What changed in this filing

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Item 5. Other Information

2021-11-15 compared with 2021-08-16 · 185 added, 285 removed, 26 unchanged (95% of the section changed)

OTHER INFORMATION

December 13, 2019, the Company entered into an Open Market Sale Agreement SM (the

“Sales Agreement”) with Jefferies LLC, as sales agent (“Jefferies”), pursuant to which the Company may offer

and sell, from time to time, through Jefferies, shares of its common stock, par value $0.0001 per share, having an aggregate offering

price of up to $20.0 million.

On April 6, 2020, the date on which the Company filed its Annual Report on Form 10-K for the

fiscal year ended December 31, 2019, the Company’s registration statement became subject to the offering limits set forth

in General Instruction I.B.6 of Form S-3.

From December 13, 2019 through August 16 2021, Jefferies sold an aggregate of 5,900,275

shares of common stock at an average price of $1.62 per share to investors.

The Company received net cash proceeds of $9,272,463, net

of commission paid to sales agent of $286,777.

On December 13, 2019, the Company entered into

an Open Market Sale Agreement SM (the “Sales Agreement”) with Jefferies LLC, as sales agent (“Jefferies”),

pursuant to which the Company may offer and sell, from time to time, through Jefferies, shares of its common stock, par value $0.0001

per share, having an aggregate offering price of up to $20.0 million.

On April 6, 2020, the date on which the Company filed its Annual

Report on Form 10-K for the fiscal year ended December 31, 2019, the Company’s registration statement became subject

to the offering limits set forth in General Instruction I.B.6 of Form S-3.

From December 13, 2019 through November 15, 2021,

Jefferies sold an aggregate of 6,204,605 shares of common stock at an average price of $1.59 per share to investors.

The Company received

net cash proceeds of $9,584,668, net of commission paid to sales agent of $296,433.

Lang BVI Acquisition and Equity Financing

June 13, 2021, the Company entered into a Share Purchase Agreement (the “Purchase Agreement”), by and among the Company,

Lonlon Biotech Ltd., a company incorporated in the British Virgin Islands (“BVI”) (“Sen Lang”), the holders of

the share capital of Sen Lang (the “Sen Lang Shareholders”), the ultimate beneficial owners of the Sen Lang Shareholders

(the “Sen Lang Beneficial Shareholders” and, together with the Sen Lang Shareholders, the “Sen Lang Owners”)

and a representative of the Sen Lang Owners (the “Sen Lang Representative”).

Pursuant to the Purchase Agreement, subject

to the satisfaction of the conditions to closing therein, including approval by the Avalon stockholders pursuant to the rules of the

Nasdaq Stock Market (“Nasdaq”), Avalon agreed to purchase (the “Acquisition”) all of the issued and outstanding

share capital of Sen Lang (the “Sen Lang Shares”).

Lang, through a “variable interest entity” structure of contractual rights held by its wholly-owned subsidiary Beijing Langlang

Runfeng Biotechnology Co., Ltd., a wholly foreign owned enterprise with limited liability organized and existing under the laws of the

People’s Republic of China (the “PRC”) (the “PRC Subsidiary”), has full economic benefit and management

control over, and is consolidated for accounting purposes with, Senlang Biotechnology Co.

Ltd., a PRC domestic company with limited liability

organized and existing under the laws of the PRC (the “OpCo” or “SenlangBio”).

The OpCo is mainly engaged in

the business of research and development in relation to CAR-T cell therapy, immune cell therapy and related drug development.

is owned 100% by certain of the Sen Lang Beneficial Shareholders.

A wholly-owned subsidiary of the OpCo, Shijiazhuang Senlang Medical

Laboratory Co., Ltd., a company with limited liability organized and existing under the laws of the PRC (“SenlangBio Clinical Laboratory”)

is engaged in the business of testing of immunology, serology and molecular genetics specialties for patients, including hematology-tumor

diagnostics and testing prior to clinical trials for cell therapy.

to the execution of the Purchase Agreement, the Board of Directors of Avalon (the “Board”), unanimously (i) determined that

the terms and provisions of the Purchase Agreement and the transactions contemplated thereby, including the Acquisition, are fair to,

advisable and in the best interests of the Company and its stockholders, (ii) approved the Purchase Agreement and the transactions contemplated

thereby, including the Acquisition, (iii) authorized, empowered and directed the Company to perform all of its obligations under the

Purchase Agreement and related documents, and (iv) resolved to recommend the adoption of the Purchase Agreement by the stockholders of

the Company in compliance with the rules of Nasdaq (the “Company Board Recommendation”).

purchase price being paid by Avalon to the Sen Lang Shareholders under the Purchase Agreement for the Sen Lang Shares is an aggregate

Lonlon Biotech Ltd., a company incorporated in the British Virgin Islands (“BVI”) (“Sen Lang BVI”), the holders

of the share capital of Sen Lang BVI (the “Sen Lang BVI Shareholders”), the ultimate beneficial owners of the Sen Lang BVI

Shareholders (the “Sen Lang BVI Beneficial Shareholders” and, together with the Sen Lang BVI Shareholders, the “Sen

Lang BVI Owners”) and a representative of the Sen Lang BVI Owners (the “Sen Lang BVI Representative”).

the Purchase Agreement, subject to the satisfaction of the conditions to closing therein, including approval by the Avalon stockholders

pursuant to the rules of the Nasdaq Stock Market (“Nasdaq”), Avalon agreed to purchase (the “Acquisition”) all

of the issued and outstanding share capital of Sen Lang BVI (the “Sen Lang BVI Shares”).

