1 unchanged sentence
Evaluation of Disclosure Controls and Procedures
−Removed: We maintain disclosure controls and procedures that are designed to ensure that information required to be disclosed in our periodic and current reports that we file with the SEC under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms, and that such information is accumulated and communicated to our management, including our principal executive officer and principal financial officer, as appropriate, to allow timely decisions regarding required disclosure.
+Added: We maintain “disclosure controls and procedures” as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended, or the Exchange Act, that are designed to ensure that information required to be disclosed in our periodic and current reports that we file with the SEC under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms, and that such information is accumulated and communicated to our management, including our principal executive officer and principal financial officer, as appropriate, to allow timely decisions regarding required disclosure.
Management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving their objectives and management necessarily applies its judgment in evaluating the cost-benefit relationship of possible controls and procedures.
−Removed: As of the end of the period covered by this Annual Report on Form 10-K, we carried out an evaluation, under the supervision and with the participation of our management, including our principal executive officer/interim principal financial officer, of the effectiveness of the design and operation of our disclosure controls and procedures pursuant to Exchange Act Rule 13a-15.
−Removed: Based upon, and as of the date of, this evaluation, our principal executive officer/interim principal financial officer concluded that our disclosure controls and procedures were effective.
−Removed: Accordingly, management believes that the financial statements included in this report fairly present in all material respects our financial condition, results of operations and cash flows for the periods presented.
−Removed: Management’s Annual Report on Internal Control Over Financial Reporting
+Added: Our management, with the participation of our principal executive officer and our principal financial officer, evaluated the effectiveness of our disclosure controls and procedures as of December 31, 2021.
+Added: Based on the evaluation of our disclosure controls and procedures as of December 31, 2021, our principal executive officer and principal financial officer concluded that, as of such date, our disclosure controls and procedures were effective at the reasonable assurance level.
+Added: Management’s Report on Internal Control Over Financial Reporting
Our management is responsible for establishing and maintaining adequate internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) of the Exchange Act).
−Removed: Under the supervision and with the participation of our management, including our principal executive officer/interim principal financial officer, we conducted an evaluation of the effectiveness of our internal control over financial reporting as of December 31, 2020 based on the guidelines established in Internal Control-Integrated Framework 2013 issued by the Committee of Sponsoring Organizations of the Treadway Commission.
−Removed: Our internal control over financial reporting includes policies and procedures that provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external reporting purposes in accordance with U.S.
−Removed: generally accepted accounting principles.
−Removed: Based on that evaluation, management concluded that our internal control over financial reporting was effective as of December 31, 2020.
+Added: Under the supervision and with the participation of our management, including our principal executive officer and principal financial officer, we conducted an evaluation of the effectiveness of our internal control over financial reporting as of December 31, 2021 based on the guidelines established in Internal Control-Integrated Framework 2013 issued by the Committee of Sponsoring Organizations of the Treadway Commission.
+Added: Based on the results of its evaluation, management concluded that our internal control over financial reporting was effective as of December 31, 2021.
Attestation Report of the Registered Public Accounting Firm
This Annual Report on Form 10-K does not include an attestation report of our independent registered public accounting firm as we are a smaller reporting company and an “emerging growth company” as of December 31, 2021, as defined in the Jumpstart Our Business Startups Act of 2012.
−Removed: Our compliance with Section 404 of the Sarbanes-Oxley Act first became subject to management’s assessment regarding internal control over financial reporting in connection with the filing of our Annual Report on Form 10-K for the fiscal year ending December 31, 2018, and we will not be required to have an independent registered public accounting firm attest to the effectiveness of our internal control over financial reporting until the filing of our first Annual Report on Form 10-K after we lose emerging growth company status, which may not be until the 2023 Annual Report on Form 10-K.
Changes in Internal Control over Financial Reporting
−Removed: We continuously seek to improve the efficiency and effectiveness of our internal controls.
−Removed: There was no change in our internal control over financial reporting identified in connection with the evaluation required by Rule 13a-15(d) and 15d-15(d) of the Exchange Act during the fiscal quarter ended December 31, 2020 that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.
+Added: There were no changes in our internal control over financial reporting during the fiscal quarter ended December 31, 2021 that have materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.
