NEONC TECHNOLOGIES HOLDINGS, INC. 10-Q

Item 1. Financial Statements NEONC TECHNOLOGIES HOLDINGS, INC. Condensed Consolidated Balance Sheets June 30, 2025 December 31, 2024 (Unaudited) Assets Current Assets Cash and cash equivalents $ 125,039 $ 64,893 Deferred offering costs – current 96,880 1,071,947 Debt issuance costs – current 671,804 671,804 Prepaid expenses and other 760,219 410,085 Total Current Assets 1,653,942 2,218,729 Non-Current Assets Debt issuance costs – net of current portion 862,609 1,198,512 Deferred offering costs – net of current portion 26,642 - Right of use asset – operating lease 397,817 - Other assets 47,177 - Total Assets $ 2,988,187 $ 3,417,241 Liabilities and Shareholders’ Deficit Current Liabilities Accounts payable $ 3,073,635 $ 2,917,801 Accounts payable - related parties 499,225 628,277 Accrued advisory fee – related party 5,882,710 - Litigation settlement payable 4,697,500 4,641,250 Accrued compensation 255,099 734,874 Lease liability, current 68,633 - Total Current Liabilities 14,476,802 8,922,202 Long Term Liabilities Lease liability, net of current portion 326,879 - Total Liabilities 14,803,681 8,922,202 Commitments and contingencies Shareholders’ Deficit: Preferred stock, $ 0.0001 par value, 10,000,000 shares authorized; no shares were issued and outstanding as of June 30, 2025 and December 31, 2024 - - Common stock, $ 0.0001 par value, 100,000,000 shares authorized; 19,026,776 and 18,090,526 shares issued and outstanding as of June 30, 2025 and December 31, 2024, respectively 1,903 1,809 Additional paid in capital 76,797,234 45,101,675 Accumulated deficit ( 88,614,631 ) ( 50,608,445 ) Total Shareholders’ Deficit ( 11,815,494 ) ( 5,504,961 ) Total Liabilities and Shareholders’ Deficit $ 2,988,187 $ 3,417,241 See accompanying notes to the condensed consolidated financial statements. 1 NEONC TECHNOLOGIES HOLDINGS, INC. Condensed Consolidated Statements of Operations (Unaudited) For the Three Months Ended June 30, For the Six Months Ended June 30, 2025 2024 2025 2024 Revenues: Revenue $ - $ 20,000 $ 39,990 $ 63,000 Operating Expenses: Research and development 677,332 394,484 1,675,554 1,009,001 Legal and professional 520,364 590,984 1,477,909 1,155,338 General and administrative 984,262 289,652 1,833,747 705,264 Share based compensation 3,526,076 - 20,923,850 - License expense - 25,000 - 25,000 Advisory fees - - 11,737,806 - Total Operating Expenses 5,708,034 1,300,120 37,648,866 2,894,603 Loss From Operations ( 5,708,034 ) ( 1,280,120 ) ( 37,608,876 ) ( 2,831,603 ) Other Income (Expense): Interest income 28,725 - 80,424 - Amortization of debt issuance and deferred offering costs ( 192,249 ) - ( 360,200 ) - Other income, net 240,138 - 240,138 - Interest expense - related parties ( 48,750 ) ( 1,171,963 ) ( 357,672 ) ( 2,559,456 ) Loss on extinguishment of Bridge loan - related party - ( 2,069,923 ) - ( 2,069,923 ) Net Loss $ ( 5,680,170 ) $ ( 4,522,006 ) $ ( 38,006,186 ) $ ( 7,460,982 ) Loss per share: Net loss per share - basic and diluted $ ( 0.30 ) $ ( 0.27 ) $ ( 2.04 ) $ ( 0.45 ) Weighted average number of common shares outstanding during the period - basic and diluted 19,026,776 16,636,455 18,589,859 16,598,227 See accompanying notes to the condensed consolidated financial statements. 2 NEONC TECHNOLOGIES HOLDINGS, INC. Condensed Consolidated Statements of Changes in Shareholders’ Deficit (Unaudited) Three and Six Months Ended June 30, 2024 Common Stock Additional Paid In Accumulated Total Shareholders’ Shares Amount Capital Deficit Deficit Balance - January 1, 2024 16,560,000 $ 1,656 $ 24,720,072 $ ( 38,709,981 ) $ ( 13,988,253 ) Net loss - - - ( 2,938,976 ) ( 2,938,976 ) Balance - March 31, 2024 16,560,000 $ 1,656 $ 24,720,072 $ ( 41,648,957 ) $ ( 16,927,229 ) Sale of common stock, net of offering costs 141,889 14 1,702,654 - 1,702,668 Common stock issued for bridge loan conversion 979,039 98 11,748,366 - 11,748,464 Common stock issued for settlement of vendor payable 114,758 12 1,377,078 - 1,377,090 Common stock issued for settlement of accrued compensation 34,375 3 412,497 412,500 Net loss - - - ( 4,522,006 ) ( 4,522,006 ) Balance - June 30, 2024 17,830,061 $ 1,783 $ 39,960,667 $ ( 46,170,963 ) $ ( 6,208,513 ) Three and Six Months Ended June 30, 2025 Balance - January 1, 2025 18,090,526 $ 1,809 $ 45,101,675 $ ( 50,608,445 ) $ ( 5,504,961 ) Sale of common stock, net of offering costs 727,750 73 10,252,425 - 10,252,498 Common stock issued for advisory services 46,000 5 557,055 - 557,060 Cashless exercise of warrants 162,500 16 ( 16 ) - - Share based compensation, as restated - - 17,397,774 - 17,397,774 Net loss ( 32,326,016 ) ( 32,326,016 ) Balance - March 31, 2025, as restated 19,026,776 $ 1,903 $ 73,308,913 $ ( 82,934,461 ) $ ( 9,623,645 ) Share based compensation - - 3,526,076 - 3,526,076 Other ( 37,755 ) - ( 37,755 ) Net loss - - - ( 5,680,170 ) ( 5,680,170 ) Balance - June 30, 2025 19,026,776 $ 1,903 $ 76,797,234 $ ( 88,614,631 ) $ ( 11,815,494 ) See accompanying notes to the condensed consolidated financial statements. 3 NEONC TECHNOLOGIES HOLDINGS, INC. Condensed Consolidated Statements of Cash Flows (Unaudited) For the Six Months Ended June 30, 2025 2024 Cash flows from operating activities: Net loss $ ( 38,006,186 ) $ ( 7,460,982 ) Adjustments to reconcile net loss to net cash used in operating activities: Increase in bridge loan - expenses paid by bridge loan provider on behalf of the Company - 476,393 Accretion of original issue discount on bridge loans - related party 300,000 2,558,241 Write off deferred issuance costs - 703,796 Share based compensation - restricted stock 20,923,850 - Loss on extinguishment of bridge loan - 2,069,923 Amortization of debt issuance costs and deferred offering costs 769,441 - Amortization of right of use asset 18,153 111,793 Changes in operating assets and liabilities: Prepaid expenses ( 350,134 ) ( 90,312 ) Other assets ( 47,177 ) - Accrued compensation ( 479,775 ) 10,724 Lease liability ( 20,458 ) ( 103,304 ) Accrued advisory fee 5,882,710 - Accounts payable and accounts payable - related parties 45,350 1,551,272 Net cash used in operating activities ( 10,964,226 ) ( 172,456 ) Cash flows from financing activities: Proceeds from the sale of common stock 11,324,372 1,702,668 Proceeds from related party loan 300,000 892,028 Repayment of related party loan ( 600,000 ) ( 791,077 ) Deferred offering costs - ( 130,491 ) Net cash provided by financing activities 11,024,372 1,673,128 Net increase in cash and cash equivalents 60,146 1,500,672 Cash and cash equivalents - beginning of period 64,893 31,862 Cash and cash equivalents - end of period $ 125,039 $ 1,532,534 Supplemental disclosure of non-cash financing activities: Original issue discount on bridge loan - related party $ 300,000 $ 1,368,421 Right of use asset, at lease commencement $ 415,970 $ 536,605 Reclassified of deferred offering costs to APIC at the completion of the offering $ 1,391,580 $ - Increase in bridge loan payable – prepaid and deferred offering costs paid directly by bridge loan provider on behalf of the Company $ - $ 31,346 Conversion of bridge loan to common stock $ - $ 11,748,464 Conversion of accrued compensation $ - $ 412,500 Conversion of account payable to common stock $ - $ 1,377,090 See accompanying notes to the condensed consolidated financial statements. 