Lang BVI, through a “variable interest entity” structure (“VIE Structure”) of contractual rights held by its

wholly-owned subsidiary Beijing Langlang Runfeng Biotechnology Co., Ltd., a wholly foreign owned enterprise with limited liability organized

and existing under the laws of the People’s Republic of China (the “PRC Subsidiary”), has full economic benefit and

management control over, and is consolidated for accounting purposes with, Senlang Biotechnology Co.

Ltd., a PRC domestic company with

limited liability organized and existing under the laws of the PRC (the “OpCo” or “SenlangBio”).

SenlangBio is

mainly engaged in the business of research and development in relation to CAR-T cell therapy, immune cell therapy and related drug development.

SenlangBio is owned 100% by certain of the Sen Lang BVI Beneficial Shareholders.

A wholly-owned subsidiary of SenlangBio, Shijiazhuang

Senlang Medical Laboratory Co., Ltd., a company with limited liability organized and existing under the laws of the PRC (“SenlangBio

Clinical Laboratory”) is engaged in the business of testing of immunology, serology and molecular genetics specialties for patients,

including hematology-tumor diagnostics and testing prior to clinical trials for cell therapy.

purchase price being paid by Avalon to the Sen Lang BVI Shareholders under the Purchase Agreement for the Sen Lang BVI Shares is an aggregate

of 81 million shares (the “Acquisition Shares”) of the common stock, par value US$0.0001 per share, of Avalon (the “Avalon

1 unchanged sentence

Ten percent (10%), or 8.1 million, of such shares will be held in escrow for 12 months following the closing to

satisfy any indemnification obligations of the Sen Lang Shareholders under the Share Purchase Agreement.

satisfy any indemnification obligations of the Sen Lang BVI Shareholders under the Share Purchase Agreement.

In addition, at the closing

of the Acquisition, it is expected that Dr.

Jianqiang Li, scientific founder and CSO of the OpCo, will join the board of the Company,

Jianqiang Li, scientific founder and CSO of SenlangBio, will join the board of the Company,

Li will also be appointed as Chief Technology Officer of the Company.

The Acquisition Shares will not be registered under the

Securities Act of 1933, as amended (the “Securities Act”) and, therefore, will be restricted securities under Rule 144 under

the Securities Act for six months or longer after the closing of the Acquisition, subject to “affiliate” status with the

Company under the Securities Act.

Purchase Agreement contains customary representations, warranties and covenants made by the parties thereto, including covenants relating

to obtaining the requisite approvals of the stockholders of Avalon and Sen Lang, regulatory approvals and Avalon’s and Sen Lang’s

conduct of their respective businesses (and that of the OpCo) between the date of signing of the Purchase Agreement and the closing of

the Acquisition.

Acquisition is expected to be accounted for as a business acquisition, with the Company identified as the accounting acquirer.

is considered the accounting acquirer since immediately following the closing:

(i) the Company’s stockholders will own a majority

of the voting rights of the post-Acquisition company;

(ii) the Company will have designate a majority (eight of nine) of the initial

members of the board of directors of the post-Acquisition company;

(iii) the Company’s senior management will hold the majority

of the key positions in senior management of the post-Acquisition company;

and (iv) the Company will continue to maintain its corporate

headquarters in Freehold, New Jersey, United States.

SenlangBio will continue to maintain operations in the Shijiazhuang High-tech Development

Zone, Hebei Province, China.

acquisition consideration is 81,000,000 shares of the Company’s Common Stock.

The purchase price will be allocated to the acquired

assets and assumed liabilities based on their fair values at the closing date, and any excess is initially allocated to identifiable

intangible assets mainly consisting of cell and gene engineering technologies with the ability to generate innovative and transformative

cellular immunotherapies for solid and hematologic cancers, which will be amortized over 10 years.

The initial allocation is subject

to change upon the final valuation which is to be done at the time of closing.

Such change could have a material impact on the Company’s

financial statements.

of June 30, 2020, the Company had incurred costs of $938,073 with respect to the Merger and these costs have been expensed.

connection with the Acquisition mentioned above, on June 13, 2021, an institutional investor (the “Investor”) entered into

an agreement with the OpCo related to the purchase of registered capital of the OpCo (the “OpCo Capital Increase Agreement”)

pursuant to which the Investor will acquire an aggregate of up to 13.5% of the equity ownership of the OpCo for an aggregate purchase

price of approximately US$30,000,000 (the “Equity Financing”), which funds will be invested in the OpCo in three equal installments

of US$10,000,000, at a fixed price, the first to be upon the closing of the Acquisition, the second to be within three months after the

closing and the third to be within six months after the closing.