+Added: Inherent Limitations on Effectiveness of Controls
+Added: Our management, including our principal executive officer and principal financial officer, believes that our disclosure controls and procedures and internal control over financial reporting are designed to provide reasonable assurance of achieving their objectives and are effective at the reasonable assurance level.
+Added: However, our management does not expect that our disclosure controls and procedures or our internal control over financial reporting will prevent all errors and all fraud.
+Added: A control system, no matter how well conceived and operated, can
+Added: provide only reasonable, not absolute, assurance that the objectives of the control system are met.
+Added: Further, the design of a control system must reflect the fact that there are resource constraints, and the benefits of controls must be considered relative to their costs.
+Added: Because of the inherent limitations in all control systems, no evaluation of controls can provide absolute assurance that all control issues and instances of fraud, if any, have been detected.
+Added: These inherent limitations include the realities that judgments in decision making can be faulty, and that breakdowns can occur because of a simple error or mistake.
+Added: Additionally, controls can be circumvented by the individual acts of some persons, by collusion of two or more people or by management override of the controls.
+Added: The design of any system of controls also is based in part upon certain assumptions about the likelihood of future events, and there can be no assurance that any design will succeed in achieving its stated goals under all potential future conditions;
+Added: over time, controls may become inadequate because of changes in conditions, or the degree of compliance with policies or procedures may deteriorate.
+Added: Because of the inherent limitations in a cost-effective control system, misstatements due to error or fraud may occur and not be detected.
Other Information.
+Added: Repricing of Outstanding and Unexercised Options
+Added: On March 24, 2022, the Board unanimously approved the repricing of all outstanding and unexercised stock options granted under the 2015 Plan and 2017 Plan (the “Plans”) and held by current employees, executive officers, and directors of the Company (the “Eligible Stock Options”).
+Added: The exercise price of the Eligible Stock Options will be reduced to the closing price of the Company’s common stock on April 1, 2022.
+Added: Except for the modification to the exercise price of the Eligible Stock Options, all other terms and conditions of each of the Eligible Stock Options will remain in full force and effect.
+Added: Pursuant to the Plans, the Board, as the administrator of the Plans, has discretionary authority, exercisable on such terms and conditions that it deems appropriate under the circumstances, to reduce the exercise price in effect for outstanding options under the Plans.
+Added: In approving the repricing, the Board considered the impact of the current exercise prices of outstanding stock options on the incentives provided to employees and directors, the lack of retention value provided by the outstanding stock options to employees and directors, and the impact of such options on the capital structure of the Company.
+Added: As of March 24, 2022, there are currently 6,996,741 stock options outstanding under the Plans, and all of the Company’s outstanding stock options have exercise prices in excess of the current fair market value of the Company’s common stock, which is why the Board made the determination to deem all outstanding and unexercised stock options held by current employees, executive officers, and directors as Eligible Stock Options.
+Added: Matthias Schroff, the Company’s Chief Executive Officer, and Elias Papadimas, the Company’s Chief Financial Officer, hold Eligible Stock Options exercisable into an aggregate of 881,200 and 375,417 shares of the Company’s common stock, respectively.
+Added: Non-employee directors Jeffrey Cleland, Elizabeth Garofalo, Bali Muralidhar and James Sulat hold Eligible Stock Options exercisable into an aggregate of 115,079, 150,000, 115,079 and 93,386 shares of the Company’s common stock, respectively.
+Added: Disclosure Regarding Foreign Jurisdictions that Prevent Inspections.
+Added: Not applicable.
We will file a definitive proxy statement for our 2022 Annual Meeting of Stockholders, or the Proxy Statement, with the SEC, pursuant to Regulation 14A, not later than 120 days after the end of our fiscal year.
2 unchanged sentences
Directors, Executive Officers and Corporate Governance.
−Removed: The information required by this item will be set forth in our Proxy Statement and is incorporated herein by reference.
+Added: The information required by Item 10 is incorporated herein by reference to the sections of the 2022 Proxy Statement under the captions “Board of Directors and Corporate Governance,” “Election of Directors,” and “Executive Officers.”
Executive Compensation.
