 1.7 million, respectively, in collaboration costs as research and development expenses.
Strategic Alliance with The University of Texas MD Anderson Cancer Center
9 unchanged sentences
Where any legal or regulatory authorization is finally withdrawn or terminated, the relevant study will also terminate automatically.
−Removed: For the three months ended March 31, 2023 and 2022, the Company recorded $ 0.4 million and $ 0.3 million, respectively, in collaboration costs as research and development expenses.
+Added: For the three and six months ended June 30, 2023, the Company recorded $ 0.6 million and $ 1.0 million, respectively, in collaboration costs as research and development expenses.
+Added: For the three and six months ended June 30, 2022, the Company recorded $ 0.6 million and $ 0.9 million, respectively, in collaboration costs as research and development expenses.
Joint Venture and License Agreement with Allogene Overland Biopharm (CY) Limited
2 unchanged sentences
Pursuant to the Share Purchase Agreement, the Company acquired Seed Preferred Shares in Allogene Overland representing 49 % of Allogene Overland's outstanding stock as partial consideration for the License Agreement, and Overland acquired Seed Preferred Shares representing 51 % of Allogene Overland's outstanding stock for $ 117.0 million in upfront and certain quarterly cash payments, to support operations of Allogene Overland.
−Removed: As of March 31, 2023, the Company and Overland are the sole equity holders in Allogene Overland.
+Added: As of June 30, 2023, the Company and Overland are the sole equity holders in Allogene Overland.
The Company received $ 40 million from Allogene Overland as partial consideration for the License Agreement.
13 unchanged sentences
The Company determined that the initial transaction price consists of the upfront payment of $ 40.0 million.
−Removed: The allocation of the transaction price is performed based on standalone selling prices, which are based on estimated amounts that the Company would charge for a performance obligation if it were sold separately .
+Added: The allocation of the transaction price is performed
+Added: based on standalone selling prices, which are based on estimated amounts that the Company would charge for a performance obligation if it were sold separately .
The transaction price allocated to the license of intellectual property and delivery of know-how will be recognized upon grant of license and delivery of know-how.
1 unchanged sentence
Funds received in advance are recorded as deferred revenue and will be recognized as the performance obligations are satisfied.
−Removed: The Company has determined that Allogene Overland is a variable interest entity as of March 31, 2023 and December 31, 2022, respectively.
+Added: The Company has determined that Allogene Overland is a variable interest entity as of June 30, 2023 and December 31, 2022, respectively.
The Company does not have the power to independently direct the activities which most significantly affect Allogene Overland's economic performance.
Accordingly, the Company did not consolidate Allogene Overland because the Company determined that it was not the primary beneficiary.
−Removed: For the three months ended March 31, 2023 and 2022, the Company recognized less than $ 0.1 million of collaboration revenue.
−Removed: For the three months ended March 31, 2023 and 2022, the Company recorded zero and $ 0.3 million, respectively, of net cost recoveries under the terms of the license agreement as a reduction to research and development expenses.
+Added: For the three and six months ended June 30, 2023 and 2022, the Company recognized less than $ 0.1 million of collaboration revenue.
+Added: Revenue recognized was due to delivery of the know-how performance obligations.
+Added: For the three and six months ended June 30, 2023, the Company recorded less than $ 0.1 million of net cost recoveries under the terms of the license agreement as a reduction to research and development expenses.
+Added: For the three and six months ended June 30, 2022, the Company recorded zero and $ 0.3 million, respectively, of net cost recoveries under the terms of the license agreement as a reduction to research and development expenses.
Collaboration and License Agreement with Antion
6 unchanged sentences
The upfront payment was fully recognized as research and development expense as the license had no foreseeable alternative future use.
−Removed: In addition, the Company made a $ 3.0 million investment in Antion's preferred stock and is expected to make an additional $ 3.0 million investment in Antion's preferred stock upon achievement of an agreed milestone.
+Added: In January 2022, the Company made a $ 3.0 million investment in Antion's preferred stock.
The Company accounts for its investment in Antion's preferred stock as an equity investment measured at cost less any impairment.
3 unchanged sentences
Antion is also entitled to receive a low single-digit royalty on the Company’s sales of licensed products, subject to certain reductions.
−Removed: For the three months ended March 31, 2023, the Company recorded $ 0.5 million in research and development expenses related to collaboration costs.
−Removed: For the three months ended March 31, 2022, the Company recorded $ 3.5 million in research and development expenses related to the upfront payment and collaboration costs.
−Removed: As of March 31, 2023 and December 31, 2022, research and development expenses recorded in accrued and other liabilities was $ 0.5 million.