In addition, pursuant to a Securities Exchange Agreement (the “Exchange

Agreement”), by and among the Company, Sen Lang, the OpCo and the Investor, dated June 13, 2021, the Investor has the right, exercisable

between the six-month and five year-anniversaries of the respective initial closing and installment closings, to elect to exchange, from

time to time, all or part of its then-owned equity ownership of the OpCo for shares (the “Exchange Shares”) of Avalon Common

Stock at a fixed exchange price of US$1.21 per share of Avalon Common Stock, which was the market price of the Avalon Common Stock as

of the date of the Exchange Agreement under Nasdaq rules.

In addition, the Exchange Agreement provides that the Investor may only exchange

up to 10% of its total investment amount in any 30-day period.

eCapital Holdings, Ltd.

(CEC Capital) served as financial advisor to Avalon in connection with the Equity Financing and will receive

a cash fee of approximately $900,000, representing 3% of the gross proceeds from the Equity Financing.

The Acquisition Shares will not be registered under the Securities

Act of 1933, as amended (the “Securities Act”) and, therefore, will be restricted securities under Rule 144 under

the Securities Act for six months or longer after the closing of the Acquisition, subject to “affiliate” status

with the Company under the Securities Act.

connection with the Acquisition, on June 13, 2021, an institutional investor (the “Investor”) entered into an agreement,

as amended on June 24, 2021, with SenlangBio related to the purchase of registered capital of SenlangBio (the “OpCo Capital Increase

Agreement”) pursuant to which the Investor will acquire an aggregate of up to 13.5% of the equity ownership of SenlangBio for an

aggregate purchase price (the “Subscription Amount) of approximately US$30,000,000 (represented by an actual investment of RMB200,000,000)

(the “Equity Financing”), which funds will be invested in SenlangBio in three equal installments of approximately US$10,000,000,

at a fixed price, the first to be upon the closing of the Acquisition, the second to be within three months after the closing and the

third to be within six months after the closing.

In addition, pursuant to a Securities Exchange Agreement, as amended on June 24, 2021

(the “Exchange Agreement”), by and among the Company, Sen Lang BVI, SenlangBio and the Investor, dated June 13, 2021, the

Investor shall have the right, exercisable between the six-month and five year-anniversaries of the respective initial closing and installment

closings, to elect to exchange, from time to time, all or part of its then-owned equity ownership of SenlangBio for shares (the “Exchange

Shares”) of Avalon Common Stock at a fixed exchange price of US$1.21 per share of Avalon Common Stock, which was the market price

of the Avalon Common Stock as of the date of the Exchange Agreement under Nasdaq rules.

In addition, the Exchange Agreement provides

that the Investor may only exchange up to 10% of its total investment amount in any 30 day period.

Line of Credit

As of November 4, 2021, the Company drew down an additional

aggregate of $1,000,000 from its credit facility under that certain credit line agreement with Wenzhao “Daniel”

Lu (the “Lender”), a significant shareholder and director of the Company, which provides the Company with a $20 million line

of credit (together with related documentation, the “Line of Credit”).

The draw down aggregating $1,000,000 is intended

to provide working capital for the Company to use on a temporary basis for certain obligations in connection with the Company’s

As a result of these draw downs, the Company has approximately $15.3 million remaining available under the Line of

This draw down increased the total principal amount outstanding under the Line of Credit to $4.7 million.

following exhibits are filed as part of, or incorporated by reference into, this Quarterly Report on Form 10-Q.

Market Sale AgreementSM, dated as of December 13, 2019, by and between Avalon GloboCare Corp.

Open Market Sale AgreementSM, dated as of December 13, 2019, by and between Avalon GloboCare Corp.

and Jefferies LLC.

(incorporated by

reference to Exhibit 1.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on December 13, 2019)

and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 of the Current Report on Form

8-K/A filed with the Securities and Exchange Commission on April 26, 2018)

and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.2 of the Current Report on Form 8-K/A filed with the

Securities and Exchange Commission on April 26, 2018)

of Subscription Agreement by and between Avalon GloboCare Corp.

and the December 2016 Accredited Investors (incorporated by reference

to Exhibit 4.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on December 21, 2016)

Option issued to Luisa Ingargiola dated February 21, 2017 (incorporated by reference to Exhibit 4.1 of the Current Report on Form

8-K filed with the Securities and Exchange Commission on February 21, 2017)

of Subscription Agreement by and between Avalon GloboCare Corp.

and the March 2017 Accredited Investor (incorporated by reference

to Exhibit 4.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on March 7, 2017)

Subscription Agreement between Avalon GloboCare Corp., Avalon (Shanghai) Healthcare Technology Co., Ltd., Beijing DOING Biomedical

Technology Co., Ltd.

and Daron Liang (incorporated by reference to Exhibit 4.2 of the Current Report on Form 8-K filed with the Securities

and Exchange Commission on March 7, 2017)

Agreement between Lu Wenzhao and Beijing DOING Biomedical Technology Co., Ltd.