−Removed: The information required by this item will be set forth in our Proxy Statement and is incorporated herein by reference.
+Added: The information required by Item 11 is incorporated herein by reference to the sections of the 2022 Proxy Statement under the captions “Executive Compensation” and “Director Compensation.”
Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters.
−Removed: The information required by this item will be set forth in our Proxy Statement and is incorporated herein by reference.
+Added: The information required by Item 12 is incorporated herein by reference to the sections of the 2022 Proxy Statement under the captions “Security Ownership of Certain Beneficial Owners and Management” and “Securities Authorized for Issuance under Equity Compensation Plans.”
Certain Relationships and Related Transactions, and Director Independence.
−Removed: The information required by this item will be set forth in our Proxy Statement and is incorporated herein by reference.
+Added: The information required by Item 13 is incorporated herein by reference to the sections of the 2022 Proxy Statement under the captions “Certain Relationships and Related Party Transactions” and “Independence of the Board of Directors.”
Principal Accounting Fees and Services.
−Removed: The information required by this item will be set forth in our Proxy Statement and is incorporated herein by reference.
−Removed: Exhibits and Financial Statement Schedules.
+Added: Our independent public accounting firm is KPMG LLP, Chicago, Illinois (PCAOB ID:
+Added: The information required by Item 14 is incorporated herein by reference to the sections of the 2022 Proxy Statement under the caption “Ratification of Selection of Independent Registered Public Accounting Firm.”
+Added: Exhibit and Financial Statement Schedules.
(a) The following documents are filed as part of this report:
2 unchanged sentences
Financial Statement Schedules
−Removed: All schedules are omitted because they are not applicable or the required information is shown in the financial statements or notes thereto.
−Removed: Except as so indicated in Exhibit 32, the following exhibits are filed as part of, or incorporated by reference into, this Annual Report on Form 10-K.
+Added: All financial statement schedules are omitted because they are not applicable or the required information is included in the financial statements or notes thereto.
Exhibit Number Exhibit Description Filed with this Report Incorporated by Reference herein from Form or Schedule Filing Date SEC File/Reg.
7 unchanged sentences
3.3 Amended and Restated Certificate of Incorporation, as filed with the Secretary of State of the State of Delaware on November 15, 2017.
+Added: 10-K (Exhibit 3.3) 3/11/2021 001-39011
3.4 Amended and Restated Bylaws, as currently in effect.
27 unchanged sentences
8-K (Exhibit 10.7) 10/2/2017 000-55764
+Added: 10.6+ Separation and Transition Agreement by and between Exicure Inc.
+Added: Giljohann, Ph.D.
+Added: 8-K (Exhibit 10.3) 2/4/2022 001-39011
10.7+ Amended and Restated Employment Agreement dated as of February 2, 2016 by and between Exicure OpCo and David S.
4 unchanged sentences
10-K (Exhibit 10.9) 3/10/2020 001-39011
+Added: 10.9+ Second Amendment to the Employment Agreement, by and between Exicure, Inc.
+Added: and Matthias Schroff, dated December 10, 2021
+Added: 8-K (Exhibit 10.3) 12/10/2021 001-39011
+Added: 10.10+ Second Amended and Restated Employment Agreement, by and between Exicure, Inc.
+Added: and Matthias Schroff, Ph.D.
+Added: 8-K (Exhibit 10.2) 2/4/2022 001-39011
10.11+ Amended and Restated Employment Agreement dated as of June 30, 2020 by and between Douglas E.
4 unchanged sentences
8-K (Exhibit 10.1) 6/9/2020 001-39011
+Added: 10.13+ Employment Agreement dated as of April 16, 2021 by and between Brian Bock and Exicure, Inc.
+Added: 8-K (Exhibit 10.1) 5/13/2021 001-39011
+Added: 10.14+ First Amendment to Employment Agreement dated as of December 10, 2021 by and between Brian Bock and Exicure, Inc.
+Added: 8-K (Exhibit 10.2) 12/10/2021 001-39011
10.15+ Consulting Agreement dated as of October 1, 2011 by and between AuraSense Therapeutics, LLC and Chad A.