4 Note 1 – Description of Business and Liquidity NeOnc Technologies, Inc. (“NTI”) was incorporated on April 13, 2005, as a California corporation. On April 7, 2023, NTI merged into NeOnc Technologies Holdings, Inc. (“NTHI” and the combined entities “NeOnc” or the “Company”). NTHI was incorporated January 5, 2023, as a Delaware Corporation. NeOnc is the developer of a novel molecular technology that provides enhanced targeted delivery of technologies for treating central nervous system diseases. The Company’s lead product, NEO100 is in clinical trials treating glioblastoma, and has Orphan Drug and Fast Track designation from the United States Food and Drug Administration (“FDA”). The Company licensed the underlying technology from the University of Southern California. (“USC”). On October 11, 2024, the Company entered into an agreement with a broker dealer to serve as placement agent and provide broker services in connection with the proposed sale of common stock up to $ 10,000,000 . Under this agreement, through December 31, 2024, the Company closed on commitments from investors to purchase 625,000 shares of common stock of the Company at $ 16 per share for total commitments of $ 10,000,000 , which were to be held in escrow until the Company’s registration statement was declared effective. During the three months ended March 31, 2025, prior to the Company having an effective registration statement, the Company closed on an additional commitment to purchase 102,750 shares of common stock of the Company at $ 16 per share, for total commitments of $ 1,644,000 , On March 10, 2025, the Company’s registration statement was declared effective at which time the $ 11,644,000 in escrow was released to the Company. On March 26, the Company was listed (“Listing”) on the NASDAQ global markets. Liquidity The accompanying financial statements have been prepared on the basis that the Company is a going concern, which contemplates, among other things, the realization of assets and satisfaction of liabilities in the normal course of business. At June 30, 2025, the Company had cash totaling $ 125,039 . For the three and six months ended June 30, 2025, the Company incurred a net loss of $ 5,680,170 and $ 38,006,186 , respectively, and has an accumulated deficit of $ 88,614,631 at June 30, 2025. The Company has financed its working capital requirements to date primarily through the sale of common stock, shareholder loans and related party bridge loans. The Company does not have sufficient available capital to fund operations for a period of twelve months from the issuance date of these financial statements. Although the Company has established agreements with several funding potential sources (see Notes 6, 7 and 10), the Company does not know whether additional financing will be available when needed, whether it will be available on favorable terms, or if it will be available at all. These factors raise substantial doubt regarding the Company’s ability to continue as a going concern. The financial statements do not include any adjustments that might result from the outcome of this uncertainty. Other risks and uncertainties The Company is subject to risks common to biopharmaceutical companies, including, but not limited to, new technological innovations, dependence on key personnel, protection of proprietary technology, compliance with government regulations, product liability, and the uncertainty of market acceptance of products and the potential need to obtain additional financing. The Company is dependent on third-party suppliers and, in some cases, single-source suppliers. The Company’s products require approval or clearance from the FDA prior to commencing commercial sales in the United States. Approvals or clearances are also required in foreign jurisdictions where the Company may license or sell its products. There can be no assurance that the Company’s products will receive all required approvals or clearances. There can be no assurance that the Company’s products, if approved, will be accepted in the marketplace, nor can there be any assurance that any future products can be developed or manufactured at an acceptable cost with appropriate performance characteristics or that such products will be successfully marketed, if at all. 5 Note 2 – Restatement of Previously Issued Financial Statements The Company has restated the previously issued unaudited consolidated financial statements as of and for the quarter ended March 31, 2025 (the “Restatement”). The Restatement corrects an error for an overstatement of amortization of stock based compensation during the three months ended March 31, 2025. As previously reported in the Company’s Current Report on Form 8-K filed on August 18, 2025, the management of the Company, after discussions with and among the Audit Committee of the Board of Directors concluded that the Company’s unaudited consolidated financial statements as of and for quarter ended March 31, 2025 should no longer be relied upon and should be restated. The following table presents the impact of the Restatement on the Condensed Consolidated Balance Sheet (Unaudited), Condensed Consolidated Statement of Operations (Unaudited), Condensed Consolidated Statement of Cashflows (Unaudited), and the notes to the financial statement as of and for the three months ended March 31, 2025: Schedule of financial statement As of or For the Three Months Ended March 31, 2025 Previously Report Restatement Adjustments Restated Condensed Balance Sheet Additional Paid In Capital 78,984,884 5,675,971 73,308,913 Accumulated Deficit (b) ( 88,610,432 ) ( 5,675,971 ) ( 82,934,461 ) Condensed Statement of Operations Share based Compensation (b)(c) 23,073,745 5,675,971 17,397,774 Total Operating Expense 37,616,803 5,675,971 31,940,832 Loss from operations ( 37,576,813 ) ( 5,675,971 ) ( 31,900,842 ) Net loss (a)(b) ( 38,001,987 ) ( 5,675,971 ) ( 32,326,016 ) Net loss per share ( 2.10 ) ( 0.32 ) ( 1.78 ) Condensed Statement of Cashflows Net Loss ( 38,001,987 ) ( 5,675,971 ) ( 32,326,016 ) Share based compensation adjustment 23,073,745 5,675,971 17,397,774 Notes to the Condensed Consolidated Financial Statement Note 8 - Stock-Based Compensation Fair value of RSUs at respective grant date 37,336,500 ( 5,839,992 ) 31,496,508 Unamortized portion 14,262,755 ( 164,021 ) 14,098,734 Remaining term 1.8 ( 1.0 ) 0.8 Catch up amortization as of the listing date 22,756,463 ( 5,608,537 ) 17,147,463 (a) Also restated as presented in Note 1 to the condensed consolidated financial statements for the three months ended March 31, 2025 (b) Also restated as presented in Note 7 to the condensed consolidated financial statements for the three months ended March 31, 2025 (c) Also restated as presented in Note 8 to the condensed consolidated financial statements for the three months ended March 31, 2025 6 Note 3 – Basis of Presentation and Summary of Significant Accounting Policies Basis of presentation The unaudited condensed consolidated financial statements contained herein have been prepared by the Company pursuant to the rules and regulations of the Securities and Exchange Commission (the “SEC”). Certain information and note disclosures normally included in annual financial statements prepared in accordance with generally accepted accounting principles have been condensed or omitted pursuant to SEC rules and regulations, although the Company believes that the disclosures made are adequate to make the information not misleading. Accordingly, the condensed consolidated financial statements reflect all normal recurring adjustments, which are, in the opinion of management, necessary for a fair presentation of the results of interim periods and may not include all disclosures required by accounting principles generally accepted in the United States (“GAAP”). The information as of June 30, 2025, and for the three and six months ended June 30, 2025, is unaudited, whereas the consolidated balance sheet as of December 31, 2024, is derived from the Company’s audited condensed consolidated financial statements as of that date. These condensed consolidated financial statements and notes hereto should be read in conjunction with the consolidated financial statements and notes thereto included in the audited financial statements for the year ended December 31, 2024, included on Form S-1, filed with the SEC on February 26, 2025. The results of operations for the interim periods presented are not necessarily indicative of results to be expected for any other interim period or for the year. Principles of consolidation The accompanying condensed consolidated financial statements and related notes to the condensed consolidated financial statements include the accounts of the Company and its wholly owned subsidiary. All significant intercompany balances and transactions have been eliminated in consolidation. Use of estimates In preparing the Company’s