(incorporated by reference to Exhibit 4.3 of the Current

Report on Form 8-K filed with the Securities and Exchange Commission on March 7, 2017)

of Subscription Agreement between Avalon GloboCare Corp.

and the October 2017 Accredited Investors (incorporated by reference to

Exhibit 4.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on October 26, 2017)

of Warrant to Boustead Securities, LLC in connection with the private placements (incorporated by reference to Exhibit 4.8 of the

Registration Statement on Form S-1/A filed with the Securities and Exchange Commission on July 27, 2018)

of Warrant (April 2019) (Incorporated by reference to Exhibit 4.1 of the Current Report on Form 8-K filed with the Securities and

Exchange Commission on April 26, 2019)

Exchange Agreement dated as of October 19, 2016 by and among Avalon Healthcare System, Inc., the shareholders of Avalon Healthcare

(incorporated by reference to Exhibit 1.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on December 13, 2019)

Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 of the Current Report on Form 8-K/A filed with the Securities and Exchange Commission on April 26, 2018)

Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3.2 of the Current Report on Form 8-K/A filed with the Securities and Exchange Commission on April 26, 2018)

Form of Subscription Agreement by and between Avalon GloboCare Corp.

and the December 2016 Accredited Investors (incorporated by reference to Exhibit 4.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on December 21, 2016)

Stock Option issued to Luisa Ingargiola dated February 21, 2017 (incorporated by reference to Exhibit 4.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on February 21, 2017)

Form of Subscription Agreement by and between Avalon GloboCare Corp.

and the March 2017 Accredited Investor (incorporated by reference to Exhibit 4.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on March 7, 2017)

Share Subscription Agreement between Avalon GloboCare Corp., Avalon (Shanghai) Healthcare Technology Co., Ltd., Beijing DOING Biomedical Technology Co., Ltd.

and Daron Liang (incorporated by reference to Exhibit 4.2 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on March 7, 2017)

Warranty Agreement between Lu Wenzhao and Beijing DOING Biomedical Technology Co., Ltd.

(incorporated by reference to Exhibit 4.3 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on March 7, 2017)

Form of Subscription Agreement between Avalon GloboCare Corp.

and the October 2017 Accredited Investors (incorporated by reference to Exhibit 4.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on October 26, 2017)

Form of Warrant to Boustead Securities, LLC in connection with the private placements (incorporated by reference to Exhibit 4.8 of the Registration Statement on Form S-1/A filed with the Securities and Exchange Commission on July 27, 2018)

Form of Warrant (April 2019) (Incorporated by reference to Exhibit 4.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on April 26, 2019)

Share Exchange Agreement dated as of October 19, 2016 by and among Avalon Healthcare System, Inc., the shareholders of Avalon Healthcare System, Inc.

and Avalon GloboCare Corp.

(incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the

Securities and Exchange Commission on October 19, 2016)

Employment Agreement, effective December 1, 2016, by and between Avalon GloboCare Corp.

and David Jin (incorporated by reference

to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on December 2, 2016)

of Sale by and between Freehold Craig Road Partnership, as Seller, and Avalon GloboCare Corp., as Buyer dated as of December 22,

2016 (incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission

on December 23, 2016)

Employment Agreement by and between Avalon (Shanghai) Healthcare Technology Ltd.

and Meng Li dated January 11, 2017 (incorporated

by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on January 11, 2017)

Retention Agreement by and between Avalon GloboCare Corp.

and Luisa Ingargiola dated February 21, 2017 (incorporated by reference

to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on February 21, 2017)

Indemnification

Agreement by and between Avalon GloboCare Corp.

and Luisa Ingargiola dated February 21, 2017 (incorporated by reference to Exhibit

10.2 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on February 21, 2017)

Agreement by and between Avalon GloboCare Corp.

(incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on October 19, 2016)

Executive Employment Agreement, effective December 1, 2016, by and between Avalon GloboCare Corp.

and David Jin (incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on December 2, 2016)

Agreement of Sale by and between Freehold Craig Road Partnership, as Seller, and Avalon GloboCare Corp., as Buyer dated as of December 22, 2016 (incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on December 23, 2016)

Executive Employment Agreement by and between Avalon (Shanghai) Healthcare Technology Ltd.

and Meng Li dated January 11, 2017 (incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on January 11, 2017)

Executive Retention Agreement by and between Avalon GloboCare Corp.

and Luisa Ingargiola dated February 21, 2017 (incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on February 21, 2017)

Indemnification Agreement by and between Avalon GloboCare Corp.

and Luisa Ingargiola dated February 21, 2017 (incorporated by reference to Exhibit 10.2 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on February 21, 2017)

Director Agreement by and between Avalon GloboCare Corp.

and Steven P.