−Removed: As of March 31, 2023 and December 31, 2022, the Company's total equity investment in Antion was $ 3.0 million and is recognized in other long-term assets in the condensed consolidated balance sheets.
+Added: For the three and six months ended June 30, 2023, the Company recorded $ 1.3 million and $ 1.8 million, respectively, in research and development expenses related to collaboration costs.
+Added: For the three and six months ended June 30, 2022, the Company recorded $ 0.4 million and $ 3.9 million, respectively, in research and development expenses related to the upfront payment and collaboration costs.
+Added: For the three and six months ended June 30, 2023, $ 0.1 million in costs were incurred related to the achievement of a milestone under the Antion Collaboration and License Agreement.
+Added: For the three and six months ended June 30, 2022, zero costs were incurred related to the achievement of milestone under the Antion Collaboration and License Agreement.
+Added: As of June 30, 2023 and December 31, 2022, research and development expenses recorded in accrued and other liabilities were $ 1.4 million and $ 0.5 million, respectively.
+Added: As of June 30, 2023 and December 31, 2022, the Company's total equity investment in Antion was $ 3.0 million and is recognized in other long-term assets in the condensed consolidated balance sheets.
+Added: On July 11, 2023, the Company and Antion entered into an amendment to the Antion Collaboration and License Agreement.
+Added: Under the terms of this amendment, Antion's exclusivity obligation relating to the collaboration was terminated;
+Added: however, Antion agreed to certain restrictions on its ability to pursue products directed against specific targets.
+Added: Also, in lieu of the
+Added: Company’s prior obligation to make a $ 3 million investment in Antion following the completion of certain milestones, the Company agreed to make a $ 2 million investment in Antion’s preferred shares and acquired warrants to purchase an additional $ 3 million of Antion’s preferred shares.
Commitments and Contingencies
11 unchanged sentences
Rent payments began in November 2018.
−Removed: In December 2021, the Company amended
−Removed: its lease agreement to extend the term of the lease to be co-terminus with the HQ Lease.
+Added: In December 2021, the Company amended its lease agreement to extend the term of the lease to be co-terminus with the HQ Lease.
The lease term will expire March 31, 2032 with an option to extend the term for eight years which is not reasonably assured of exercise.
4 unchanged sentences
The Company maintains letters of credit for the benefit of landlords which is disclosed as restricted cash in the condensed consolidated balance sheets.
−Removed: Restricted cash related to letters of credit due to landlords was $ 6.0 million as of March 31, 2023 and December 31, 2022.
+Added: Restricted cash related to letters of credit due to landlords was $ 6.0 million as of June 30, 2023 and December 31, 2022.
The balance sheet classification of our lease liabilities were as follows (in thousands):
−Removed: March 31, 2023 December 31, 2022
+Added: June 30, 2023 December 31, 2022
Operating lease liabilities
4 unchanged sentences
Three Months Ended
+Added: June 30, Six Months Ended June 30,
+Added: 2023 2022 2023 2022
Operating lease cost $ 3,175 $ 3,177 $ 6,356 $ 5,299
1 unchanged sentence
Total lease costs $ 3,847 $ 3,574 $ 7,719 $ 6,151
−Removed: Cash paid for amounts included in the measurement of lease liabilities for the three months ended March 31, 2023 was $ 3.0 million and was included in net cash used in operating activities in the Company's condensed consolidated statements of cash flows.
−Removed: The undiscounted future non-cancellable lease payments under the Company's operating leases as of March 31, 2023 were as follows:
+Added: Cash paid for amounts included in the measurement of lease liabilities for the six months ended June 30, 2023 was $ 6.0 million and was included in net cash used in operating activities in the Company's condensed consolidated statements of cash flows.
+Added: The undiscounted future non-cancellable lease payments under the Company's operating leases as of June 30, 2023 were as follows:
Year ending December 31:
8 unchanged sentences
The weighted average discount rate used to determine the operating lease liability was 6.88 %.
−Removed: As of March 31, 2023, the weighted average remaining lease term for our operating leases is 9.74 years.
+Added: As of June 30, 2023, the weighted average remaining lease term for our operating leases is 9.50 years.
Other Commitments
3 unchanged sentences
Termination of the agreement by the Company will result in a termination payment due of approximately $ 4.3 million.
−Removed: In connection with the agreement, the Company maintains a letter of credit for the benefit of the service provider in the amount of $ 4.3 million which is recorded as restricted cash in the condensed consolidated balance sheets as of March 31, 2023 and December 31, 2022.