1 unchanged sentence
8-K (Exhibit 10.11) 10/2/2017 000-55764
+Added: 10.16+ Inducement Award Agreement dated as of May 13, 2021 by and between Brian Bock and Exicure, Inc.
+Added: 8-K (Exhibit 10.2) 5/13/2021 001-39011
+Added: 10.17+ Advisor Agreement by and between Exicure, Inc.
+Added: 8-K (Exhibit 10.1) 2/4/2022 001-39011
+Added: 10.18+ Amended and Restated Employment Agreement dated as of June 1, 2021 by and between Elias D.
+Added: Papadimas and Exicure, Inc.
+Added: 10-Q (Exhibit 10.3) 8/12/2021 001-39011
+Added: 10.19+ First Amendment to Amended and Restated Employment Agreement by and between Exicure, Inc.
+Added: Papadimas, dated January 17, 2022
+Added: 8-K (Exhibit 10.2) 1/18/2022 001-39011
+Added: 10.20+ Retention Agreement by and between Exicure, Inc.
10.21 Lease Agreement dated as of February 28, 2020 by and between 2430 N.
6 unchanged sentences
10-Q (Exhibit 10.2) 11/12/2020 001-39011
+Added: 10.23.1 Amendment No.
+Added: 2 dated as of July 30, 2021 to Credit and Security Agreement, dated as of September 25, 2020 by and among Exicure, Inc., Exicure Operating Company, the lenders party thereto from time to time and MidCap Financial Trust, as agent.
+Added: 10-Q (Exhibit 10.4) 8/12/2021 001-39011
+Added: 10.23.2 Amendment No.
+Added: 3 dated as of September 30, 2021 to Credit and Security Agreement, dated as of September 25, 2020 by and among Exicure, Inc., Exicure Operating Company, the lenders party thereto from time to time and MidCap Financial Trust, as agent.
+Added: 8-K (Exhibit 10.1) 10/6/2021 001-39011
+Added: 10.23.3 Amendment No.
+Added: 4 dated as of December 10, 2021 to Credit and Security Agreement, dated as of September 25, 2020 by and among Exicure, Inc., Exicure Operating Company, the lenders party thereto from time to time and MidCap Financial Trust, as agent.
+Added: 8-K (Exhibit 10.1) 12/10/2021 001-39011
10.24 Loan and Security Agreement dated as of February 17, 2016 by and between Exicure OpCo and Hercules.
22 unchanged sentences
10-K (Exhibit 10.24) 3/10/2020 001-39011
+Added: 10.27.4 Amendment Five to the Amended Restated License Agreement between Exicure OpCo and Northwestern University dated as of September 8, 2021.
+Added: 10- Q (Exhibit 10.5) 11/19/2021 001-39011
10.28* License Agreement between Exicure OpCo and Northwestern University dated as of February 10, 2016 and effective as of May 27, 2014.
22 unchanged sentences
10-K (Exhibit 10.34) 3/10/2020 001-39011
+Added: 10.37* Collaboration, Option and License Agreement between Exicure, Inc.
+Added: and Ipsen Biopharm Limited dated as of July 30, 2021
+Added: 10- Q (Exhibit 10.3) 11/19/2021 001-39011
+Added: 10.38 Side Agreement to Northwestern Agreements by and among Exicure Inc., Northwestern University and Ipsen Biopharm Limited dated as of July 30, 2021.
+Added: 10- Q (Exhibit 10.4) 11/19/2021 001-39011
+Added: 10.39 Form of Securities Purchase Agreement, dated December 14, 2021, by and among Exicure, Inc.
+Added: and the purchaser parties thereto.
+Added: 8-K (Exhibit 10.1) 12/16/2021 001-39011
10.40 Form of Subscription Agreement by and between the Company and each investor in the initial closing of the 2017 Private Placement.
8-K (Exhibit 10.5) 10/2/2017 000-55764
−Removed: 10.28 Equity Distribution Agreement, dated as of December 21, 2020, between the Registrant and BMO Capital Markets Corp.