Sukel dated April 28, 2017 (incorporated by reference to Exhibit 10.1

of the Current Report on Form 8-K filed with the Securities and Exchange Commission on April 28, 2017)

Agreement by and between Avalon GloboCare Corp.

and Yancen Lu dated April 28, 2017 (incorporated by reference to Exhibit 10.2 of

the Current Report on Form 8-K filed with the Securities and Exchange Commission on April 28, 2017)

Service Contract between Daopei Investment Management (Shanghai) Co., Ltd.

Sukel dated April 28, 2017 (incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on April 28, 2017)

Director Agreement by and between Avalon GloboCare Corp.

and Yancen Lu dated April 28, 2017 (incorporated by reference to Exhibit 10.2 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on April 28, 2017)

Consultation Service Contract between Daopei Investment Management (Shanghai) Co., Ltd.

and Avalon HealthCare System Inc.

dated April 1, 2016

(English translation) (incorporated by reference to Exhibit 10.8 of Amendment No.

1 to the Registration Statement on Form S-1 filed

with the Securities and Exchange Commission on July 7, 2017)

Service Contract between Hebei Yanda Ludaopei Hospital Co., Ltd and Avalon HealthCare System Inc.

dated April 1, 2016 (English translation)

(incorporated by reference to Exhibit 10.9 of Amendment No.

1 to the Registration Statement on Form S-1 filed with the Securities

and Exchange Commission on July 7, 2017)

Service Contract between Nanshan Memorial Stem Cell Biotechnology Co., Ltd.

dated April 1, 2016 (English translation) (incorporated by reference to Exhibit 10.8 of Amendment No.

1 to the Registration Statement on Form S-1 filed with the Securities and Exchange Commission on July 7, 2017)

Consultation Service Contract between Hebei Yanda Ludaopei Hospital Co., Ltd and Avalon HealthCare System Inc.

dated April 1, 2016 (English translation) (incorporated by reference to Exhibit 10.9 of Amendment No.

1 to the Registration Statement on Form S-1 filed with the Securities and Exchange Commission on July 7, 2017)

Consultation Service Contract between Nanshan Memorial Stem Cell Biotechnology Co., Ltd.

and Avalon HealthCare System Inc.

dated April 1, 2016

(English translation) (incorporated by reference to Exhibit 10.10 of Amendment No.

1 to the Registration Statement on Form S-1 filed

with the Securities and Exchange Commission on July 7, 2017)

Agreement between Lotus Capital Overseas Limited and Avalon (Shanghai) Healthcare Technology Co., Ltd.

dated April 19, 2017 (English

translation) (incorporated by reference to Exhibit 10.12 of the Quarterly Report on Form 10-Q filed with the Securities and Exchange

Commission on August 14, 2017)

Purchase Agreement between Avalon GloboCare Corp.

dated April 1, 2016 (English translation) (incorporated by reference to Exhibit 10.10 of Amendment No.

1 to the Registration Statement on Form S-1 filed with the Securities and Exchange Commission on July 7, 2017)

Loan Agreement between Lotus Capital Overseas Limited and Avalon (Shanghai) Healthcare Technology Co., Ltd.

dated April 19, 2017 (English translation) (incorporated by reference to Exhibit 10.12 of the Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on August 14, 2017)

Securities Purchase Agreement between Avalon GloboCare Corp.

and Genexosome Technologies Inc.

dated October 25, 2017 (incorporated by reference

to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on October 26, 2017)

Purchase Agreement between Genexosome Technologies Inc.

and Yu Zhou dated October 25, 2017 (incorporated by reference to Exhibit

10.2 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on October 26, 2017)

Purchase Agreement between Genexosome Technologies Inc., Beijing Jieteng (Genexosome) Biotech Co.

and Yu Zhou dated October

25, 2017 (incorporated by reference to Exhibit 10.3 of the Current Report on Form 8-K filed with the Securities and Exchange Commission

on October 26, 2017)

Retention Agreement between Genexosome Technologies Inc.

and Yu Zhou dated October 25, 2017 (incorporated by reference to Exhibit

10.4 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on October 26, 2017)

Assignment, Confidentiality, Non-Compete and Non-Solicit Agreement between Genexosome Technologies Inc.

and Yu Zhou dated October

25, 2017 (incorporated by reference to Exhibit 10.5 of the Current Report on Form 8-K filed with the Securities and Exchange Commission

on October 26, 2017)

Agreement by and between Avalon GloboCare Corp.

dated October 25, 2017 (incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on October 26, 2017)

Asset Purchase Agreement between Genexosome Technologies Inc.

and Yu Zhou dated October 25, 2017 (incorporated by reference to Exhibit 10.2 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on October 26, 2017)