financial statements in conformity with GAAP, management is required to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosures of contingent assets and liabilities at the date of the financial statements, as well as the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates. Cash and cash equivalents The Company, from time to time during the period covered by these financial statements, may have had bank account balances in excess of federally insured limits. The Company has not experienced losses in such accounts. For the statements of cash flows, the Company considers all short-term investments purchased with a maturity of three months or less to be cash equivalents. At June 30, 2025 and December 31, 2024, the Company has money market funds in the amount of approximately $ 80,000 and $ 25,000 , respectively. Deferred offering costs The Company complies with the requirements of the ASC 340-10-S99-1 and SEC Staff Accounting Bulletin (“SAB”) Topic 5A “ Expenses of Offering ”. Offering costs consist principally of professional and registration fees incurred through the condensed consolidated balance sheet dated December 31, 2024 that are related to the planned public offering of its securities (See Note 3). These costs have been capitalized and were recognized in equity upon the completion of the securities offering. At June 30, 2025, deferred offering costs consist of the fair value of shares issued in conjunction with the issuance of an equity purchase agreement. These costs have been capitalized and are being amortized over the term of the availability of the equity purchase agreement (Note 6). If planned offerings are terminated, the related capitalized deferred offering costs are written off. 7 Debt issuance costs Debt issuance costs represent costs directly attributable to warrants issued for a line of credit commitment. Such costs represent the fair value of warrants issued to the debt facility provider and are amortized to the statement of operations on a straight-line basis which approximates the effective interest rate method, over the term of the debt instrument. The debt issuance costs, net of accumulated amortization, are classified as a long-term asset until the Company begins to draw funds from the debt facility, in accordance with ASC 815: “ Derivatives and Hedging ”. At such time, the pro-rata portion of amounts borrowed as compared to the total debt facility will be reclassified as a contra-debt account. Warrants The Company evaluates the terms of warrants issued and determines if the instrument requires liability or equity accounting classification under ASC 815: Derivatives and Hedging and ASC 480: “ Distinguishing Liabilities from Equity ”. Leases The Company classifies its leases either as operating or financing lease at inception. The company has an operating lease. This lease is recorded as an operating lease, right of use (ROU) assets and operating lease liabilities on the accompanying consolidated balance sheets. Operating lease ROU assets and the related lease liabilities are recognized based on the present value of the future minimum lease payments over the lease term at commencement date. The operating lease ROU assets also include lease incentives and initial direct costs incurred. For operating leases, interest on the lease liability and the amortization of ROU asset result in straight-line rent expense over the lease term. Leases may include options to extend or terminate the lease which are included in the ROU operating lease assets and operating lease liability when they are reasonably certain of exercise. Certain leases include lease and non-leased components, which are accounted for as one single lease component. Operating lease expense associated with minimum lease payments is recognized on a straight-line basis over the lease term. Fair value measurements FASB ASC Topic 820, “ Fair Value Measurements and Disclosures ” (“ASC 820”), defines fair value, the methods used to measure fair value and the expanded disclosures about fair value measurements. Fair value is the price received to sell an asset or paid to transfer a liability in an orderly transaction between the buyer and the seller at the measurement date. In determining fair value, the valuation techniques consistent with the market approach, income approach and cost approach shall be used to measure fair value. ASC 820 establishes a fair value hierarchy for inputs, representing the assumptions the buyer and seller use in pricing the asset or liability. These inputs are further defined as observable and unobservable inputs. Observable inputs are those that the buyer and seller would use in pricing the asset or liability based on market data obtained from sources independent of the Company. Unobservable inputs reflect the Company’s assumptions about the inputs the buyer and seller would use to price the asset or liability developed based on the best information available in the circumstances. The Company’s money market funds are valued at quoted prices in active markets and are classified as Level 1 within the fair value hierarchy. The carrying value of the Company’s accounts payable approximates its fair value because of the short-term nature of these financial instruments. The note payable - related party is reported at fair value as the Company elected the fair value option for such a note (see Note 4). 8 The fair value hierarchy is categorized into three levels based on the inputs as follows: ● Level 1 — Valuations based on unadjusted quoted prices in active markets for identical assets or liabilities that the Company has the ability to access. Valuation adjustments and block discounts are not being applied. Since valuations are based on quoted prices that are readily and regularly available in an active market, the valuation of these securities does not entail a significant degree of judgment. ● Level 2 — Valuations based on (i) quoted prices in active markets for similar assets and liabilities, (ii) quoted prices in markets that are not active for identical or similar assets, (iii) inputs other than quoted prices for the assets or liabilities, or (iv) inputs that are derived principally from or corroborated by the market through correlation or other means. ● Level 3 — Valuations based on unobservable inputs and significant to the overall fair value measurement. Revenue The Company recognized point-in-time revenue of $ 0 and $ 39,990 for the three and six months ended June 30, 2025, and $ 20,000 and $ 63,000 for the three and six months ended June 30, 2024, respectively, for the sale/license of technology where the Company has no further performance obligations. Research and development Research and development costs are expensed as incurred. Research and development expenses include personnel costs associated with research and development activities, including third-party contractors performing research, conducting clinical trials, and manufacturing drug supplies and materials. Patent costs All patent-related costs incurred in filing and prosecuting patent applications are expensed as incurred due to the uncertainty about the recovery of the expenditure. Amounts incurred are classified as legal and professional expenses in the accompanying consolidated statements of operations. Share-based compensation The Company has granted stock options and common shares to employees, non-employee consultants and non-employee members of our Board of Directors. The Company measures the compensation cost associated with all share-based payments based on the grant date fair values. Compensation costs associated with grants of common shares are measured at fair value at the date of grant, which has historically been the most recent price paid by investors to purchase shares of the Company’s common stock prior to such grant. The Company recognizes share-based compensation expense over the requisite service period of each award, which generally equals the vesting period, using the straight-line method for awards that contain only service conditions. If the stock grant is contingent upon events that have not yet