+Added: In connection with the agreement, the Company maintains a letter of credit for the benefit of the service provider in the amount of $ 4.3 million which is recorded as restricted cash in the condensed consolidated balance sheets as of June 30, 2023 and December 31, 2022.
The Company has entered into certain license agreements for intellectual property which is used as part of its development and manufacturing processes.
1 unchanged sentence
These agreements require payment of annual license fees and may include conditional milestone payments for achievement of specific research, clinical and commercial events, and royalty payments.
−Removed: The timing and likelihood of any significant conditional milestone payments or royalty payments becoming due was not probable as of March 31, 2023.
+Added: The timing and likelihood of any significant conditional milestone payments or royalty payments becoming due was not probable as of June 30, 2023.
The Company enters into contracts in the normal course of business that includes arrangements with clinical research organizations, vendors for preclinical research and vendors for manufacturing.
These agreements generally allow for cancellation with notice.
−Removed: As of March 31, 2023, the Company had non-cancellable purchase commitments of $ 0.3 million.
+Added: As of June 30, 2023, the Company had non-cancellable purchase commitments of $ 0.4 million.
Equity Method Investments
5 unchanged sentences
Immediately following this transaction, the Company's share in Notch was 23.0 % on a voting interest basis.
−Removed: The Company’s total equity investment in Notch as of March 31, 2023 and December 31, 2022 was $ 11.1 million and $ 12.8 million, respectively, and the Company accounted for the investment using the equity method of accounting.
−Removed: During the three months ended March 31, 2023 and 2022, the Company recognized its share of Notch's net loss under the other expenses caption within the condensed consolidated statements of operations.
+Added: The Company’s total equity investment in Notch as of June 30, 2023 and December 31, 2022 was $ 9.9 million and $ 12.8 million, respectively, and the Company accounted for the investment using the equity method of accounting.
+Added: During the three and six months ended June 30, 2023 and 2022, the Company recognized its share of Notch's net loss under the other expenses caption within the condensed consolidated statements of operations.
Allogene Overland Biopharm (CY) Limited
1 unchanged sentence
The Company accounts for its investment in Allogene Overland as an equity method investment at carrying value.
−Removed: The Company's total equity investment in Allogene Overland was zero as of March 31, 2023 and December 31, 2022.
−Removed: The Company’s equity investment in Allogene Overland as of March 31, 2023 and December 31, 2022 had a zero carryover basis.
+Added: The Company's total equity investment in Allogene Overland was zero as of June 30, 2023 and December 31, 2022.
+Added: The Company’s equity investment in Allogene Overland as of June 30, 2023 and December 31, 2022 had a zero carryover basis.
Therefore, the Company did not account for its share of losses incurred by Allogene Overland.
11 unchanged sentences
This requirement is applicable to incentive stock options only.
−Removed: As of March 31, 2023, there were 5,111,513 shares reserved by the Company under the 2018 Plan for the future issuance of equity awards.
+Added: As of June 30, 2023, there were 6,377,914 shares reserved by the Company under the 2018 Plan for the future issuance of equity awards.
Stock Option Exchange Program
15 unchanged sentences
Balance, December 31, 2022 17,569,575 $ 12.90 7.73 $ 6,658
−Removed: Options granted 6,698,130 5.24 9.95
−Removed: Options exercised — — $ —
−Removed: Options forfeited ( 719,219 ) 17.32
−Removed: Balance, March 31, 2023 23,548,486 $ 10.59 8.13 $ 4,001
−Removed: Exercisable, March 31, 2023 13,913,480 $ 12.01 7.80 $ 4,001
−Removed: Vested and expected to vest, March 31, 2023 23,548,486 $ 10.59 8.13 $ 4,001
−Removed: The aggregate intrinsic values of options outstanding, exercisable, vested and expected to vest were calculated as the difference between the exercise price of the options and the closing price of the Company’s common stock on the Nasdaq Global Select Market on March 31, 2023.
−Removed: For the three months ended March 31, 2023, the estimated weighted-average grant-date fair value of employee options granted was $ 3.54 per share.
−Removed: As of March 31, 2023, there was $ 94.1 million of unrecognized stock-based compensation related to unvested stock options, which is expected to be recognized over a weighted-average period of 2 years, 314 days .