Stock Purchase Agreement between Genexosome Technologies Inc., Beijing Jieteng (Genexosome) Biotech Co.

and Yu Zhou dated October 25, 2017 (incorporated by reference to Exhibit 10.3 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on October 26, 2017)

Executive Retention Agreement between Genexosome Technologies Inc.

and Yu Zhou dated October 25, 2017 (incorporated by reference to Exhibit 10.4 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on October 26, 2017)

Invention Assignment, Confidentiality, Non-Compete and Non-Solicit Agreement between Genexosome Technologies Inc.

and Yu Zhou dated October 25, 2017 (incorporated by reference to Exhibit 10.5 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on October 26, 2017)

Director Agreement by and between Avalon GloboCare Corp.

and Wilbert J.

Tauzin II dated November 1, 2017 (incorporated by reference to Exhibit

10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on November 7, 2017)

between Avalon GloboCare Corp.

and Tauzin Consultants, LLC dated November 1, 2017 (incorporated by reference to Exhibit 10.2 of the

Current Report on Form 8-K filed with the Securities and Exchange Commission on November 7, 2017)

Agreement by and between Avalon GloboCare Corp.

and David Jin dated April 3, 2018 (incorporated by reference to Exhibit 10.1 of the

Current Report on Form 8-K filed with the Securities and Exchange Commission on April 4, 2018)

Agreement by and between Avalon GloboCare Corp.

and Meng Li dated April 3, 2018 (incorporated by reference to Exhibit 10.2 of the

Current Report on Form 8-K filed with the Securities and Exchange Commission on April 4, 2018)

Service Contract between Ludaopei Hematology Research Institute Co., Ltd.

Tauzin II dated November 1, 2017 (incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on November 7, 2017)

Agreement between Avalon GloboCare Corp.

and Tauzin Consultants, LLC dated November 1, 2017 (incorporated by reference to Exhibit 10.2 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on November 7, 2017)

Letter Agreement by and between Avalon GloboCare Corp.

and David Jin dated April 3, 2018 (incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on April 4, 2018)

Letter Agreement by and between Avalon GloboCare Corp.

and Meng Li dated April 3, 2018 (incorporated by reference to Exhibit 10.2 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on April 4, 2018)

Advisory Service Contract between Ludaopei Hematology Research Institute Co., Ltd.

and Avalon (Shanghai) Healthcare Technology Co., Ltd.

April 1, 2018 (English translation) (Incorporated by reference to that Form S-1 Registration Statement filed with the Securities

and Exchange Commission on April 19, 2018)

of Subscription Agreement by and between Avalon GloboCare Corp.

and the April 2018 Accredited Investors (incorporated by reference

to Exhibit 4.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on April 18, 2018)

Supplementary

Agreement Related to Share Subscription by and between Avalon GloboCare Corp., Avalon (Shanghai) Healthcare Technology Co., Ltd.,

Beijing DOING Biomedical Technology Co., Ltd.

and Daron Liang dated April 23, 2018 (English translation) (incorporated by reference

to Exhibit 4.2 of the Current Report on Form 8-K/A filed with the Securities and Exchange Commission on April 26, 2018)

Extension Agreement between Lotus Capital Overseas Limited and Avalon (Shanghai) Healthcare Technology Co., Ltd.

dated May 3, 2018

(English translation) (incorporated by reference to Exhibit 10.18 of the Quarterly Report on Form 10-Q filed with the Securities

and Exchange Commission on May 11, 2018)

Agreement by and between Avalon GloboCare Corp.

and Tevi Troy dated June 4, 2018 (incorporated by reference to Exhibit 10.1

of the Current Report on Form 8-K filed with the Securities and Exchange Commission on June 6, 2018)

Venture Agreement by and between Avalon (Shanghai) Healthcare Technology Co., Ltd.

and Jiangsu Unicorn Biological Technology Co.,

dated May 29, 2018 (English translation) (incorporated by reference to Exhibit 99.1 of the Current Report on Form 8-K filed

with the Securities and Exchange Commission on June 6, 2018)

Agreement by and between Avalon GloboCare Corp.

and William Stilley, III dated July 5, 2018 (incorporated by reference to Exhibit

10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on July 10, 2018)

Agreement by and between Avalon GloboCare Corp.

dated April 1, 2018 (English translation) (Incorporated by reference to that Form S-1 Registration Statement filed with the Securities and Exchange Commission on April 19, 2018)

Form of Subscription Agreement by and between Avalon GloboCare Corp.

and the April 2018 Accredited Investors (incorporated by reference to Exhibit 4.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on April 18, 2018)

Supplementary Agreement Related to Share Subscription by and between Avalon GloboCare Corp., Avalon (Shanghai) Healthcare Technology Co., Ltd., Beijing DOING Biomedical Technology Co., Ltd.