happened, then the grant is not considered issued. If an award holder leaves the company prior to vesting, and adjustment of the compensation expense will be made to reflect only those awards that vested. The Company recognizes the stock-based compensation expense for the restricted stock units (“RSU”) based upon the fair value of the common stock at the date of the grant. The expense is recognized over the service period provided in the RSU awards, however expense will not be recognized until the listing date (“Listing Date”), as prior to such date it was not probable that condition to commence vesting would be met. When the vesting contingency is met, the Company will commence to recognize expense related to the RSU’s. For time based vested RSU’s, the expense will be recognized on a straight-line basis from the grant date to the last vesting date. The expense recognized will include the expense from the date of the grant over the total vesting period and reflect the portion attributable to the service provided prior to the listing. For performance based RSU’s, the Company will determine the probability of the contingency being met each quarter end based upon an assessment of progress made under such performance criteria. 9 Net loss per share Basic net loss per share is computed by dividing net loss available to common stockholders by the weighted average number of common shares outstanding during the period. Diluted net loss per share is computed by dividing net loss by the sum of the weighted average number of common shares outstanding during the period. For periods in which the Company reports a net loss, the diluted net loss per share is the same as basic net loss per share. For the six months ended June 30, 2025 there are potentially dilutive securities outstanding of 3,010,000 potentially dilutive restricted stock units which are not included in the diluted net loss per share calculation since their effect is anti-dilutive. For the six months ended June 30, 2024, respectively, there were no potentially dilutive warrants outstanding and no potentially dilutive restricted stock units. Income taxes The Company recognizes federal, state, and foreign current tax liabilities or assets based on its estimate of taxes payable to or refundable by tax authorities in the current fiscal year. For the periods ended June 30, 2025 and 2024, there is no current tax provision due to losses generated. The Company also recognizes federal and state deferred tax liabilities or assets based on the Company’s estimate of future tax effects attributable to temporary differences and carry forwards. Deferred tax assets and liabilities are measured using enacted tax rates expected to apply to taxable income in the years those temporary differences are expected to be recovered or settled. Deferred tax assets are reduced by valuation allowances if, based on the consideration of all available evidence, it is more likely than not that some portion of the deferred tax asset will not be realized. The Company evaluates deferred income taxes quarterly to determine if valuation allowances are required by considering available evidence. If the Company is unable to generate sufficient future taxable income in certain tax jurisdictions, or if there is a material change in the actual effective tax rates or time period within which the underlying temporary differences become taxable or deductible, the Company could be required to increase its valuation allowance against its deferred tax assets which could result in an increase in the Company’s effective tax rate and an adverse impact on operating results. The Company will continue to evaluate the necessity of the valuation allowance based on the remaining deferred tax assets. The difference between the statutory and effective rates for the three and six months ended June 30, 2025 and 2024 is a result of the Company applying a full valuation allowance against any deferred tax assets as a result of net operating losses due to uncertainties surrounding the usability of such net operating losses. The ability to utilize such net operating loss carry forwards may be limited due to possible changes in ownership as defined under Internal Revenue Code section 382. The Company follows the accounting guidance related to financial statement recognition, measurement and disclosure of uncertain tax positions. The Company recognizes the impact of an uncertain income tax position on an income tax return at the largest amount that is more likely than not to be sustained upon audit by the relevant taxing authority. An uncertain income tax position will not be recognized if it is less than 50% likely to be sustained. Uncertain tax positions are recognized in the first subsequent financial reporting period in which that threshold is met or from changes in circumstances such as the expiration of applicable statutes of limitations. The Company will recognize interest and penalties related to tax positions in income tax expense. Segment Reporting In November 2023, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) 2023-07, “ Segment Reporting (Topic 280): Improvements to Reportable Segment Disclosures .” The standard expands reportable segment disclosure requirements for public business entities primarily through enhanced disclosures about significant segment expenses that are regularly provided to the chief operating decision maker (“CODM”) and included within each reported measure of segment profit (referred to as the “significant expense principle”). The standard has been adopted for our fiscal year 2024 annual financial statements and interim financial statements thereafter and have applied this standard retrospectively for all prior periods presented in the financial statements. 10 Note 4 – Related p arty t ransactions AFH Holdings and Advisory, LLC advisory agreement On December 19, 2022, the Company entered into an advisory agreement with AFH Holdings and Advisory, LLC, an affiliate to assist the Company in connection with its intent to affect a public listing. AFH was retained to assist the Company with investor presentations and decks, coordinate the retention of an investment banker for an initial public offering, identify legal and accounting professionals to assist in connection with such public offering, identify investor relations/public relations firms, advise on private capital markets activities prior to the initial public offering and coordinate the closing process for the offering. On July 12, 2024, the Company amended the AFH advisory agreement section to allow for an upfront payment on the Listing Date of $ 2,500,000 and the remaining amount of the fee to be paid in equal monthly instalments for one year. AFH was paid a fee of $ 500,000 for the amendment. On March 26, 2025, and as a result of the listing of the Company on Nasdaq, the Company incurred $ 11,328,565 for the fee earned in accordance with the AFH advisory agreement which was recorded as advisory fee expense in the condensed consolidated statement of operations. In accordance with the amendment, the Company paid $ 2,500,000 of such fee on March 26, 2025. The remaining balance of $ 8,828,565 is payable in 12 equal monthly installments commencing in April 2025. As of June 30, 2025, the remaining outstanding accrued advisory fee totaled $ 5,882,710 recorded on the condensed consolidated balance within accrued advisory fee – related party. In addition, the Company agreed to retain AFH as an exclusive advisor to the Company on all financing and mergers and acquisitions for a period of two (2) years from the closing of the private securities offering. Transactions with USC The Company maintains a license agreement with USC, under which the Company will pay USC an annual patent maintenance fee of $ 20,000 and nonrefundable earned royalties of 4 % on Net Sales (as defined in the Amended Agreement) of Licensed Products covered by the licensed patents in all countries in which the manufacture, use, sale, offer for sale, or import of such Licensed Products, as such capitalized terms are defined in the Amended Agreement. To date, no