24 unchanged sentences
In terms of preliminary efficacy, where scores are compared against baseline before transplantation, we observed a potential dose-dependent response, with an apparent peak effectiveness at our middle dose.
−Removed: The % OFF-Time, which is the time during the day when levodopa medication is not performing optimally and PD symptoms return, decreased an average 47% from the baseline at 12 months post transplantation in cohort 2.
+Added: The % OFF-Time, which is the time during the day when levodopa medication is not performing optimally and Parkinson’s disease symptoms return, decreased an average 47% from the baseline at 12 months post transplantation in cohort 2.
This trend continued through 24 months where the % OFF-Time in the second cohort dropped by 55% from the initial reading.
1 unchanged sentence
The % ON-Time increased an average of 42% above the initial evaluation at 12 months post-transplantation in the second cohort.
−Removed: Each of these product candidates will require extensive preclinical and clinical development and may require specific unforeseen licensing rights obtained at substantial cost before regulatory approval may be achieved and the products sold for therapeutic use.
+Added: Our therapeutic product candidates will require extensive preclinical and clinical development and may require specific unforeseen licensing rights obtained at substantial cost before regulatory approval may be achieved and the products sold for therapeutic use.
Additionally, we are subject to various other risks;
12 unchanged sentences
Our corporate website address is www.internationalstemcell.com, Lifeline Cell Technology’s website address is www.lifelinecelltech.com, and Lifeline Skin Care’s website address is www.lifelineskincare.com.
+Added: Our filings with the Securities and Exchange Commission (the “SEC”) are available free of charge on the SEC’s website at www.sec.gov and our website at www.internationalstemcell.com .
Information found on, or accessible through, our websites is not a part of, and is not incorporated into, this Annual Report on Form 10-K.
105 unchanged sentences
encapsulated extract derived from hpSC and specially selected targeted small molecules.
−Removed: As of December 31, 2023, LSC’s products include:
+Added: At December 31, 2024, LSC’s products include:
• ProPlus Advanced Defense Complex
53 unchanged sentences
The global skin care market is generally comprised of three categories of product – facial care, body care, and special needs products.
−Removed: Top selling products in the facial skincare category include skin brighteners, anti-aging creams and serums, toners, masks, anti-acne and sun protection products.
−Removed: Facial skincare products that provide anti-aging benefits represent a significant portion of the global skincare market.
−Removed: Increased longevity leads consumers to seek out high quality, technologically advanced skincare products that can help them maintain a youthful appearance.
+Added: Top selling products in the facial skin care category include skin brighteners, anti-aging creams and serums, toners, masks, anti-acne and sun protection products.
+Added: Facial skin care products that provide anti-aging benefits represent a significant portion of the global skin care market.
+Added: Increased longevity leads consumers to seek out high quality, technologically advanced skin care products that can help them maintain a youthful appearance.
Anti-aging products that are backed by scientific research remain in high demand among sophisticated consumers despite premium prices.
22 unchanged sentences
The patent, issued in the USA, covers the use of Parthenogenic Activation of Human Oocytes.
−Removed: As of December 31, 2023, we held a total of 39 patents.
+Added: At December 31, 2024, we held a total of 39 patents.
These patents expire from January 2025 through May 2037.
106 unchanged sentences
Human Capital
−Removed: As of December 31, 2023, including our 2 executive officers, we had 29 full-time employees.
+Added: At December 31, 2024, including our 2 executive officers, we had 32 full-time employees.
None of our employees are represented by labor unions or covered by collective bargaining agreements.
13 unchanged sentences
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.