and Daron Liang dated April 23, 2018 (English translation) (incorporated by reference to Exhibit 4.2 of the Current Report on Form 8-K/A filed with the Securities and Exchange Commission on April 26, 2018)

Loan Extension Agreement between Lotus Capital Overseas Limited and Avalon (Shanghai) Healthcare Technology Co., Ltd.

dated May 3, 2018 (English translation) (incorporated by reference to Exhibit 10.18 of the Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on May 11, 2018)

Director Agreement by and between Avalon GloboCare Corp.

and Tevi Troy dated June 4, 2018 (incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on June 6, 2018)

Joint Venture Agreement by and between Avalon (Shanghai) Healthcare Technology Co., Ltd.

and Jiangsu Unicorn Biological Technology Co., Ltd.

dated May 29, 2018 (English translation) (incorporated by reference to Exhibit 99.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on June 6, 2018)

Director Agreement by and between Avalon GloboCare Corp.

and William Stilley, III dated July 5, 2018 (incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on July 10, 2018)

Director Agreement by and between Avalon GloboCare Corp.

and Steven A.

Sanders dated July 30, 2018 (incorporated by reference to Exhibit

10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on July 31, 2018)

Extension Agreement between Lotus Capital Overseas Limited and Avalon (Shanghai) Healthcare Technology Co., Ltd.

dated August 3,

2018 (English translation) (incorporated by reference to Exhibit 10.30 of the Registration Statement on Form S-1/A filed with the

Securities and Exchange Commission on August 7, 2018)

Partnership Agreement between Avalon GloboCare Corp.

and Weill Cornell Medical College of Cornell University dated August 6, 2018

(incorporated by reference to Exhibit 10.31 of the Registration Statement on Form S-1/A filed with the Securities and Exchange Commission

on August 7, 2018)

Joint Venture Agreement by and between Avactis Biosciences, Inc., a wholly-owned subsidiary of Avalon GloboCare Corp., and Arbele

Limited for the establishment of AVAR (China) BioTherapeutics Ltd.

dated October 23, 2018 (incorporated by reference to Exhibit 10.1

of the Current Report on Form 8-K filed with the Securities and Exchange Commission on October 29, 2018)

Agreement by and between Avalon GloboCare Corp.

and David Jin dated January 3, 2019 (incorporated by reference to Exhibit 10.1 of

the Current Report on Form 8-K filed with the Securities and Exchange Commission on January 4, 2019)

Agreement by and between Avalon GloboCare Corp.

and Luisa Ingargiola dated January 3, 2019 (incorporated by reference to Exhibit

10.2 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on January 4, 2019)

Agreement by and between Avalon (Shanghai) Healthcare Technology Co.

and Meng Li dated January 3, 2019 (incorporated by reference

to Exhibit 10.3 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on January 4, 2019)

Note issued to Daniel Lu dated Mach 18, 2019 (incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with

the Securities and Exchange Commission on March 22, 2019)

Agreement by and between Avalon GloboCare Corp.

and Meng Li dated April 5, 2019 (Incorporated by reference to Exhibit 10.1 of the

Current Report on Form 8-K filed with the Securities and Exchange Commission on April 8, 2019)

Agreement by and between Avalon GloboCare Corp.

and Yue “Charles” Li dated April 5, 2019 (Incorporated by reference to

Exhibit 10.2 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on April 8, 2019)

of Securities Purchase Agreement dated April 25, 2019 (Incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K

filed with the Securities and Exchange Commission on April 26, 2019)

Line of Credit Agreement dated as of August 29, 2019 between Avalon GloboCare Corp.

and Wenzhao “Daniel” Lu dated August

29, 2019 (Incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission

on September 3, 2019)

of Warrant Redemption and Cancellation Agreement (Incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed

with the Securities and Exchange Commission on October 21, 2019)

Agreement by and between Avalon GloboCare Corp.

and David Jin dated February 20, 2020 (Incorporated by reference to Exhibit 10.1

of the Current Report on Form 8-K filed with the Securities and Exchange Commission on February 24, 2020)

Agreement by and between Avalon GloboCare Corp.

and Meng Li dated February 20, 2020 (Incorporated by reference to Exhibit 10.2 of

the Current Report on Form 8-K filed with the Securities and Exchange Commission on February 24, 2020)

Agreement by and between Avalon GloboCare Corp.

and Luisa Ingargiola dated February 20, 2020 (Incorporated by reference to Exhibit

10.3 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on February 24, 2020)

of Subsidiaries (incorporated by reference to Exhibit 21.1 of the Registration Statement on Form S-1/A filed with the Securities

and Exchange Commission on July 20, 2018)

Certification

of Chief Executive Officer pursuant to Section 302 of the Sarbanes Oxley Act

Certification

of Chief Financial Officer pursuant to Section 302 of the Sarbanes Oxley Act

Certification

of Chief Executive Officer and Chief Financial Officer pursuant to Section 906 of the Sarbanes-Oxley Act

XBRL Instance Document

XBRL Taxonomy Extension Schema Document.