sales have been made using Licensed Products, and no royalties are due to USC. In addition, the Company will assume responsibility for patent-related costs. The Company also utilizes laboratory and patent maintenance services from USC. The Company incurred $ 82,225 and $ 184,449 and $ 191,239 and $ 283,473 related to such services for the three and six months ended June 30, 2025 and 2024, respectively, of which $ 82,225 , $ 164,449 and $ 191,239 and $ 263,473 are recorded within research and development expenses and $ 0 , $ 20,000 and $ 0 and 20,000 are recorded within general administrative expenses on the condensed consolidated statements of operations. At June 30, 2025 and December 31, 2024, the Company has outstanding payables to USC for such services of $ 499,225 and $ 272,328 respectively, which is included in accounts payable - related parties in the accompanying consolidated balance sheets. Accrued compensation The amount accrued for the management team, including related payroll taxes, was $ 255,105 and $ 734,874 as June 30, 2025 and December 31, 2024, respectively. Note 5 – Related Party Loans Payable Bridge Loan In April 2023, the Company entered into a non-interest bearing, non-convertible promissory note with HCWG LLC (the “Bridge Loan”). Borrowings under the Bridge Loan carry a 50% (or 1 times cash amounts borrowed) original issue discount (“OID”) on principal and through subsequent amendments the maximum cash borrowing was increased to $ 10,000,000 . The outstanding amounts under this Bridge Loan were payable at the earlier of the date the Company completes an IPO or December 4, 2024 (the “Maturity Date”). 11 Through March 31, 2024, the Company had received under the Bridge Loan an aggregate of $ 7,116,335 . The OID was recognized ratably over the term of each draw-down under the Bridge Loan through the Maturity Date unless settled earlier, at which point the accretion is accelerated. Accretion of the OID for the three months ended March 31, 2024, amounted to $ 1,387,493 , which is included in interest expense in the accompanying consolidated statement of operations. Summary of the bridge loan activity for the three and six months ended June 30, 2024 is as follows: Schedule of debt For the Three Months Ended June 30, 2024 Bridge loan – carrying value Balance – March 31, 2024 $ 11,378,683 Borrowings 221,075 OID 221,075 Repayments ( 72,369 ) Balance – June 30, 2024 11,748,464 Conversion to common stock ( 11,748,464 ) Principal outstanding at June 30, 2024 $ - For the Six Months Ended June 30, 2024 Bridge loan – carrying value Balance – January 1, 2024 $ 9,802,697 Borrowings 1,368,422 OID 1,368,422 Repayments ( 791,077 ) Balance – June 30, 2024 11,748,464 Conversion to common stock ( 11,748,464 ) Principal outstanding at June 30, 2024 $ - On June 14, 2024, the Company reached an agreement with HCWG LLC to convert the outstanding principal and interest on the Bridge Loan into 979,039 shares of common stock. As a result of this conversion, the Bridge Loan was terminated and is no longer available to the Company for borrowing. The Company has a receivable due from HCWG LLC totaling $ 148,705 which is recorded within prepaid expenses and other on the condensed consolidated balance sheet at June 30, 2025 and December 31, 2024, respectively. Advances from Executive Chairman In February 2025, our Executive Chairman advanced the Company approximately $ 300,000 . The advances carry a 50% (or 1 times amounts borrowed) original issue discount (“OID”) on the principal. On March 10, 2025, the advance and 1x interest was repaid. Interest expense in the amount of $ 300,000 is included in the condensed consolidated statement of operations as interest expense – related parties for the six months ended June 30, 2025. 12 Note 6 – Leases On February 1, 2024, the Company entered a 24-month lease for office space, which calls for a monthly base rent of $ 25,000 , increasing at 3 % per annum. The Company has only one operating lease and has no financing leases. The Company’s lease does not contain options to renew or extend the lease term or options to terminate leases early, except for insolvency. On November 27, 2024, the Company amended the lease expiration date from January 31, 2026, to January 31, 2025. As of December 31, 2024, the consolidated balance sheet reflects a right-of-use asset of $ 23,526 and a lease liability of $ 24,722 . The lease liability was computed using an interest rate of 13.49 % and as of December 31, 2024, the lease has a remaining life of one month. In April 2025, the Company entered into a 63 month lease for office space which calls for a monthly base rent of $ 6,778 .25 , increasing at approximately 3 % per annum. The lease liability was computed using an interest rate of 3.72 % and as of June 30, 2025 the lease has a remaining 61 months. In calculating the present value of future lease payments, the Company utilized its incremental borrowing rate based on the lease term. The Company’s net lease non-lease components (e.g., standard area maintenance, maintenance, consumables, etc.) are paid separately from rent based on actual costs incurred and, therefore, are not included in the right-of-use asset and lease liability and are reflected as an expense in the period incurred. At June 30, 2025 the consolidated balance sheet reflects a right-of-use asset of $ 397,817 and a lease liability of $ 395,512 . The Company recorded lease expense of $ 15,581 and $ 56,325 during the three months ended June 30, 2025 and 2024, respectively, and $ 40,303 and $ 111,793 during the six months ended June 30, 2025, and 2024, respectively, within general and administrative expenses on the consolidated statements of operations. Cash paid for amounts included in the measurement of lease liability was $ 13,557 and $ 75,000 and $ 38,557 and $ 125,000 , respectively, during the three and six months ended June 30, 2025, and 2024, respectively. The following are the expected maturities of lease liabilities for operating leases as of June 30, 2025: Schedule of lease liabilities for operating leases Twelve Months Ended December 31, 2025 $ 40,670 2026 83,137 2027 85,663 2028 88,231 2029 90,928 Thereafter 44,944 Total 433,573 Less: interest ( 38,061 ) Present value of lease liability 395,512 Less: current portion ( 68,633 ) Noncurrent portion $ 326,879 Note 7 – Common and Preferred Stock The total number of shares of common stock available for issue by NTHI is 100,000,000 shares of common stock at $ 0.0001 par value per share and the total number of shares of preferred stock is 10,000,000 at a par value of $ 0.0001 . As of June 30, 2025, no preferred shares have been issued. The board of directors is authorized, subject to any limitations prescribed by law, to provide for the issuance of shares of Preferred Stock in one or more series, and by filing a certificate pursuant to the applicable law of the State of Delaware , to establish from time to time the number of shares to be included in each such series, and to fix the designation, powers, preferences, and rights of the shares of each wholly unissued series and any qualifications, limitations or restrictions thereof. The number of authorized shares of Preferred Stock may be increased or decreased (but not below the number of shares thereof then outstanding) by the affirmative vote of the holders of a majority of the Common Stock, without a vote of the holders of the Preferred Stock, or any series thereof, unless a vote of any such holders is required pursuant to the terms of any Preferred Stock Designation. 