−Removed: S-3 (Exhibit 1.2) 12/21/2020 333-251555
21.1 Subsidiaries of Exicure, Inc.
1 unchanged sentence
24.1 Power of Attorney (included on the signature page hereto).
−Removed: 31.1 Certification of Principal Executive Officer /Principal Financial Officer Pursuant to Rule 13a-14(a) of the Securities Exchange Act of 1934, As Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
−Removed: 32.1** Certifications of Principal Executive Officer/Principal Financial Officer Pursuant to 18 U.S.C.
+Added: 31.1 Certification of Principal Executive Officer Pursuant to Rule 13a-14(a) of the Securities Exchange Act of 1934, As Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
+Added: 31.2 Certification of Principal Financial Officer Pursuant to Rule 13a-14(a) of the Securities Exchange Act of 1934, As Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.
+Added: 32.1** Certifications of Principal Executive Officer and Principal Financial Officer Pursuant to 18 U.S.C.
Section 1350, As Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
15 unchanged sentences
EXICURE, INC.
−Removed: Giljohann, Ph.D.
−Removed: President, Chief Executive Officer, Interim Chief Financial Officer and Director
+Added: /s/ Matthias Schroff, Ph.D.
+Added: Matthias Schroff, Ph.D.
+Added: Chief Executive Officer
+Added: Chief Financial Officer
POWER OF ATTORNEY
−Removed: We, the undersigned directors and officers of Exicure, Inc., hereby severally constitute and appoint David A.
−Removed: Giljohann and Timothy P.
−Removed: Walbert, and each of them singly, our true and lawful attorneys-in-fact, with full power to them, and to each of them singly, to sign for us and in our names in the capacities indicated below, any and all amendments to this Annual Report on Form 10-K and to file or cause to be filed the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as each of them might or could do in person, and hereby ratifying and confirming all that said attorneys-in-fact, and each of them, or their substitute or substitutes, shall do or cause to be done by virtue of this Power of Attorney.
+Added: We, the undersigned directors and officers of Exicure, Inc., hereby severally constitute and appoint Matthias Schroff, Ph.D.
+Added: Papadimas, and each of them singly, our true and lawful attorneys-in-fact, with full power to them, and to each of them singly, to sign for us and in our names in the capacities indicated below, any and all amendments to this Annual Report on Form 10-K and to file or cause to be filed the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as each of them might or could do in person, and hereby ratifying and confirming all that said attorneys-in-fact, and each of them, or their substitute or substitutes, shall do or cause to be done by virtue of this Power of Attorney.
This Power of Attorney does not revoke any power of attorney previously granted by the undersigned, or any of them.
−Removed: Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated:
+Added: Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, this Annual Report on Form 10-K has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated:
SIGNATURE TITLE DATE
−Removed: Giljohann President, Chief Executive Officer, Interim Chief Financial Officer and Director
−Removed: ( Principal Executive Officer, Interim Principal Financial Officer and Interim Principal Accounting Officer)
+Added: /s/ Matthias Schroff, Ph.D.
+Added: President, Chief Executive Officer, and Director
+Added: ( Principal Executive Officer)
March 25, 2022
−Removed: Giljohann, Ph.D.
−Removed: /s/ Timothy P.
−Removed: Walbert Director and Chairman of the Board of Directors March 11, 2021
+Added: Matthias Schroff, Ph.D.
+Added: Papadimas Chief Financial Officer
+Added: ( Principal Financial Officer and Principal Accounting Officer)
+Added: March 25, 2022
+Added: /s/ Elizabeth Garofalo, M.D.
+Added: Chair of the Board of Directors March 25, 2022
+Added: Elizabeth Garofalo, M.D.
/s/ Jeffrey L.
−Removed: Cleland Director March 11, 2021
Cleland, Ph.D.
−Removed: Elizabeth Garofalo, M.D.
−Removed: /s/ Bosun Hau Director March 11, 2021
−Removed: Mirkin Director March 11, 2021
−Removed: Mirkin, Ph.D.
−Removed: /s/ Bali Muralidhar Director March 11, 2021
+Added: Director March 25, 2022
+Added: Cleland, Ph.D.
+Added: /s/ Bali Muralidhar, M.D., Ph.D.
+Added: Director March 25, 2022
Bali Muralidhar, M.D., Ph.D.
−Removed: Andrew Sassine
Sulat Director March 25, 2022
−Removed: Walt Director March 11, 2021
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.