+Added: Granted 8,103,938 5.28
+Added: Exercised ( 712,931 ) 2.27 2,226
+Added: Forfeited ( 3,016,808 ) 11.55
+Added: Balance, June 30, 2023 21,943,774 $ 10.62 7.86 $ 2,142
+Added: Exercisable, June 30, 2023 13,354,883 $ 12.35 7.14 $ 2,135
+Added: Vested and expected to vest, June 30, 2023 21,943,774 $ 10.62 7.86 $ 2,142
+Added: The aggregate intrinsic values of options outstanding, exercisable, vested and expected to vest were calculated as the difference between the exercise price of the options and the closing price of the Company’s common stock on the Nasdaq Global Select Market on June 30, 2023.
+Added: For the six months ended June 30, 2023, the estimated weighted-average grant-date fair value of employee options granted was $ 3.55 per share.
+Added: As of June 30, 2023, there was $ 77.2 million of unrecognized stock-based compensation related to unvested stock options, which is expected to be recognized over a weighted-average period of 2 years, 248 days .
The fair value of employee, consultant and director stock option awards was estimated at the date of grant using a Black-Scholes option-pricing model with the following assumptions:
−Removed: Three Months Ended March 31,
+Added: Six Months Ended June 30,
Expected term in years 5.27 - 6.08
Expected volatility 73.37 % - 73.85 %
+Added: 70.82 % - 72.57 %
Expected risk-free interest rate 3.45 % - 4.10 %
23 unchanged sentences
Forfeited ( 1,901,277 ) 10.30
−Removed: Unvested March 31, 2023 13,587,470 $ 8.28 2.52 $ 67,122
−Removed: Vested and expected to vest, March 31, 2023 13,587,470 $ 8.28 2.52 $ 67,122
−Removed: As of March 31, 2023, there was $ 87.4 million of unrecognized stock-based compensation related to unvested restricted stock units, which is expected to be recognized over a weighted-average period of 2 years, 279 days .
−Removed: For the quarter ended March 2023, the Company granted 2,665,449 performance-based restricted stock units and 1,902,307 restricted stock units with a market condition to certain executive officers and other employees pursuant to the 2018 Plan.
+Added: Unvested June 30, 2023 12,833,995 $ 7.74 2.34 $ 63,785
+Added: Vested and expected to vest, June 30, 2023 12,833,995 $ 7.74 2.34 $ 63,785
+Added: As of June 30, 2023, there was $ 71.9 million of unrecognized stock-based compensation related to unvested restricted stock units, which is expected to be recognized over a weighted-average period of 2 years, 223 days .
+Added: For the six months ended June 2023, the Company granted 3,015,272 performance-based restricted stock units and 1,939,646 restricted stock units with a market condition to certain executive officers and other employees pursuant to the 2018 Plan.
These awards are subject to the holders' continuous service to the Company through each applicable vesting event.
−Removed: Through March 31, 2023, the Company believes that the achievement of the requisite performance conditions for these awards are not probable.
−Removed: As a result, no compensation expense has been recognized related to the performance-based restricted stock units in the quarter ended March 31, 2023.
−Removed: The Company recognized $ 0.1 million in stock-based compensation expense related to the restricted units with a market condition in the quarter ended March 31, 2023.
+Added: Through June 30, 2023, the Company believes that the achievement of the requisite performance conditions for these awards are not probable.
+Added: As a result, no compensation expense has been recognized related to the performance-based restricted stock units in the quarter ended June 30, 2023.
+Added: The Company recognized $ 0.9 million in stock-based compensation expense related to the restricted units with a market condition for the six months ended June 30, 2023.
Total stock-based compensation expense related to stock options, restricted stock units, employee stock purchase plan and vesting of the founders’ common stock was as follows (in thousands):
−Removed: Three Months Ended March 31,
+Added: Three Months Ended June 30, Six Months Ended June 30,
+Added: 2023 2022 2023 2022
Research and development $ 6,919 $ 12,972 $ 16,116 $ 24,052
8 unchanged sentences
In May 2021, 293,594 options were early exercised, resulting in proceeds of $ 5.3 million.
−Removed: As of March 31, 2023 and December 31, 2022 there was $ 1.9 million recorded in accrued and other liabilities and zero and $ 0.6 million, respectively, recorded in other long-term liabilities related to shares held by employees and directors that were subject to repurchase.
+Added: As of June 30, 2023 and December 31, 2022, there was $ 1.5 million and $ 1.9 million, respectively, recorded in accrued and other liabilities and zero and $ 0.6 million, respectively, recorded in other long-term liabilities related to shares held by employees and directors that were subject to repurchase.
The underlying shares are shown as outstanding in the condensed consolidated financial statements but the shares which are subject to future vesting conditions are not included in the calculation of earnings per share.
