Unregistered Sales of Equity Securities, Use of Proceeds, and Issuer Purchases of Equity Securities.
−Removed: Unregistered Sales of Equity Securities during the Three Months Ended June 30, 2025
−Removed: There were no unregistered sales of equity securities during the three months ended June 30, 2025.
+Added: Unregistered Sales of Equity Securities during the Three Months Ended September 30, 2025
+Added: There were no unregistered sales of equity securities during the three months ended September 30, 2025.
+Added: Tabl e of Contents
3.1 Amended and Restated Certificate of Incorporation of Caribou Biosciences, Inc.
6 unchanged sentences
001-40631), filed with the SEC on March 21, 2022)
−Removed: Advisory Consulting Agreement by and between the Registrant and Steven B.
−Removed: Kanner, Ph.D., effective as of July 1, 2025 (incorporated by reference to Exhibit 10.
−Removed: 2 to the Registrant’s Quarte rly Report on Form 10- Q for the three months ended March 31, 202 5 (File No.
−Removed: 001-40631), filed with the SEC on May 8 , 2025)
+Added: Form of Performance-Based Stock Option Agreement under the 2021 Equity Incentive Plan of the Registra nt
31.1* Certification of Principal Executive Officer Pursuant to Rules 13a-14(a) and 15d-14(a) under the Exchange Act, as Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
15 unchanged sentences
+ Indicates management contract or compensatory plan
+Added: Tabl e of Contents
Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
Caribou Biosciences, Inc.
−Removed: August 12, 2025
+Added: November 12, 2025
/s/ Rachel E.
2 unchanged sentences
(Principal Executive Officer)
−Removed: August 12, 2025
+Added: November 12, 2025
/s/ Sriram Ryali
3 unchanged sentences
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.