13 During the six months ended June 30, 2025, the Company sold 727,750 shares of common stock at a price of $ 16 per share for gross proceeds of $ 11,644,005 pursuant to a private placement of its securities, issued 46,000 shares as part of advisory services related to the listing and as part of the private placement fee for our equity line of credit, 162,500 shares were issued for the cashless exercise of warrants, and the release of 3,310,000 shares for restricted stock units. The net proceeds from the sale of common stock, were calculated as follows: Schedule of proceeds from the sale of common stock Gross proceeds from sale of common stock $ 11,644,005 Less: Reclassification of deferred offering costs to APIC at the completion of the offering ( 1,391,580 ) Net proceeds from the sale of common stock $ 10,252,425 Private Placement On October 11, 2024, the Company entered into an agreement with RBW Capital Partners LLC, a division of Dawson James Securities, Inc. (“Broker”) to serve as placement agent and provide broker services in connection with the possible sale of common stock up to $10 million. If a sale is made between the Company and any institutional or individual third-party funding source introduced by the placement agent, the Company will pay a placement fee of 8% of the gross proceeds. In addition, the company agrees to pay; (a) 1.0% of the gross proceeds for non-accountable expenses; and (b) out of pocket expenses plus the costs associated with the use of a third-party electronic road show service up to $10,000. The agreement expired on January 11, 2025 and was amended and restated on January 29, 2025 to extend the term for another six months through July 29, 2025 and increased the placement fee to 12% from 8% of the gross proceeds, and eliminated the 1% non-accountable expense fee. Under this agreement, through December 31, 2024, the Company closed on commitments from investors to purchase 625,000 shares of common stock of the Company at $ 16 per share for total commitments of $ 10,000,000 , which were to be held in escrow until the Company’s registration statement was declared effective. During the three months ended March 31, 2025, prior to the Company having an effective registration statement, the Company closed on an additional commitment to purchase 102,750 shares of common stock of the Company at $ 16 per share, for total commitments of $ 1,644,005 , also to be held in escrow until the Company’s registration statement was declared effective. On March 25, 2025, the Company’s registration statement was declared effective at which time the $ 11,644,005 in escrow was released to the Company. In connection with the agreement, the Company paid $ 300,000 in placement agent fees to Broker for securing $2,500,000 in commitments for the Private Placement. This fee was paid when the funds were released from escrow and recorded as a reduction to additional paid-in capital on the condensed consolidated statement of shareholders’ deficit as of June 30, 2025. Advisory Services On October 3, 2024, as amended on January 23, 2025, the Company entered into an agreement with Broker, for financial advisory and investment banking services in connection with a direct listing of the Company’s common stock on the Nasdaq Global Market or other major US market. The agreement provides for a one-time fee of $250,000 payable three days after the direct listing and the issuance of 30,000 shares of common stock (which are restricted until the shares are registered by filing a resale S-1 within 30 days after the effective date of the direct listing). In addition, the Company agreed to pay up to $ 100,000 for fees and expenses of legal counsel and other out-of-pocket expenses plus the costs associated with the use of a third-party electronic road show service. Such fees were included in accounts payable and deferred offering costs in the accompanying consolidated balance sheets as of December 31, 2024. The fair value of the 30,000 shares issued in March 2025, amounting to $ 363,300 , was determined using the closing day price of $ 12.11 . This amount was recorded as an advisory fee on the condensed consolidated statement of operations. The agreement expired on January 3, 2025 and was amended and restated on January 23, 2025 to extend the term for another six months through July 23, 2025. No additional fees are expected under this agreement. 14 Deferred Offering Costs Deferred offering costs relating to the Private Placement and direct listing at December 31, 2024 totaled $ 1,071,947 . At June 30, 2025, this amount plus $ 0 and $ 319,633 incurred in the three and six months ended June 30, 2025, respectively was reclassified against the common stock issued in the condensed consolidated statement of changes in shareholder’s deficit. Equity Purchase Agreement On October 22, 2024, we entered into an equity purchase agreement (the “Equity Purchase Agreement”) with Mast Hill Fund, LP (“Mast Hill”) pursuant to which the Company may sell and issue to Mast Hill, and the investor may purchase from the Company, up to $50,000,000 of Company’s common shares. Under the Equity Purchase Agreement, the Company has the right, but not the obligation, to direct Mast Hill, by its delivery to the Mast Hill of a Put Notice from time to time, to purchase Put Shares (i) in a minimum amount not less than $50,000 and (ii) in a maximum amount up to the lesser of (a) $750,000 or (b) 150% of the average trading volume of the Company’s common stock during the five trading days immediately preceding the Put Date. The Company could draw down any funds under the Equity Purchase Agreement until the Company has an effective registration statement. The actual amount of proceeds we receive pursuant to each Put Notice (each, the “Put Amount”) is determined by multiplying the Put Amount requested by the applicable purchase price. The purchase price for each of the Put Shares equals 95% of the Market Price, (as defined below) less the Clearing Costs (as defined below). Market Price is the lowest volume weighted average prices of the Company’s common shares on its principal market on any trading day during the Valuation Period (as defined below). The Valuation Period is the five trading days immediately following the date on which Mast Hill receives the Put Shares in its brokerage account. Clearing Costs are all the fees incurred by Mast Hill with respect to its brokerage firm, clearing firm, Company transfer agent fees, and attorney fees, with respect to the Put Shares. The term of the Equity Purchase Agreement will commence on the effective date of the direct listing and will terminate on the earlier of i) the date on which the Mast Hill shall have purchased Put Shares equal to the $50,000,000, (ii) twenty-four (24) months after the date of the Equity Purchase Agreement, (iii) written notice of termination by the Company to Mast Hill, (iv) this Registration Statement is no longer effective after the initial effective date of this Registration Statement, or (v) the date that, pursuant to or within the meaning of any Bankruptcy Law, the Company commences a voluntary case or any Person commences a proceeding against the Company, a receiver, trustee, assignee, liquidator or similar official is appointed for the Company or for all or substantially all of its property or the Company makes a general assignment for the benefit of its creditors. As of June 30, 2025, nothing has been transacted under this agreement. In connection with this agreement, we issued 16,000 shares of common stock to Mast Hill. The fair value of the shares granted to Mast Hill upon issuance was determined by using the closing day price of $ 12.11 . Such amount net of amortization was recorded as deferred offering cost on the condensed consolidated balance sheet as of March 31, 2025. For the three and six months ended June 30, 2025, the Company reported $ 48,440 and $ 70,238 , respectively as amortization expense in the condensed consolidated statement of operations, and the remaining deferred offering costs of $ 123,520 at June 30, 2025 are to be amortized over the remaining term of the Equity Purchase Agreement. Investment agreement In July 2025, the Company sold 132,342 shares of common stock at $3.73 per share for gross proceeds of approximately $493,000 pursuant to Equity Purchase Agreement with Mast Hill Note 8 – Segment Reporting The company manages our business activities on a consolidated basis and operates as a single operating segment: Biotechnology. The accounting policies of the Biotechnology segment are the same as those described in Note 1 – Summary of Significant Accounting Policies. 