4 unchanged sentences
On April 1, 2022, Allogene Overland HK assigned the license agreement to Allogene Overland Biopharm (PRC) Co., Limited.
−Removed: During the three months ended March 31, 2023 and 2022, the Company recognized less than $ 0.1 million of collaboration revenue under this arrangement.
−Removed: For the three months ended March 31, 2023 and 2022, the Company recorded zero and $ 0.3 million, respectively, of net cost recoveries under the terms of the license agreement as a reduction to research and development expenses.
+Added: For the three and six months ended June 30, 2023 and 2022, the Company recognized less than $ 0.1 million of collaboration revenue under this agreement.
+Added: For the three and six months ended June 30, 2023, the Company recorded less than $ 0.1 million of net cost recoveries under the terms of the license agreement as a reduction to research and development expenses.
+Added: For the three and six months ended June 30, 2022, the Company recorded zero and $ 0.3 million, respectively, of net cost recoveries under the terms of the license agreement as a reduction to research and development expenses.
Sublease Agreement
5 unchanged sentences
The Company’s executive chairman, Arie Belldegrun, M.D., FACS, is a trustee of the Belldegrun Family Trust, which controls Bellco Capital Advisors Inc.
−Removed: The total right of use asset and associated liability recorded related to this related party lease was $ 0.2 million at March 31, 2023 and December 31, 2022.
+Added: The total right of use asset and associated liability recorded related to this related party lease was $ 0.1 million and $ 0.2 million at June 30, 2023 and December 31, 2022, respectively.
+Added: In February 2023, the Company subleased an additional 2,030 square feet of office space in Los Angeles, California, from Bellco.
+Added: The sublease term is 115 months, subject to certain early termination rights.
+Added: The sublease is expected to commence January 1, 2024.
+Added: The Company paid approximately $ 0.2 million towards the monthly base rent due for the first month of the sublease term and its share of the security deposit.
+Added: The total estimated amount of base rent is $ 2.9 million, subject to rent abatement.
+Added: The Company also expects to contribute to certain tenant improvements to the space totaling to its share of the total tenant contribution.
Consulting Agreements
In June 2018, the Company entered into a services agreement with Two River Consulting, LLC (Two River), a firm affiliated with the Company’s President and Chief Executive Officer, the Company’s Executive Chair of the board of directors, and a director of the Company to provide various managerial, clinical development, administrative, accounting and financial services to the Company.
−Removed: The costs incurred for services provided under this agreement were $ 0.1 million and $ 0.2 million for the three months ended March 31, 2023 and 2022, respectively.
+Added: The costs incurred for services provided under this agreement were $ 0.1 million and $ 0.2 million for the three and six months ended June 30, 2023, respectively.
+Added: The costs incurred for services provided under this agreement were $ 0.3 million and $ 0.5 million for the three and six months ended June 30, 2022, respectively.
In August 2018, the Company entered into a consulting agreement with Bellco.
Pursuant to the consulting agreement, Bellco provides certain services for the Company, which are performed by Dr.
−Removed: Belldegrun, the Company's executive chair, and inc lude without limitation, providing advice and analysis with respect to the Company’s business, business strategy and potential opportunities in the field of allogeneic CAR T cell therapy and any other aspect of the CAR T cell therapy business as the Company may agree.
+Added: Belldegrun, the Company's executive chair, and include without limitation, providing advice and analysis with respect to the Company’s business, business strategy and potential opportunities in the field of allogeneic CAR T cell therapy and any other aspect of the CAR T cell therapy business as the Company may agree.
In consideration for these services, the Company paid Bellco $ 40,217 per month in arrears commencing January 2022.
1 unchanged sentence
The Company also reimburses Bellco for out-of-pocket expenses incurred in performing the services.
−Removed: The costs incurred for services provided, bonus, and out-of-pocket expenses incurred under this consulting agreement were $ 0.2 million for the three months ended March 31, 2023 and 2022.
+Added: The costs incurred for services provided, bonus, and out-of-pocket expenses incurred under this consulting agreement were $ 0.2 million and $ 0.4 million for the three and six months ended June 30, 2023, respectively.
+Added: The costs incurred for services provided and out-of-pocket expenses incurred under this consulting agreement were $ 0.2 million and $ 0.4 million for the three and six months ended June 30, 2022, respectively.
The Company has a history of losses and expects to record a loss in 2023.
5 unchanged sentences
Expected shares to be purchased under Employee Stock Purchase Plan 1,749,295 1,300,989
−Removed: Founders' shares of common stock subject to future vesting — —
Early exercised stock options subject to future vesting 82,051 186,224
2 unchanged sentences
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.