XBRL Taxonomy Extension Calculation Linkbase Document.

XBRL Taxonomy Extension Definition Linkbase Document.

XBRL Taxonomy Extension Label Linkbase Document.

XBRL Taxonomy Extension Presentation Linkbase Document.

Page Interactive Data File (formatted as Inline XBRL and contained in Exhibit 101).

Sanders dated July 30, 2018 (incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on July 31, 2018)

Loan Extension Agreement between Lotus Capital Overseas Limited and Avalon (Shanghai) Healthcare Technology Co., Ltd.

dated August 3, 2018 (English translation) (incorporated by reference to Exhibit 10.30 of the Registration Statement on Form S-1/A filed with the Securities and Exchange Commission on August 7, 2018)

Strategic Partnership Agreement between Avalon GloboCare Corp.

and Weill Cornell Medical College of Cornell University dated August 6, 2018 (incorporated by reference to Exhibit 10.31 of the Registration Statement on Form S-1/A filed with the Securities and Exchange Commission on August 7, 2018)

Equity Joint Venture Agreement by and between Avactis Biosciences, Inc., a wholly-owned subsidiary of Avalon GloboCare Corp., and Arbele Limited for the establishment of AVAR (China) BioTherapeutics Ltd.

dated October 23, 2018 (incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on October 29, 2018)

Letter Agreement by and between Avalon GloboCare Corp.

and David Jin dated January 3, 2019 (incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on January 4, 2019)

Letter Agreement by and between Avalon GloboCare Corp.

and Luisa Ingargiola dated January 3, 2019 (incorporated by reference to Exhibit 10.2 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on January 4, 2019)

Letter Agreement by and between Avalon (Shanghai) Healthcare Technology Co.

and Meng Li dated January 3, 2019 (incorporated by reference to Exhibit 10.3 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on January 4, 2019)

Promissory Note issued to Daniel Lu dated Mach 18, 2019 (incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on March 22, 2019)

Director Agreement by and between Avalon GloboCare Corp.

and Meng Li dated April 5, 2019 (Incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on April 8, 2019)

Director Agreement by and between Avalon GloboCare Corp.

and Yue “Charles” Li dated April 5, 2019 (Incorporated by reference to Exhibit 10.2 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on April 8, 2019)

Form of Securities Purchase Agreement dated April 25, 2019 (Incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on April 26, 2019)

Revolving Line of Credit Agreement dated as of August 29, 2019 between Avalon GloboCare Corp.

and Wenzhao “Daniel” Lu dated August 29, 2019 (Incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on September 3, 2019)

Form of Warrant Redemption and Cancellation Agreement (Incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on October 21, 2019)

Letter Agreement by and between Avalon GloboCare Corp.

and David Jin dated February 20, 2020 (Incorporated by reference to Exhibit 10.1 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on February 24, 2020)

Letter Agreement by and between Avalon GloboCare Corp.

and Meng Li dated February 20, 2020 (Incorporated by reference to Exhibit 10.2 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on February 24, 2020)

Letter Agreement by and between Avalon GloboCare Corp.

and Luisa Ingargiola dated February 20, 2020 (Incorporated by reference to Exhibit 10.3 of the Current Report on Form 8-K filed with the Securities and Exchange Commission on February 24, 2020)

List of Subsidiaries (incorporated by reference to Exhibit 21.1 of the Registration Statement on Form S-1/A filed with the Securities and Exchange Commission on July 20, 2018)

Certification of Chief Executive Officer pursuant to Section 302 of the Sarbanes Oxley Act

Certification of Chief Financial Officer pursuant to Section 302 of the Sarbanes Oxley Act

Certification of Chief Executive Officer and Chief Financial Officer pursuant to Section 906 of the Sarbanes-Oxley Act

Instance Document

Taxonomy Extension Schema Document.

Taxonomy Extension Calculation Linkbase Document.

Taxonomy Extension Definition Linkbase Document.

Taxonomy Extension Label Linkbase Document.

Taxonomy Extension Presentation Linkbase Document.

Interactive Data File (formatted as Inline XBRL and contained in Exhibit 101).

Filed herewith

3 unchanged sentences

the undersigned hereunto duly authorized.

AVALON GLOBOCARE CORP.

August 16, 2021

Chief Executive Officer, President and Director

(Principal Executive Officer)

August 16, 2021

/s/ Luisa Ingargiola

AVALON GLOBOCARE

November 15, 2021

Chief Executive Officer,

President and Director (Principal Executive Officer)

November 15, 2021

Luisa Ingargiola

Chief Financial Officer

1 unchanged sentence

Compared sentence by sentence after normalising whitespace, quotation marks, case and digits, so re-formatting and restated figures do not read as changed language. Wording changes appear as one removal and one addition. The current filing and the prior one are authoritative.

What changed 10-Q

Item 5. Other Information