15 Our Chief Operating Decision Maker (“CODM”) is our President and Chief Executive Officer, Dr. Chen. The CODM uses net loss, as reported on our condensed consolidated statement of operations, in evaluating the performance of the biotechnology segment and determining how to allocate resources of the Company as a whole, including investing in our research and development programs and acquisition/licensing strategy. The CODM does not review assets in evaluating the results of the biotechnology segment, and therefore, such information is not presented. The following supplemental information breaks down the research and development costs for the three and six months ended June 30, 2025 and 2024, respectively. Schedule of segment reporting For the Six Months Ended June 30, 2025 2024 Revenues $ 39,990 $ 63,000 Less: Significant and other segment expenses: NEO100 688,628 456,721 NEO100-02 201,787 123,431 NEO212 455,629 359,696 Pediatric 99,010 68,988 Laboratory 192,377 - Other 38,123 165 Total research and development expense 1,675,554 1,009,001 Advisory fee 11,737,806 - Legal and accounting 1,477,909 1,155,338 Employee Expenses 334,160 145,724 Debt issuance and deferred offering costs amortization 360,200 111,793 Investor relations 771,073 6,663 Share based compensation 20,923,850 - Other general and administrative expense 728,514 466,084 Interest expense - related parties’ loans 357,672 2,559,456 Loss on extinguishment of Bridge loan - related party - 2,069,923 Interest income ( 80,424 ) - Other Income ( 240,138 ) - Net loss $ ( 38,006,186 ) $ ( 7,460,982 ) For the Three Months Ended June 30, 2025 2024 Revenues $ - $ 20,000 Less: Significant and other segment expenses: NEO100 109,166 98,399 NEO100-02 93,326 96,367 NEO212 279,074 197,962 Pediatric 50,178 1,591 Laboratory 107,465 - Other 38,123 165 Total research and development expense 677,332 394,484 Advisory fee - - Legal and accounting 520,364 590,984 Employee Expenses 163,887 - Debt issuance and deferred offering costs amortization 192,249 111,793 Investor relations 226,766 - Share based compensation 3,526,076 - Other general and administrative expense 593,609 205,860 Interest expense - related parties’ loans 48,750 1,171,963 Interest income ( 28,725 ) 2,069,923 Other Income ( 240,138 ) - Net loss $ ( 5,680,170 ) $ ( 4,522,006 ) 16 Note 9 – Stock-Based Compensation On April 12, 2023, the Company adopted the 2023 Equity Incentive Plan (the “2023 Plan”), which allows the issuance of up to 3,440,000 shares of the Company’s authorized and unissued common stock in the form of incentive stock options, non-qualified stock options, restricted stock units, performance share units, or other forms of equity as may be added in the future to employees, directors and consultants of the Company and its affiliates. The allowable number of shares that can be issued under the 2023 Plan increased upon the completion of the listing to 4,764,507 which represents 20% of the fully diluted capitalization of the Company on the closing of Company’s initial public price. In January and February 2024, 2,460,000 and 200,000 , respectively, restricted stock units (“RSUs”) were granted to the executive officers and members of the Board of Directors further to the 2023 Plan as described above. Of the total RSUs granted (tranche 1) 1,686,667 vest 100% seven months from the date that the Company lists on a national exchange, (tranche 2) 486,667 will vest in equal monthly instalments over a one (1) year period commencing on the eighth month from the effective date of the listing on a national exchange and (tranche 3) 486,666 are performance-based, the vesting of which will be predicated on certain financial and operational performance metrics being met after the effective date of the listing on a national exchange as set forth the grant agreements. Since tranche 3 is performance based, it is not yet probable that all of the performance vesting conditions will be met and as such no expense has been recognized for tranche 3 as of June 30, 2025. On October 23, 2024, 200,000 RSUs were granted to each of the CEO and the Executive Chairman, for a total of 400,000 , and 100,000 granted to two members of the Board of Directors were canceled. These RSUs vest 100% seven months from the date the Company lists on a national exchange. On March 26, 2025, 150,000 RSUs were granted to the three board members, in the amount of 50,000 each. These RSUs vest 100% seven months from the date the Company lists on a national exchange. Prior to March 26, 2025, the Company determined that no expense should be recognized for the RSUs since the contingency related to the commencement of vesting (i.e., the listing) of the RSUs had not been met. On March 26, 2025, the listing occurred, satisfying the contingency required for vesting to begin and defining the service period. On June 1, 2025, 300,000 RSUs were forfeited resulting in a reversal of $ 1,329,062 of shared based compensation during the six months ended June 30, 2025. On June 5, 2025, 200,000 RSUs were granted to the one board member. 66,667 RSUs vest 100% seven months from the date of issuance, 66,667 RSUs vest 100% thirty-six months from the date of issuance. The remaining 66,667 RUS’s vest thirty-six months from the date certain performance metrics are achieved. The Company determined the fair value of all the RSUs at their respective grant dates to be $ 32,495,174 based on the price of the most recent sale of common stock prior to each grant date for those RSU’s granted prior to the Listing Date or the quoted market value for the RSU’s granted after the Listing Date. For the six months ended June 30, 2025, the company recognized $20,923,850. As of June 30, 2025, there was unamortized stock-based compensation of approximately $ 9,171,324 which the Company expects to recognize over approximately 7 years. 17 The activity related to RSUs is summarized as follows: Schedule of restricted stock units activity Restricted Stock Units Activity RSUs Granted 2024 January 1, 2024 - Granted 3,060,000 Cancelled ( 100,000 ) December 31, 2024 2,960,000 2025 Granted during six months ended June 30, 2025 350,000 Forfeited ( 300,000 ) Balance at June 30, 2025 3,010,000 Released RSUs for six months ended June 30, 2025 - As of June 30, 2025, an aggregate of 3,010,000 RSU’s were granted, and 1,754,500 RSU’s remain unissued in the 2023 Plan. Note 10 – Commitments and Contingencies Line of Credit Commitment – Related Party On October 11, 2024, the Company entered into a Line of Credit Agreement (“the Agreement”) with HCWG for borrowings of up to $ 10.0 million. Borrowings under the Line of Credit Agreement bear interest at 10.0 % per annum and increases to 14% if the Agreement is extended. Interest payments are due on the first business day of each calendar month and the unpaid principal is due on October 12, 2027. No amounts have been borrowed under the facility through June 30, 2025. In connection with the agreement, the Company issued HCWG five-year warrants to purchase up to 312,500 shares of our common stock at an exercise price of $ 12.00 per share. These warrants expire on October 23, 2029 . As of December 31, 2024, there were 312,500 warrants issued, outstanding and fully vested. In March 2025, 162,500 warrants were exercised in a cashless exercise, resulting in the issuance of 162,500 shares of common stock. At June 30, 2025, there are 150,000 shares of common stock remaining available to be purchased under the warrant. The fair value of the warrants on the grant date was determined using the Black-Scholes valuation model, with the following key assumptions: ● Fair value of common stock: $ 12.00 ● Expected volatility: 86 % ● Risk-free interest rate: 4.82 % ● Term: 2.5 years The fair value of warrants at inception was $ 2,015,413 , which was recorded as additional paid-in capital on the condensed consolidated statement of changes stockholders’ deficit for the year ended December 31, 2024, and as debt issuance costs on the balance sheet. The debt issuance costs are being amortized over the term of the line of credit and amounted to $ 167,951 and $ 335,903 for the three and six months ended June 30, 2025. At June 30, 2025 and December 31, 2024, unamortized debt issuance costs total $ 1,534,413 and $ 1,870,316 , respectively, which will be amortized over the remaining 19 months of the facility. 