5 unchanged sentences
Rule 10b5-1 under the Exchange Act provides an affirmative defense that enables directors and officers to prearrange transactions in our securities in a manner that avoids concerns about initiating transactions while in possession of material nonpublic information.
−Removed: During the first quarter of 2026, none of our directors or officers adopted or terminated a Rule 10b5-1 trading arrangement or a non-Rule 10b5-1 trading arrangement (each as defined in Item 408 of Regulation S-K).
−Removed: Restated Certificate of Incorporation of the Registrant, as amended
−Removed: Pre-Funded Warrant to Purchase Common Stock, dated March 26, 2026, by and between the Registrant and RA Capital Management.
−Removed: Warrant to Purchase Common Stock dated March 26, 2026, by and between the Registrant and RA Capital Management.
−Removed: Second Amendment to Credit and Guaranty Agreement, dated February 27, 2026 (incorporated by reference to Exhibit 10.1 to the Registrant’s Current Report on Form 8-K (File No.
−Removed: 001-36167) filed with the SEC on March 3, 2026).
−Removed: Securities Purchase Agreement, dated March 24, 2026, by and between the Company and RA Capital Management (incorporated by reference to Exhibit 10.1 to the Registrant’s Current Report on Form 8-K (File No.
−Removed: 001-36167) filed with the SEC on March 24, 2026).
−Removed: Registration Rights Agreement, dated March 26, 2026, by and between the Company and RA Capital Management.
+Added: During the second quarter of 2026, none of our directors or officers adopted or terminated a Rule 10b5-1 trading arrangement or a non-Rule 10b5-1 trading arrangement (each as defined in Item 408 of Regulation S-K).
+Added: Amendment No.
+Added: 4 to the 2022 Equity Incentive Plan (incorporated herein by reference to Appendix A to the Company’s Definitive Proxy Statement on Schedule 14A (File No.
+Added: 001-36167) filed with the SEC on April 13, 2026)
+Added: Amendment No.
+Added: 5 to the 2022 Equity Incentive Plan
+Added: Form of Restricted Stock Unit Agreement (Performance Vested) under the 2022 Equity Incentive Plan adopted May 22, 2026
+Added: Form of Restricted Stock Unit Agreement (Performance Vested) under the 2022 Equity Incentive Plan adopted May 22, 2026
+Added: Form of Restricted Stock Unit Agreement for Non-Employee Directors under the 2022 Equity Incentive Plan adopted May 19, 2026
+Added: Non-Employee Director Compensation Policy
Certification of principal executive officer pursuant to Rule 13a-14(a)/15d-14(a) of the Securities Exchange Act of 1934,as amended.
8 unchanged sentences
Cover Page Interactive Data File (formatted as inline XBRL with applicable taxonomy extension information contained in Exhibits 101)
−Removed: * Certain exhibits have been omitted pursuant to Item 601(a)(5) of Regulation S-K.
+Added: * Certain portions of this exhibit (indicated by “[***]”) have been omitted pursuant to Item 601(b)(10)(iv) of Regulation S-K.
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
KARYOPHARM THERAPEUTICS INC.
+Added: August 13, 2026
/s/ Richard Paulson
2 unchanged sentences
(Principal executive officer)
+Added: August 13, 2026
/s/ Lori Macomber
3 unchanged sentences
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.