263 unchanged sentences
Type Hypersensitivity (DTH) skin test.
−Removed: The HER2/ neu 3+ population’s immune response was similar to the HER2/ neu 1-2+
−Removed: population’s immune response, suggesting the potential to treat the HER2/ neu 1-2+ population (including triple negative
−Removed: breast cancer) with GP2 immunotherapy in combination with trastuzumab (Herceptin) based products and other synergistic clinically active
−Removed: The broad based immune response suggests the potential for GP2 to treat other HER2/ neu 1-3+ expressing cancers.
−Removed: booster injections given every 6 months after the PIS were observed to elicit a prolonged immune response, which may provide longer term
+Added: The HER2/neu 3+ population’s immune response was similar to the HER2/neu 1-2+ population’s
+Added: immune response, suggesting the potential to treat the HER2/neu 1-2+ population (including triple negative breast cancer) with GP2 immunotherapy
+Added: in combination with trastuzumab (Herceptin) based products and other synergistic clinically active agents.
+Added: The broad based immune response
+Added: suggests the potential for GP2 to treat other HER2/neu 1-3+ expressing cancers.
+Added: Further, booster injections given every 6 months after
+Added: the PIS were observed to elicit a prolonged immune response, which may provide longer term protection.
III Trial, Flamingo-01
11 unchanged sentences
The American Cancer Society estimates that approximately 1 in 8 U.S.
−Removed: women (12.8%) will
−Removed: develop invasive breast cancer over her lifetime.
−Removed: American Cancer Society, Economic Impact, & European Cancer Information System 2025 estimate
−Removed: approximately 700,000 new breast cancer patients per year and 9.5 million current breast cancer survivors in the U.S.
−Removed: and Europe in
+Added: women (12.8%) will develop
+Added: invasive breast cancer over her lifetime.
+Added: The American Cancer Society, Economic Impact, & European Cancer Information System 2025
+Added: estimate approximately 700,000 new breast cancer patients per year and 9.5 million current breast cancer survivors in the U.S.
An estimated 42,000 female breast cancer deaths will occur in the U.S.
−Removed: HER2/ neu 3+ breast
−Removed: cancer patients comprise approximately 25% of all breast cancer patients.
+Added: HER2/ neu 3+ breast cancer patients comprise
+Added: approximately 25% of all breast cancer patients.
Approximately 40% to 50% of the U.S.
−Removed: population contains the HLA-A*02 allele, while node positive and high risk node negative patients comprise approximately 50% of the
+Added: and European population contains the HLA-A*02 allele,
+Added: while node positive and high risk node negative patients comprise approximately 50% of the market.
Therefore, we believe that the U.S.
−Removed: market for the first indication for GP2, if approved, could be the combination of the
−Removed: three populations above which together comprises approximately 6.25% of breast cancer patients who undergo surgery.
+Added: market for the first indication for GP2, if approved, could be the combination of the three populations above which together comprises
+Added: approximately 6.25% of breast cancer patients who undergo surgery.
immunotherapy has become a significant growth area for the biopharmaceutical industry, attracting large pharmaceutical companies as well
545 unchanged sentences
Capital Management
−Removed: of April 11, 2025 we had 4 full-time employees and 4 part-time employees.
+Added: of May 26, 2026 we had 4 full-time employees and 9 part-time employees.
We are not a party to any collective bargaining agreements.
7 unchanged sentences
Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.