18 Litigation From time to time, the Company is involved in various disputes, claims, liens and litigation matters arising out of the normal course of business which could result in a material adverse effect on the Company’s combined financial position, results of operations or cash flows. Liabilities for loss contingencies arising from claims, assessments, litigation, fines and penalties and other sources are recorded when it is probable that a liability has been incurred, and the amount of the assessment can be reasonably estimated. As of June 30, 2025 and December 31, 2024, the Company had no liabilities recorded for loss contingencies, except as below. License Agreement - Orient EuroPharma Co., Ltd. On November 8, 2013, the Company entered into a collaboration agreement (“Agreement”) with Orient EuroPharma Co., Ltd. (“OEP”), pursuant to which the parties will develop certain licensed products defined in the Agreement. NeOnc will license OEP the right to commercialize the Company’s drug NEO100, a highly purified form of perillyl alcoho l (“Licensed Product”), in the territories specified in the license agreement (“Territory”). In 2023, the Company sent notice to OEP indicating their intent to terminate the Agreement with OEP, after which OEP threatened litigation. On February 15, 2024, OEP and the Company entered into a settlement agreement whereas the Company and OEP terminated the Agreement in exchange for a payment in the amount of $ 4,000,000 payable by the Company to OEP within ten days of the date the Company completes its initial public offering. The Company has a litigation settlement payable of $ 4,000,000 in the accompanying condensed consolidated balance sheets as of June 30, 2025 and December 31, 2024, respectively. As of the date of this filing, the Company has not paid the litigation settlement amount. On June 6, 2023, a vendor filed a complaint against the Company for breach of contract in the Central District of California. The vendor alleged that the Company improperly terminated an Intellectual Property License and Supply Agreement (“IPLSA”) and that the Company also defrauded the vendor in connection with IPLSA. This matter was settled on October 16, 2023, and the Company agreed to pay the vendor $ 600,000 within 5 business days of the close of the date that the Company completes an IPO or March 31, 2024, whichever occurs first. The Company has a litigation settlement payable in the accompanying condensed consolidated balance sheet at June 30, 2025 and December 31, 2024. As of the date of this filing, the Company has not paid the litigation settlement amount. On March 31, 2024, a vendor agreed to extend the payment until May 15, 2024 for payment of an additional $25,000, payable on demand. On July 25, 2024, the arbitrator granted the implementation of interest at the statutory rate on the unpaid balance commencing May 15, 2024 until paid, therefore an additional $ 48,750 and $ 56,250 of interest expense is recognized in the accompanying condensed consolidated statement of operations during the three and six months ended June 30, 2025, respectively. At June 30, 2025 and December 31, 2024, $ 97,500 and $ 41,250 of accrued interest is included in litigation settlement payable in the accompanying condensed consolidated balance sheet. Note 11 – Subsequent Events Convertible debt In July 2025, the Company entered into a series of convertible promissory notes with a group of investors for the aggregate purchase price of $4 million. The notes are payable three months after purchase for a total amount of $ 5 million (20% OID). The Company may extend the payment date for up to three additional one-month periods with the OID on the Notes increasing to 25%, 30% and 35% with respect to any such monthly extensions. Further, upon the occurrence of an Event of Default, as that term is defined in the Notes, the Notes shall be convertible into shares of the Common stock of the Company at a price equal to 80% of the lowest closing sale price of the Company’s common stock as reported on the Nasdaq Global Market on any trading day during the five (5) trading days prior to the respective conversion date. As of August 13, 2025, the Company has received the full proceeds from the issuance of $ 4,000,000 of such promissory notes. 19 Investment and Joint Venture In June 2025, the Company (through a soon to be formed entity – Nuromena Holdings Ltd. “NuroMena”) entered into a letter of intent to form an investment and joint venture agreement with a Middle-East investor (“Investor”), names Quazar Investments. At the formation date, the Company would own 10 million shares of NuroMena and contribute a license to its technology to NuroMena, and the Investor will purchase 2.5 million shares of NuroMena for a subscription price of $400,000 (“Initial Investment”). Following the formation of the entity and closing of the Initial Investment, the Investor shall source one or more future investors to purchase up to $50.0 million at $25/share in common stock of the Company, of which 70% of the proceeds will be maintained by the Company and 30% will be transferred to an operating entity to be formed under NuroMena, to conduct clinical trials in the middle-east markets. As of August 13, 2025, the entity has not yet been formed, and therefore the Initial Investment has not yet occurred. In July 2025, the Company satisfied a key milestone in connection with the anticipated closing of its previously announced strategic transaction with Quazar Investment. Specifically, the Company executed and transferred a Sub-License Agreement from NeOnc Technologies Holdings, Inc. to its Abu Dhabi onshore operating subsidiary, NuroCure. The Sub-License grants rights within the United Arab Emirates and the broader GCC and MENA regions for NEO100 and NEO212 pursuant to the Company’s existing license from the USC Stevens Center for Innovation. On July 8, 2025, the Company announced that it had entered into a non-binding term sheet with Quazar Investment for a proposed $50 million equity investment and regional expansion into the MENA markets. The Sub-License Agreement constituted the second of five conditions precedent to closing the transaction. Subsequent to execution of the Sub-License, the Company satisfied all remaining conditions precedent to closing, including: 1. Finalization of definitive offering documents, including subscription agreements and a shareholder agreement; 2. Approval of a comprehensive two-year business plan and budget, setting forth operational and clinical development milestones; and 3. Legal formation of NuroMENA Holdings Ltd., incorporated under the Abu Dhabi Global Market framework. The completion of these steps fulfills all the required conditions for closing and positions the Company to consummate the Quazar Investment transaction. Binding Letter of Intent On July 24, 2025, the Company entered into a binding Letter of Intent (“LOI”) with Dr. Ishwar K. Puri and Beth R. Levinson, setting forth the principal terms for the acquisition by NeOnc of all equity interests in a to-be-formed limited liability company (the “Target Company”). The Target Company was subsequently organized as JandB Holdings LLC, a California limited liability company. Under the terms of the binding LOI, the transaction consideration includes: (i) a cash payment of $500,000 to McMaster University on or before October 31, 2025; and (ii) $3.0 million, less expenses, payable in shares of the Company’s common stock valued at $25.00 per share, to JandB Holdings LLC. The Company believes this acquisition represents a strong strategic fit and supports its long-term growth initiatives. The closing of the transaction is subject to the negotiation and execution of definitive agreements, including a Share Exchange Agreement and related documentation, to be prepared by the Company’s legal counsel and reviewed by the Target Company’s legal counsel. 20